CN113101272B

CN113101272B - Ganoderma lucidum granules

Info

Publication number: CN113101272B
Application number: CN202110384818.8A
Authority: CN
Inventors: 陈尚杰; 梁烽焱; 黄瑞伟; 颜正; 张妍
Original assignee: Yili Pharmaceutical Co ltd; Yili Pharmaceutical Nanning Co Ltd
Current assignee: Yili Pharmaceutical Co ltd; Yili Pharmaceutical Nanning Co Ltd
Priority date: 2021-04-09
Filing date: 2021-04-09
Publication date: 2021-11-09
Anticipated expiration: 2041-04-09
Also published as: CN113101272A

Abstract

The invention provides a ganoderma lucidum granule, relating to the technical field of traditional Chinese medicines, and the ganoderma lucidum granule comprises the following raw materials: ganoderma lucidum, fructus Lycii, Angelica Keiskei Koidz, chia seed, bamboo leaf flavone and adjuvants. The prepared ganoderma lucidum granules can calm heart and calm nerves, invigorate spleen and stomach, can be used for regulating insomnia, amnesia, asthenia and neurasthenia, and can also be used for adjuvant treatment of coronary heart disease by taking ganoderma lucidum as a main material and reasonably compounding the ganoderma lucidum granules with other raw materials.

Description

Ganoderma lucidum granules

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to lucid ganoderma granules.

Background

Ganoderma lucidum is used as a raw material of homology of medicine and food, has the effects of invigorating qi, tranquilizing mind, relieving cough and asthma, and is mainly used for treating unsteadiness of heart-mind, insomnia, palpitation due to fright, cough, asthma and excessive phlegm, consumptive disease and the like. Among 120 superior traditional Chinese medicines recorded in the book Shen nong Ben Cao Jing of traditional Chinese medicine, Ganoderma is listed above Ginseng radix and is superior, while in the description of Ganoderma in the book Ben Cao gang mu, there are theories of "Ganoderma is bitter and flat in taste, nontoxic, benefiting heart qi, promoting blood circulation, entering heart congestion, helping heart to invigorate pulse, tranquilizing mind, benefiting lung qi, nourishing liver qi, invigorating middle warmer, improving intelligence and wisdom, good color, benefiting joint, strengthening tendons and bones" and the like. However, when the ganoderma lucidum is taken alone, the consumption is large and the optimal effect is difficult to achieve, so the ganoderma lucidum is usually taken as a main drug and is combined with other raw materials for eating. Until now, most health care products related to ganoderma lucidum are health care wine or oral liquid and are inconvenient to store or use, so products such as ganoderma lucidum particles, ganoderma lucidum tea and ganoderma lucidum capsules which are easy to store and convenient to eat are produced in recent years.

Chinese patent CN104095993B discloses a ganoderma lucidum granule for enhancing immunity and a preparation method thereof, which is prepared by taking radix codonopsitis, radix astragali, ganoderma lucidum, medlar and Chinese date as main active ingredients and dextrin as an auxiliary material. The finally prepared traditional Chinese medicine composition has the effect of enhancing the immunity of the organism, and has the advantages of obvious curative effect and mild effect. However, the main function of the ganoderma lucidum granules in the invention is to enhance immunity, and the effects of qi tonifying and nerve soothing of the ganoderma lucidum are not fully exerted. Chinese patent CN101069701B discloses an ant-ganoderma granule and its preparation method, which is prepared by mixing ant powder, ganoderma powder, sesame powder, royal jelly and auxiliary materials, the granule has obvious health-care function, long shelf life, convenient carrying and eating, and its preparation method is simple and scientific. However, the multifunctional effects of the ganoderma lucidum granules emphasized in the invention comprise: nourishing, strengthening body constitution, invigorating qi, tranquilizing, replenishing vital essence, relieving inflammation, promoting urination, and strengthening spleen and stomach; removing toxic substances from liver, reducing blood lipid, and lowering blood pressure; oxygen free radical scavenging and anti-inflammatory effects; delaying senility, relieving spasm and asthma, beautifying, blackening hair and improving eyesight, seems to be complete in function, but is not targeted in practice, is difficult to achieve effect in a short term, and needs to be taken for a long term for conditioning.

Aiming at the problems that related products of the ganoderma lucidum are difficult to store and eat or the ganoderma lucidum granules generally have the main effect of improving immunity or other effects and neglect the property of qi tonifying and nerve soothing of the ganoderma lucidum, the ganoderma lucidum granules are urgently needed to be found, so that the granules can fully exert the property of the ganoderma lucidum and have more excellent effects on calming and nerve soothing, spleen strengthening and stomach harmonizing and the like.

