CN112007132A - Anti-hair loss hair restorer and preparation method thereof - Google Patents

Abstract

The anti-hair loss pilatory and the preparation method thereof are characterized in that the anti-hair loss pilatory adopts safe Chinese herbal medicines and biological source nutrients, has stable anti-hair loss and hair growth effects, simple production process, short production period and high yield, and is suitable for industrial production.

Description

Anti-hair loss hair restorer and preparation method thereof

Technical Field

The invention relates to the field of anti-hair loss pilatory, in particular to an anti-hair loss pilatory and a preparation method thereof.

Background

In recent years, with social development, under the influence of factors such as working pressure, eating habits, regular work and rest and the like, the number of alopecia people in China is increased dramatically, 8000 ten thousand of alopecia patients in China in 1990 report by the clinical and financial sciences, 2.5 hundred million alopecia people in China 2019 account for 1/6 of the general population in China, and the alopecia people are also further younger, accounting for 38% after 80 and about 36% after 90. Alopecia causes serious psychological troubles to patients, and further affects the quality of life.

At present, common anti-hair loss and hair growth products have various types, but have different using effects.

Disclosure of Invention

Aiming at the short board of the existing anti-hair loss and hair growth technology, the invention provides an anti-hair loss and hair growth agent formula which mainly uses Chinese herbal medicines, biological source nutrients and vitamins, has stable effect and can effectively solve the problems in the background technology.

The invention aims to provide a pharmaceutical composition for preventing hair loss and promoting hair growth, which comprises the following components in parts by weight: 50-150 parts of ginger extract, 15-30 parts of radix polygoni multiflori preparata extract, 20-35 parts of ginseng extract, 10-25 parts of lucid ganoderma extract, 10-20 parts of radix sophorae flavescentis extract, 10-20 parts of salvia miltiorrhiza extract, 10-30 parts of cacumen biotae extract, 1-3 parts of menthol, 10-25 parts of rhizoma alismatis extract, 10-25 parts of raw white paeony root extract, 10-25 parts of rhizoma cimicifugae extract and 35-55 parts of tea bran powder.

The radix polygoni multiflori preparata extracting solution, the ginseng extracting solution, the radix sophorae flavescentis extracting solution and the salvia miltiorrhiza extracting solution are respectively prepared by the following steps: drying the medicinal materials (namely ginseng, radix sophorae flavescentis, salvia miltiorrhiza or radix polygoni multiflori preparata), then crushing the dried medicinal materials to obtain medicinal powder, adding the medicinal powder into a mixed solvent to obtain a solution, wherein the mixed solvent is a mixed solvent of ethanol and water in a volume ratio of 3:1, and the mass ratio of the medicinal powder to the mixed solvent is 1: 5; carrying out ultrasonic treatment on the solution, and then filtering the solution through a filter to obtain a filtered solution; adding the filtered solution into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain radix Polygoni Multiflori Preparata extract, Ginseng radix extract, radix Sophorae Flavescentis extract and Saviae Miltiorrhizae radix extract respectively.

The ginger extract, the lucid ganoderma extract, the cacumen biotae extract, the rhizoma alismatis extract, the raw white paeony root extract and the rhizoma cimicifugae extract are respectively prepared by the following steps: mixing the raw materials (rhizoma Zingiberis recens, Ganoderma, folium Platycladi, Alismatis rhizoma, radix Paeoniae alba or cimicifugae rhizoma) with water at a mass ratio of 1:4, heating to 100 deg.C, maintaining for 15 min, adjusting to 80 deg.C, and maintaining for 2-3 hr to obtain medicinal liquid; mixing the liquid medicine with ethanol according to the volume ratio of 1:2 to obtain mixed liquid medicine; carrying out ultrasonic treatment on the mixed liquid medicine, and then filtering the mixed liquid medicine through a filter to obtain filtered liquid medicine; adding the filtered liquid medicine into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain a ginger extract, a lucid ganoderma extract, a cacumen biotae extract, an alisma orientale extract, a raw white paeony root extract and a cimicifuga foetida extract respectively.

The tea bran powder is prepared by placing dried tea bran into a pulverizer to pulverize, and filtering with a sieve with the fineness of 1000 meshes to obtain the tea bran powder with the fineness of 1000 meshes.

In order to obtain a powder of a suitable size, the skilled person can select a filter sieve with suitable parameters according to the actual situation. In some embodiments, the mesh number of the filter sieve is 200 meshes, so that 200 meshes of medicinal powder is obtained.

The ultrasonic treatment aims to ensure that the extraction process is complete and can be adjusted according to conditions such as production scale and the like. In some embodiments, the specific operations of the sonication are: sonicate at 25KHz for 10 minutes and then stand for 2 hours. Furthermore, the ultrasonic standing operation can be repeated for multiple times to achieve a more sufficient effect; in some embodiments, the ultrasonic resting operation is repeated 3-4 times, or more.

The filter may be selected from the types commonly used in the art, such as 10um, 15um, 25um, 50um filters. In some embodiments, a 15um filter is employed.

In order to obtain a dried crude material, in some embodiments, the dried crude material can be obtained by drying the crude material at 60 ℃ for 4 hours.

The second purpose of the invention is to provide the application of the pharmaceutical composition in preparing a medicament for preventing alopecia and promoting hair growth, in particular to an anti-alopecia hair growth agent. The medicinal composition adopts safe Chinese herbal medicines and biological source nutrients, and experiments prove that the anti-hair loss and hair growth effect is stable.

In order to make the pharmaceutical composition suitable for industrial production, transportation and use, the pharmaceutical composition generally needs to be mixed with appropriate excipients. Therefore, the third object of the present invention is to provide an anti-hair loss hair restorer, which comprises excipients and an effective amount of the above pharmaceutical composition. The anti-hair loss hair restorer can be in various forms such as solution, lotion, cream, etc. which can be applied to the head and can be dispersed to some extent.

