CN113082160A

CN113082160A - Hair growth cream formula and preparation method thereof

Info

Publication number: CN113082160A
Application number: CN202110525476.7A
Authority: CN
Inventors: 易良杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-05-14
Filing date: 2021-05-14
Publication date: 2021-07-09

Abstract

The invention relates to a hair growing cream formula which comprises the following raw materials in parts by weight: 15g of prepared rehmannia root, 10g of ligusticum wallichii, 10g of bran-fried bighead atractylodes rhizome, 10g of achyranthes root, 10g of fructus psoraleae, 10g of radix angelicae, 15g of rhizoma polygonati preparata, 15g of radix paeoniae alba, 10g of prepared polygonum multiflorum, 15g of poria cocos, 10g of wolfberry fruit, 5g of dried orange peel, 10g of cacumen biotae, 10g of fructus viticis, 10g of salvia miltiorrhiza, 10g of angelica sinensis, 15g of cooked codonopsis pilosula, 5g of honey-fried licorice root, 15g of salted dodder, 10g of fructus cannabis, 5g of divaricate saposhnikovi. The medicine has reasonable raw material compatibility, obvious curative effect and aromatic smell, is very effective to the alopecia with the syndrome of deficiency of both qi and blood caused by radiotherapy and chemotherapy, can effectively tonify qi and blood, promote hair growth, and has certain treatment effect on the seborrheic alopecia with the liver and kidney deficiency type.

Description

Hair growth cream formula and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a hair growing cream formula and a preparation method thereof.

Background

Alopecia is one of the common side effects caused by radiotherapy and chemotherapy for treating malignant tumors, most chemotherapy drugs can cause alopecia of different degrees, and alopecia usually occurs 1-2 weeks after chemotherapy and reaches the most serious degree within 2 months. According to the latest statistics of the national cancer center, about 392.9 thousands of people suffer from malignant tumors in 2015 years in China, and the incidence rate of the malignant tumors keeps about 3.9% of increase every year. The population suffering from the alopecia caused by radiotherapy and chemotherapy in China is increasing every year, and the serious alopecia causes the patients to lose the appearance integrity, thereby causing the drug-resistant psychology and even abandoning the comprehensive intervention treatment on tumors.

The main characteristics of the qi and blood deficiency type alopecia caused by radiotherapy and chemotherapy are as follows: patients are tired, lack of strength and poor appetite, the whole head hair slowly falls off or falls off locally in a large range, and the more serious patients may have eyebrow, axillary hair, hand hair, body hair and even yin hair. For some young women, not only the appearance is incomplete, but also great inconvenience is brought to life. The traditional Chinese medicine ointment has few medicines for treating alopecia caused by radiotherapy and chemotherapy, and at present, no medicine capable of effectively preventing and treating alopecia caused by radiotherapy and chemotherapy exists, so that the problem to be solved is urgent to develop the hair growth ointment which can supplement qi and blood for adjuvant chemotherapy and can maintain the appearance integrity of patients.

Disclosure of Invention

The hair is the rest of blood, the kidney is in the hair, and the liver and kidney are full of essence and blood, so the hair is black, dense and glossy; if the liver and kidney are deficient in essence and blood, the mild case will have yellow and lusterless hair, and the severe case will have premature white or fallen beard and hair. After radiotherapy and chemotherapy, the liver and kidney of a tumor patient are damaged, marrow does not produce blood, qi and blood are insufficient, the hair is not nourished, and the hair is withered and even falls off completely. Aiming at the disease, the invention deeply analyzes the etiology and pathogenesis of the disease, deeply researches the classical Chinese medical records of the past generations, combines the clinical medication curative effect, provides the hair-growing ointment which is prepared by adopting a method of liver and kidney two-treatment and qi and blood simultaneous supplementation and is mainly used for treating the alopecia of tumor patients after radiotherapy and chemotherapy, can tonify qi and blood of human bodies to assist the tumor patients in the radiotherapy and chemotherapy, achieves the effects of synergy and attenuation, and can effectively maintain the appearance integrity of the patients.

