CN112006279A - Medicine and food homologous preparation for nourishing bone marrow - Google Patents
Medicine and food homologous preparation for nourishing bone marrow Download PDFInfo
- Publication number
- CN112006279A CN112006279A CN202010920534.1A CN202010920534A CN112006279A CN 112006279 A CN112006279 A CN 112006279A CN 202010920534 A CN202010920534 A CN 202010920534A CN 112006279 A CN112006279 A CN 112006279A
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- parts
- preparation
- rhizoma polygonati
- bone marrow
- edible
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to the technical field of health-care food, and provides a medicine-food homologous preparation for nourishing bone marrow, which consists of the following components in parts by weight: 30-40 parts of rhizoma polygonati, 20-30 parts of radix puerariae, 15-20 parts of radix astragali, 10-15 parts of fructus lycii, 10-15 parts of sea buckthorn, 10-15 parts of poria cocos, 5-10 parts of spina date seeds, 20-30 parts of spirulina and 5-8 parts of platycodon grandiflorum. The preparation method comprises the following steps: steaming rhizoma Polygonati in wine; parching radix Puerariae and grinding; putting fructus Lycii, fructus Hippophae and Poria into alcohol, and keeping the temperature to obtain concentrated solution I; putting spirulina, radix astragali and semen Ziziphi Spinosae into alcohol, and keeping the temperature to obtain concentrated solution II; decocting radix Platycodi and rhizoma Polygonati to obtain concentrated solution III, mixing with concentrated solution I, and mixing with starch to obtain compound rhizoma Polygonati powder; mixing radix Puerariae powder and compound rhizoma Polygonati powder to obtain medicinal and edible preparation for nourishing bone marrow. Through the technical scheme, the problem of low utilization rate of the effective components of the traditional Chinese medicine of the medicinal and edible preparation in the prior art is solved.
Description
Technical Field
The invention belongs to the technical field of health-care food, and relates to a medicine-food homologous preparation for nourishing bone marrow.
Background
Traditional Chinese medicine has long recognized that bone marrow is an organ that produces blood cells (red blood cells, white blood cells, etc.). The book "classics-visceral manifestation class" says: the marrow is the filling of bone. "here, the bone includes the brain, the vertebra, other bones, correspondingly includes the brain marrow, the spinal cord, other bone marrow. The statement of the Jing Yi (Jing Yi-Shang-Tou) of the Chinese and Western languages: the term "marrow covers" refers to the generation of kidney essence, while the essence is sufficient to produce marrow and foot. "Su Wen-Sheng Qi Tong Tian Lun" (plain questions-Sheng Qi Tong Tian Lun) says: "bone marrow is firm, both qi and blood are good. The above Chinese medicine discussion forms a 'mechanism of generating marrow and essence, transforming blood and generating marrow-blood mutually', which ensures the physiological balance and regulation of the quantity of immune cells of human body.
Rhizoma polygonati: the weight of the spleen of a mouse can be increased, and the effect of sealwort on increasing peripheral white blood cells is prompted, and the spleen interstitial cell proliferation is possibly promoted to play a compensatory extramedullary hematopoiesis function. Rhizoma Polygonati can increase leukocyte and erythrocyte value of mouse with marrow hematopoietic function damaged by cyclophosphamide (Liyan, antagonistic action of rhizoma Polygonati crude polysaccharide on mouse leukocyte reduction caused by cyclophosphamide, Jilin Chinese medicine, 1996, 16 (2): 38).
Kudzu root: has anticancer and cancer cell differentiation inducing effects. Can inhibit cancer cell proliferation (Jingyongquini, daidzein (S86019) inducing HL-60 cell differentiation, Proc. Pharmacopeia, 1993, 28 (1): 11).
Wolfberry fruit: has certain effects on maintaining normal cell development, improving DNA repair capability and delaying cell aging (Liu Ju year, observation of influence of Lycium Barbarum Polysaccharide (LBP) extracted from Lycium barbarum on immunity of the elderly, China microorganism and immunology journal, 1988, 8 (3): 192).
Sea-buckthorn: has good therapeutic effect on myelodysplastic syndrome and leukopenia (HUZHONGYU, animal experiment and clinical research on treating hematopoietic disorder with oleum Hippophae, Ningxia J.Med., 1994, 16 (6): 343).