As one embodiment of the present invention, the above anti-hair loss hair restorer is prepared by the following method:

(1) dissolving Mentholum in water to obtain Mentholum solution;

(2) mixing the ginger extract, the prepared fleece flower root extract, the ginseng extract, the lucid ganoderma extract, the sophora flavescens extract, the salvia miltiorrhiza extract, the cacumen biotae extract, the rhizoma alismatis extract, the raw white paeony root extract, the rhizoma cimicifugae extract, the tea bran powder and the menthol solution according to the proportion and then uniformly stirring to prepare the anti-hair loss pilatory.

As a further embodiment of the present invention, the above-mentioned alopecia preventing and hair growing agent is prepared by the following method:

(1) dissolving 1-3 parts of menthol in 50 parts of water to prepare a menthol solution;

(2) mixing 50-150 parts of ginger extract, 15-30 parts of radix polygoni multiflori preparata extract, 20-35 parts of ginseng extract, 10-25 parts of lucid ganoderma extract, 10-20 parts of radix sophorae flavescentis extract, 10-20 parts of salvia miltiorrhiza extract, 10-30 parts of cacumen biotae extract, 10-25 parts of rhizoma alismatis extract, 10-25 parts of raw white paeony root extract, 10-25 parts of rhizoma cimicifugae extract, 35-55 parts of tea bran powder, menthol solution, 0.001 part of panthenol, 7 parts of polyethylene glycol-400, 6 parts of polysorbate-80, 6 parts of 1, 3-propylene glycol, 5 parts of glycerol, 0.07 part of xanthan gum, 0.016 part of propyl hydroxybenzoate, 0.016 part of 2-bromo-2-nitropropane-1, 3-diol and 1000 parts of water, and uniformly stirring to obtain the anti-hair loss hair growth agent.

In addition, in order to make the anti-hair loss and hair growth agent have fragrance, in some embodiments, essence may be further added in the step (2), and the essence may be one commonly used in the art. It can be understood that, since the amount of the essence added is very low (in some embodiments, 0.01 part), whether the essence is added or not does not substantially affect the hair loss prevention and hair growth effect of the present invention.

Unless otherwise specified, "parts" in the present invention mean "parts by weight".

The anti-hair loss pilatory and the preparation method thereof provided by the invention have the beneficial effects that: the anti-hair loss pilatory adopts safe Chinese herbal medicines and biological source nutrients without side effects. Stable hair loss prevention and hair growth effect, simple production process, short production period, high yield and suitability for industrial production.

Detailed Description

In order to make the objects, technical solutions and technical effects of the present invention more clear, the present invention is described in detail below with reference to embodiments. It should be understood that the embodiments described in this specification are only for the purpose of illustrating the invention and are not to be construed as limiting the invention, and the parameters, proportions and the like of the embodiments may be suitably selected without materially affecting the results. For example, in the following examples, the amounts of the components are merely exemplary to indicate the amounts used under specific production conditions (such as the volume of a container). Depending on the production conditions, the amounts of the components in the same embodiment may be increased or decreased in the same ratio (for example, when a container with a higher capacity is used, the amounts of the components may be increased in equal ratio) without substantially affecting the performance.

Example 1

The formula of the anti-hair loss hair restorer comprises the following components: 50g of ginger extract, 15g of radix polygoni multiflori preparata extract, 20g of ginseng extract, 10g of lucid ganoderma extract, 10g of radix sophorae flavescentis extract, 10g of salvia miltiorrhiza extract, 10g of cacumen biotae extract, 1g of menthol, 10g of rhizoma alismatis extract, 10g of raw radix paeoniae alba extract, 10g of rhizoma cimicifugae extract, 35g of tea bran powder, 0.001g of panthenol, 7g of polyethylene glycol-400, 6g of polysorbate-80, 6g of 1, 3-propylene glycol, 5g of glycerol, 0.07g of xanthan gum, 0.016g of propyl hydroxybenzoate, 0.016g of 2-bromo-2-nitropropane-1, 3-diol, 0.01g of essence and 1000g of distilled water.

The preparation method comprises the following steps:

(1) the radix polygoni multiflori preparata extracting solution, the ginseng extracting solution, the radix sophorae flavescentis extracting solution and the salvia miltiorrhiza extracting solution are respectively prepared by the following steps: drying the medicinal materials (namely ginseng, radix sophorae flavescentis, salvia miltiorrhiza or radix polygoni multiflori preparata) at 60 ℃ for 4 hours, crushing after drying, adding the crushed powder into a mixed solvent of ethanol and water in a volume ratio of 3:1 to obtain a solution, wherein the mass ratio of the medicinal powder to the mixed solvent is 1: 5; treating the solution with ultrasound (25KHz, 10 min), standing for 2 hr, repeating the ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered solution into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain radix Polygoni Multiflori Preparata extract, Ginseng radix extract, radix Sophorae Flavescentis extract and Saviae Miltiorrhizae radix extract respectively.

(2) The ginger extract, the lucid ganoderma extract, the cacumen biotae extract, the rhizoma alismatis extract, the raw white paeony root extract and the rhizoma cimicifugae extract are respectively prepared by the following steps: mixing the raw materials (rhizoma Zingiberis recens, Ganoderma, folium Platycladi, Alismatis rhizoma, radix Paeoniae alba or cimicifugae rhizoma) with water at a mass ratio of 1:4, heating to 100 deg.C, holding for 15 min, adjusting to 80 deg.C, and holding for 2-3 hr to obtain medicinal liquid; mixing the liquid medicine with ethanol at a volume ratio of 1:2, performing ultrasonic treatment (25KHz for 10 min), standing for 2 hr, repeating ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered liquid medicine into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain a ginger extract, a lucid ganoderma extract, a cacumen biotae extract, an alisma orientale extract, a raw white paeony root extract and a cimicifuga foetida extract respectively.

