CN112023017A - Traditional Chinese medicine preparation for treating alopecia and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating alopecia and preparation method thereof Download PDF

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CN112023017A
CN112023017A CN202011098055.2A CN202011098055A CN112023017A CN 112023017 A CN112023017 A CN 112023017A CN 202011098055 A CN202011098055 A CN 202011098055A CN 112023017 A CN112023017 A CN 112023017A
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chinese medicine
traditional chinese
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slicing
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段晓剑
韩利华
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/64Orobanchaceae (Broom-rape family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00Essential oils; Perfumes
    • C11B9/02Recovery or refining of essential oils from raw materials
    • C11B9/027Recovery of volatiles by distillation or stripping
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention relates to a traditional Chinese medicine preparation for treating alopecia, which is prepared from a traditional Chinese medicine composition containing the following medicinal materials: 50-90 parts of prepared rehmannia root, 40-80 parts of black sesame, 40-80 parts of Chinese angelica, 30-70 parts of platycladi seed, 20-60 parts of prepared fleece-flower root, 20-60 parts of cacumen biotae, 50-90 parts of honey, 30-80 parts of cistanche, 10-50 parts of ginger, 20-60 parts of scutellaria baicalensis, 20-70 parts of ligusticum wallichii and 15-80 parts of codonopsis pilosula. The traditional Chinese medicine preparation has a medicinal material formula which is proved and improved in nearly 40 years, has a cure rate of up to 95 percent through clinical effects and follow-up survey of countless actual cases, and generates side effects. According to the traditional Chinese medicine formula, by means of balancing and regulating functions of various organs, the traditional Chinese medicine formula has the functions of tonifying liver and kidney, moistening the five internal organs, benefiting essence and blood, strengthening immunity, expelling toxin, beautifying, benefiting sleep, benefiting qi, nourishing blood, resisting oxidation, promoting hair follicle growth and the like, and finally achieves the purposes of growing hair, nourishing hair and fixing hair.

Description

Traditional Chinese medicine preparation for treating alopecia and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine preparation for treating various alopecia and a preparation method thereof.
Background
Alopecia (hair loss) refers to a phenomenon in which hair falls off due to various factors, and it is a normal phenomenon that about 50 to 100 hairs fall off every day. If the hair loss is too large, the patient can have slight or even obvious baldness, which affects the appearance and makes the person appear vicious. Hair growth is periodic, including anagen, catagen and telogen phases. Normally, hair grows to some extent and then enters the catagen and telogen phases, resulting in physiological loss. The normal amount of hair is maintained because the hair entering the anagen phase and newly entering the catagen phase is constantly in dynamic balance. But is considered to be abnormal hair loss when the balance of the hair growth and shedding cycle is disrupted. The causes of alopecia are complex and various, and mainly comprise congenital factors, infection, systemic diseases, endocrine disorders, neuropsychiatric factors, physical factors, skin diseases, medicaments and the like. According to the form and severity of hair loss, it can be classified into: alopecia areata, shaving head, alopecia, puerperal alopecia, hereditary alopecia, chronic alopecia, seborrheic alopecia, etc.
At present, the medicines for treating alopecia are few, part of the medicines contain hormones and have great side effects, and part of the medicines have poor curative effect and treat the symptoms but not the root causes. For example: at present, western medicines for treating alopecia are single, wide adaptability is not provided, the curative effect is needless to say, the consumption of nursing in a hair nursing and caring shop is high, the time is long, the effect is slow, the hair planting cost is high, the pain is large, and the temporary solution and the permanent solution are not treated.
Disclosure of Invention
Technical problem to be solved
In view of the above disadvantages and shortcomings of the prior art, the present invention provides a Chinese medicinal preparation for treating alopecia, wherein the formula of the Chinese medicinal preparation has been improved through demonstration in nearly 40 years, and has a cure rate of up to 95% through clinical effects and follow-up survey of countless actual cases, and no side effects are generated.
(II) technical scheme
In order to achieve the purpose, the invention adopts the main technical scheme that:
the embodiment of the invention provides a traditional Chinese medicine preparation for treating alopecia, which is prepared from a traditional Chinese medicine composition containing the following medicinal materials: 50-90 parts of prepared rehmannia root, 40-80 parts of black sesame, 40-80 parts of Chinese angelica, 30-70 parts of platycladi seed, 20-60 parts of prepared fleece-flower root, 20-60 parts of cacumen biotae, 50-90 parts of honey, 30-80 parts of cistanche, 10-50 parts of ginger, 20-60 parts of scutellaria baicalensis, 20-70 parts of ligusticum wallichii and 15-80 parts of codonopsis pilosula.