Tuckahoe, poria cocos: can obviously increase the rosette formation rate and the lymphocyte transformation rate induced by phytohemagglutinin. Has effects in resisting thymus atrophy and spleen enlargement (Chenxiangxia, physiological activity of carboxymethyl pachyman, edible fungus of China (1990), 9 (4): 12).
Spirulina: can make spleen white marrow lymphocytes densely arranged and red marrow macrophages significantly increased (Lidinghai, Spirulina-Beijing, Chinese agriculture science and technology publishing Co.).
Astragalus root: can promote the synthesis of deoxyribose and protein of bone marrow cells, accelerate the division of nucleated cells and increase the number of cells. Meanwhile, astragalus has the functions of reducing the generation of free radicals and increasing the purification capacity of the free radicals (Deng Shansan, the blood science of the combination of Chinese and Western medicine in the present country, Chinese medical science and technology Press, 1997, 362).
Wild jujube seed: orally taken spina date seed (5g/kg. d.times.20) has obviously increased appetite and weight of mice, can enhance the cellular immunity and humoral immunity of the mice, and can antagonize the inhibition of delayed type hypersensitivity of the mice caused by cyclophosphamide (Langxing Cai, Limingxian, Wu Tree gao, etc., Chinese traditional medicine journal, 1988, 11).
Balloon flower: platycodin D can promote lymphocyte proliferation, enhance phagocytic function of macrophage, and stimulate secretion of lymphocyte IL-2, IL-4 and macrophage TNF-alpha, IL-12 (Lijing, Von Hui, Wangming, etc., platycodin D has influence on immune function of mouse lymphocyte and macrophage, reported by northwest university of agriculture and forestry science and technology, 2019, 47, 1).
At present, the application of rhizoma polygonati, radix puerariae and other medicinal and edible preparations in traditional Chinese medicine is related, but the utilization rate of the effective components of the traditional Chinese medicine is low, and the effects of strengthening spleen and tonifying kidney, and replenishing marrow and producing sperm are limited.
Disclosure of Invention
The invention provides a medicine-food homologous preparation for nourishing bone marrow, which solves the problem of low utilization rate of effective components of traditional Chinese medicines of the medicine-food homologous preparation in the prior art.
The technical scheme of the invention is realized as follows:
a medicine-food homologous preparation for nourishing bone marrow comprises the following components in parts by weight: 30-40 parts of rhizoma polygonati, 20-30 parts of radix puerariae, 15-20 parts of radix astragali, 10-15 parts of fructus lycii, 10-15 parts of sea buckthorn, 10-15 parts of poria cocos, 5-10 parts of spina date seeds, 20-30 parts of spirulina and 5-8 parts of platycodon grandiflorum.
Further, the composition comprises the following components in parts by weight: 35 parts of rhizoma polygonati, 24 parts of kudzu root, 16 parts of astragalus, 12 parts of wolfberry fruit, 12 parts of sea buckthorn, 15 parts of poria cocos, 7 parts of spina date seed, 25 parts of spirulina and 7 parts of platycodon grandiflorum.
A preparation method of a medicine-food homologous preparation for nourishing bone marrow comprises the following steps:
A. weighing the components according to the formula of the medicine-food homologous preparation for nourishing bone marrow for later use;
B. putting the rhizoma polygonati weighed in the step A into wine, steaming the wine in a water-proof way until the wine is absorbed by the rhizoma polygonati, and taking out the rhizoma polygonati and drying the rhizoma polygonati in the sun;
C. and B, weighing the kudzu root and the wheat bran weighed in the step A according to the ratio of 10: 3, stir-frying until the kudzu root turns brown, taking out, sieving to remove wheat bran, cooling and grinding to obtain kudzu root powder;
D. b, putting the medlar, the sea buckthorn and the poria cocos weighed in the step A into edible alcohol, preserving heat for 1-2 hours at 40-50 ℃, filtering, adding 1-1.5 times of water by weight into filtrate, and concentrating until the alcohol is completely eliminated to obtain concentrated solution I;
E. soaking the spirulina, the astragalus and the spina date seed weighed in the step A into edible alcohol, then preserving heat for 1-2 hours at the temperature of 60-80 ℃, filtering, adding 1-1.5 times of water by weight into the filtrate, and concentrating until the alcohol is completely eliminated to obtain a concentrated solution II;
F. putting the dried rhizoma polygonati obtained in the step B and the platycodon grandiflorum weighed in the step A into the concentrated solution II obtained in the step E, decocting for 1-2 h, filtering, and concentrating the filtrate to obtain a concentrated solution III; then mixing the concentrated solution I and the concentrated solution III to obtain a mixed solution, mixing the mixed solution with starch, drying, and grinding into composite yellow fine powder;
G. and D, mixing the kudzu root powder obtained in the step C and the compound rhizoma polygonati powder obtained in the step F to obtain the bone marrow nourishing medicinal and edible preparation.