The technical scheme adopted by the invention is as follows: the hair growth cream formula comprises the following raw materials in parts by weight: 10-20g of prepared rehmannia root, 5-15g of ligusticum wallichii, 5-15g of bran-fried bighead atractylodes rhizome, 5-15g of achyranthes root, 5-15g of fructus psoraleae, 5-15g of angelica dahurica, 10-20g of rhizoma polygonati preparata, 10-20g of radix paeoniae alba, 5-15g of prepared polygonum multiflorum, 10-20g of poria cocos, 5-15g of wolfberry fruit, 2-8g of dried orange peel, 5-15g of cacumen biotae, 5-15g of fructus viticis, 5-15g of salvia miltiorrhiza, 5-15g of angelica sinensis, 10-20g of cooked codonopsis pilosula, 2-8g of honey-fried licorice root, 10-20g of salted semen cuscutae, 5-15g of fructus cannabis, 2-8g of divaricate saposhnikovia root; .

Preferably, the hair growing cream formula comprises the following raw materials in parts by weight: 15g of prepared rehmannia root, 10g of ligusticum wallichii, 10g of bran-fried bighead atractylodes rhizome, 10g of achyranthes root, 10g of fructus psoraleae, 10g of radix angelicae, 15g of rhizoma polygonati preparata, 15g of radix paeoniae alba, 10g of prepared polygonum multiflorum, 15g of poria cocos, 10g of wolfberry fruit, 5g of dried orange peel, 10g of cacumen biotae, 10g of fructus viticis, 10g of salvia miltiorrhiza, 10g of angelica sinensis, 15g of cooked codonopsis pilosula, 5g of honey-fried licorice root, 15g of salted dodder, 10g of fructus cannabis, 5g of divaricate saposhnikovi; the ointment prepared by the proportion has the best effect.

Preferably, the hair growing cream formula comprises the following raw materials in parts by weight: 15g of prepared rehmannia root, 10g of ligusticum wallichii, 10g of bran-fried bighead atractylodes rhizome, 10g of achyranthes root, 10g of fructus psoraleae, 10g of radix angelicae, 15g of rhizoma polygonati preparata, 15g of radix paeoniae alba, 15g of prepared polygonum multiflorum, 15g of poria cocos, 10g of wolfberry fruit, 5g of dried orange peel, 10g of cacumen biotae, 10g of fructus viticis, 10g of salvia miltiorrhiza, 10g of angelica sinensis, 15g of cooked codonopsis pilosula, 5g of honey-fried licorice root, 15g of salted dodder, 10g of fructus cannabis, 5g of divaricate saposhnikovi; the proportion is the ointment formula proportion which is prepared according to the monarch, minister, assistant and guide, and the treatment effect of the prepared ointment formula is slightly inferior to that of the previous preferred scheme.

Preferably, the hair growing cream formula comprises the following raw materials in parts by weight: 10g of prepared rehmannia root, 5g of szechuan lovage rhizome, 5g of bran-fried largehead atractylodes rhizome, 5g of twotooth achyranthes root, 5g of malaytea scurfpea fruit, 5g of dahurian angelica root, 10g of alcohol-processed polygonatum rhizome, 10g of white paeony root, 5g of prepared tuber fleeceflower root, 10g of Indian buead, 5g of barbary wolfberry fruit, 2g of tangerine peel, 5g of cacumen biotae, 5g of chastetree fruit, 5g of danshen root, 5g of Chinese angelica, 10g of cooked pilose asiabell root, 2g of honey-fried licorice root, 10; the curative effect of the ointment formula prepared by the proportion is inferior to that of the last preferred scheme.