According to the preferred embodiment of the Chinese medicinal preparation, the Chinese medicinal preparation is a pill, oral liquid or external preparation.
According to a preferred embodiment of the Chinese medicinal preparation of the invention, the Chinese medicinal composition comprises: 65-75 parts of prepared rehmannia root, 55-65 parts of black sesame, 55-65 parts of Chinese angelica, 45-55 parts of platycladi seed, 35-45 parts of prepared fleece-flower root, 35-45 parts of cacumen biotae, 65-75 parts of honey, 50-60 parts of cistanche, 25-35 parts of ginger, 35-45 parts of scutellaria baicalensis, 40-50 parts of ligusticum wallichii and 45-50 parts of codonopsis pilosula.
According to a preferred embodiment of the Chinese medicinal preparation of the invention, the Chinese medicinal composition comprises: 70 parts of prepared rehmannia root, 60 parts of black sesame, 60 parts of Chinese angelica, 50 parts of platycladi seed, 40 parts of prepared fleece-flower root, 40 parts of cacumen biotae, 70 parts of honey, 55 parts of cistanche, 30 parts of ginger, 40 parts of scutellaria baicalensis, 45 parts of ligusticum wallichii and 47.5 parts of codonopsis pilosula.
On the other hand, the invention also relates to a preparation method of the traditional Chinese medicine preparation for treating alopecia, wherein the traditional Chinese medicine preparation is a pill, an oral liquid or an external preparation;
wherein, when the traditional Chinese medicine preparation is a pill, the preparation method comprises the following steps:
step 1: separating the size of the cleaned radix Aconiti, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until there is no white core in the cut of the large and solid, taking out when there is slight tongue numbness in mouth, air drying to six times, slicing, air drying, and pulverizing;
step 2: drying radix Angelicae sinensis, semen Platycladi, semen Sesami Niger, folium Platycladi, radix Codonopsis, Scutellariae radix, rhizoma Ligustici Chuanxiong, radix rehmanniae Preparata, and Cistanchis herba, and pulverizing; cleaning rhizoma Zingiberis recens, and pulverizing;
the processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying;
and step 3: decocting Mel until the Mel drips into beads, adding the above medicinal materials, stirring, and kneading into pill;
wherein, when the traditional Chinese medicine preparation is oral liquid, the preparation method comprises the following steps:
step 1: separating the size of the cleaned radix Aconiti, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until there is no white core in the cut of the large and solid, taking out when there is slight tongue numbness in mouth, air drying to six times, slicing, and air drying;
step 2: drying and slicing radix Angelicae sinensis, folium Platycladi, radix Codonopsis, Scutellariae radix, rhizoma Ligustici Chuanxiong, radix rehmanniae Preparata, and Cistanchis herba; cleaning rhizoma Zingiberis recens, air drying, and slicing; the processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying;
and step 3: respectively extracting the above medicinal materials, semen Platycladi and semen Sesami Niger by pure steam extraction with intelligent volatile oil extraction and collection separator to obtain mixed volatile oil; mixing the materials after extracting volatile oil with 8-10 times of water, extracting, collecting and filtering the extractive solution, and concentrating to 20-30% of the original volume;
and 4, step 4: mixing the mixed volatile oil and the concentrated solution obtained in the step (3), adding honey, and preparing into oral liquid;
the traditional Chinese medicine preparation is an external preparation which is a spray or a smearing preparation, and the preparation method comprises the following steps:
step 1: separating the size of the cleaned radix Aconiti, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until there is no white core in the cut of the large and solid, taking out when there is slight tongue numbness in mouth, air drying to six times, slicing, and air drying;
step 2: drying and slicing radix Angelicae sinensis, folium Platycladi, radix Codonopsis, Scutellariae radix, rhizoma Ligustici Chuanxiong, radix rehmanniae Preparata, and Cistanchis herba; cleaning rhizoma Zingiberis recens, air drying, and slicing; the processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying;
and step 3: respectively extracting the above medicinal materials, semen Platycladi and semen Sesami Niger by pure steam extraction with intelligent volatile oil extraction and collection separator to obtain mixed volatile oil; mixing the materials after extracting volatile oil with 8-10 times of water, extracting, collecting and filtering the extractive solution, and concentrating to 35-40% of the original volume;
and 4, step 4: mixing the mixed volatile oil and the concentrated solution obtained in the step (3), adding honey, a surfactant and a penetrant, and filling into a spray bottle to prepare a spray; or mixing the mixed volatile oil and the concentrated solution obtained in the step 3, and adding honey, vaseline and penetrant to prepare the liniment.