Further, the wine in the step B is one of yellow wine, rice wine and white spirit.
Further, in the step B, the weight part ratio of the sealwort to the wine is 10: 1.
further, the volume fraction of the edible alcohol in the step D and the step E is 60-70%.
Further, the adding amount of the edible alcohol in the step D is 8-10 times of the total mass of the barbary wolfberry fruit, the sea buckthorn and the poria cocos.
Furthermore, the adding amount of the edible alcohol in the step E is 10-12 times of the total mass of the spirulina, the astragalus and the spina date seed.
Furthermore, the soaking time in the step E is more than or equal to 12 h.
Further, the mass ratio of the starch to the mixed solution in the step F is 2: 1.
the working principle and the beneficial effects of the invention are as follows:
1. according to the invention, through reasonable compatibility of monarch, minister, assistant and guide among various traditional Chinese medicines and a specific preparation process, the effect of the medicine-food homologous preparation for nourishing bone marrow is improved under the combined action, in clinical observation, the effective rate reaches 98%, the symptoms of soreness and weakness of waist and knees, tinnitus, spermatorrhea, insomnia and memory decline of patients caused by kidney deficiency and inappetence, pale tongue, reddish tongue without coating and constipation caused by spleen deficiency are effectively improved, and the problem of low utilization rate of effective components of traditional Chinese medicines of the medicine-food homologous preparation in the prior art is solved.
2. The medicinal and edible preparation has the effects of tonifying spleen and kidney, replenishing marrow and producing sperm, and has the effects of improving immunity, and improving spermatorrhea, insomnia and irregular menstruation. Wherein the meridian tropism of rhizoma Polygonati is spleen meridian, lung meridian, kidney meridian, it has effects of invigorating spleen and replenishing qi, nourishing kidney and replenishing essence, it is monarch drug; the radix puerariae and the radix astragali are used as assistant drugs to enhance the absorption, transportation and transformation capability of the spleen and the stomach; the sea-buckthorn meridian tropism is the stomach channel and the lung channel, the efficacy of benefiting the lung and nourishing the stomach can enhance the capacity of qi-absorbing diet, the medlar meridian tropism is the liver channel and the kidney channel, the efficacy of benefiting the lung and nourishing the stomach can enhance the capacity of qi-absorbing diet, the tuckahoe meridian tropism is the spleen channel, the heart channel, the lung channel and the kidney channel, the efficacy of promoting diuresis and calming the heart, and tonifying the spleen can enhance the capacity of transporting and transforming balance of water, the spina date seed can nourish heart yin and calm the heart and calm the nerves, and the sea-buckthorn, the medlar, the tuckahoe and the spina; the platycodon grandiflorum carries the medicine upwards to enable the potency of the medicine to be sustained in kidney channels, the spirulina is an internationally recognized full-nutrient plant and has the effect of supplying nutrients to all parties needing to be supplemented comprehensively, and the platycodon grandiflorum and the spirulina serve as the guiding medicines together. The medicines are combined to play the effects of invigorating spleen and replenishing qi, and nourishing kidney and replenishing essence.
3. In the invention, the formula of the medicine-food homologous preparation for nourishing bone marrow surrounds the core of human body marrow nourishing, rhizoma polygonati is taken as a main radix puerariae to play roles of strengthening spleen, stomach and kidney, and meanwhile, the medlar, the sea buckthorn, the poria cocos, the spina date seed and the platycodon grandiflorum have the functions of strengthening spleen and kidney and also have the function of balancing the five organs of liver, lung, heart, spleen and kidney, and the spirulina can supplement all nutritional deficiencies comprehensively.
