CN112005119A - 检测和定量fgf21的方法 - Google Patents

检测和定量fgf21的方法 Download PDF

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Publication number
CN112005119A
CN112005119A CN201980022872.9A CN201980022872A CN112005119A CN 112005119 A CN112005119 A CN 112005119A CN 201980022872 A CN201980022872 A CN 201980022872A CN 112005119 A CN112005119 A CN 112005119A
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amino acid
seq
acid sequence
conservative substitutions
antibody
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Chinese (zh)
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约翰·霍·宁·劳
园田纯一郎
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201980022872.9A 2018-04-04 2019-04-04 检测和定量fgf21的方法 Pending CN112005119A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862652701P 2018-04-04 2018-04-04
US62/652,701 2018-04-04
PCT/US2019/025726 WO2019195514A1 (en) 2018-04-04 2019-04-04 Methods for detecting and quantifying fgf21

Publications (1)

Publication Number Publication Date
CN112005119A true CN112005119A (zh) 2020-11-27

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CN201980022872.9A Pending CN112005119A (zh) 2018-04-04 2019-04-04 检测和定量fgf21的方法

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US (1) US20210025890A1 (enExample)
EP (1) EP3775930A1 (enExample)
JP (1) JP2021520492A (enExample)
KR (1) KR20200140852A (enExample)
CN (1) CN112005119A (enExample)
AU (1) AU2019247778A1 (enExample)
BR (1) BR112020019756A2 (enExample)
CA (1) CA3092388A1 (enExample)
IL (1) IL277726A (enExample)
MX (1) MX2020010387A (enExample)
TW (1) TW202011029A (enExample)
WO (1) WO2019195514A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022218277A1 (zh) * 2021-04-13 2022-10-20 广东东阳光药业有限公司 一种抗fgf21羧基末端的抗体及其应用
CN118294677A (zh) * 2024-04-12 2024-07-05 杭州戴格生物技术有限公司 一种检测成纤维细胞生长因子21的方法

Families Citing this family (8)

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CN105601748B (zh) 2011-07-01 2021-08-27 恩格姆生物制药公司 用于代谢病症和疾病治疗的组合物、应用和方法
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
CA3034399A1 (en) 2016-08-26 2018-03-01 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
WO2021092140A1 (en) * 2019-11-06 2021-05-14 Ngm Biopharmaceuticals, Inc. Methods of reducing lactate in liver disease patients using variants and fusions of fgf19/fgf21 polypeptides
CN110954693A (zh) * 2019-11-29 2020-04-03 郑州大学 一种肿瘤标志物Cyfra21-1的Simoa试剂盒及其应用
CN112255415A (zh) * 2020-09-10 2021-01-22 温州医科大学 食蟹猴血清中fgf-21浓度的检测方法
CN113030469B (zh) * 2021-03-18 2024-04-09 贵州省分析测试研究院 一种新型冠状病毒检测方法

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WO2001036640A2 (en) * 1999-11-18 2001-05-25 Chiron Corporation Human fgf-21 gene and gene expression products
CN102352407A (zh) * 2011-10-17 2012-02-15 温州医学院 Fgf-21活性测定的方法
US20140206023A1 (en) * 2013-01-24 2014-07-24 Ping Gao Methods, Kits & Antibodies for Detecting Intact Fibroblast Growth Factor 21
CN104215774A (zh) * 2014-08-22 2014-12-17 黑龙江八一农垦大学 一种利用fgf21因子诊断奶牛隐性酮病的方法
US20160033534A1 (en) * 2013-03-14 2016-02-04 Beth Israel Deaconess Medical Center, Inc. Measurement Of FGF21 As A Biomarker Of Fructose Metabolism And Metabolic Disease

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
WO2022218277A1 (zh) * 2021-04-13 2022-10-20 广东东阳光药业有限公司 一种抗fgf21羧基末端的抗体及其应用
CN118294677A (zh) * 2024-04-12 2024-07-05 杭州戴格生物技术有限公司 一种检测成纤维细胞生长因子21的方法

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BR112020019756A2 (pt) 2021-01-26
IL277726A (en) 2020-11-30
MX2020010387A (es) 2020-10-22
TW202011029A (zh) 2020-03-16
CA3092388A1 (en) 2019-10-10
JP2021520492A (ja) 2021-08-19
KR20200140852A (ko) 2020-12-16
WO2019195514A1 (en) 2019-10-10
US20210025890A1 (en) 2021-01-28

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