Wherein, the surfactant is helpful for keeping the component uniformity of the spray, and the penetrant can be nitrogen ketone and other penetrants without toxic and side effects. Wherein the honey and vaseline have effects of thickening and keeping moisture, preventing volatile oil from volatilizing and drying rapidly, and prolonging the action time of the liniment to reach scalp cells and capillary vessels.
In the traditional Chinese medicine formula of the invention, the functions of the medicinal materials in the formula are as follows:
prepared rehmannia root: it is combined with shou Wu to tonify essence and marrow, so as to treat deficiency of essence and blood and early white beard and hair. Black sesame seed: has effects in nourishing liver and kidney, benefiting five internal organs, nourishing blood, and moistening intestine dryness, and can be used for treating dizziness, premature gray hair, and alopecia. Chinese angelica: enriching blood, promoting blood circulation, increasing body resistance, promoting blood circulation of head skin, and improving DP cell activity of hair follicle. Arborvitae seed: moistening skin and nourishing blood, adding Mel for nourishing liver, loosening bowel to relieve constipation, nourishing heart and blood, and treating vexation and insomnia. Preparing fleece-flower root: nourishing liver and kidney, nourishing yin and blood, blackening hair and beard, caring skin, etc., and strengthening hair follicle by improving microcirculation to achieve the effects of preventing alopecia, and promoting hair growth. Honey: detoxicating, caring skin, inhibiting bacteria, moistening feces, protecting liver, resisting oxidation, promoting cell regeneration and immunity, and promoting wound healing. Cacumen biotae: it is bitter, astringent and cold in property, has the effects of cooling blood and stopping bleeding, astringing to stop bleeding, clearing lung-heat, eliminating phlegm and relieving cough, and growing and blackening hair. Cistanche deserticola: warming and invigorating kidney yang entering large intestine meridian, replenishing essence and blood, loosening bowel to relieve constipation, warming and invigorating yang, salty taste in blood, replenishing blood and replenishing essence, warming and relieving fever, and can be used for treating kidney yang deficiency. Ginger: the ginger contains a large amount of ginger essence, which is beneficial to stimulating hair follicles of scalp and promoting hair growth. Scutellaria baicalensis: is cold in nature and bitter in taste, enters lung, gallbladder, spleen, large intestine and small intestine channels, has effects of clearing heat and eliminating dampness, clearing pathogenic fire and removing toxic substance, and stopping bleeding, and can be used for cooling blood and stopping bleeding when being combined with rhizoma Ligustici Chuanxiong and cortex moutan, and can be used for treating alopecia caused by blood heat.
Ligusticum wallichii: the hemlock parsley is warm in nature and pungent in taste, and has the effects of promoting qi circulation, relieving depression, promoting blood circulation, relieving pain, dispelling wind, removing dryness, removing dampness and the like due to the fact that the hemlock parsley belongs to a traditional Chinese medicine plant, is rich in volatile oil, niacin, sucrose, polysaccharide and the like, and can supplement qi, nourish blood and grow hair by being matched with codonopsis pilosula according to various amino acids, vitamins B1 and B2, vitamin E, zinc, copper and other trace elements. Codonopsis pilosula: is a Chinese medicament with the functions of tonifying qi and deficiency, mainly has the functions of strengthening the middle-jiao and replenishing qi, promoting the production of body fluid and nourishing blood, is often combined with prepared rhizome of rehmannia, angelica and the like to form eight-treasure decoction, and is combined with szechuan lovage rhizome to tonify qi, nourish blood and grow hair.
The treatment principle of the traditional Chinese medicine formula provided by the invention is as follows: the functions of each organ are balanced and regulated, and the aims of growing, nourishing and strengthening hair are achieved through the ways of tonifying liver and kidney, moistening the five internal organs, benefiting essence and blood, strengthening immunity, expelling toxin, beautifying, benefiting sleep, benefiting qi, nourishing blood, resisting oxidation, promoting hair follicle growth and the like.
(III) advantageous effects
The invention has the beneficial effects that:
the formula of the traditional Chinese medicine preparation is proved and improved by traditional Chinese medicine demonstration for nearly 40 years, hundreds of thousands of patients are cured through the clinical effect of a plurality of actual cases, and the cure rate is more than ninety-five percent especially in follow-up survey for nearly forty years.