Disclosure of Invention

Aiming at the problems in the prior art, the invention provides the ganoderma lucidum granules which can calm heart and calm nerves, strengthen spleen and stomach, can be used for regulating insomnia, amnesia, asthenia and neurasthenia and can also be used for the auxiliary treatment of coronary heart disease.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows:

the invention provides lucid ganoderma granules, which comprise the following raw materials: ganoderma lucidum, fructus Lycii, Angelica Keiskei Koidz, chia seed, bamboo leaf flavone and adjuvants.

Further, the ganoderma lucidum granules comprise the following raw materials in parts by weight: 10-20 parts of lucid ganoderma, 15-25 parts of medlar, 5-10 parts of angelica keiskei, 5-15 parts of chia seeds, 0.5-1 part of bamboo leaf flavone and 2-3 parts of auxiliary materials.

Preferably, the ganoderma lucidum granules comprise the following raw materials in parts by weight: 12-18 parts of lucid ganoderma, 18-22 parts of medlar, 6-8 parts of angelica keiskei, 8-10 parts of chia seeds, 0.5-0.8 part of bamboo leaf flavone and 2-3 parts of auxiliary materials.

Further preferably, the ganoderma lucidum granules comprise the following raw materials in parts by weight: 15 parts of lucid ganoderma, 20 parts of medlar, 7 parts of angelica keiskei, 9 parts of chia seeds, 0.6 part of bamboo leaf flavone and 1.5 parts of auxiliary materials.

Further, the weight ratio of the lucid ganoderma, the angelica keiskei and the chia seeds is 2-4:1-2: 1-3.

Preferably, the weight ratio of the ganoderma lucidum, the angelica keiskei and the chia seeds is 6-9:3-4: 4-5.

Further, the weight ratio of the ganoderma lucidum to the bamboo leaf flavone is 10-20: 0.5-1.

Preferably, the weight ratio of the ganoderma lucidum to the bamboo leaf flavone is 12-18: 0.5-0.8.

Further, the auxiliary materials comprise one or more of powdered sugar, honey and vitamin E.

The invention also provides a preparation method of the ganoderma lucidum granules, which comprises the following steps: mixing Ganoderma, fructus Lycii, Angelica Keiskei Koidz and semen chiae, pulverizing, decocting in water for three times, mixing decoctions, filtering, concentrating the filtrate to obtain soft extract, adding bamboo leaf flavone and adjuvants, mixing, granulating, and drying.

Further, the decocting is carried out for three times, specifically: the adding amount of the first water is 10-15 times of the total weight of the raw materials, and the decoction is carried out for 3-4h, and the adding amounts of the second water and the third water are both 3-5 times of the total weight of the raw materials, and are both decocted for 2-3 h.

Further, the relative density of the thick paste is 1.18 to 1.20(80 ℃).

The technical effects obtained by the invention are as follows:

according to the invention, ganoderma lucidum is used as a main material, and is reasonably proportioned with other raw materials, particularly, ganoderma lucidum, angelica keiskei and chia seed are compounded, and ganoderma lucidum and bamboo leaf flavone are compounded, so that ganoderma lucidum granules are finally prepared, and the ganoderma lucidum granules can calm heart and calm nerves, strengthen spleen and stomach, can be used for regulating insomnia, amnesia, asthenia and neurasthenia, and can also be used for auxiliary treatment of coronary heart disease.

Detailed Description

It should be noted that the bamboo leaf flavonoid used in the present invention is purchased from sheng shi biotechnology limited of zhejiang, and other raw materials are all common commercially available products, so the source thereof is not particularly limited.

Example 1

The ganoderma lucidum granules comprise the following raw materials in parts by weight: 10 parts of lucid ganoderma, 15 parts of medlar, 5 parts of angelica keiskei, 5 parts of chia seeds, 0.5 part of bamboo leaf flavone and 2 parts of auxiliary materials. Wherein the adjuvant is sugar powder.

The preparation method of the ganoderma lucidum granules comprises the following steps: mixing Ganoderma, fructus Lycii, Angelica Keiskei and chia seed, pulverizing, decocting with water for three times, i.e. the first time the amount of water is 10 times of the total weight of the raw materials, decocting for 3h, and the second time and the third time the amount of water is 3 times of the total weight of the raw materials, and decocting for 2 h. Mixing decoctions, filtering, concentrating the filtrate to obtain soft extract with relative density of 1.18-1.20(80 deg.C), adding bamboo leaf flavone and adjuvants, mixing, granulating, and drying.

Example 2

The ganoderma lucidum granules comprise the following raw materials in parts by weight: 20 parts of lucid ganoderma, 25 parts of medlar, 10 parts of angelica keiskei, 15 parts of chia seeds, 1 part of bamboo leaf flavone and 3 parts of auxiliary materials. Wherein the adjuvant is Mel.