Preferably, the hair growing cream formula comprises the following raw materials in parts by weight: 20g of prepared rehmannia root, 15g of ligusticum wallichii, 15g of bran-fried bighead atractylodes rhizome, 15g of achyranthes root, 15g of fructus psoraleae, 15g of radix angelicae, 20g of rhizoma polygonati preparata, 20g of radix paeoniae alba, 15g of prepared polygonum multiflorum, 20g of poria cocos, 15g of wolfberry fruit, 8g of dried orange peel, 15g of cacumen biotae, 15g of fructus viticis, 15g of salvia miltiorrhiza, 15g of angelica sinensis, 20g of cooked codonopsis pilosula, 8g of honey-fried licorice root, 20g of salted dodder, 15g of fructus cannabis, 2-8g of divaricate saposhnikovi; the curative effect of the ointment formula prepared by the proportion is inferior to that of the last preferred scheme.

As a further preferable scheme, the hair growth cream formula also comprises the following auxiliary materials in parts by weight: 15-25g of xylitol; the xylitol is used for improving the taste of the paste formula.

A preparation method of a hair growth cream formula comprises the following steps:

s1: taking raw materials and auxiliary materials according to the weight parts, mixing the raw materials except for the black sesame with water, and soaking for 12 hours to obtain a mixed solution;

s2: decocting the mixed liquid obtained in the step S1, and filtering the mixed liquid by using a 100-mesh screen after the mixed liquid is boiled for 1 hour to obtain primary filtrate and primary filter residue;

s3: mixing the primary filter residue obtained in the step S2 with water, decocting again, and filtering by using a 100-mesh screen after the mixed liquid is boiled for 50 minutes to obtain secondary filtrate;

s4: mixing the primary filtrate obtained in the step S2 with the secondary filtrate obtained in the step S3, and concentrating the mixture for 3.5 hours by strong fire to obtain a concentrated solution;

s5: and (4) adding xylitol serving as an auxiliary material in parts by weight into the concentrated solution obtained in the step (S4), continuously decocting for 15 minutes by adopting slow fire and a continuous stirring mode, then adding black sesame serving as an auxiliary material in parts by weight, continuously decocting for 15 minutes to obtain paste, subpackaging and cooling when the concentrated solution appears as fish eye bubbles, flag hanging and water dripping beads, and thus obtaining the hair growing paste formula.

Preferably, the weight ratio of the raw material to the water in the step S1 is 1: 8, and cold soaking for 12 hours.

Preferably, in the step S3, the ratio of the first filter residue to water is 1: 6, and mixing.

The characters of the medicines adopted by the invention are discussed as follows:

prepared rehmannia root, radix rehmanniae Praeparata is sweet and bitter in taste and warm in nature, and enters heart, liver and kidney three meridians; [ EFFECT ] can nourish blood, nourish yin, replenish essence, benefit marrow, benefit ears and eyes, and blacken beard and hair.

Chuan Xiong is pungent in flavor and warm in nature, and enters liver, gallbladder and pericardium channels; [ EFFECT ] the product has effects in promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain; the fragrant, warm and dry herbs that go up to the head and face and descend into the blood sea are called qi-in-blood herbs; it is often combined with Dang Gui to regulate qi and blood for promoting hair growth.

Bighead atractylodes rhizome, bitter in taste, sweet and warm in nature, enters spleen and stomach meridians; [ EFFECT ] can invigorate qi and invigorate the spleen.

Achyranthes root, radix Achyranthis bidentatae, which is bitter in flavor, neutral in nature and enters liver and kidney meridians; [ EFFECT ] the product has effects of promoting blood circulation, dispelling blood stasis, nourishing liver and kidney, and strengthening tendons and bones.

The fructus psoraleae is black in color, like a flower, fragrant, bitter and warm in nature and taste; [ EFFECT ] can nourish kidney and nourish kidney, and blacken beard and hair.