4. According to the invention, the astragalus and the spina date seed are added, and the fishy smell of the spirulina is neutralized under the combined action of the astragalus and the spina date seed and other components, so that the monarch, minister, assistant and guide compatibility effect is achieved, the taste of a medicine-food homologous preparation is effectively improved, and the monarch, minister, assistant and guide compatibility effect is more acceptable to the public.
5. According to the invention, rhizoma polygonati and other medicinal materials or medicinal material extracting solutions are steamed step by step, so that the effects of tonifying spleen and kidney and replenishing marrow and producing sperm of the medicinal and edible preparation are effectively improved, in clinical observation, the effective rate reaches 98%, and the symptoms of soreness and weakness of waist and knees, tinnitus, spermatorrhea, insomnia and memory decline of patients caused by kidney deficiency, as well as inappetence, pale tongue, reddened tongue without coating and constipation caused by spleen deficiency are effectively improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A. Weighing 30 parts of rhizoma polygonati, 20 parts of radix puerariae, 15 parts of radix astragali, 10 parts of fructus lycii, 15 parts of sea buckthorn, 10 parts of poria cocos, 5 parts of spina date seeds, 20 parts of spirulina and 8 parts of platycodon grandiflorum for later use;
B. putting the rhizoma polygonati weighed in the step A into 3 parts of yellow wine, steaming the yellow wine in a water-proof way until the yellow wine is absorbed by the rhizoma polygonati, and taking out the rhizoma polygonati and drying the rhizoma polygonati in the sun;
C. heating wheat bran in a medicine frying pot, adding the radix puerariae weighed in the step A after smoking in the medicine frying pot, continuously stir-frying, taking out the radix puerariae when the radix puerariae is brown, cooling the radix puerariae, and grinding the radix puerariae into powder to obtain radix puerariae powder for later use; the mass ratio of the kudzu root to the wheat bran is 10: 3;
D. b, putting the medlar, the sea buckthorn and the poria cocos weighed in the step A into 280 parts of edible alcohol with the volume fraction of 70%, preserving heat for 2 hours at 40 ℃, filtering, adding 1 time of water by weight into the filtrate, and concentrating until all the alcohol is eliminated to obtain a concentrated solution I;
E. soaking the spirulina, the astragalus and the spina date seed weighed in the step A in 480 parts of 60% edible alcohol by volume for 12 hours, then preserving heat at 80 ℃ for 1 hour, filtering, adding 1 time of water by weight into the filtrate, and concentrating until the alcohol is completely eliminated to obtain a concentrated solution II;
F. putting the dried rhizoma polygonati obtained in the step B and the platycodon grandiflorum weighed in the step A into the concentrated solution II obtained in the step E, decocting for 1h, filtering, concentrating the filtrate to obtain a concentrated solution III, mixing the concentrated solution I and the concentrated solution III to obtain a mixed solution, mixing the mixed solution with starch, drying, and grinding into composite yellow fine powder; wherein the mass ratio of the starch to the mixed liquor is 2: 1.
G. and D, mixing the kudzu root powder obtained in the step C and the compound rhizoma polygonati powder obtained in the step F to obtain the bone marrow nourishing medicinal and edible preparation.
