CN112020363A - 烟酰胺核苷氯化物的结晶形式 - Google Patents

烟酰胺核苷氯化物的结晶形式 Download PDF

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Publication number
CN112020363A
CN112020363A CN201880090063.7A CN201880090063A CN112020363A CN 112020363 A CN112020363 A CN 112020363A CN 201880090063 A CN201880090063 A CN 201880090063A CN 112020363 A CN112020363 A CN 112020363A
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crystalline form
subject
administering
sleep
compound
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Chinese (zh)
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E·马科图利
D·阿尔米纳纳
R·德林格尔
M·莫里斯
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Elysium Health Inc
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Elysium Health Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201880090063.7A 2017-12-22 2018-12-20 烟酰胺核苷氯化物的结晶形式 Pending CN112020363A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762609512P 2017-12-22 2017-12-22
US62/609,512 2017-12-22
PCT/US2018/066769 WO2019126482A1 (en) 2017-12-22 2018-12-20 Crystalline forms of nicotinamide riboside chloride

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CN112020363A true CN112020363A (zh) 2020-12-01

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US (2) US11414407B2 (https=)
EP (1) EP3727400A4 (https=)
JP (1) JP2021506898A (https=)
CN (1) CN112020363A (https=)
CA (1) CA3086535A1 (https=)
WO (1) WO2019126482A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11129843B2 (en) 2017-04-24 2021-09-28 Elysium Health, Inc. Treating and preventing kidney damage
CN112020363A (zh) 2017-12-22 2020-12-01 益力舒健康公司 烟酰胺核苷氯化物的结晶形式
BR112022000963A2 (pt) 2019-07-19 2022-04-05 Biosynth Ag Método de fabricação de sais de nicotinamida ribofuranosídeo, sais de nicotinamida ribofuranosídeo como tal e usos dos mesmos
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN111808156A (zh) * 2020-07-15 2020-10-23 许昌远志生物科技有限公司 一种β-烟酰胺核糖氯化物的晶型1A、晶型1B及其制备方法
CN121793959A (zh) 2023-06-14 2026-04-03 可劳迈戴斯有限公司 静脉内配制品中的烟酰胺核苷及其衍生物与使用方法

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Publication number Publication date
CA3086535A1 (en) 2019-06-27
WO2019126482A1 (en) 2019-06-27
US20210094936A1 (en) 2021-04-01
US12043616B2 (en) 2024-07-23
US20230063175A1 (en) 2023-03-02
JP2021506898A (ja) 2021-02-22
EP3727400A4 (en) 2021-10-20
EP3727400A1 (en) 2020-10-28
US11414407B2 (en) 2022-08-16

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Application publication date: 20201201