The dahurian angelica root is pungent in flavor and warm in nature, and enters stomach channel, large intestine channel and lung channel; [ EFFECT ] radix Angelicae Dahuricae contains volatile oil, and topical application can dilate blood vessel, improve blood circulation, and promote hair absorption, nutrition and pigment absorption.

Rhizoma Polygonati is sweet in nature and flavor, and flat, and enters spleen, lung and kidney meridians; [ EFFECT ] the product has effects of moistening lung, nourishing yin, invigorating spleen, invigorating qi, tonifying kidney, and replenishing vital essence; for instance, it is used in the formula of kidney deficiency and essence deficiency syndrome or spleen and stomach deficiency after drying in the sun and grinding into honeyed pills (Qixiao Liang Fang), it can tonify spleen qi and spleen yin, for instance, it is combined with qi-tonifying and spleen-invigorating herbs such as Dang Shen, Fu Ling and Bai Zhu for spleen and stomach qi deficiency syndrome with lassitude, weakness, anorexia and weak pulse.

White peony root is bitter and sour in taste and slightly cold in nature; entering liver and spleen meridians; [ EFFECT ] the medicine has effects of nourishing blood and astringing yin.

The fleece-flower root is bitter, sweet and astringent in flavor and slightly warm in flavor, and enters liver and kidney meridians; [ EFFECT ] can tonify essence and blood, and can be used for the treatment of essence and blood deficiency, dizziness, dim eyesight, and premature gray hair; the prepared fleece-flower root is a good tonic medicine because it can tonify liver and kidney, benefit essence and blood, and astringe without cold, dryness and greasiness.

Poria cocos is sweet in flavor, bland in nature and flat, and enters heart, spleen and kidney meridians; [ EFFECT ] invigorate the spleen, soothe the nerves; it is indicated for spleen deficiency syndrome. For spleen-tonifying, spleen-deficiency, fatigue, poor appetite and loose stool, Fu Ling is combined with spleen-tonifying herbs to generate qi and blood, such as Dang Shen, Bai Zhu and gan Cao, i.e. Sijunzi Tang.

Fructus Lycii is neutral in nature and sweet in flavor, and enters liver, kidney and lung meridians; [ EFFECT ] the effective medicine for nourishing liver and kidney is applicable to various syndromes of liver and kidney deficiency, and can be used for treating alopecia caused by liver and kidney channel blood deficiency.

The dried orange peel has the following properties and tastes and is meridian tropism: pungent and bitter in flavor and warm in nature, and enter spleen, stomach and lung meridians; [ EFFECT ] the product has effects of promoting blood circulation, strengthening hair follicle nutrition, stimulating hair growth, and closing hair scales due to the acidic nature of pericarpium Citri Tangerinae, and can be used as natural hair conditioner.

Cacumen biotae (efficacy) has effects of cooling blood, stopping bleeding, promoting hair growth and blackening hair; can be used for treating premature gray hair, and topical application for treating alopecia caused by seborrheic dermatitis.

Fructus Viticis, pungent and bitter in flavor and slightly cold in nature, enters stomach, bladder and liver meridians; [ EFFECT ] it is indicated for wind of scouring and mustache.

Salvia miltiorrhiza, bitter in flavor and slightly cold in nature, enters heart, pericardium and liver meridians; [ EFFECT ] can promote blood circulation and nourish blood.

Chinese angelica is pungent, warm and sweet in flavor and enters liver, heart and spleen meridians; [ EFFECT ] this herb can tonify blood and activate blood, and is indicated for various syndromes due to blood deficiency, because it is a good herb to tonify blood, it is indicated for blood deficiency syndromes.

Dang Shen is neutral in nature and sweet in flavor, and enters spleen and lung meridians; [ EFFECT ] the product has effects of invigorating middle warmer, replenishing qi, promoting fluid production, and nourishing blood; can be used for treating deficiency of middle-warmer energy, blood deficiency, sallow complexion, dizziness, and palpitation; it has the actions of tonifying qi and nourishing blood, and is combined with herbs such as Shu Di Huang and Dang Gui, as in Bazhen Tang.