Example 2
A. Weighing 40 parts of rhizoma polygonati, 30 parts of radix puerariae, 20 parts of radix astragali, 15 parts of fructus lycii, 10 parts of sea buckthorn, 15 parts of poria cocos, 10 parts of spina date seeds, 30 parts of spirulina and 5 parts of platycodon grandiflorum for later use;
B. putting the rhizoma polygonati weighed in the step A into 4 parts of yellow wine, steaming the yellow wine in a water-proof way until the yellow wine is absorbed by the rhizoma polygonati, and taking out the rhizoma polygonati and drying the rhizoma polygonati in the sun;
C. heating wheat bran in a medicine frying pot, adding the radix puerariae weighed in the step A after smoking in the medicine frying pot, continuously stir-frying, taking out the radix puerariae when the radix puerariae is brown, cooling the radix puerariae, and grinding the radix puerariae into powder to obtain radix puerariae powder for later use; the mass ratio of the kudzu root to the wheat bran is 10: 3;
D. b, putting the medlar, the sea buckthorn and the poria cocos weighed in the step A into 400 parts of edible alcohol with the volume fraction of 60%, preserving heat for 1 hour at 50 ℃, filtering, adding 1.5 times of water by weight into the filtrate, and concentrating until all alcohol is eliminated to obtain a concentrated solution I for later use;
E. soaking the spirulina, the astragalus and the spina date seed weighed in the step A in 600 parts of edible alcohol with the volume fraction of 70% for 16 hours, then preserving heat at 60 ℃ for 2 hours, filtering, adding 1.5 times of water in weight into the filtrate, and concentrating until the alcohol is completely eliminated to obtain a concentrated solution II;
F. putting the dried rhizoma polygonati obtained in the step B and the platycodon grandiflorum weighed in the step A into the concentrated solution II obtained in the step E, decocting for 2 hours, filtering, concentrating the filtrate to obtain a concentrated solution III, mixing the concentrated solution I and the concentrated solution III to obtain a mixed solution, mixing the mixed solution with starch, drying, and grinding into composite yellow fine powder; wherein the mass ratio of the starch to the mixed liquor is 2: 1
G. And D, mixing the kudzu root powder obtained in the step C and the compound rhizoma polygonati powder obtained in the step F to obtain the bone marrow nourishing medicinal and edible preparation.
Example 3
A. Weighing 35 parts of rhizoma polygonati, 24 parts of radix puerariae, 16 parts of radix astragali, 12 parts of fructus lycii, 12 parts of sea buckthorn, 15 parts of poria cocos, 7 parts of spina date seed, 25 parts of spirulina and 7 parts of platycodon grandiflorum for later use;
B. putting the rhizoma polygonati weighed in the step A into 3.5 parts of yellow wine, steaming the yellow wine in a water-proof way until the yellow wine is absorbed by the rhizoma polygonati, and taking out the rhizoma polygonati and drying the rhizoma polygonati in the sun;
C. heating wheat bran in a medicine frying pot, adding the radix puerariae weighed in the step A after smoking in the medicine frying pot, continuously stir-frying, taking out the radix puerariae when the radix puerariae is brown, cooling the radix puerariae, and grinding the radix puerariae into powder to obtain radix puerariae powder for later use; the mass ratio of the kudzu root to the wheat bran is 10: 3;
D. b, putting the medlar, the sea buckthorn and the poria cocos weighed in the step A into 350 parts of 65% edible alcohol by volume fraction, preserving heat for 2 hours at 40 ℃, filtering, adding 1.2 times of water by weight into the filtrate, and concentrating until all the alcohol is eliminated to obtain a concentrated solution I;
E. soaking the spirulina, the astragalus and the spina date seed weighed in the step A in 500 parts of 65% edible alcohol by volume for 14 hours, then preserving heat at 70 ℃ for 1.5 hours, filtering, adding 1.2 times of water by weight into filtrate, and concentrating until all alcohol is eliminated to obtain a concentrated solution II;
F. putting the dried rhizoma polygonati obtained in the step B and the platycodon grandiflorum weighed in the step A into the concentrated solution II obtained in the step E, decocting for 2 hours, filtering, concentrating the filtrate to obtain a concentrated solution III, mixing the concentrated solution I and the concentrated solution III to obtain a mixed solution, mixing the mixed solution with starch, drying, and grinding into composite yellow fine powder; wherein the mass ratio of the starch to the mixed liquor is 2: 1
G. And D, mixing the kudzu root powder obtained in the step C and the compound rhizoma polygonati powder obtained in the step F to obtain the bone marrow nourishing medicinal and edible preparation.
Comparative example 1
Comparative example 1 differs from example 3 only in that no astragalus root was added to comparative example 1; the rest of the procedure was the same as in example 3.
Comparative example 2
Comparative example 2 differs from example 3 only in that no spina date seed was added in comparative example 2; the rest of the procedure was the same as in example 3.