The traditional Chinese medicine preparation of the formula can be pills (honeyed pills, water-honeyed pills and concentrated pills) with the quality guarantee period of five years, and oral liquid and external application (spray and liniment) with the quality guarantee period of 2-3 years, and is easy to carry and convenient to take and use.
When the traditional Chinese medicine preparation is a pill, all medicinal material components are directly used as the medicine, so that the waste of the medicinal materials is avoided; when the oral liquid and the external preparation are prepared, the volatile oil is firstly extracted, then the water extraction is carried out, the volatile oil extract and the water extract are mixed and are jointly used as the active ingredients to prepare the oral liquid or the external preparation, the active ingredients of various traditional Chinese medicine components are completely eaten and squeezed as much as possible, and the utilization efficiency of medicinal material resources is improved.
Detailed Description
For the purpose of better explaining the present invention and to facilitate understanding, the present invention will be described in detail below with reference to specific embodiments.
Based on the research on the cause of the hair loss, the main reason of the hair loss is found to be that: alopecia is caused by metabolism disorder of human bodies caused by fast pace of life, high mental stress, irregular life, frequent overtime, etc. of modern people, and the current situation is gradually popularized and younger, and the reason of the alopecia is analyzed from the perspective of traditional Chinese medicine:
(1) loss of kidney deficiency leading to hair loss: the kidney stores essence of five internal organs and six internal organs, deficiency of essence and blood causes deficiency of essence and blood, and deficiency of essence and blood causes lack of nutrition supply to hair, thus causing alopecia, namely 'kidney stores essence, which is bloomed to hair, kidney qi deficiency and hair loss'; lung governs the skin and hair, and failure of lung leads to the exhaustion of skin and hair.
(2) Accumulation of toxins can lead to hair loss: worry, pollution, bad habits and the like can cause a large amount of toxins to be absorbed and generated and accumulated by human bodies, and the toxins can damage various systems of human organs and influence various organs and hairs of the human bodies to absorb nutrients, so that alopecia is caused.
(3) Insufficient sleep leads to hair loss: according to the research, the optimal growth time of the hair is from twelve o 'clock at night to two o' clock in the morning, and the insomnia caused by the absence of the feeling is that the hair can not obtain normal nutrients and has rest, and the hair is prone to lose hair because of overstrain and illness.
(4) Endocrine dyscrasia leads to hair loss: alopecia can be caused by hypothyroidism or hyperthyroidism, hypopituitarism, early and postpartum, menopause, oral contraceptive, anemia, hepatorenal disease, malnutrition, etc.
(5) The loss of trace elements can cause alopecia.
(6) Poor dietary habits can lead to alopecia.
(7) Hereditary alopecia.
Based on the reasons, the treatment principle of the compatibility of the traditional Chinese medicines of each component of the traditional Chinese medicine composition is that fleece-flower root is taken as a monarch drug to mainly nourish yin and tonify the kidney, enrich the blood and promote blood circulation, and blacken beard and hair, prepared rehmannia root, Chinese angelica, Szechuan lovage rhizome, pilose asiabell root and desertliving cistanche are taken as ministerial drugs to enhance the efficacy of the monarch drug, and platycladi seed, baical skullcap root, Chinese arborvitae twig. The prepared rehmannia root and the tuber of multiflower knotweed serving as a monarch drug can supplement essence and fill marrow, and treat essence and blood deficiency and early white beard and hair, mainly aiming at (1) alopecia caused by kidney deficiency and loss; the compatibility of the scutellaria baicalensis, the platycladi seed and the honey and the black sesame has the effects of nourishing liver, moistening intestines, expelling toxin and beautifying, and the compatibility of the platycladi seed and the honey treats dysphoria, insomnia and excessive anxiety, mainly aims at (2) toxin accumulation and (3) alopecia caused by insufficient sleep; radix rehmanniae preparata and angelica are matched with codonopsis pilosula, eight-treasure soup can be combined, the body resistance is increased, the blood circulation of the skin of the head is promoted, the cell activity of hair follicles is improved while the yin and the liver are nourished, and various amino acids, vitamin B1, vitamin B2, vitamin E, zinc, copper and other trace elements are also contained, wherein the codonopsis pilosula is matched with ligusticum wallichii and has the effects of benefiting qi, nourishing blood and growing hair, and mainly aims at (4) the hair caused by endocrine dysimmunity and (5) the lack of the trace elements; wherein the combination of the scutellaria baicalensis and the oriental arborvitae twig and the ligusticum wallichii can cool blood and stop bleeding, is used for treating alopecia caused by blood heat, and can treat alopecia caused by the reasons; (6) the factors of (7) alopecia caused by poor dietary habits and (7) hereditary alopecia were also all improved.