The liquorice is sweet in taste and enters heart, lung, spleen and stomach meridians; [ EFFECT ] the product has effects of invigorating spleen, invigorating qi, relieving spasm, relieving pain, and alleviating drug property; it is combined with qi-tonifying and spleen-invigorating herbs such as ren Shen, Bai Zhu and Fu Ling, as in Si Jun Zi Tang.

Dodder seed, pungent in flavor, sweet in flavor, enters liver and kidney meridians; [ EFFECT ] the formula is indicated for deficiency of liver and kidney, because it can tonify yang and yin, secure essence and reduce urination.

Fructus cannabis is sweet in nature and neutral in nature, and enters spleen and large intestine meridians; [ EFFECT ] can be used for treating blood deficiency, preventing generation of beard and hair, and promoting hair growth.

Divaricate saposhnikovia root, pungent, sweet and slightly warm, enters bladder, liver and spleen meridians; [ EFFECT ] can nourish blood, tonify blood, treat anemia due to blood deficiency and alopecia due to pale complexion, and promote ruddy and glossy complexion to achieve the effects of maintaining beauty and keeping young.

Huang Qi is sweet and warm in nature and enters spleen and lung meridians. [ EFFECT ] can replenish qi and blood and promote hair growth, and can be used for treating alopecia and poor hair quality caused by deficiency of both qi and blood.

Fingered citron is pungent, bitter and sour in flavor and warm in nature, and enters liver, spleen, stomach and lung meridians. [ EFFECT ] the compatibility of astragalus root can achieve the efficacy of invigorating qi and blood of the whole body and promoting hair growth.

Semen Sesami Niger is sweet and neutral, and enters liver and kidney meridians; [ EFFECT ] can tonify essence and blood, and can be used for early whitening of beard and hair due to deficiency of essence and blood.

The function of each drug in the present hair cream formulation is explained in detail below:

in the hair growth paste formula, the prepared fleece-flower root has the effects of tonifying liver and kidney, benefiting essence and blood, blackening beard and hair and astringing; the black sesame can tonify essence and blood, and is used for early whitening of beard and hair caused by essence and blood deficiency; the codonopsis pilosula has the effects of tonifying middle-jiao and Qi, promoting the production of body fluid and nourishing blood; prepared rehmannia root, radix rehmanniae Praeparata has the effects of nourishing blood and yin, replenishing essence and benefiting marrow, benefiting ears and eyes and blackening beard and hair. Radix Codonopsis is matched with radix rehmanniae Preparata, and has effects of invigorating qi and replenishing blood, and promoting hair growth when qi and blood are sufficient, and the above 4 medicines are used as principal medicines together.

Fructus Lycii has effects in replenishing kidney essence, nourishing liver and blood, and can be used for treating alopecia due to liver and kidney channel blood deficiency; semen Cuscutae has effects of warming kidney, strengthening waist, tonifying yang, stopping nocturnal emission, and promoting hair growth; the fructus psoraleae warms yang and tonifies the kidney, and blackens the beard and hair; the largehead atractylodes rhizome has the effects of tonifying qi and strengthening spleen, and the codonopsis pilosula has the effect of tonifying qi and spleen; dang Gui can nourish blood and tonify liver, and is also helpful for tonifying yin and blood of prepared rhizome of rehmannia for treating various blood deficiency syndromes; radix astragali has effects of invigorating qi and blood and promoting hair growth, and can be used for treating alopecia and poor hair quality caused by deficiency of qi and blood; the dried orange peel has the effects of regulating qi-flowing, reducing phlegm, promoting blood circulation, strengthening hair follicle nutrition and stimulating hair growth, is obviously acidic, has the effect of closing hair scales and plays the effect of natural hair conditioner; cacumen biotae cools blood and stops bleeding, grows hair and blackens hair, prevents excessive warmth and tonifies, and can be used for early whitening of beard and hair; radix Saposhnikoviae has effects of nourishing blood, replenishing blood, and can be used for treating alopecia caused by anemia and pale complexion due to blood deficiency, and promoting ruddy and glossy complexion to achieve effects of caring skin. The 9 medicines are used as ministerial medicines.

