CN201156048Y - Optical fiber biological sensor for Opioid drug concentration measurement - Google Patents
Optical fiber biological sensor for Opioid drug concentration measurement Download PDFInfo
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- CN201156048Y CN201156048Y CNU2007203120195U CN200720312019U CN201156048Y CN 201156048 Y CN201156048 Y CN 201156048Y CN U2007203120195 U CNU2007203120195 U CN U2007203120195U CN 200720312019 U CN200720312019 U CN 200720312019U CN 201156048 Y CN201156048 Y CN 201156048Y
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- optical fiber
- metal level
- opioid drug
- porous silicon
- drug concentration
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Abstract
The utility model discloses an optical fiber biosensor for detecting the concentration of opium type drugs, which comprises optical fiber, a metallic layer, and a nanometer porous silicon sol-gel layer, wherein, the metallic layer is coated on the optical fiber, the nanometer porous silicon sol-gel layer is covered on the metallic layer, a sensitive layer which can react with the opium type drugs is arranged between the metallic layer and the nanometer porous silicon sol-gel layer, and is connected with the metallic layer through a connecting object, and the coupling object is albumen A, dextran, or mercaptan. The optical fiber biosensor has the advantages that the structure is simple, the concentration of the blood drug of the opium type drugs can be directly measured, special treatment for the sample is not required, the data is reliable, the security is good, the performance is steady, the continuous, online, and real-time measurement to the blood drug concentration can be realized, the resources can be saved, and the labor intensity of the working personnel can be reduced.
Description
Technical field
The utility model relates to a kind of biology sensor, the especially a kind of optical fiber biosensor that can measure opioid drug concentration.
Background technology
At present, the analgesia in the operation adopts opioid drug to keep suitable depth of anesthesia in the anesthesia surgery process.The control of depth of anesthesia is of crucial importance, is related to the life and death of patient with operation.The blood concentration of arcotic just is first determinative of the anesthesia depth, can not accomplish real-time, online, METHOD FOR CONTINUOUS DETERMINATION blood concentration now, the factor that influences blood concentration simultaneously is also many, causes the arcotic blood concentration fluctuation very big, and this is in danger patient with operation.
Thereby adopt target controlled infusion to control the blood concentration control depth of anesthesia of arcotic at present.Target controlled infusion is the pharmacokinetic parameter programming input computing machine that former studies is measured, and the infusion rates of computing machine follow procedure control infusion pump keeps and regulate and control institute requiring the target blood concentration that reaches, and the purpose of blood concentration is controlled in realization.But the parameter that target controlled infusion uses is not patient's a pharmacokinetic parameter, but used the result of pharmacokinetics and pharmacodynamic study in the past, this and patient's pharmacokinetics feature is inconsistent, so the blood concentration diversity ratio of target control concentration during target controlled infusion and practical measurement is bigger.This is in danger the patient, as the delay of reviving, gerontal patient's fluctuation of blood pressure are big, even causes death etc.Thereby, in time measure blood concentration and in time adjust infusion rates, realize individual administration, can greatly improve security, the controllability of anesthesia.In addition, Instrument measuring blood concentrations such as high performance liquid chromatograph also commonly used, fluorescence spectrophotometry instrument, liquid matter simultaneous determination instrument, these appliance requires are handled sample, need certain man power and material, and expend time in, can not on-line determination, the blood concentration value that determines has not had the actual clinical meaning for the patient in the operation.
Summary of the invention
The purpose of this utility model provides a kind of optical fiber biosensor of measuring opioid drug concentration, it can be real-time, online, the blood concentration of METHOD FOR CONTINUOUS DETERMINATION opiates medicine, the blood concentration of adjusting the opiates medicine for the speed of regulation and control administration provides foundation, thereby realize carrying out individual administration, guarantee the safety of anesthesia.
For achieving the above object, the technical solution of the utility model is: a kind of optical fiber biology sensor of measuring opioid drug concentration, comprise optical fiber, metal level and nano-structure porous silicon sol-gel layer, described metal level is plated on the optical fiber, described nano-structure porous silicon sol-gel layer is coated on the metal level, also have between described metal level and the nano-structure porous silicon sol-gel layer-sensitive layer that layer can react to opioid drug, described sensitive layer connects with metal level mutually by connecting thing, and described connection thing is albumin A or glucosan or mercaptan.
Described metal level is a composite metal membrane.
Described metal level is the metal island.
The end shape of described sensor is cylindrical or conical or wedge shape or a truncated cone-shaped of semisphere.
In the nano-structure porous silicon sol-gel layer of described biology sensor the material that combines with the opiates medicine is arranged.
The beneficial effects of the utility model are, it is simple in structure, can directly measure the blood concentration of opioid drug, do not need the sample special processing, data are reliable, and security is good, stable performance, can realize continuous, online and the The real time measure blood concentration, economize on resources, reduce staff's labour intensity.
Description of drawings
Fig. 1 is a kind of stereographic map of the present utility model;
Fig. 2 is a cross-sectional structure synoptic diagram of the present utility model;
Fig. 3 is second kind of stereographic map of the present utility model;
Fig. 4 is the third stereographic map of the present utility model;
Fig. 5 is the 4th a kind of stereographic map of the present utility model;
Fig. 6 is the 5th a kind of stereographic map of the present utility model.