(3) The tea bran powder is prepared by the following steps: pulverizing dried tea bran (Camellia oleifera Abel., Hainan, same below) in micronizer for 5 min, and filtering with 1000 mesh sieve to obtain 1000 mesh tea bran powder.

(4) Dissolving Mentholum in 50g distilled water to obtain Mentholum solution.

(5) Mixing fleece-flower root extract, ginseng extract, sophora flavescens extract, salvia miltiorrhiza extract, ginger extract, lucid ganoderma extract, cacumen biotae extract, rhizoma alismatis extract, raw white paeony root extract, rhizoma cimicifugae extract, tea bran powder, menthol solution, panthenol, polyethylene glycol-400, polysorbate-80, 1, 3-propylene glycol, glycerol, xanthan gum, propyl hydroxybenzoate, 2-bromo-2-nitropropane-1, 3-diol, essence and distilled water in proportion, and stirring for 2 hours to obtain the anti-hair loss pilatory.

Example 2

The formula of the anti-hair loss hair restorer comprises the following components: 100g of ginger extract, 25g of radix polygoni multiflori preparata extract, 30g of ginseng extract, 20g of lucid ganoderma extract, 20g of radix sophorae flavescentis extract, 20g of salvia miltiorrhiza extract, 20g of cacumen biotae extract, 2g of menthol, 20g of rhizoma alismatis extract, 20g of raw radix paeoniae alba extract, 20g of rhizoma cimicifugae extract, 45g of tea bran powder, 0.001g of panthenol, 7g of polyethylene glycol-400, 6g of polysorbate-80, 6g of 1, 3-propylene glycol, 5g of glycerol, 0.07g of xanthan gum, 0.016g of propyl hydroxybenzoate, 0.016g of 2-bromo-2-nitropropane-1, 3-diol, 0.016g of essence and 1000g of distilled water.

The preparation method comprises the following steps:

(1) the radix polygoni multiflori preparata extracting solution, the ginseng extracting solution, the radix sophorae flavescentis extracting solution and the salvia miltiorrhiza extracting solution are respectively prepared by the following steps: drying the medicinal materials (namely ginseng, radix sophorae flavescentis, salvia miltiorrhiza or radix polygoni multiflori preparata) at 60 ℃ for 4 hours, crushing after drying, adding the crushed powder into a mixed solvent of ethanol and water in a volume ratio of 3:1 to obtain a solution, wherein the mass ratio of the medicinal powder to the mixed solvent is 1: 5; treating the solution with ultrasound (25KHz, 10 min), standing for 2 hr, repeating the ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered solution into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain radix Polygoni Multiflori Preparata extract, Ginseng radix extract, radix Sophorae Flavescentis extract and Saviae Miltiorrhizae radix extract respectively.

(2) The ginger extract, the lucid ganoderma extract, the cacumen biotae extract, the rhizoma alismatis extract, the raw white paeony root extract and the rhizoma cimicifugae extract are respectively prepared by the following steps: mixing the raw materials (rhizoma Zingiberis recens, Ganoderma, folium Platycladi, Alismatis rhizoma, radix Paeoniae alba or cimicifugae rhizoma) with water at a mass ratio of 1:4, heating to 100 deg.C, holding for 15 min, adjusting to 80 deg.C, and holding for 2-3 hr to obtain medicinal liquid; mixing the liquid medicine with ethanol at a volume ratio of 1:2, performing ultrasonic treatment (25KHz for 10 min), standing for 2 hr, repeating ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered liquid medicine into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain a ginger extract, a lucid ganoderma extract, a cacumen biotae extract, an alisma orientale extract, a raw white paeony root extract and a cimicifuga foetida extract respectively.

(3) And (3) putting the dried tea bran into an ultrafine pulverizer to pulverize for 5 minutes, and filtering by using a sieve with the fineness of 1000 meshes to obtain the tea bran powder with the fineness of 1000 meshes.

(4) Dissolving Mentholum in 50g distilled water to obtain Mentholum solution.

(5) Mixing fleece-flower root extract, ginseng extract, sophora flavescens extract, salvia miltiorrhiza extract, ginger extract, lucid ganoderma extract, cacumen biotae extract, rhizoma alismatis extract, raw white paeony root extract, rhizoma cimicifugae extract, tea bran powder, menthol solution, panthenol, polyethylene glycol-400, polysorbate-80, 1, 3-propylene glycol, glycerol, xanthan gum, propyl hydroxybenzoate, 2-bromo-2-nitropropane-1, 3-diol, essence and distilled water in proportion, and stirring for 2 hours to obtain the anti-hair loss pilatory.

Example 3

The formula of the anti-hair loss hair restorer comprises the following components: 150g of ginger extract, 30g of prepared fleece flower root extract, 35g of ginseng extract, 25g of lucid ganoderma extract, 20g of sophora flavescens extract, 20g of salvia miltiorrhiza extract, 30g of cacumen biotae extract, 3g of menthol, 25g of rhizoma alismatis extract, 25g of raw white peony root extract, 25g of rhizoma cimicifugae extract, 55g of tea bran powder, 0.001g of panthenol, 7g of polyethylene glycol-400, 6g of polysorbate-80, 6g of 1, 3-propylene glycol, 5g of glycerol, 0.07g of xanthan gum, 0.016g of propyl hydroxybenzoate, 0.016g of 2-bromo-2-nitropropane-1, 3-diol, 0.01g of essence and 1000g of distilled water.

The preparation method comprises the following steps:

(1) the radix polygoni multiflori preparata extracting solution, the ginseng extracting solution, the radix sophorae flavescentis extracting solution and the salvia miltiorrhiza extracting solution are respectively prepared by the following steps: drying the medicinal materials (namely ginseng, radix sophorae flavescentis, salvia miltiorrhiza or radix polygoni multiflori preparata) at 60 ℃ for 4 hours, crushing after drying, adding the crushed powder into a mixed solvent of ethanol and water in a volume ratio of 3:1 to obtain a solution, wherein the mass ratio of the medicinal powder to the mixed solvent is 1: 5; treating the solution with ultrasound (25KHz, 10 min), standing for 2 hr, repeating the ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered solution into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain radix Polygoni Multiflori Preparata extract, Ginseng radix extract, radix Sophorae Flavescentis extract and Saviae Miltiorrhizae radix extract respectively.

