CN112033931B - Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system - Google Patents
Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system Download PDFInfo
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- CN112033931B CN112033931B CN202010930664.3A CN202010930664A CN112033931B CN 112033931 B CN112033931 B CN 112033931B CN 202010930664 A CN202010930664 A CN 202010930664A CN 112033931 B CN112033931 B CN 112033931B
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- 230000003287 optical effect Effects 0.000 title claims abstract description 113
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- 238000001514 detection method Methods 0.000 claims abstract description 12
- 238000000018 DNA microarray Methods 0.000 claims description 15
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 7
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 7
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 238000010146 3D printing Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 description 5
- 230000005284 excitation Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000007547 defect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
Abstract
The invention discloses an optical waveguide, wherein the top and the bottom of the optical waveguide are conical surfaces, and the conical surfaces and the optical waveguide main body part are integrally formed. In addition, a manufacturing method of the optical waveguide, a biosensing system comprising the optical waveguide and application of the biosensing system are also provided. The optical waveguide of the invention is easy to integrate and miniaturize, is easy to construct and is quick to shape, and the detection precision can be improved.
Description
Technical Field
The present invention relates to the field of optics, and more particularly to an optical waveguide, a method of manufacturing the same, a biosensing system comprising the same, and applications thereof.
Background
Optical waveguides are dielectric devices, also known as dielectric optical waveguides, that guide the propagation of light waves therein, and are used in optoelectronic integrated devices or optical fiber sensors. In the conventional optical waveguide application, in order to realize functions such as light condensation and splitting, an optical device such as an additional condenser or a beam splitter is often arranged between a light source and the optical waveguide, which causes defects that integration or miniaturization is difficult. Moreover, in the application of the existing optical waveguide in the sensor, the requirement of the incidence angle when the total reflection occurs is not considered, so that the detection precision is insufficient. In addition, the conventional optical waveguide is mostly made of quartz glass, and has the defects of complex process, difficult structure and low molding efficiency.
Therefore, there is an urgent need for an optical waveguide structure that is not only easy to integrate and miniaturize, easy to construct, rapid prototyping, but also can improve the detection accuracy.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to: provided are an optical waveguide structure which is easy to integrate and miniaturize, is easy to construct, is rapid to mold, and can improve detection accuracy, a method for manufacturing the same, a biosensing system including the same, and applications thereof.
In order to achieve the above purpose, the technical scheme of the invention is as follows:
in one aspect, the present invention provides an optical waveguide, wherein the top and bottom of the optical waveguide are tapered surfaces, the tapered surfaces being integrally formed with the optical waveguide body portion.
In a preferred embodiment, the top and bottom of the optical waveguide are concave conical surfaces.
In a preferred embodiment, the material of the optical waveguide is one or more of PMMA, PC, PS, more preferably a polymer of PMMA or PC, most preferably a PMMA polymer.
In a preferred embodiment, the optical waveguide is a column; more preferably a cylinder.
In a preferred embodiment, the diameter of the optical waveguide is in the order of microns, more preferably 100-500 microns, most preferably about 200 microns.
In a preferred embodiment, the optical waveguide described above is useful in a biochip, more preferably in a localized surface plasmon resonance biochip.
In a preferred embodiment, a plurality of said optical waveguides are integrated together to form an optical waveguide array for use in a biochip, more preferably in a localized surface plasmon resonance biochip.
In another aspect, the present invention provides a method of manufacturing the above optical waveguide structure, comprising: the optical waveguide is formed at one time through 3D printing.
In another aspect, the present invention provides a biosensing system comprising the optical waveguide structure described above.
In another aspect, the present invention provides the use of the optical waveguide described above or a biosensing system comprising the same, for the detection of a fluid sample.
The invention has the beneficial effects that:
1. the integrally formed optical waveguide structure is used, and an additional optical device is not required to be arranged between the light source and the optical waveguide, so that the optical waveguide structure is easy to integrate and miniaturize;
2. the top and bottom of the optical waveguide adopt conical surface design, so that not only can the miniaturization of the optical waveguide related devices be realized, but also the incidence angle when total reflection occurs is fully considered, thereby improving the detection precision of the sample.
3. Polymers such as PMMA and PC can be used as the constituent materials of the optical waveguide, can be formed at one time through 3D printing, and are easy to construct and can be formed rapidly.
In summary, the optical waveguide of the present invention is easy to integrate and miniaturize, is easy to construct, is rapid to mold, and can improve the detection accuracy.