The preparation method of the ganoderma lucidum granules comprises the following steps: mixing Ganoderma, fructus Lycii, Angelica Keiskei and chia seed, pulverizing, decocting with water for three times, i.e. the first time the amount of water is 15 times of the total weight of the raw materials, decocting for 4h, and the second and third times the amount of water is 5 times of the total weight of the raw materials, and decocting for 3 h. Mixing decoctions, filtering, concentrating the filtrate to obtain soft extract with relative density of 1.18-1.20(80 deg.C), adding bamboo leaf flavone and adjuvants, mixing, granulating, and drying.

Example 3

The ganoderma lucidum granules comprise the following raw materials in parts by weight: 15 parts of lucid ganoderma, 20 parts of medlar, 7 parts of angelica keiskei, 9 parts of chia seeds, 0.6 part of bamboo leaf flavone and 1.5 parts of auxiliary materials. Wherein the adjuvant is sugar powder.

The preparation method of the ganoderma lucidum granules comprises the following steps: mixing Ganoderma, fructus Lycii, Angelica Keiskei and chia seed, pulverizing, decocting with water for three times, i.e. the first time the amount of water is 12 times of the total weight of the raw materials, decocting for 3.5 hr, and the second time and the third time the amount of water is 4 times of the total weight of the raw materials, and decocting for 2.5 hr. Mixing decoctions, filtering, concentrating the filtrate to obtain soft extract with relative density of 1.18-1.20(80 deg.C), adding bamboo leaf flavone and adjuvants, mixing, granulating, and drying.

Example 4

The ganoderma lucidum granules comprise the following raw materials in parts by weight: 12 parts of lucid ganoderma, 18 parts of medlar, 6 parts of angelica keiskei, 8 parts of chia seeds, 0.5 part of bamboo leaf flavone and 2 parts of auxiliary materials. Wherein the adjuvant is Mel.

Example 5

The ganoderma lucidum granules comprise the following raw materials in parts by weight: 18 parts of lucid ganoderma, 22 parts of medlar, 8 parts of angelica keiskei, 10 parts of chia seeds, 0.8 part of bamboo leaf flavone and 3 parts of auxiliary materials. Wherein the adjuvant is sugar powder.

Comparative example 1

The only difference from example 1 is that the weight ratio of ganoderma lucidum, angelica keiskei and chia seed is 1:3:0.8 (the total weight of the three is identical to that of example 1).

Comparative example 2

The only difference from example 1 is that the weight ratio of ganoderma lucidum to bamboo leaf flavonoid is 8:1.5 (the total weight of both is the same as example 1).

Comparative example 3

The only difference from example 1 is that the preparation steps were adjusted depending on whether or not the bamboo leaf flavonoid was added to the raw material without adding the bamboo leaf flavonoid.

Comparative example 4

The difference from the example 1 is only that the raw materials only comprise the lucid ganoderma and the auxiliary materials, and the preparation steps are adjusted according to whether the raw materials are added or not.

First, the influence of the ganoderma lucidum granules on the sleep time of mice

Test animals: 100 Kunming mice, each half of male and female, were randomly divided into 10 groups of 10 mice each;

the test method comprises the following steps: the administration amount of the ganoderma lucidum granule liquid medicine (granules are dissolved in deionized water to prepare a 0.2g/mL medicament) of each example of the invention is 10mL/kg for 9 groups of mice, the rest group of mice is used as a control group, and the particles are intragastrically administered with the same amount of physiological saline once in the morning and at night for 5 days, pentobarbital sodium is intraperitoneally injected 1h after the last administration, the administration amount is 1mL/kg, the time from administration to disappearance of righting reflex, the time from disappearance of righting reflex to restoration, the sleep latency of the mice is recorded, and the results are counted in Table 1.

TABLE 1

Examples of the invention	Sleep latency(s)	Sleep time (min)
			Control group	232±43	102±26
Example 1	164±51*	173±35*
			Example 2	160±50*	176±45*
Example 3	153±44*	189±41*
			Example 4	158±62*	180±33*
Example 5	155±43*	184±42*
			Comparative example 1	179±39	160±44
Comparative example 2	167±40*	169±35*
			Comparative example 3	170±45	165±50
Comparative example 4	193±44	144±49

(Note: P < 0.05 compared with control group)

As can be seen from table 1, the sleep latency of the mice in each example of the present invention is significantly shortened compared to the control group, and the sleep time is significantly prolonged, so that the ganoderma lucidum granules of the present invention have the effect of calming heart and tranquilizing mind on the body, and can be used for adjusting insomnia symptoms, etc., wherein the effect is the best in the case of the formulation of example 3. In comparison, the sleep latency of comparative examples 1 to 4 is prolonged and the sleep time is shortened compared with example 1, and particularly, the cases of comparative examples 1 and 4 are particularly obvious, so that when the mixture ratio of ganoderma lucidum, angelica keiskei and chia seeds is poor or when part of raw materials are not added in the formula, the effect of calming the heart and soothing the nerves of the body is weakened, and for the rest of comparative examples, the whole body is not obvious although the sleep condition of the body is also influenced to a certain extent.