Embodiment
As illustrated in fig. 1 and 2, the optical fiber biosensor of mensuration opioid drug concentration of the present utility model, its end shape is a truncated cone-shaped, it comprises glass optical fiber 1, metal level 4, sensitive layer 3 and nano-structure porous silicon sol-gel layer 2, metal level 4 is plated on the optical fiber 1, sensitive layer 3 connects with metal level 4 mutually by connecting thing, and nano-structure porous silicon sol-gel layer 2 is coated on the sensitive layer 3.This metal level 4 is metal island or metal film.Manufacturing process of the present utility model is: the bag tegillum of glass optical fiber one end peeled off, and through after the cleaning, metal cladding 4 on glass optical fiber 1 (comprising zinc or metals such as aluminium or silver or chromium or gold); The antibody that connects metal level 4 and μ acceptor (containing μ 1 acceptor) then with albumin A, glucosan or mercaptan equijoin thing, the antibody of μ acceptor combines with μ acceptor (containing μ 1 acceptor) again, connect with phospholipid molecule between the acceptor, generate the sensitive layer 3 of measuring opioid drug with method from combination; Afterwards, with or wrap processedly without the end that silicon sol-gel contains acceptor to optical fiber, promptly make the detecting head of the biology sensor of a kind of mensuration opiates (making fourth, morphine, fentanyl, Remifentanil, alfentanil etc. as degree) medicine blood concentration.
Shown in Fig. 3 to 6, the optical fiber biosensor of mensuration opioid drug concentration of the present utility model, its end shape can be made semisphere cylindrical or conical or wedge shape or truncated cone-shaped.
Method of operating of the present utility model is: when measuring the blood concentration of opiates medicine, detecting head is inserted in the blood, light with certain intensity and wavelength reaches detecting head through the conduction of y-type optical fiber one end, according to the surface plasma body resonant vibration principle, the light intensity of reflection is relevant with the amount of metal surface bound substances, enter fiber spectrometer mensuration from the reflected light of detecting head reflection through the other end conduction of y-type optical fiber, can measure opiates (making fourth, morphine, fentanyl, Remifentanil, alfentanil etc. as degree) medicine blood concentration in view of the above.
Claims (4)
1. optical fiber biosensor of measuring opioid drug concentration, comprise optical fiber (1), metal level (4) and nano-structure porous silicon sol-gel layer (2), described metal level (4) is plated in (1) on the optical fiber, described nano-structure porous silicon sol-gel layer (2) is coated on the metal level (4), it is characterized in that: the sensitive layer (3) that also has one deck to react to opioid drug between described metal level (4) and the nano-structure porous silicon sol-gel layer (2), described sensitive layer (3) connects with metal level (4) mutually by connecting thing, and described connection thing is albumin A or glucosan or mercaptan.
2. the optical fiber biosensor of mensuration opioid drug concentration according to claim 1 is characterized in that: described metal level (4) is a composite metal membrane.
3. the optical fiber biosensor of mensuration opioid drug concentration according to claim 1 is characterized in that: described metal level (4) is the metal island.
4. the optical fiber biosensor of mensuration opioid drug concentration according to claim 1 is characterized in that: the end shape of described sensor is cylindrical or conical or wedge shape or a truncated cone-shaped of semisphere.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007203120195U CN201156048Y (en) | 2007-12-05 | 2007-12-05 | Optical fiber biological sensor for Opioid drug concentration measurement |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007203120195U CN201156048Y (en) | 2007-12-05 | 2007-12-05 | Optical fiber biological sensor for Opioid drug concentration measurement |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201156048Y true CN201156048Y (en) | 2008-11-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007203120195U Expired - Fee Related CN201156048Y (en) | 2007-12-05 | 2007-12-05 | Optical fiber biological sensor for Opioid drug concentration measurement |
Country Status (1)
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| CN (1) | CN201156048Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108535220A (en) * | 2018-07-17 | 2018-09-14 | 河南师范大学 | Wedge shaped tip nanostructure integrated optical fiber surface plasma resonance biochemical sensor |
| CN108982422A (en) * | 2018-07-17 | 2018-12-11 | 河南师范大学 | Self-correcting conical end face surface plasma resonance integrated biochemical sensor |
| WO2019122006A1 (en) * | 2017-12-19 | 2019-06-27 | Vn Jr-Ip Limited | A sensor comprising a nanoporous material and method for detecting an analyte using the sensor |
| CN112033931A (en) * | 2020-09-07 | 2020-12-04 | 科竟达生物科技有限公司 | Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system |
-
2007
- 2007-12-05 CN CNU2007203120195U patent/CN201156048Y/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019122006A1 (en) * | 2017-12-19 | 2019-06-27 | Vn Jr-Ip Limited | A sensor comprising a nanoporous material and method for detecting an analyte using the sensor |
| CN108535220A (en) * | 2018-07-17 | 2018-09-14 | 河南师范大学 | Wedge shaped tip nanostructure integrated optical fiber surface plasma resonance biochemical sensor |
| CN108982422A (en) * | 2018-07-17 | 2018-12-11 | 河南师范大学 | Self-correcting conical end face surface plasma resonance integrated biochemical sensor |
| CN108982422B (en) * | 2018-07-17 | 2024-02-27 | 河南师范大学 | Self-calibrating conical end surface plasma resonance integrated biochemical sensor |
| CN108535220B (en) * | 2018-07-17 | 2024-02-27 | 河南师范大学 | Wedge-shaped tip nanostructure integrated optical fiber surface plasma resonance biochemical sensor |
| CN112033931A (en) * | 2020-09-07 | 2020-12-04 | 科竟达生物科技有限公司 | Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system |
| CN112033931B (en) * | 2020-09-07 | 2024-04-12 | 科竟达生物科技有限公司 | Optical waveguide, manufacturing method thereof, biosensing system comprising optical waveguide and application of biosensing system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081126 Termination date: 20111205 |