Drawings
The invention is described in further detail below with reference to the accompanying drawings and examples, it being noted that the examples or embodiments described below are intended to facilitate an understanding of the invention and are not limiting.
FIG. 1 shows an embodiment of the structure of the optical waveguide of the present invention, in which the top and bottom of the optical waveguide are convex tapered surfaces;
FIG. 2 shows an embodiment of the structure of the optical waveguide of the present invention, in which the top and bottom of the optical waveguide are tapered surfaces that are concave;
FIG. 3 shows an exemplary embodiment of the optical waveguide of the present invention forming an optical waveguide array;
fig. 4 shows a light path diagram of light on an optical waveguide of an exemplary embodiment.
Fig. 5 shows an embodiment of the taper angle of the optical waveguide of the present invention.
Detailed Description
As required, detailed embodiments of the present invention are disclosed herein. However, those skilled in the art will appreciate that the disclosed detailed embodiments are merely exemplary of the invention, which may be embodied in various and suitable forms. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but as a basis for the claims and as a basis for teaching one skilled in the art to variously employ the present invention in virtually any appropriately detailed structure, structure or system.
Referring to fig. 1 to 2, there is shown a preferred embodiment of the structure of the optical waveguide of the present invention, the top and bottom of the optical waveguide in fig. 1 being outwardly convex tapered surfaces; the top and bottom of the optical waveguide in fig. 2 are concave conical surfaces. The conical surface structure of the optical waveguide is integrally formed with the optical waveguide main body part, and no additional optical device is required to be arranged. Those skilled in the art will appreciate that the tapered surface and optical waveguide shapes shown in fig. 1-2 are for illustration only and not for limitation. The optical waveguide of the present invention may have other suitable shapes, and the top and bottom of the optical waveguide may have other conical surfaces, so long as the refractive index of the incident light can be accurately measured.
Referring to fig. 3, an exemplary embodiment of the optical waveguide of the present invention forming an optical waveguide array is shown. The optical waveguide of the present invention can be used in a biochip, preferably a localized surface plasmon resonance biochip. Wherein the optical waveguides may be individually disposed in the substrate of the biochip, alternatively, a plurality of optical waveguides may be formed into an optical waveguide array disposed in the substrate of the biochip, such as the optical waveguide array shown in fig. 3. Those skilled in the art will appreciate that the shape of the optical waveguide array, the number of optical waveguides, and other features shown in fig. 3 are intended to be illustrative and not limiting.
Referring to fig. 4, an optical path diagram of light on an optical waveguide of an exemplary embodiment is shown. It will be appreciated by those skilled in the art that the light path diagram is illustrative only and does not limit the light to be incident from below, but may be incident from above or exit from below.
Referring to FIG. 5, there is shown the taper angle of the optical waveguide of the present inventionOne embodiment is a method. Wherein the method comprises the steps ofIn order to achieve an angle of entry,the incident angle is a conical angle. /> Where n1 is the air index and n2 is the index of refraction of the polymer optical waveguide. At a known angle of incidence +.>In the case of (2), the entry angle can be obtained by the above-mentioned relation>And a cone angle a. It will be understood by those skilled in the art that the entry angle, angle of incidence and cone angle shown in the drawings are for illustration only and not for limitation.
The optical waveguide is made of polymer materials, can be integrally formed by printing by adopting a 3D technology, and is easy to construct and quick to form.
The following description will be given by taking the application of the optical waveguide to a biochip as an example, in which different taper angles or different incident angles of the optical waveguide affect the accuracy of detecting a sample by the biochip.
This example was used to demonstrate the effect of different angles of incidence or cone angle on the accuracy of fluid sample concentration measurement. The principle of measuring the sample concentration in this embodiment is that: when the light waveguide array is irradiated by light, the surface plasmon resonance of the titanium nitride nanocubes is excited. The radial and circumferential polarization components can be phase shifted by a phase shifting device, thereby yielding differential phase values for the two polarization directions. The magnitude of the differential phase value is known to be related to the refractive index of the perimeter of the titanium nitride nanocube, which in turn is related to the concentration of the target object captured by the receptor (in this embodiment, the fluid sample), and the refractive index of each biological target object is different from the molecule, so that the measured concentration of the different fluid samples can be obtained by the measured differential phase value or the differential phase change value calculated based thereon.
