CN112033931A - Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system - Google Patents
Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system Download PDFInfo
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- CN112033931A CN112033931A CN202010930664.3A CN202010930664A CN112033931A CN 112033931 A CN112033931 A CN 112033931A CN 202010930664 A CN202010930664 A CN 202010930664A CN 112033931 A CN112033931 A CN 112033931A
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- optical waveguide
- biosensing system
- biochip
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- 230000003287 optical effect Effects 0.000 title claims abstract description 106
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- 238000001514 detection method Methods 0.000 claims abstract description 11
- 238000000018 DNA microarray Methods 0.000 claims description 16
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 7
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 238000010146 3D printing Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 description 5
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 description 4
- 230000005284 excitation Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000007547 defect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000013076 target substance Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
Abstract
The invention discloses an optical waveguide, wherein the top and the bottom of the optical waveguide are conical surfaces, and the conical surfaces and the main body part of the optical waveguide are integrally formed. In addition, a manufacturing method of the optical waveguide, a biosensing system comprising the optical waveguide and application of the optical waveguide are also provided. The optical waveguide of the present invention is easy to integrate and miniaturize, easy to construct, and fast to form, and can improve detection accuracy.
Description
Technical Field
The present invention relates to the field of optics, and in particular, to an optical waveguide, a method for manufacturing the same, a biosensing system including the same, and applications thereof.
Background
The optical waveguide is a dielectric device for guiding light waves to propagate in the optical waveguide, is also called as a dielectric optical waveguide, and can be applied to optoelectronic integrated devices or optical fiber sensors. In the application of the existing optical waveguide, in order to realize the functions of light condensation, division and the like, optical devices such as an additional condenser lens, a beam splitter and the like are often arranged between a light source and the optical waveguide, which causes the defect of difficult integration or miniaturization. In addition, the conventional optical waveguide does not consider the requirement on the incident angle when total reflection occurs in the application of the sensor, and thus the detection accuracy is insufficient. In addition, the existing optical waveguide is mostly composed of quartz glass, and has the defects of complex process, difficult structure and low forming efficiency.
Therefore, there is an urgent need for an optical waveguide structure that is easy to integrate and miniaturize, easy to construct, and quick to mold, and can improve detection accuracy.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to: an optical waveguide structure which is easily integrated and miniaturized, is easily constructed, is rapidly molded, and can improve detection accuracy, a method of manufacturing the same, a biosensing system including the same, and applications thereof are provided.
In order to achieve the purpose, the technical scheme of the invention is as follows:
in one aspect, the present invention provides an optical waveguide wherein the top and bottom of the optical waveguide are tapered surfaces that are integrally formed with the optical waveguide body portion.
In a preferred embodiment, the top and bottom of the optical waveguide are concave tapered surfaces.
In a preferred embodiment, the material of the optical waveguide is one or more of PMMA, PC, PS, more preferably a polymer of PMMA or PC, most preferably a PMMA polymer.
In a preferred embodiment, the optical waveguide is a cylindrical body; more preferably a cylinder.
In a preferred embodiment, the diameter of the optical waveguide is on the order of microns, more preferably 100-500 microns, and most preferably about 200 microns.
In a preferred embodiment, the above optical waveguide is used in a biochip, more preferably in a localized surface plasmon resonance biochip.
In a preferred embodiment, a plurality of said optical waveguides are integrated together to form an optical waveguide array for use in a biochip, more preferably for use in a localized surface plasmon resonance biochip.
In another aspect, the present invention provides a method of manufacturing the above optical waveguide structure, comprising: the optical waveguide is formed in one step through 3D printing.
In another aspect, the present invention provides a biosensing system comprising the optical waveguide structure described above.
In another aspect, the present invention provides the use of the optical waveguide described above or a biosensing system comprising the same for the detection of a fluid sample.
The invention has the beneficial effects that:
1. the integrated optical waveguide structure is used, and an additional optical device is not required to be arranged between the light source and the optical waveguide, so that the optical waveguide structure is easy to integrate and miniaturize;
2. the top and the bottom of the optical waveguide adopt the conical surface design, so that the optical waveguide related device can be miniaturized, and the incident angle when the total reflection occurs is fully considered, thereby improving the detection precision of the sample.
3. The polymer such as PMMA, PC and the like is used as a composition material of the optical waveguide, can be formed at one time through 3D printing, is easy to construct and can be quickly formed.
In conclusion, the optical waveguide of the present invention is easy to integrate and miniaturize, easy to construct, and fast to form, and can improve the detection precision.