Achyranthes root has the effects of tonifying liver and kidney, strengthening muscles and bones, removing blood stasis and promoting tissue regeneration; poria cocos strengthens the spleen to assist transportation, so that the medicines are greasy; white peony root, radix Paeoniae alba nourishes blood and astringes yin; the ligusticum wallichii is used for activating blood and promoting qi circulation, so that the effect of tonifying can be achieved without stagnation, and the prepared rhizome of rehmannia and the angelica are used for regulating qi and blood to promote hair growth; the angelica dahurica dispels wind and dampness, can improve blood circulation, promotes hair to absorb nutrition and promotes pigment absorption; rhizoma Polygonati has effects in tonifying kidney, replenishing vital essence, and invigorating kidney and spleen. Fructus viticis, for its action of clearing heat and treating wind caused by scouring, can grow mustache: the salvia miltiorrhiza promotes blood circulation and nourishes blood, and improves blood circulation; fructus Cannabis has effects of nourishing blood, tonifying deficiency, treating blood deficiency and hair loss, and promoting hair growth. The fingered citron regulates qi and the middle, eliminates dampness and phlegm, and can help the astragalus root to tonify qi and blood of the whole body so as to promote hair growth. The above 10 medicines are all adjuvant medicines.

Moxibustion of licorice root, radix Glycyrrhizae Praeparata coordinates the properties of the drugs as a guiding drug.

The medicines are combined to help essence and blood to fill and grow hair, the qi and blood are vigorous and inexhaustible, the channels are communicated to nourish the hair, the liver and kidney are sufficient to make the hair firm, and the hair-growing, hair-blacking and hairdressing effects are realized.

The invention has the beneficial effects that: the formula has the effects of tonifying liver and kidney, tonifying qi and enriching blood, is a formula for tonifying yin and yang, has the effects of nourishing essence and blood, tonifying kidney and growing hair, and strives to be active in growing hair, so that the formula gives consideration to qi and blood, is matched with qi-regulating, blood-activating and spleen-tonifying transportation-assisting products among various tonifying medicaments, and has the advantages of tonifying, no stagnation of tonifying and no disadvantage of being vicious after long-term administration. The prepared ointment has the advantages that the effective components of the medicine are more easily and fully utilized, the curative effect is greatly improved, the ointment has good taste and is convenient to carry, the ointment is willing to be widely accepted by patients, the medication compliance of the patients is improved, and finally, the majority of patients have good traditional Chinese medicine treatment experience and benefit to more patients. Is suitable for patients with alopecia caused by radiotherapy and chemotherapy, and sallow and white hair and alopecia caused by deficiency of qi and blood and deficiency of spleen and kidney. The traditional Chinese medicine composition is very effective to the qi-blood deficiency type alopecia caused by radiotherapy and chemotherapy, can improve the qi-blood deficiency condition of tumor patients, can effectively keep the appearance integrity of the patients, and greatly improves the life quality of the patients and the confidence of cancer resistance.

Drawings

The invention will be further described in detail with reference to examples of embodiments shown in the drawings to which, however, the invention is not restricted.

FIG. 1 is a summary table of the therapeutic effects of clinical trials of embodiments of the present invention;

FIG. 2 is a graph showing the effect of 2 patients before and after treatment according to the embodiment of the present invention.