Secondly, the influence of the ganoderma lucidum granules on the spleen and stomach of a mouse

Test animals: kunming mice, weighing 20 + -2 g, and 110 males were randomly divided into 11 groups of 10 mice each.

The test method comprises the following steps: wherein 1 group is used as normal group, feeding conventional feed, molding the rest groups, and feeding high protein and high heat feed (prepared by mixing wheat flour, corn flour, bean flour, fish meal and milk at a ratio of 1:1:2:1:1, adding appropriate amount of water, and mixing well), wherein each group of mice can drink water via free diet. And (3) feeding the mice of other groups except the normal group with cow milk with the mass fraction of 25% on the second day, wherein each time is 0.5mL, and after 5 continuous days, calculating the abdominal circumference, the food intake and the excrement intake of the mice before and after molding, wherein when the food intake and the excrement intake of the mice after molding are obviously reduced compared with the normal group, and meanwhile, the abdominal circumference increase is obviously increased compared with the normal group and has statistical significance, the mice are successful in molding (the molding in the invention is successful). 9 groups of mice randomly selected from each group successfully molded were respectively gavaged with ganoderma lucidum granule liquid medicine (granules were dissolved in deionized water to prepare 0.2g/mL medicament) of each example of the present invention, the remaining group was used as a model control group and gavaged with physiological saline of the same amount, and the results of changes in abdominal circumference, food intake and feces amount of mice before and after administration were counted in table 2.

TABLE 2

(Note: comparison with model control, P < 0.05)

As can be seen from Table 2, after administration, compared with before administration, the mice of each example group of the invention have the advantages that the food intake and the excrement intake are obviously increased better than those of the model control group, and the abdominal circumference is decreased more than that of the model control group, so that food accumulation occurs in the mice of the model control group due to the fact that the mice eat high-protein and high-heat feed, and certain problems occur in the spleen and the stomach, and the ganoderma lucidum granules can have certain regulation and mitigation effects on the health of the spleen and the stomach of the organism. Comparative examples 2 to 4 showed significantly less reduction in abdominal circumference and significantly less increase in food intake and stool volume than example 1. Therefore, when the bamboo leaf flavonoid is added and compounded with the lucid ganoderma, and the lucid ganoderma is compounded with other raw materials except auxiliary materials, the conditions of spleen and stomach feeding and the like of mice are influenced to a certain extent. The comparative example 1 also has similar performance, and the compound of the ganoderma lucidum, the angelica keiskei and the chia seed can also influence the spleen and stomach conditions of mice under certain conditions.

Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A ganoderma lucidum particle is characterized in that: the raw materials comprise the following components in parts by weight: 10-20 parts of lucid ganoderma, 15-25 parts of medlar, 5-10 parts of angelica keiskei, 5-15 parts of chia seeds, 0.5-1 part of bamboo leaf flavone and 2-3 parts of auxiliary materials.

2. The ganoderma lucidum particle of claim 1, wherein: the raw materials comprise the following components in parts by weight: 12-18 parts of lucid ganoderma, 18-22 parts of medlar, 6-8 parts of angelica keiskei, 8-10 parts of chia seeds, 0.5-0.8 part of bamboo leaf flavone and 2-3 parts of auxiliary materials.

3. The ganoderma lucidum particle of claim 1, wherein: the adjuvants include one or more of sugar powder, Mel and vitamin E.

4. A method for preparing the ganoderma lucidum granules according to any one of claims 1 to 3, wherein: the method comprises the following steps: mixing Ganoderma, fructus Lycii, Angelica Keiskei Koidz and semen chiae, pulverizing, decocting in water for three times, mixing decoctions, filtering, concentrating the filtrate to obtain soft extract, adding bamboo leaf flavone and adjuvants, mixing, granulating, and drying.

5. The method of claim 4, wherein: the decoction is carried out for three times, and specifically comprises the following steps: the adding amount of the first water is 10-15 times of the total weight of the raw materials, and the decoction is carried out for 3-4h, and the adding amounts of the second water and the third water are both 3-5 times of the total weight of the raw materials, and are both decocted for 2-3 h.