Drawings
The invention is described in further detail below with reference to the figures and examples, it being noted that the examples or embodiments described below are intended to facilitate the understanding of the invention and are not intended to be limiting.
FIG. 1 shows one embodiment of the structure of an optical waveguide of the present invention, wherein the top and bottom of the optical waveguide are convexly tapered surfaces;
FIG. 2 shows one embodiment of the structure of an optical waveguide of the present invention in which the top and bottom of the optical waveguide are concave tapered surfaces;
FIG. 3 shows an illustrative embodiment of an optical waveguide of the present invention forming an optical waveguide array;
fig. 4 shows an optical path diagram of light on an optical waveguide of an illustrative embodiment.
Fig. 5 illustrates one embodiment of the taper angle of the optical waveguide of the present invention.
Detailed Description
As required, detailed embodiments of the present invention are disclosed herein. However, it is to be understood by those skilled in the art that the disclosed embodiments are merely exemplary of the invention, which can be embodied in various and suitable forms. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a basis for teaching one skilled in the art to variously employ the present invention in any appropriate arrangement, structure or system.
Referring to fig. 1 to 2, showing a preferred embodiment of the structure of the optical waveguide of the present invention, the top and bottom of the optical waveguide in fig. 1 are convex tapered surfaces; the top and bottom of the optical waveguide in fig. 2 are concave tapered surfaces. The conical surface structure of the optical waveguide is integrally formed with the main body part of the optical waveguide, and an additional optical device is not required to be arranged. Those skilled in the art will appreciate that the taper and optical waveguide shapes shown in fig. 1-2 are for illustration only, and not for limitation. The optical waveguide of the present invention may have other suitable shapes, and the top and bottom thereof may have other tapered surfaces, as long as the refractive index of incident light can be accurately measured.
Referring to fig. 3, there is shown an exemplary embodiment of the optical waveguides of the present invention forming an optical waveguide array. The optical waveguide of the present invention can be used in a biochip, preferably in a localized surface plasmon resonance biochip. Wherein the optical waveguides can be individually and separately disposed in the substrate of the biochip, alternatively, a plurality of optical waveguides can also form an optical waveguide array disposed in the substrate of the biochip, such as the optical waveguide array shown in fig. 3. Those skilled in the art will appreciate that the shape of the array of optical waveguides, the number of optical waveguides, and other features shown in FIG. 3 are intended to be illustrative, and not limiting.
Referring to fig. 4, a diagram of the path of light on an optical waveguide of an exemplary embodiment is shown. It will be understood by those skilled in the art that the light path diagram is only illustrative and not limiting, and the light must be incident from below, and can be incident from above and exiting from below.
Referring to fig. 5, one embodiment of the taper angle of the optical waveguide of the present invention is shown. Wherein
In order to be an angle of entry,
is the angle of incidence, and A is the cone angle.
Where n1 is the refractive index of air and n2 is the refractive index of the polymer optical waveguide. At a known angle of incidence
In the case of (3), the entrance angle can be obtained by the above relational expression
And a cone angle a. Those skilled in the art will appreciate that the entry angles, incident angles, and cone angles shown in the figures are for illustration only and not for limitation.
The optical waveguide is made of polymer materials, can be printed and integrally formed by adopting a 3D technology, and is easy to construct and fast to form.
The following is an example of the application of the optical waveguide in a biochip, and it is explained that different cone angles or different incident angles of the optical waveguide affect the accuracy of detecting a sample by the biochip.
This example is used to demonstrate the effect of different incident or cone face angles on the accuracy of the fluid sample concentration measurement. The principle of measuring the concentration of the sample in this embodiment is as follows: when the optical waveguide array is irradiated by light, the surface plasma resonance of the titanium nitride nano-cubic body is excited. The radial and circumferential polarization components can be phase-shifted by means of a phase shifting device, whereby a differential phase value is obtained for both polarization directions. It is known that the magnitude of the differential phase value is related to the refractive index of the periphery of the titanium nitride nanocube, which is related to the concentration of the target substance (in this embodiment, the fluid sample) captured by the receptor, and the refractive index of each biological target substance is different, so that the measured concentration of different fluid samples can be obtained by measuring the differential phase value or the differential phase change value calculated based on the measured differential phase value.
An exemplary detection method is as follows:
the optical waveguide with the top and the bottom both being concave conical surfaces is used as a light receiving device of the biochip, the titanium nitride nanocubes dispersed and fixed on the side surface of the optical waveguide are used as an optical waveguide excitation surface plasma resonance part, and 633 nanometer laser is used as excitation light. It should be understood that the method steps, structures, arrangements, wavelengths, substances, etc. used in the present embodiment are all examples, and those skilled in the art can adjust the method steps, structures, arrangements, wavelengths, substances, etc. according to the fluid sample to be tested and the detection purpose.