Through the compatibility of the 12 medicinal materials, the functions of each organ are balanced and regulated, and the traditional Chinese medicine composition has the functions of tonifying liver and kidney, moistening the five internal organs, benefiting essence and blood, strengthening immunity, expelling toxin, beautifying, benefiting sleep, benefiting qi, nourishing blood, resisting oxidation, promoting hair follicle growth and the like, and finally achieves the purposes of growing hair, nourishing hair and fixing hair.
The following description will be made in conjunction with specific embodiments of the present invention.
Example 1
A method for preparing traditional Chinese medicine honeyed pill for treating alopecia comprises:
firstly, preparing medicinal materials:
70g of prepared rehmannia root, 60g of black sesame, 60g of Chinese angelica, 50g of platycladi seed, 40g of prepared fleece-flower root, 40g of cacumen biotae, 70g of honey, 55g of cistanche, 30g of ginger, 40g of scutellaria baicalensis, 45g of ligusticum wallichii and 45g of codonopsis pilosula.
The processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying.
The processing method of the prepared fleece-flower root comprises the following steps: separating radix Aconiti from small ones, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until large and solid ones have no white core, taking out, air drying to six degrees, slicing, and air drying.
Secondly, drying the rest of the medicinal materials except the honey and the ginger till the medicinal materials are dried to 8-9 parts, grinding the medicinal materials into fine powder with the granularity of 60 meshes, and filling the fine powder into a disinfection basin for later use. Grinding rhizoma Zingiberis recens (old rhizoma Zingiberis recens).
And step three, boiling the honey, removing impurities, destroying enzymes in the honey, killing bacteria, evaporating water and enhancing viscosity. When the honey is refined, the honey is boiled with strong fire, then is slowly boiled with slow fire, meanwhile, a bowl of cold water is placed beside the honey, and the color of the honey is observed. When the honey turns yellow, a bamboo chopstick is used for dipping a drop of honey, then the bamboo chopstick is moved to the upper part of a cold water bowl, the honey is dropped into the water, and if the honey does not spread in the water and directly sinks to the water bottom, the dropping of the honey into beads is achieved, even if the honey is refined.
And fourthly, pouring the decocted honey into the medicinal powder contained in the disinfection basin by using a spoon, stirring the medicinal powder by using thick bamboo chopsticks while pouring the honey, uniformly mixing the medicinal powder, rubbing the medicinal powder into strips, and rubbing 9.5-11g of each pill into honeyed pills. After the pill sweats and the appearance becomes hard, the pill is wrapped by wax paper and wax shells and stored in a cool and dry place.
Example 2
A method for preparing Chinese medicinal oral liquid for treating alopecia comprises:
firstly, preparing medicinal materials:
70g of prepared rehmannia root, 60g of black sesame, 60g of Chinese angelica, 50g of platycladi seed, 40g of prepared fleece-flower root, 40g of cacumen biotae, 70g of honey, 55g of cistanche, 30g of ginger, 40g of scutellaria baicalensis, 45g of ligusticum wallichii and 45g of codonopsis pilosula.
The processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying.
The processing method of the prepared fleece-flower root comprises the following steps: separating radix Aconiti from small ones, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until large and solid ones have no white core, taking out, air drying to six degrees, slicing, and air drying.
Secondly, drying and slicing angelica, cacumen biotae, codonopsis pilosula, scutellaria baicalensis, ligusticum wallichii, prepared rehmannia root and cistanche; cleaning rhizoma Zingiberis recens, air drying, and slicing;
the third step: respectively extracting the above medicinal materials, semen Platycladi and semen Sesami Niger by pure steam extraction with intelligent volatile oil extraction and collection separator to obtain mixed volatile oil; mixing the materials after the volatile oil extraction with 8-10 times of water for extraction, collecting and filtering the extract, filtering by a microfiltration membrane, and concentrating the filtered liquid medicine to 25% of the volume;
the fourth step: mixing the volatile oil and the water extract concentrate, adding Mel, and making into oral liquid. In the preparation of oral liquid, antioxidant and flavoring components such as citric acid can be added.
Example 3
A preparation method of a Chinese medicinal liniment for treating alopecia comprises:
firstly, preparing medicinal materials:
70g of prepared rehmannia root, 60g of black sesame, 60g of Chinese angelica, 50g of platycladi seed, 40g of prepared fleece-flower root, 40g of cacumen biotae, 70g of honey, 55g of cistanche, 30g of ginger, 40g of scutellaria baicalensis, 45g of ligusticum wallichii and 45g of codonopsis pilosula.
The processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying.
The processing method of the prepared fleece-flower root comprises the following steps: separating radix Aconiti from small ones, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until large and solid ones have no white core, taking out, air drying to six degrees, slicing, and air drying.
Secondly, drying and slicing angelica, cacumen biotae, codonopsis pilosula, scutellaria baicalensis, ligusticum wallichii, prepared rehmannia root and cistanche; cleaning rhizoma Zingiberis recens, air drying, and slicing;
the third step: respectively extracting the above medicinal materials, semen Platycladi and semen Sesami Niger by pure steam extraction with intelligent volatile oil extraction and collection separator to obtain mixed volatile oil; mixing the materials after the volatile oil extraction with 8-10 times of water for extraction, collecting and filtering the extract, filtering by a microfiltration membrane, and concentrating the filtered liquid medicine to 35% of the volume;
the fourth step: mixing the volatile oil and the concentrated solution, adding Mel, 2% azone (penetrating agent), and vaseline for thickening, and concocting to obtain paste liniment.
Use example
Example 1: zhang one: women, 48 years old, Hebei Zhao county, because of the great working pressure, the excessive mental stress, the alopecia for more than ten years, when patients see a doctor, the hair is totally faded, even the hair follicle is totally necrotic, the scalp is shiny, just like the bareheaded head which is just shaved, the patients have been treated in a plurality of three hospitals, and the patients have no food, light food, little oil, spicy food and the like all the year round, so the pain is very great, and the effect is not ideal. Then, the patient is recommended by relatives and friends and returned to the clinic for hospitalization.
Treatment protocols were determined in the clinic: honeyed pills are prepared according to example 1, wherein 9.5-11g of honeyed pills are taken, and 2 pills are taken every day. After the medicine is taken for 3 months continuously for one treatment course, the scalp is blackened, the hair follicle is gradually restored to grow, after the second treatment course, a plurality of hairs in a relatively fine and soft villiform shape gradually start to grow from the hair follicle, and the patient feels happy and happy. After more than one year of treatment, each hair follicle of the patient grows 2-3 hairs, and the patient specially sends the silk banner to the clinic. The hair loss problem does not recur after half a year of follow-up visit.
Example 2: forest culture: male, 20 years old, and a college student in Hebei, typical seborrheic alopecia. Patients have more hair oil, more scurf, scalp itch, more hair loss amount every day, and thin and soft hair, even accompanied by seborrheic dermatitis of scalp, oily scalp, yellow and oily crust, a great amount of grey bran-like scurf, and M-type alopecia caused by slow hair loss on both sides of forehead and top of head. The patients were recommended by the classmates who were previously cured in the clinic.
Treatment protocols were determined in the clinic: honeyed pills are prepared according to example 1, wherein 9.5-11g of honeyed pills are taken, and 2 pills are taken every day. After the honeyed pill is taken for more than one month, yellow oily scab of the hair is obviously improved, the greasy degree of the hair is obviously improved, the itching symptom of the scalp is relieved, and after the honeyed pill is taken for more than 3 months, fine, soft and small hairs grow on two sides of the forehead; after 7 months of treatment, the hair is completely cured, the hair does not produce much oil, the scalp does not have itching symptom, and black and bright hair grows on the two sides of the forehead and the top area of the head. Follow-up visit after half a year without recurrence.
Example 3: lie a certain: women, 17 years old, who are in the school, have three or four round and oval non-cicatricial alopecia in the hindbrain due to heavy learning tasks, time strain and high mental stress, and have exclamatory-mark-like hair visible at the margin of alopecia areata and the area of alopecia areata continues to spread. Through the introduction of relatives, the clinic is used for treatment.
Treatment protocols were determined in the clinic: honeyed pills are prepared according to example 1, wherein 9.5-11g of honeyed pills are taken, and 2 pills are taken every day. After 1 month of oral honeyed pills, the patients feel pricked by touching with hands, fine and soft villi grow at the position of alopecia areata, and the complexion is obviously improved. After 6 months of treatment, the hair at the position of alopecia areata completely grows out. Follow-up after half a year without recurrence.
Example 4: allowing for some: a28-year-old Handan full-time Ma of women, who suffer from spleen injury and kidney injury and alopecia due to great fluctuation of hormone level of postpartum women, mental factors, insufficient sleep during night feeding, unbalanced diet and the like. After 6 months of delivery, a large amount of hair falls off in a short time, and when the hair is combed and washed, the hair falls off in a large amount and is easy to break, and the hair is easily pulled to any part of the scalp and is easily pulled to fall off without pain.