Detailed Description

The following examples of the invention are further illustrated:

the hair growth cream formula comprises the following raw materials in parts by weight: 15g of prepared rehmannia root, 10g of ligusticum wallichii, 10g of bran-fried bighead atractylodes rhizome, 10g of achyranthes root, 10g of fructus psoraleae, 10g of radix angelicae, 15g of rhizoma polygonati preparata, 15g of radix paeoniae alba, 10g of prepared polygonum multiflorum, 15g of poria cocos, 10g of wolfberry fruit, 5g of dried orange peel, 10g of cacumen biotae, 10g of fructus viticis, 10g of salvia miltiorrhiza, 10g of angelica sinensis, 15g of cooked codonopsis pilosula, 5g of honey-fried licorice root, 15g of salted dodder, 10g of fructus cannabis, 5g of divaricate saposhnikovi; and the following auxiliary materials in parts by weight: xylitol 20g

The paste formula is prepared by the following steps:

s1: taking raw materials and auxiliary materials according to parts by weight, and mixing the raw materials except for black sesame with water according to a weight ratio of 1: 8, and cold soaking for 12 hours after mixing.

s3: mixing the primary filter residue obtained in the step S2 with water according to the weight ratio of 1: 6, decocting again after mixing in proportion, and filtering by adopting a 100-mesh screen after the mixed solution boils for 50 minutes to obtain secondary filtrate;

s5: adding xylitol serving as an auxiliary material in parts by weight into the concentrated solution obtained in the step S4, continuously decocting for 15 minutes by adopting slow fire and continuously stirring, then adding black sesame serving as an auxiliary material in parts by weight, continuously decocting for 15 minutes to obtain paste, subpackaging in a 200 g/bottle mode when the concentrated solution is subjected to fish eye blister, flag hanging and water dripping beading, and completely cooling to obtain the hair growing paste formula.

The application method of the cream formula comprises the following steps: the paste formula of the invention is directly taken orally with warm water or with warm boiled water, preferably on an empty stomach, 15-20g each time, 2 times a day.

Pharmacological toxicity test:

1. mice were tested for toxicity by oral administration.

The test method comprises the following steps: selecting 20 healthy mice, 10 male mice and female mice respectively, dividing the mice into 5 groups by taking 2 male mice and 2 female mice as one group, designing the dosage to be one period every 5 days for 4 periods, weighing the weight once every 5 days, adjusting the dosage, and administering the dosage in an oral gavage mode in each period, wherein the dosage of each group in each period is 0.5, 0.75, 1, 1.25 and 1.5g/kgBW respectively. After 20 days no mice died and the test was completed.

2. Acute toxicity test of mice.

Mice were orally gavaged with 10g/kg BW per day for 7 consecutive days. All animals have no adverse reaction within 7 days, no abnormality in activity, diet, hair and excrement, and no shedding phenomenon in normal hair growth.

Toxicity tests prove that the ointment formula has no toxic effect and adverse reaction and is safe in clinical application.

Clinical experiments are as follows:

1. case selection: selecting 20 patients suffering from seborrheic alopecia, alopecia areata or alopecia totalis as an experimental group, and selecting 20 patients causing alopecia after radiotherapy, chemotherapy and other anti-tumor treatments as an experimental group; the age of the experimental patients is 25-55 years, the disease course of the experimental group is 2-10 years, and the disease course of the experimental group is 1 month-2 years.

2. The treatment scheme comprises the following steps: patients in two groups of experimental groups take the ointment formula of the invention by warm water or warm boiled water in a buccal manner every day, 15-20g each time, 2 times every day; 7 days are 1 course of treatment, the treatment results are counted after 2 courses of clinical observation, and two groups of patients are fast on the hot substances of the tobacco and the wine during the treatment period and keep the mood stable.

3. And (3) judging the curative effect:

and (3) curing: the alopecia phenomenon is obviously reduced, and the newly grown hair on the head is thick.

Improvement: the alopecia phenomenon is reduced, and the new hair on the head is increased.

And (4) invalidation: the hair loss phenomenon is not reduced, and the new hair on the head is little or no.