Comparative example 3
A. Weighing 35 parts of rhizoma polygonati, 24 parts of radix puerariae, 16 parts of radix astragali, 12 parts of fructus lycii, 12 parts of sea buckthorn, 15 parts of poria cocos, 7 parts of spina date seed, 25 parts of spirulina and 7 parts of platycodon grandiflorum for later use;
B. putting the rhizoma polygonati weighed in the step A into 3.5 parts of yellow wine, steaming the yellow wine in a water-proof way until the yellow wine is absorbed by the rhizoma polygonati, and taking out the rhizoma polygonati and drying the rhizoma polygonati in the sun;
C. heating wheat bran in a medicine frying pot, adding the radix puerariae weighed in the step A after smoking in the medicine frying pot, continuously stir-frying, taking out the radix puerariae when the radix puerariae is brown, cooling the radix puerariae, and grinding the radix puerariae into powder to obtain radix puerariae powder for later use; the mass ratio of the kudzu root to the wheat bran is 10: 3;
D. b, soaking the medlar, the sea buckthorn, the poria cocos, the spirulina, the astragalus membranaceus and the spina date seed weighed in the step A in 850 parts of 65% edible alcohol by volume for 14 hours, then preserving heat at 70 ℃ for 1.5 hours, filtering, adding 1.2 times of water by weight into the filtrate, and concentrating until all alcohol is eliminated to obtain a concentrated solution I;
E. putting the dried rhizoma polygonati obtained in the step B and the platycodon grandiflorum weighed in the step A into the concentrated solution I obtained in the step D, decocting for 2 hours, filtering, concentrating the filtrate to obtain a concentrated solution II, mixing the concentrated solution I and the concentrated solution II to obtain a mixed solution, mixing the mixed solution with starch, drying, and grinding into compound rhizoma polygonati powder; wherein the mass ratio of the starch to the mixed liquor is 2: 1
F. And D, mixing the kudzu root powder obtained in the step C and the compound rhizoma polygonati powder obtained in the step E to obtain the bone marrow nourishing medicinal and edible preparation. 1. Taste test of medicinal and edible preparation for nourishing bone marrow
100 volunteers, 50 volunteers above 45 years old, 33 volunteers 30-45 years old and 17 volunteers below 30 years old were collected, 10g of the mixture was taken with warm water under the condition of blindness, and the taste of the medicinal and edible preparation prepared in examples 1-3 and comparative examples 1-3 was evaluated, and the results are shown in table 1.
Table 1 taste test results
| Example 1 | Sweet taste and no fishy smell |
| Example 2 | Sweet taste and no fishy smell |
| Example 3 | Sweet taste and no fishy smell |
| Comparative example 1 | Sweet in flavor and with severe fishy smell |
| Comparative example 2 | Sweet in flavor and with severe fishy smell |
| Comparative example 3 | Sweet taste and no fishy smell |
As can be seen from data in table 1, the astragalus and the spina date seed are added in the embodiments 1-3 simultaneously, the prepared medicinal and edible preparation is sweet in taste and free of fishy smell, and the fishy smell of the spirulina is eliminated, the astragalus is not added in the comparative example 1, compared with the embodiments 1-3, the prepared medicinal and edible preparation is sweet in taste and has serious fishy smell, and the spina date seed is not added in the comparative example 2, compared with the embodiments 1-3, the prepared medicinal and edible preparation is sweet in taste and has serious fishy smell, so that the astragalus and the spina date seed are reasonably compatible with other components in the medicinal and edible preparation in a monarch, ministerial, assistant and guide manner, the fishy smell of the spirulina is neutralized together, the taste of the medicinal and edible preparation is improved, and the public acceptance degree is higher.
2. Clinical observations
(1) Selecting an object:
the total of 400 volunteers were collected, 121 volunteers over 45 years old, male-female ratio 71: 207 volunteers of 30-45 years old, 127:80 male and female proportion, 72 volunteers of 30 years old or younger, 36 male and female proportion: 36, the volunteers included one or more of the following conditions: soreness and weakness of waist and knees, tinnitus, spermatorrhea, insomnia, hypomnesis, inappetence, pale tongue, reddened tongue without coating, and constipation.