The patient then visits the clinic. Determining a treatment scheme: honeyed pills are prepared according to example 1, wherein 9.5-11g of honeyed pills are taken, and 2 pills are taken every day. After 3 months of treatment by taking the medicine, the hair loss of the patient is obviously reduced, the patient gradually turns into normal hair loss with a small amount, the hair is not easy to break, the sleeping quality is improved, and the mood is smooth. The medicine is pure traditional Chinese medicine, and does not affect lactation. Follow-up after half a year without recurrence.
Example 5: zhang one: for men and 43 years old, the individual Shijiazhuang family often returns to the morning and evening, is remunerated and works irregularly due to doing business by oneself, which results in more than one year of serious hair loss and serious temples and vertex on both sides of the forehead. The treatment in other special hospitals before, even the puncture on the scalp, has great pain and poor effect. The treatment is recommended by the people to the clinic.
Determining a treatment scheme: honeyed pills are prepared according to example 1, wherein 9.5-11g of honeyed pills are taken, and 2 pills are taken every day. After oral honeyed pill treatment for 4 months, hair grows on temples on both sides of forehead and on top of head. The follow-up was followed half a year without recurrence.
Example 6: wangzhi: women, 48 years old, nurses in certain hospitals had thin hair at the top of the head, clear and visible scalp at the top of the head, and hair was frequently combed and washed to lose a great deal of hair after the hairline was close. Patients have been treated in many hospitals, but the effect is not ideal. The treatment is recommended by the people to the clinic.
Determining a treatment scheme: honeyed pills are prepared according to example 1, wherein 9.5-11g of honeyed pills are taken, and 2 pills are taken every day. After oral honeyed pills are used for treating 9 months, the hair grows on the top of the head, and the hair grows on the root of the head which is white before the treatment. The effect is enhanced after taking for 2 months. Follow-up after half a year without recurrence.
Such as the above-mentioned application examples are numerous and numerous. According to the observation of years, the medicament formula has the effects of treating both the root and the symptoms of various types of alopecia and alopecia caused by hair follicle problems, and can fundamentally regulate internal secretion and qi and blood of each organ in vivo, thereby achieving the effects of fixing roots, growing hair, nourishing blood and protecting hair.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (5)

1. A traditional Chinese medicine preparation for treating alopecia is characterized by being prepared from a traditional Chinese medicine composition containing the following medicinal materials: 50-90 parts of prepared rehmannia root, 40-80 parts of black sesame, 40-80 parts of Chinese angelica, 30-70 parts of platycladi seed, 20-60 parts of prepared fleece-flower root, 20-60 parts of cacumen biotae, 50-90 parts of honey, 30-80 parts of cistanche, 10-50 parts of ginger, 20-60 parts of scutellaria baicalensis, 20-70 parts of ligusticum wallichii and 15-80 parts of codonopsis pilosula.
2. The traditional Chinese medicine preparation for treating alopecia according to claim 1, wherein the traditional Chinese medicine preparation is a pill, an oral liquid or an external preparation.
3. The traditional Chinese medicine preparation for treating alopecia according to claim 1, wherein the traditional Chinese medicine composition comprises: 65-75 parts of prepared rehmannia root, 55-65 parts of black sesame, 55-65 parts of Chinese angelica, 45-55 parts of platycladi seed, 35-45 parts of prepared fleece-flower root, 35-45 parts of cacumen biotae, 65-75 parts of honey, 50-60 parts of cistanche, 25-35 parts of ginger, 35-45 parts of scutellaria baicalensis, 40-50 parts of ligusticum wallichii and 45-50 parts of codonopsis pilosula.
4. The traditional Chinese medicine preparation for treating alopecia according to claim 1, wherein the traditional Chinese medicine composition comprises: 70 parts of prepared rehmannia root, 60 parts of black sesame, 60 parts of Chinese angelica, 50 parts of platycladi seed, 40 parts of prepared fleece-flower root, 40 parts of cacumen biotae, 70 parts of honey, 55 parts of cistanche, 30 parts of ginger, 40 parts of scutellaria baicalensis, 45 parts of ligusticum wallichii and 47.5 parts of codonopsis pilosula.