(2) The ginger extract, the lucid ganoderma extract, the cacumen biotae extract, the rhizoma alismatis extract, the raw white paeony root extract and the rhizoma cimicifugae extract are respectively prepared by the following steps: mixing the raw materials (rhizoma Zingiberis recens, Ganoderma, folium Platycladi, Alismatis rhizoma, radix Paeoniae alba or cimicifugae rhizoma) with water at a mass ratio of 1:4, heating to 100 deg.C, holding for 15 min, adjusting to 80 deg.C, and holding for 2-3 hr to obtain medicinal liquid; mixing the liquid medicine with ethanol at a volume ratio of 1:2, performing ultrasonic treatment (25KHz for 10 min), standing for 2 hr, repeating ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered liquid medicine into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain a ginger extract, a lucid ganoderma extract, a cacumen biotae extract, an alisma orientale extract, a raw white paeony root extract and a cimicifuga foetida extract respectively.

(3) And (3) putting the dried tea bran into an ultrafine pulverizer to pulverize for 5 minutes, and filtering by using a sieve with the fineness of 1000 meshes to obtain the tea bran powder with the fineness of 1000 meshes.

(4) Dissolving Mentholum in 50g distilled water to obtain Mentholum solution.

(5) Mixing fleece-flower root extract, ginseng extract, sophora flavescens extract, salvia miltiorrhiza extract, ginger extract, lucid ganoderma extract, cacumen biotae extract, rhizoma alismatis extract, raw white paeony root extract, rhizoma cimicifugae extract, tea bran powder, menthol solution, panthenol, polyethylene glycol-400, polysorbate-80, 1, 3-propylene glycol, glycerol, xanthan gum, propyl hydroxybenzoate, 2-bromo-2-nitropropane-1, 3-diol, essence and distilled water in proportion, and stirring for 2 hours to obtain the anti-hair loss pilatory.

The effects of the products of examples 1-3 were tested experimentally and comparative examples 1, 2, 3, 4, 5 were set up.

240 male and female volunteers aged 30-60 were selected and divided into 8 groups of 30 individuals each. Groups 1-3 used the products of examples 1-3, respectively, and groups 4-8 used the products of comparative examples 1-5, respectively. When in use, the preparation is applied uniformly after hair is wetted completely, and massaged for 5-10 min for 20 times at an interval of 1 day. After 20 times of use, the condition of hair and skin on the head was observed.

Observation indexes are as follows:

A. condition of hair loss

No hair loss, score 0 (the amount of hair loss is less than 100/d); 2 points (the hair loss amount is 100-150 per day) are taken for a small amount of hair loss; the hair loss is counted for 4 points (the hair loss amount is 150-200 per day); large amount of hair loss was counted at 6 points (the amount of hair loss was greater than 200/day).

B. Degree of itching

No itch, score 0; occasionally pruritus, no scratching at ordinary times, 2 points are recorded; pruritus can be tolerated occasionally, scratching times are few, and 4 points are recorded; the itching is difficult to endure all the time, the life quality is seriously affected, and 6 points are recorded after scratching for many times.

C. Degree of greasiness

The hair is fresh and cool, the hair is not cleaned for 3 days and is consciously greasy, and the score is 0; the hair is slightly greasy, the hair is not washed for 2 days, the hair feel is obviously greasy, and the score is 2; the hair is greasy, and if the hair is not washed for 1 day, the hair is obviously greasy, and the score is 4; the hair was very greasy, and the daily cleansing of the greasy hair was not reduced by 6 points.

D. Degree of scale

Marking 0 point when no scale is found; a small amount of scales attached to the scalp can be seen when the hair is pulled open, and 2 points are recorded; 4 points are marked without pulling hair to see that more scales are attached to the scalp; many scales were accumulated and mark 6 was observed on the collar.

E. New hair condition

The hair is grown on the bald part, and the color, the thickness and the distribution density are the same as those of the normal hair, and the score is 0; the newly grown hair is more than two thirds of the hair and is thin and soft, and the score is 2; the newly grown hair is more than one third, and the score is 4; no obvious effect was seen after the treatment of the area with hair loss, which was scored 6. The default integral of new hair condition for all patients before treatment was 6 points.

Comparative example 1

The hair was washed once every 1 day using a certain brand of ordinary shampoo.

Comparative example 2

The hair is washed once every 1 day by using a certain brand of hair loss prevention shampoo.

Comparative example 3

The formula of the anti-hair loss hair restorer comprises the following components: 100g of ginger extract, 25g of radix polygoni multiflori preparata extract, 30g of ginseng extract, 20g of lucid ganoderma extract, 20g of radix sophorae flavescentis extract, 20g of salvia miltiorrhiza extract, 20g of cacumen biotae extract, 2g of menthol, 45g of tea bran powder, 0.001g of panthenol, 7g of polyethylene glycol-400, 6g of polysorbate-80, 6g of 1, 3-propylene glycol, 5g of glycerol, 0.07g of xanthan gum, 0.016g of propyl hydroxybenzoate, 0.016g of 2-bromo-2-nitropropane-1, 3-diol, 0.01g of essence and 1000g of distilled water.