Volunteers were divided into four groups, A, B, C, D, and were equally assigned according to age and gender:
group A includes: 30 cases over 45 years old, male and female ratio 18: 12, 52 volunteers of 30-45 years old, 32 male and female: 20, 18 volunteers under 30 years old, male and female ratio 9: 9;
group B includes: 31 cases above age 45, male-female ratio 18: 13, 51 volunteers of 30-45 years old, 31 male and female proportion: 20, 18 volunteers under 30 years old, male and female ratio 9: 9;
group C includes: 30 cases over 45 years old, male and female ratio 18: 12, 52 volunteers of 30-45 years old, 32 male and female: 20, 18 volunteers under 30 years old, male and female ratio 9: 9;
group D includes: 30 cases over 45 years old, male-female ratio 17: 13, 52 volunteers of 30-45 years old, 32 male and female: 20, 18 volunteers under 30 years old, male and female ratio 9: 9;
(2) the observation method comprises the following steps:
the medicinal and edible preparation prepared in examples 1-3 and comparative example 3 was taken 10g with warm water, taken once in the morning and at night after meals, and observed after two weeks after other health products and medicines were stopped taking during observation.
The medicinal and edible preparation prepared in the group A of the medicinal and edible preparations prepared in the group B of the medicinal and edible preparations prepared in the group C of the medicinal and edible preparations prepared in the group D of the comparative example 3 are taken with water.
(3) Determination of therapeutic effect
The detection indexes comprise: blood routine, biochemical indicators of blood (including white blood cell count (WBC), red blood cell count (RBC), platelet count (PLT), lymphocyte count (LY), ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALB (albumin), A/G (serum albumin/globulin), IgA (immunoglobulin), IgG (immunoglobulin), IgM (immunoglobulin), C.C.R (creatinine clearance);
the effect is shown: the clinical symptoms are obviously improved or close to normal, and the blood routine, blood biochemistry and most indexes are obviously improved or tend to normal;
the method has the following advantages: the clinical symptoms are partially improved, and the blood routine, blood biochemistry and partial indexes are obviously improved or tend to be normal;
and (4) invalidation: the clinical symptoms are not obviously improved or aggravated.
(4) Clinical results
The results are shown in Table 2.
TABLE 2 clinical results
As can be seen from the data in table 2, the medicinal and edible preparation prepared by the process in examples 1 to 3 has 187 cases (62.33%), 107 cases (35.67%) and 6 cases (2.00%) of effects after being eaten in groups a to C, while the medicinal and edible preparation prepared by the process in comparative example 3 has obvious effects (35.00%), effects (48.00%) and inefficiencies (17%) after being eaten in group D, and compared with examples 1 to 3, the medicinal effect of the medicinal and edible preparation prepared by the process in comparative example 3 is obviously reduced.
3. Typical cases
Case 1: liu Zhi, male, 37 years old, frequent spermatorrhea in nearly one month, twice a week on average, with symptoms of soreness and weakness of waist and knees, insomnia, and serious influence on daily life and work.
After a patient takes the medicinal and edible preparation prepared in the embodiment 3 for one week, the spermatorrhea symptom disappears, and after taking the medicinal and edible preparation for two weeks, the soreness and weakness of the waist and the knees is obviously improved, and the sleep is normal.
Case 2: zhangiao, female, age 42, insomnia is severe, and the average sleeping time in evening is less than 5 hours in two months, accompanied by symptoms of poor appetite, hypomnesis, pale tongue, reddish tongue and no coating.
After a patient takes the medicinal and edible preparation prepared in the example 3 for two weeks, the average sleeping time at night reaches 7 hours, the appetite is good, the tongue is normal, and the memory is improved.
Case 3: in Sunzhi, male, age 35, the number of urination and urine output increases at night in half a month, the male gets up 3-4 times at night, has poor rest at night, and sleepiness in the day with symptoms of dizziness, weakness, soreness and weakness of waist and knees, and constipation.
After a patient takes the medicinal and edible preparation prepared in the embodiment 2 for two weeks, the patient gets up at most once every night, the rest condition at night is improved, and simultaneously symptoms of dizziness, hypodynamia, soreness and weakness of waist and knees and constipation disappear, so that the health is recovered.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A medicine-food homologous preparation for nourishing bone marrow is characterized by comprising the following components in parts by weight: 30-40 parts of rhizoma polygonati, 20-30 parts of radix puerariae, 15-20 parts of radix astragali, 10-15 parts of fructus lycii, 10-15 parts of sea buckthorn, 10-15 parts of poria cocos, 5-10 parts of spina date seeds, 20-30 parts of spirulina and 5-8 parts of platycodon grandiflorum.