5. A method for preparing the traditional Chinese medicine preparation for treating alopecia according to claim 1, wherein the traditional Chinese medicine preparation is a pill, an oral liquid or an external preparation;
wherein, when the traditional Chinese medicine preparation is a pill, the preparation method comprises the following steps:
step 1: separating the size of the cleaned radix Aconiti, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until there is no white core in the cut of the large and solid, taking out when there is slight tongue numbness in mouth, air drying to six times, slicing, air drying, and pulverizing;
step 2: drying radix Angelicae sinensis, semen Platycladi, semen Sesami Niger, folium Platycladi, radix Codonopsis, Scutellariae radix, rhizoma Ligustici Chuanxiong, radix rehmanniae Preparata, and Cistanchis herba, and pulverizing; cleaning rhizoma Zingiberis recens, and pulverizing;
the processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying;
and step 3: decocting Mel until the Mel drips into beads, adding the above medicinal materials, stirring, and kneading into pill;
wherein, when the traditional Chinese medicine preparation is oral liquid, the preparation method comprises the following steps:
step 1: separating the size of the cleaned radix Aconiti, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until there is no white core in the cut of the large and solid, taking out when there is slight tongue numbness in mouth, air drying to six times, slicing, and air drying;
step 2: drying and slicing radix Angelicae sinensis, folium Platycladi, radix Codonopsis, Scutellariae radix, rhizoma Ligustici Chuanxiong, radix rehmanniae Preparata, and Cistanchis herba; cleaning rhizoma Zingiberis recens, air drying, and slicing; the processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying;
and step 3: respectively extracting the above medicinal materials, semen Platycladi and semen Sesami Niger by pure steam extraction with intelligent volatile oil extraction and collection separator to obtain mixed volatile oil; mixing the materials after extracting volatile oil with 8-10 times of water, extracting, collecting and filtering the extractive solution, and concentrating to 20-30% of the original volume;
and 4, step 4: mixing the mixed volatile oil and the concentrated solution obtained in the step (3), adding honey, and blending to obtain an oral liquid;
the traditional Chinese medicine preparation is an external preparation which is a spray or a smearing preparation, and the preparation method comprises the following steps:
step 1: separating the size of the cleaned radix Aconiti, soaking in water until there is no dry core, taking out, adding water, boiling for 4-6 hr or steaming for 6-8 hr until there is no white core in the cut of the large and solid, taking out when there is slight tongue numbness in mouth, air drying to six times, slicing, and air drying;
step 2: drying and slicing radix Angelicae sinensis, folium Platycladi, radix Codonopsis, Scutellariae radix, rhizoma Ligustici Chuanxiong, radix rehmanniae Preparata, and Cistanchis herba; cleaning rhizoma Zingiberis recens, air drying, and slicing; the processing method of the prepared rehmannia root comprises the following steps: adding wine into clean radix rehmanniae, adding yellow wine 30-50kg per radix rehmanniae 100kg, placing in a container, sealing, heating over water or heating with steam, stewing until the wine is absorbed completely, taking out, sun drying until the mucus on the outer skin is slightly dry, slicing into thick slices, and drying; or placing cleaned radix rehmanniae in a container, heating and steaming to black, taking out, drying to about 8 days, slicing into thick pieces, and drying;
and step 3: respectively extracting the above medicinal materials, semen Platycladi and semen Sesami Niger by pure steam extraction with intelligent volatile oil extraction and collection separator to obtain mixed volatile oil; mixing the materials after extracting volatile oil with 8-10 times of water, extracting, collecting and filtering the extractive solution, and concentrating to 35-40% of the original volume;
and 4, step 4: mixing the mixed volatile oil and the concentrated solution obtained in the step (3), adding honey, a surfactant and a penetrant, and filling into a spray bottle to prepare a spray; or mixing the mixed volatile oil and the concentrated solution obtained in the step 3, and adding honey, vaseline and penetrant to prepare the liniment.
CN202011098055.2A 2020-10-14 2020-10-14 Traditional Chinese medicine preparation for treating alopecia and preparation method thereof Pending CN112023017A (en)

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Citations (2)

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Publication number Priority date Publication date Assignee Title
CN106728340A (en) * 2017-03-11 2017-05-31 广州煜明生物科技有限公司 Chinese medicine composition with hair care effect and its preparation method and application
CN108721584A (en) * 2018-07-06 2018-11-02 周晓玲 Anticreep black hair composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728340A (en) * 2017-03-11 2017-05-31 广州煜明生物科技有限公司 Chinese medicine composition with hair care effect and its preparation method and application
CN108721584A (en) * 2018-07-06 2018-11-02 周晓玲 Anticreep black hair composition

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Application publication date: 20201204