The preparation method comprises the following steps:

(1) the radix polygoni multiflori preparata extracting solution, the ginseng extracting solution, the radix sophorae flavescentis extracting solution and the salvia miltiorrhiza extracting solution are respectively prepared by the following steps: drying the medicinal materials (namely ginseng, radix sophorae flavescentis, salvia miltiorrhiza or radix polygoni multiflori preparata) at 60 ℃ for 4 hours, crushing after drying, adding the crushed powder into a mixed solvent of ethanol and water in a volume ratio of 3:1 to obtain a solution, wherein the mass ratio of the medicinal powder to the mixed solvent is 1: 5; treating the solution with ultrasound (25KHz, 10 min), standing for 2 hr, repeating the ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered solution into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain radix Polygoni Multiflori Preparata extract, Ginseng radix extract, radix Sophorae Flavescentis extract and Saviae Miltiorrhizae radix extract respectively.

(2) The ginger extract, the lucid ganoderma extract and the cacumen biotae extract are respectively prepared by the following steps: mixing the medicinal materials with water at a mass ratio of 1:4, heating to 100 deg.C, holding for 15 min, adjusting to 80 deg.C, and holding for 2-3 hr to obtain medicinal liquid; mixing the liquid medicine with ethanol at a volume ratio of 1:2, performing ultrasonic treatment (25KHz for 10 min), standing for 2 hr, repeating ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered medicinal liquid into a heating reflux device, heating and refluxing at 75 deg.C for 1 hr, and cooling to obtain rhizoma Zingiberis recens extractive solution, Ganoderma extractive solution, and folium Platycladi extractive solution.

(3) And (3) putting the dried tea bran into an ultrafine pulverizer to pulverize for 5 minutes, and filtering by using a sieve with the fineness of 1000 meshes to obtain the tea bran powder with the fineness of 1000 meshes.

(4) Dissolving Mentholum in 50g distilled water to obtain Mentholum solution.

(5) Mixing Polygoni Multiflori radix extract, Ginseng radix extract, radix Sophorae Flavescentis extract, Saviae Miltiorrhizae radix extract, rhizoma Zingiberis recens extract, Ganoderma extract, folium Platycladi extract, tea bran powder, Mentholum solution, panthenol, polyethylene glycol-400, polysorbate-80, 1, 3-propylene glycol, glycerol, xanthan gum, propyl hydroxybenzoate, 2-bromo-2-nitropropane-1, 3-diol, essence and distilled water at a certain proportion, stirring for 2 hr, and making into preparation.

Comparative example 4

The formula of the anti-hair loss hair restorer comprises the following components: 100g of ginger extract, 25g of radix polygoni multiflori preparata extract, 30g of ginseng extract, 20g of lucid ganoderma extract, 20g of radix sophorae flavescentis extract, 20g of salvia miltiorrhiza extract, 20g of cacumen biotae extract, 2g of menthol, 20g of rhizoma alismatis extract, 20g of raw radix paeoniae alba extract, 20g of rhizoma cimicifugae extract, 45g of tea bran powder, 0.001g of panthenol, 7g of polyethylene glycol-400, 6g of polysorbate-80, 6g of 1, 3-propylene glycol, 5g of glycerol, 0.07g of xanthan gum, 0.016g of propyl hydroxybenzoate, 0.016g of 2-bromo-2-nitropropane-1, 3-diol, 0.016g of essence and 1000g of distilled water.

The preparation method comprises the following steps:

(1) the radix polygoni multiflori preparata extracting solution, the ginseng extracting solution, the radix sophorae flavescentis extracting solution, the radix salviae miltiorrhizae extracting solution, the ginger extracting solution, the lucid ganoderma extracting solution, the cacumen biotae extracting solution, the rhizoma alismatis extracting solution, the raw white paeony root extracting solution and the rhizoma cimicifugae extracting solution are respectively prepared by the following steps: mixing the medicinal materials with water at a mass ratio of 1:4, heating to 100 deg.C, holding for 15 min, adjusting to 80 deg.C, and holding for 2-3 hr to obtain medicinal liquid; mixing the liquid medicine with ethanol at a volume ratio of 1:2, performing ultrasonic treatment (25KHz for 10 min), standing for 2 hr, repeating ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered medicinal liquid into a heating reflux device, heating and refluxing at 75 deg.C for 1 hr, cooling to obtain radix Polygoni Multiflori Preparata extractive solution, Ginseng radix extractive solution, radix Sophorae Flavescentis extractive solution, Saviae Miltiorrhizae radix extractive solution, rhizoma Zingiberis recens extractive solution, Ganoderma extractive solution, folium Platycladi extractive solution, Alismatis rhizoma extractive solution, radix Paeoniae alba extractive solution and cimicifugae rhizoma extractive solution.

(2) And (3) putting the dried tea bran into an ultrafine pulverizer to pulverize for 5 minutes, and filtering by using a sieve with the fineness of 1000 meshes to obtain the tea bran powder with the fineness of 1000 meshes.

(3) Dissolving Mentholum in 50g water to obtain Mentholum solution.

(4) Mixing fleece-flower root extract, ginseng extract, sophora flavescens extract, salvia miltiorrhiza extract, ginger extract, lucid ganoderma extract, cacumen biotae extract, rhizoma alismatis extract, raw white paeony root extract, rhizoma cimicifugae extract, tea bran powder, menthol solution, panthenol, polyethylene glycol-400, polysorbate-80, 1, 3-propylene glycol, glycerol, xanthan gum, propyl hydroxybenzoate, 2-bromo-2-nitropropane-1, 3-diol, essence and distilled water in proportion, and stirring for 2 hours to obtain the anti-hair loss pilatory.

Comparative example 5

The formula of the anti-hair loss hair restorer comprises the following components: 100g of ginger extract, 25g of radix polygoni multiflori preparata extract, 30g of ginseng extract, 20g of lucid ganoderma extract, 20g of radix sophorae flavescentis extract, 20g of salvia miltiorrhiza extract, 20g of cacumen biotae extract, 2g of menthol, 20g of rhizoma alismatis extract, 20g of raw radix paeoniae alba extract, 20g of rhizoma cimicifugae extract, 45g of tea bran powder, 0.001g of panthenol, 7g of polyethylene glycol-400, 6g of polysorbate-80, 6g of 1, 3-propylene glycol, 5g of glycerol, 0.07g of xanthan gum, 0.016g of propyl hydroxybenzoate, 0.016g of 2-bromo-2-nitropropane-1, 3-diol, 0.016g of essence and 1000g of distilled water.