An exemplary detection method is as follows:
the light receiving device uses light waveguide with top and bottom as concave conical surface as biological chip, uses titanium nitride nanometer cube with dispersed and fixed side surface as light waveguide to excite surface plasma resonance part, uses 633 nanometer laser as excitation light. It should be understood that the steps, structures, arrangements, wavelengths, substances, etc. of the method used in the present embodiment are examples, and those skilled in the art can adjust the steps according to the fluid sample to be measured, the purpose of detection, etc.
(1) Performing functional adsorption according to a conventional method, creating a base line value and a calibration curve;
(2) Introducing IgG antibody with fixed concentration of 10+/-0.1 pM into a biochip, and exciting the surface resonance of the titanium nitride nanocube by exciting light;
(3) The optical waveguide is irradiated by using the different incident angles of the collimated 633nm excitation light in the following table, the differential phase change value is obtained through the liquid crystal phase shifting device and substituted into the linear relation established through the calibration curve, and the measured concentration of the sample can be obtained, and the specific table is shown below.
(4) The effect of different angles of incidence on measurement accuracy can be derived by comparing the fixed concentration of the sample with the measured concentration of the sample obtained when incident at different angles of incidence.
As can be seen from the above table, this embodiment shows that the optical waveguide of the present invention has different effects on the measurement accuracy of the sample when different incident angles (corresponding to different cone angles of the optical waveguide) are adopted, and those skilled in the art can select different cone angles of the optical waveguide or different incident angles of the excitation light according to the wavelength of the excitation light adopted and the difference of the substances of the surface plasmon resonance portion of the optical waveguide, so as to realize accurate measurement of the sample to be measured.
In summary, the optical waveguide of the present invention has a tapered structure, which is easy to integrate and miniaturize and can improve the detection accuracy, and is made of a polymer material, which is easy to construct and mold quickly.
It is to be understood that although preferred embodiments have been described in detail hereinabove, the invention is not limited to the materials, structures and arrangements of features described and illustrated herein, which are merely exemplary preferred embodiments of the invention, which can be embodied in various equivalent forms.
Claims (16)
1. The optical waveguide is characterized in that the top and the bottom of the optical waveguide are conical surfaces, the conical surfaces and the optical waveguide main body part are integrally formed, the optical waveguide is made of one or more of PMMA, PC, PS, the conical surfaces are concave conical surfaces, and the excited surface plasmon resonance part of the optical waveguide is a titanium nitride nanocube.
2. The optical waveguide according to claim 1, wherein the material of the optical waveguide is a polymer of PMMA or PC.
3. The optical waveguide of claim 2, wherein the material of the optical waveguide is PMMA polymer.
4. The optical waveguide of claim 1, wherein the optical waveguide is a columnar body.
5. The optical waveguide of claim 4, wherein the optical waveguide is a cylinder.
6. The optical waveguide of claim 1, wherein the optical waveguide has a diameter on the order of microns.
7. The optical waveguide of claim 6, wherein the optical waveguide has a diameter of 100-500 microns.
8. The optical waveguide of claim 6, wherein the optical waveguide has a diameter of 200 microns.
9. The optical waveguide according to any one of claims 1 to 8, wherein the optical waveguide is for a biochip.
10. The optical waveguide of claim 9, wherein the optical waveguide is used in a localized surface plasmon resonance biochip.
11. The optical waveguide of any one of claims 1-8, wherein a plurality of the optical waveguides are integrated together to form an optical waveguide array for a biochip.
12. The optical waveguide of claim 11, wherein the optical waveguide array is for a localized surface plasmon resonance biochip.
13. A method of manufacturing the optical waveguide of any one of claims 1-8, comprising: the optical waveguide is formed at one time through 3D printing.
14. A biosensing system comprising the optical waveguide of any of claims 1-8.
15. Use of the optical waveguide of any one of claims 1-8 for fluid sample detection.
16. Use of the biosensing system of claim 14 in fluid sample detection.
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| CN202010930664.3A CN112033931B (en) | 2020-09-07 | 2020-09-07 | Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system |
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| CN112033931B true CN112033931B (en) | 2024-04-12 |
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| CN112848282B (en) * | 2021-01-07 | 2021-11-26 | 芯体素(杭州)科技发展有限公司 | Organic optical waveguide preparation method based on embedded 3D printing |
| CN115290605B (en) * | 2022-04-29 | 2024-01-02 | 科竟达生物科技有限公司 | Incandescent surface plasmon resonance biochip, method for manufacturing the same, biosensing system comprising the same and use thereof |
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