(1) Performing functional adsorption, establishing a baseline value and establishing a calibration curve according to a conventional method;
(2) introducing IgG antibody with fixed concentration of 10 +/-0.1 pM into a biochip, and exciting the surface of the titanium nitride nano cube to resonate by exciting light;
(3) the method comprises the steps of irradiating the optical waveguide by adopting different incidence angles in the following table of a standard 633nm exciting light, obtaining a differential phase change value through a liquid crystal phase shift device, substituting the differential phase change value into a linear relation established through a calibration curve, and obtaining the measured concentration of a sample, wherein the specific table is shown below.
(4) The fixed concentration of the sample is compared with the measured concentration of the sample obtained when the sample is incident at different incident angles, so that the influence of different incident angles on the measurement precision can be obtained.
As can be seen from the above table, this embodiment shows that the optical waveguide of the present invention has different effects on the measurement accuracy of the sample when different incident angles (corresponding to different cone angles of the optical waveguide) are used, and those skilled in the art can select different cone angles of the optical waveguide or different incident angles of the excitation light according to the wavelength of the excitation light used and the material of the surface plasmon resonance portion of the optical waveguide, so as to realize the accurate measurement of the sample to be measured.
In summary, the optical waveguide of the present invention is easy to integrate and miniaturize and can improve the detection accuracy due to the tapered structure, and the optical waveguide of the present invention is made of a polymer material, and is easy to construct and quickly mold.
It is to be understood that while preferred embodiments have been described in detail hereinabove, the invention is not limited to the arrangement of materials, structures and features described and illustrated herein, which are merely exemplary of preferred embodiments of the invention, which may be embodied in various equivalent forms.
Claims (10)
1. An optical waveguide, wherein the top and bottom of the optical waveguide are tapered surfaces, and the tapered surfaces are integrally formed with the body portion of the optical waveguide.
2. The optical waveguide of claim 1, wherein the tapered surface is a concave tapered surface.
3. Optical waveguide according to claim 1, characterized in that the material of the optical waveguide is one or more of PMMA, PC, PS, preferably PMMA or a polymer of PC, most preferably PMMA polymer.
4. The optical waveguide of claim 1, wherein the optical waveguide is a cylinder; preferably a cylinder.
5. Optical waveguide according to claim 1, characterized in that the diameter of the optical waveguide is of the order of microns, preferably 100-500 microns, preferably about 200 microns.
6. Optical waveguide according to any of claims 1-5, characterized in that the optical waveguide is used in a biochip, preferably in a localized surface plasmon resonance biochip.
7. Optical waveguide according to any of claims 1-5, characterized in that a plurality of said optical waveguides are integrated together to form an optical waveguide array for a biochip, preferably for a localized surface plasmon resonance biochip.
8. A method of manufacturing an optical waveguide according to any of claims 1 to 7, comprising: the optical waveguide is formed in one step through 3D printing.
9. A biosensing system comprising the optical waveguide of any of claims 1-7.
10. Use of the optical waveguide of any one of claims 1-7 or the biosensing system of claim 9 for the detection of a fluid sample.
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| CN202010930664.3A CN112033931B (en) | 2020-09-07 | 2020-09-07 | Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system |
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| CN202010930664.3A CN112033931B (en) | 2020-09-07 | 2020-09-07 | Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system |
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| CN112033931B CN112033931B (en) | 2024-04-12 |
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Cited By (2)
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| CN115290605A (en) * | 2022-04-29 | 2022-11-04 | 科竟达生物科技有限公司 | Incandescent surface plasmon resonance biochip, method for manufacturing same, biosensing system comprising same and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112848282A (en) * | 2021-01-07 | 2021-05-28 | 西湖未来智造(杭州)科技发展有限公司 | Organic optical waveguide preparation method based on embedded 3D printing |
| CN115290605A (en) * | 2022-04-29 | 2022-11-04 | 科竟达生物科技有限公司 | Incandescent surface plasmon resonance biochip, method for manufacturing same, biosensing system comprising same and application thereof |
| CN115290605B (en) * | 2022-04-29 | 2024-01-02 | 科竟达生物科技有限公司 | Incandescent surface plasmon resonance biochip, method for manufacturing the same, biosensing system comprising the same and use thereof |
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| CN112033931B (en) | 2024-04-12 |
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