The preparation method comprises the following steps:

(1) the radix polygoni multiflori preparata extracting solution, the ginseng extracting solution, the radix sophorae flavescentis extracting solution, the radix salviae miltiorrhizae extracting solution, the ginger extracting solution, the lucid ganoderma extracting solution, the cacumen biotae extracting solution, the rhizoma alismatis extracting solution, the raw white paeony root extracting solution and the rhizoma cimicifugae extracting solution are respectively prepared by the following steps: drying the medicinal materials at 60 ℃ for 4 hours, crushing after drying, adding the crushed powder into a mixed solvent of ethanol and water in a volume ratio of 3:1 to obtain a solution, wherein the mass ratio of the medicinal powder to the mixed solvent is 1: 5; treating the solution with ultrasound (25KHz, 10 min), standing for 2 hr, repeating the ultrasonic standing operation for 2-3 times (total 3-4 times), and filtering with 15um filter; adding the filtered solution into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to obtain fleece-flower root extract, ginseng extract, sophora flavescens extract, salvia miltiorrhiza extract, ginger extract, ganoderma lucidum extract, cacumen biotae extract, rhizoma alismatis extract, raw white paeony root extract and cimicifugae foetida extract respectively.

(2) And (3) putting the dried tea bran into an ultrafine pulverizer to pulverize for 5 minutes, and filtering by using a sieve with the fineness of 1000 meshes to obtain the tea bran powder with the fineness of 1000 meshes.

(3) Dissolving Mentholum in 50g water to obtain Mentholum solution.

(4) Extracting Polygoni Multiflori radix, Ginseng radix, radix Sophorae Flavescentis, Saviae Miltiorrhizae radix, rhizoma Zingiberis recens, Ganoderma, folium Platycladi, Alismatis rhizoma, radix Paeoniae alba, cimicifugae rhizoma, tea bran powder, Mentholum, panthenol, polyethylene glycol-400, polysorbate-80, 1, 3-propylene glycol, glycerol, xanthan gum, propyl hydroxybenzoate, 2-bromo-2-nitropropane-1, 3-diol, essence and distilled water. After mixing according to the proportion, stirring for 2 hours to prepare the anti-hair loss pilatory.

Result statistics and analysis

The statistical results are shown in tables one to nine. After 20 times of use, examples 1, 2 and 3 all had the effects of preventing alopecia, relieving itching and promoting new hair growth. The best results are obtained in example 2. Through comparison of example 2 and comparative example 3, it is found that the three traditional Chinese medicine components of rhizoma alismatis, raw white paeony root and rhizoma cimicifugae are reduced, and the anti-alopecia, itching relieving and new hair growth promoting effects of the comparative example 3 are much lower than those of the examples. It was found by comparing example 2 with comparative examples 4 and 5 that different extraction methods also affected efficacy with the same composition.

Table one group of statistical results

Table two example 1 usage statistics table

Serial number	Condition of hair loss	Degree of itching	Degree of greasiness	Degree of scale	New hair condition
						1	0	0	0	2	0
2	0	4	0	0	2
						3	2	0	2	2	2
4	0	0	0	0	2
						5	0	4	0	2	0
6	0	2	4	4	4
						7	0	0	0	0	4
8	0	0	0	2	2
						9	0	0	0	4	0
10	0	0	2	6	4
						11	4	0	0	6	0
12	2	4	0	0	4
						13	2	0	0	0	4
14	0	2	2	6	0
						15	4	4	0	4	2
16	0	0	0	2	4
						17	0	4	2	6	2
18	2	0	0	2	0
						19	4	4	2	2	4
20	0	0	4	0	2
						21	2	2	2	0	2
22	0	0	0	4	2
						23	2	2	2	0	6
24	0	4	0	4	4
						25	0	2	2	4	2
26	0	0	2	0	0
						27	2	4	0	0	2
28	0	0	2	4	2
						29	2	0	2	2	2
30	0	0	0	0	6
						Mean value of	0.93	1.40	1.00	2.27	2.33

Table three example 2 data statistics table

Serial number	Condition of hair loss	Degree of itching	Degree of greasiness	Degree of scale	New hair condition
						1	0	0	0	0	0
2	0	0	0	0	2
						3	0	0	0	0	2
4	0	0	0	2	0
						5	0	0	0	0	0
6	2	2	2	2	2
						7	0	0	0	0	0
8	0	0	0	0	2
						9	0	0	0	0	0
10	0	0	0	0	2
						11	0	0	0	0	0
12	2	0	0	0	0
						13	0	0	0	0	2
14	0	2	2	2	0
						15	0	0	0	2	0
16	0	0	0	0	4
						17	0	0	0	0	2
18	0	0	0	0	0
						19	0	0	2	0	0
20	0	0	0	2	2
						21	0	0	0	0	2
22	0	0	0	2	0
						23	2	2	2	2	0
24	0	0	0	0	0
						25	0	2	2	0	0
26	0	2	0	0	0
						27	2	0	0	0	2
28	0	0	0	0	2
						29	0	0	2	2	2
30	0	0	0	0	0
						Mean value of	0.27	0.33	0.40	0.53	0.93