2. The bone marrow nourishing medicinal and edible preparation according to claim 1, which is characterized by comprising the following components in parts by weight: 35 parts of rhizoma polygonati, 24 parts of kudzu root, 16 parts of astragalus, 12 parts of wolfberry fruit, 12 parts of sea buckthorn, 15 parts of poria cocos, 7 parts of spina date seed, 25 parts of spirulina and 7 parts of platycodon grandiflorum.
3. A preparation method of a medicine-food homologous preparation for nourishing bone marrow is characterized by comprising the following steps:
A. weighing the components according to the formula of the medicine-food homologous preparation for nourishing bone marrow of any one of claims 1-2 for later use;
B. putting the rhizoma polygonati weighed in the step A into wine, steaming the wine in a water-proof way until the wine is absorbed by the rhizoma polygonati, and taking out the rhizoma polygonati and drying the rhizoma polygonati in the sun;
C. and B, weighing the kudzu root and the wheat bran weighed in the step A according to the ratio of 10: 3, stir-frying until the kudzu root turns brown, taking out, sieving to remove wheat bran, cooling and grinding to obtain kudzu root powder;
D. b, putting the medlar, the sea buckthorn and the poria cocos weighed in the step A into edible alcohol, preserving heat for 1-2 hours at 40-50 ℃, filtering, adding 1-1.5 times of water by weight into filtrate, and concentrating until the alcohol is completely eliminated to obtain concentrated solution I;
E. soaking the spirulina, the astragalus and the spina date seed weighed in the step A into edible alcohol, then preserving heat for 1-2 hours at the temperature of 60-80 ℃, filtering, adding 1-1.5 times of water by weight into the filtrate, and concentrating until the alcohol is completely eliminated to obtain a concentrated solution II;
F. putting the dried rhizoma polygonati obtained in the step B and the platycodon grandiflorum weighed in the step A into the concentrated solution II obtained in the step E, decocting for 1-2 h, filtering, and concentrating the filtrate to obtain a concentrated solution III; then mixing the concentrated solution I and the concentrated solution III to obtain a mixed solution, mixing the mixed solution with starch, drying, and grinding into composite yellow fine powder;
G. and D, mixing the kudzu root powder obtained in the step C and the compound rhizoma polygonati powder obtained in the step F to obtain the bone marrow nourishing medicinal and edible preparation.
4. The preparation method of the bone marrow nourishing medicinal and edible preparation as claimed in claim 3, wherein the wine in step B is one of yellow wine, rice wine and Chinese liquor.
5. The preparation method of the bone marrow nourishing medicinal and edible preparation as claimed in claim 3, wherein the weight part ratio of rhizoma Polygonati to wine in the step B is 10: 1.
6. the preparation method of a bone marrow nourishing medicinal and edible preparation as claimed in claim 3, wherein the volume fraction of edible alcohol in step D and step E is 60-70%.
7. The preparation method of the bone marrow nourishing medicinal and edible preparation as claimed in claim 3, wherein the amount of edible alcohol added in the step D is 8-10 times of the total mass of fructus Lycii, fructus Hippophae and Poria.
8. The preparation method of the bone marrow nourishing medicinal and edible preparation as claimed in claim 3, wherein the amount of edible alcohol added in step E is 10-12 times of the total mass of spirulina, astragalus and spina date seed.
9. The preparation method of the bone marrow nourishing medicinal and edible preparation as claimed in claim 3, wherein the soaking time in step E is not less than 12 h.
10. The preparation method of a bone marrow nourishing medicinal and edible preparation as claimed in claim 3, wherein the mass ratio of starch to the mixed solution in the step F is 2: 1.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711233A (en) * | 2019-11-04 | 2020-01-21 | 迪国生物高科技有限公司 | Traditional Chinese medicine composition, medicinal liquor and decoction for conditioning sub-health |
| CN110731508A (en) * | 2019-11-14 | 2020-01-31 | 南充观音山农业科技有限公司 | Preparation method of traditional Chinese medicine food for enhancing human immunity and product |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711233A (en) * | 2019-11-04 | 2020-01-21 | 迪国生物高科技有限公司 | Traditional Chinese medicine composition, medicinal liquor and decoction for conditioning sub-health |
| CN110731508A (en) * | 2019-11-14 | 2020-01-31 | 南充观音山农业科技有限公司 | Preparation method of traditional Chinese medicine food for enhancing human immunity and product |
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