4. The treatment effect is as follows: after the two groups of patients are treated by the medicine, the treatment results are shown in figure 1, the effective rate of one group of experiments is 85%, and the effective rate of the other group of experiments is 95%. And as can be seen from fig. 1, the medicine of the present invention is very effective for treating alopecia symptoms caused by radiotherapy and chemotherapy, and has a slightly poor effect for treating patients with seborrheic alopecia, alopecia areata or alopecia totalis.

As shown in fig. 2, case 1 in fig. 2 is a patient in the experimental group, and case 2 is a patient in the experimental group.

Case 1 is specifically: for a male, 28 years old, seborrheic alopecia is more than 4 years, the forehead is the main one, and progressive alopecia is in the form of 'M'. After two bottles of the medicine are eaten, the hair of the forehead begins to grow, the hair is thicker and black, and the growth of the beard is obviously increased before the hair grows.

Case 2 is specifically: in the multiple-stage chemotherapy of leiomyosarcoma in 29 years old of a woman, the head is yellow and thin and is near bald, and after the medicine is used for 2 weeks, the newly grown head hair is thick, thick and tough, and black, bright and glossy. And chemotherapy was not discontinued during this period.

Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims.

Claims

1. The hair growth cream formula is characterized by comprising the following raw materials in parts by weight: 10-20g of prepared rehmannia root, 5-15g of ligusticum wallichii, 5-15g of bran-fried bighead atractylodes rhizome, 5-15g of achyranthes root, 5-15g of fructus psoraleae, 5-15g of radix angelicae, 10-20g of rhizoma polygonati preparata, 10-20g of radix paeoniae alba, 5-15g of prepared polygonum multiflorum, 10-20g of poria cocos, 5-15g of wolfberry fruit, 2-8g of dried orange peel, 5-15g of cacumen biotae, 5-15g of fructus viticis, 5-15g of salvia miltiorrhiza, 5-15g of angelica sinensis, 10-20g of cooked codonopsis pilosula, 2-8g of honey-fried licorice root, 10-20g of salted semen cuscutae, 5-15g of fructus cannabis, 2-8g of divaricate saposhnikovia root.

2. The hair growth cream formula according to claim 1, characterized by comprising the following raw materials in parts by weight: 15g of prepared rehmannia root, 10g of ligusticum wallichii, 10g of bran-fried bighead atractylodes rhizome, 10g of achyranthes root, 10g of fructus psoraleae, 10g of radix angelicae, 15g of rhizoma polygonati preparata, 15g of radix paeoniae alba, 10g of prepared polygonum multiflorum, 15g of poria cocos, 10g of wolfberry fruit, 5g of dried orange peel, 10g of cacumen biotae, 10g of fructus viticis, 10g of salvia miltiorrhiza, 10g of angelica sinensis, 15g of cooked codonopsis pilosula, 5g of honey-fried licorice root, 15g of salted dodder, 10g of fructus cannabis, 5g of divaricate saposhnikovi.

3. The hair growth cream formula according to claim 1 or 2, further comprising the following auxiliary materials in parts by weight: 15-25g of xylitol.

4. The preparation method of the hair growing cream formula according to claim 3, characterized by comprising the following steps:

s5: and (4) adding xylitol serving as an auxiliary material in parts by weight into the concentrated solution obtained in the step (S4), continuously decocting for 15 minutes by adopting slow fire and continuously stirring, then adding black sesame serving as an auxiliary material in parts by weight, continuously decocting for 15 minutes to obtain paste, subpackaging and cooling when the concentrated solution appears as fish eye bubbles, flag hanging and water dripping beads, and thus obtaining the hair growing paste formula.

5. The preparation method of the hair growing cream formula according to claim 4, characterized in that: in the step S1, the weight ratio of the raw material to water is 1: 8, and cold soaking for 12 hours.

6. The preparation method of the hair growing cream formula according to claim 4, characterized in that: and in the step S3, mixing the primary filter residue with water according to the weight ratio of 1: 6, and mixing.