TABLE EXAMPLE 3 data statistics Table

Serial number	Condition of hair loss	Degree of itching	Degree of greasiness	Degree of scale	New hair condition
						1	0	2	2	4	4
2	0	0	0	2	2
						3	0	0	0	0	2
4	0	2	2	2	0
						5	0	0	0	0	0
6	2	2	2	2	2
						7	0	0	4	0	0
8	0	2	0	0	2
						9	2	0	4	2	4
10	0	4	0	0	2
						11	0	0	4	0	0
12	2	0	0	2	0
						13	2	0	0	0	2
14	0	4	4	6	4
						15	0	2	0	2	0
16	0	2	4	4	4
						17	0	4	0	0	2
18	0	0	0	0	0
						19	0	4	4	0	0
20	4	4	0	6	6
						21	0	0	0	0	2
22	0	0	2	2	0
						23	2	2	2	2	0
24	0	0	0	0	0
						25	0	2	2	0	0
26	2	2	2	0	0
						27	2	0	4	4	6
28	2	0	0	0	2
						29	0	0	2	2	2
30	0	0	0	0	0
						Mean value of	0.67	1.27	1.47	1.40	1.60

Table five comparative example 1 data statistics table

Serial number	Condition of hair loss	Degree of itching	Degree of greasiness	Degree of scale	New hair condition
						1	6	4	4	2	6
2	2	4	4	2	4
						3	6	2	4	4	6
4	4	2	2	2	6
						5	4	6	2	2	6
6	2	2	6	2	4
						7	2	4	6	4	4
8	6	2	6	2	6
						9	4	2	2	4	4
10	4	4	4	4	4
						11	6	2	4	2	6
12	2	4	2	2	4
						13	4	2	4	2	4
14	4	6	4	2	6
						15	4	2	4	2	4
16	4	4	0	2	4
						17	2	4	4	2	6
18	4	2	4	2	2
						19	4	0	2	4	4
20	4	2	4	2	2
						21	2	2	2	6	4
22	4	2	4	6	6
						23	6	6	2	2	6
24	4	2	4	4	6
						25	4	6	2	2	6
26	2	2	4	2	4
						27	4	2	6	2	6
28	4	4	4	4	6
						29	4	2	2	2	4
30	2	4	2	4	4
						Mean value of	3.80	3.07	3.47	2.80	4.80

Table six comparative example 2 data statistics table

Serial number	Condition of hair loss	Degree of itching	Degree of greasiness	Degree of scale	New hair condition
						1	2	2	2	4	2
2	2	4	0	2	4
						3	2	2	2	4	2
4	4	2	2	2	6
						5	2	4	0	4	6
6	2	2	2	2	6
						7	2	2	2	0	0
8	2	2	0	0	2
						9	0	2	2	2	2
10	2	4	0	0	4
						11	4	2	2	2	4
12	2	0	2	2	2
						13	2	2	0	0	2
14	2	0	2	6	6
						15	2	2	0	2	2
16	2	2	2	4	4
						17	0	4	6	2	6
18	4	2	4	4	6
						19	0	4	2	4	6
20	4	0	6	6	6
						21	2	2	2	0	2
22	2	4	2	2	2
						23	2	4	4	2	4
24	0	0	0	4	2
						25	2	2	2	0	2
26	2	2	2	2	2
						27	2	0	6	4	6
28	2	4	6	4	2
						29	2	0	2	2	2
30	2	0	4	2	4
						Mean value of	2.00	2.07	2.27	2.47	3.53

TABLE seventhly data statistics table for comparative example 3

Serial number	Condition of hair loss	Degree of itching	Degree of greasiness	Degree of scale	New hair condition
						1	2	4	4	2	4
2	4	2	2	2	6
						3	4	2	2	4	2
4	2	2	2	2	4
						5	2	4	0	2	4
6	2	4	4	4	4
						7	2	2	2	2	2
8	0	2	4	2	2
						9	2	4	2	4	2
10	2	2	4	6	6
						11	4	4	4	6	4
12	2	4	2	0	4
						13	2	2	0	0	2
14	2	2	2	6	4
						15	2	4	2	4	4
16	4	2	2	2	2
						17	2	4	2	6	2
18	4	2	0	2	4
						19	2	4	2	2	2
20	2	2	4	2	4
						21	2	2	2	4	2
22	4	2	2	2	4
						23	2	2	2	2	2
24	2	4	0	2	2
						25	2	2	2	2	2
26	0	0	2	2	4
						27	2	4	0	0	2
28	2	0	2	2	2
						29	2	2	2	4	4
30	0	0	0	4	2
						Mean value of	2.20	2.53	2.00	2.80	3.13

Table eight comparative example 4 data statistics table

Serial number	Condition of hair loss	Degree of itching	Degree of greasiness	Degree of scale	New hair condition
						1	4	2	4	2	6
2	2	2	4	4	4
						3	2	2	4	4	2
4	2	4	2	2	4
						5	2	2	6	2	2
6	0	2	4	4	4
						7	2	4	2	4	4
8	4	4	2	4	2
						9	4	2	4	2	2
10	2	2	4	2	4
						11	2	0	2	6	4
12	4	2	4	4	4
						13	2	4	2	4	4
14	2	2	2	6	4
						15	2	4	4	4	4
16	0	0	2	2	2
						17	4	2	4	6	2
18	4	4	4	2	4
						19	2	4	2	4	4
20	2	2	2	0	2
						21	2	4	2	2	2
22	2	2	2	4	6
						23	2	2	2	0	4
24	2	4	2	4	4
						25	2	2	4	4	6
26	2	2	4	0	2
						27	2	4	0	0	4
28	2	2	4	4	4
						29	0	2	2	2	2
30	2	0	4	0	6
						Mean value of	2.20	2.47	3.00	2.93	3.60

Table nine comparative example 5 data statistics table

Serial number	Condition of hair loss	Degree of itching	Degree of greasiness	Degree of scale	New hair condition
						1	4	2	4	6	6
2	2	2	4	4	4
						3	4	2	4	2	2
4	4	2	2	4	4
						5	2	4	2	2	4
6	4	2	2	2	2
						7	4	4	4	2	4
8	4	4	2	6	6
						9	2	4	2	4	4
10	2	2	2	2	2
						11	4	2	2	4	2
12	2	2	4	2	4
						13	4	4	2	2	4
14	2	2	4	2	2
						15	4	4	2	4	2
16	4	2	0	2	2
						17	2	2	6	4	2
18	4	2	4	4	2
						19	2	2	2	2	6
20	2	6	0	4	6
						21	4	2	2	6	4
22	4	2	2	4	2
						23	2	0	0	2	6
24	2	2	2	4	4
						25	4	2	4	2	4
26	2	4	4	4	6
						27	2	2	4	2	4
28	2	2	6	2	4
						29	6	4	4	4	4
30	4	2	2	4	6
						Mean value of	3.13	2.60	2.80	3.27	3.80

Claims (6)

1. The pharmaceutical composition for preventing hair loss and growing hair is characterized by comprising the following components in parts by weight: 50-150 parts of ginger extract, 15-30 parts of radix polygoni multiflori preparata extract, 20-35 parts of ginseng extract, 10-25 parts of lucid ganoderma extract, 10-20 parts of radix sophorae flavescentis extract, 10-20 parts of salvia miltiorrhiza extract, 10-30 parts of cacumen biotae extract, 1-3 parts of menthol, 10-25 parts of rhizoma alismatis extract, 10-25 parts of raw white paeony root extract, 10-25 parts of rhizoma cimicifugae extract and 35-55 parts of tea bran powder; wherein:

the radix polygoni multiflori preparata extracting solution, the ginseng extracting solution, the radix sophorae flavescentis extracting solution and the salvia miltiorrhiza extracting solution are respectively prepared by the following steps: drying the medicinal materials (namely ginseng, radix sophorae flavescentis, salvia miltiorrhiza or radix polygoni multiflori preparata), then crushing the dried medicinal materials to obtain medicinal powder, adding the medicinal powder into a mixed solvent to obtain a solution, wherein the mixed solvent is a mixed solvent of ethanol and water in a volume ratio of 3:1, and the mass ratio of the medicinal powder to the mixed solvent is 1: 5; carrying out ultrasonic treatment on the solution, and then filtering the solution through a filter to obtain a filtered solution; adding the filtered solution into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to respectively obtain radix Polygoni Multiflori Preparata extract, Ginseng radix extract, radix Sophorae Flavescentis extract and Saviae Miltiorrhizae radix extract;

the ginger extract, the lucid ganoderma extract, the cacumen biotae extract, the rhizoma alismatis extract, the raw white paeony root extract and the rhizoma cimicifugae extract are respectively prepared by the following steps: mixing the raw materials (rhizoma Zingiberis recens, Ganoderma, folium Platycladi, Alismatis rhizoma, radix Paeoniae alba or cimicifugae rhizoma) with water at a mass ratio of 1:4, heating to 100 deg.C, maintaining for 15 min, adjusting to 80 deg.C, and maintaining for 2-3 hr to obtain medicinal liquid; mixing the liquid medicine with ethanol according to the volume ratio of 1:2 to obtain mixed liquid medicine; carrying out ultrasonic treatment on the mixed liquid medicine, and then filtering the mixed liquid medicine through a filter to obtain filtered liquid medicine; adding the filtered liquid medicine into a heating reflux device, heating and refluxing for 1 hour at 75 ℃, and cooling to respectively obtain a ginger extract, a lucid ganoderma extract, a cacumen biotae extract, an alisma orientale extract, a raw white paeony root extract and a cimicifuga foetida extract;

the tea bran powder is prepared by placing dried tea bran into a pulverizer to pulverize, and filtering with a sieve with the fineness of 1000 meshes to obtain the tea bran powder with the fineness of 1000 meshes.

2. The pharmaceutical composition of claim 1, wherein said powder is 200 mesh; the ultrasonic treatment is ultrasonic treatment for 10 minutes under 25KHz, then standing for 2 hours, and the ultrasonic standing operation is repeated for 3-4 times; the filter is a 15um filter.

3. Use of the pharmaceutical composition according to claim 1 or 2 for the preparation of an anti-hair loss hair restorer.

4. An anti-hair loss and hair growth agent, which is characterized by comprising auxiliary materials and an effective dose of the pharmaceutical composition of claim 1 or 2.

5. A method for producing the agent for hair loss prevention and hair growth of claim 4, comprising the steps of:

(1) dissolving Mentholum in water to obtain Mentholum solution;

(2) mixing the ginger extract, the prepared fleece flower root extract, the ginseng extract, the lucid ganoderma extract, the sophora flavescens extract, the salvia miltiorrhiza extract, the cacumen biotae extract, the rhizoma alismatis extract, the raw white paeony root extract, the rhizoma cimicifugae extract, the tea bran powder and the menthol solution according to the proportion and then uniformly stirring to prepare the anti-hair loss pilatory.

6. A method for producing the agent for hair loss prevention and hair growth of claim 4, comprising the steps of:

(1) dissolving 1-3 parts of menthol in 50 parts of water to prepare a menthol solution;

(2) mixing 50-150 parts of ginger extract, 15-30 parts of radix polygoni multiflori preparata extract, 20-35 parts of ginseng extract, 10-25 parts of lucid ganoderma extract, 10-20 parts of radix sophorae flavescentis extract, 10-20 parts of salvia miltiorrhiza extract, 10-30 parts of cacumen biotae extract, 10-25 parts of rhizoma alismatis extract, 10-25 parts of raw white paeony root extract, 10-25 parts of rhizoma cimicifugae extract, 35-55 parts of tea bran powder, menthol solution, 0.001 part of panthenol, 7 parts of polyethylene glycol-400, 6 parts of polysorbate-80, 6 parts of 1, 3-propylene glycol, 5 parts of glycerol, 0.07 part of xanthan gum, 0.016 part of propyl hydroxybenzoate, 0.016 part of 2-bromo-2-nitropropane-1, 3-diol and 1000 parts of water, and uniformly stirring to obtain the anti-hair loss hair growth agent.