CN112004832A - 结合cd83的嵌合抗原受体 - Google Patents

结合cd83的嵌合抗原受体 Download PDF

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Publication number
CN112004832A
CN112004832A CN201980027877.0A CN201980027877A CN112004832A CN 112004832 A CN112004832 A CN 112004832A CN 201980027877 A CN201980027877 A CN 201980027877A CN 112004832 A CN112004832 A CN 112004832A
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马可·达维拉
布莱恩·贝茨
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H Lee Moffitt Cancer Center and Research Institute Inc
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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CN201980027877.0A 2018-02-23 2019-02-22 结合cd83的嵌合抗原受体 Pending CN112004832A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862634435P 2018-02-23 2018-02-23
US62/634,435 2018-02-23
US201862677783P 2018-05-30 2018-05-30
US62/677,783 2018-05-30
PCT/US2019/019065 WO2019165156A1 (en) 2018-02-23 2019-02-22 Cd83-binding chimeric antigen receptors

Publications (1)

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CN112004832A true CN112004832A (zh) 2020-11-27

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US (1) US12492254B2 (enExample)
EP (1) EP3755722A4 (enExample)
JP (1) JP7358369B2 (enExample)
KR (1) KR20200130324A (enExample)
CN (1) CN112004832A (enExample)
AU (1) AU2019226101A1 (enExample)
BR (1) BR112020017015A2 (enExample)
IL (1) IL276836A (enExample)
MA (1) MA51917A (enExample)
MX (1) MX2020008803A (enExample)
PH (1) PH12020500632A1 (enExample)
SG (1) SG11202007755YA (enExample)
WO (1) WO2019165156A1 (enExample)
ZA (1) ZA202005837B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119331093A (zh) * 2024-11-04 2025-01-21 武汉伊莱瑞特生物科技股份有限公司 一种抗CD30的兔源Fab抗体及其制备方法和应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019226101A1 (en) 2018-02-23 2020-09-17 H. Lee Moffitt Cancer Center And Research Institute Inc. CD83-binding chimeric antigen receptors
JP7701908B2 (ja) * 2019-08-16 2025-07-02 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 抗ｃｄ３８キメラ抗原受容体を発現する制御性ｔ細胞
EP4013515A4 (en) * 2019-08-16 2023-09-27 H. Lee Moffitt Cancer Center & Research Institute, Inc. CHIMERIC ANTIGEN RECEPTORS FOR THE TREATMENT OF MYELOID MALIGNANCIES
WO2021067290A1 (en) 2019-09-30 2021-04-08 The Trustees Of The University Of Pennsylvania HUMANIZED ANTI-GDNF FAMILY ALPHA-RECEPTOR 4 (GRF-ALPHA-4) ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS (CARs)
US20230051885A1 (en) * 2019-12-18 2023-02-16 H. Lee Moffitt Cancer Center And Research Institute Inc. Systems and Methods for Producing Efficacious Regulatory T Cells
EP4093767A1 (en) * 2020-01-22 2022-11-30 H. Lee Moffitt Cancer Center & Research Institute, Inc. Bi-specific chimeric antigen receptor t cells targeting cd83 and interleukin 6 receptor
US20230107770A1 (en) * 2020-02-20 2023-04-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Method of enhancing immunotherapy using er stress pathway inhibitors
US20230321239A1 (en) * 2020-08-14 2023-10-12 H. Lee Moffitt Cancer Center And Research Institute Inc. Chimeric antigen receptor t cells for treating autoimmunity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103906766A (zh) * 2011-07-01 2014-07-02 弗·哈夫曼-拉罗切有限公司 抗cd83激动剂抗体用于治疗自身免疫疾病的用途
CN105531289A (zh) * 2013-02-01 2016-04-27 全氏生物有限公司 抗cd83抗体及其用途
WO2016126608A1 (en) * 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
WO2017149515A1 (en) * 2016-03-04 2017-09-08 Novartis Ag Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040185040A1 (en) 2001-11-21 2004-09-23 Celltech R & D Limited Modulating immune responses
AU2003300817A1 (en) 2002-11-21 2004-06-18 Celltech R And D, Inc. Modulating immune responses
GB0624500D0 (en) 2006-12-07 2007-01-17 Istituto Superiore Di Sanito A novel passive vaccine for candida infections
US9228172B2 (en) 2008-06-19 2016-01-05 The Trustees Of The University Of Pennsylvania Inducible regulatory T-cell generation for hematopoietic transplants
JP6096677B2 (ja) 2011-01-10 2017-03-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 同種造血幹細胞移植の増強
JP2013150592A (ja) 2011-07-01 2013-08-08 Genentech Inc 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用
SG11201506696TA (en) 2013-02-26 2015-09-29 Axiomx Inc Methods for the production of libraries for directed evolution
JP6645968B2 (ja) 2013-09-13 2020-02-14 ソリジェニックス インコーポレーテッド 口腔粘膜炎の処置における使用のための新規ペプチド及び類似体
CA2965170A1 (en) 2014-10-23 2016-04-28 Dendrocyte Biotech Pty Ltd Cd83 binding proteins and uses thereof
HK1243333A1 (zh) * 2014-10-31 2018-07-13 The Trustees Of The University Of Pennsylvania 用於修饰的t细胞的方法和组合物
CA2874083C (en) 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
PT3280729T (pt) 2015-04-08 2022-08-01 Novartis Ag Terapias para cd20, terapias para cd22 e terapias de combinação com uma célula que expressa o recetor de antigénio quimérico (car) para cd19
CN107708741A (zh) 2015-06-12 2018-02-16 免疫医疗公司 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法
TW202444897A (zh) * 2015-06-25 2024-11-16 美商生物細胞基因治療有限公司 嵌合抗原受體(car)、組合物及其使用方法
JP2019535262A (ja) 2016-11-11 2019-12-12 オートラス リミテッド キメラ抗原受容体
CA3074379A1 (en) 2017-09-13 2019-03-21 Kira Biotech Pty Limited Treatment method
JP7654240B2 (ja) 2017-09-19 2025-04-01 マサチューセッツ インスティテュート オブ テクノロジー キメラ抗原受容体ｔ細胞治療のための組成物およびその使用
EP3710040A1 (en) 2017-11-15 2020-09-23 Novartis AG Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies
WO2019136335A1 (en) 2018-01-05 2019-07-11 Gencyte Therapeutics, Inc. Precision molecular adaptor system for car-t immunotherapy
CN111971052B (zh) 2018-02-08 2024-07-05 小利兰.斯坦福大学托管委员会 用于异基因造血干细胞移植的方法
AU2019226101A1 (en) 2018-02-23 2020-09-17 H. Lee Moffitt Cancer Center And Research Institute Inc. CD83-binding chimeric antigen receptors
US20200108098A1 (en) 2018-02-23 2020-04-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. Anti-cd83 chimeric antigen receptor expressing t regulatory cells
EP3887507A1 (en) 2018-11-30 2021-10-06 Janssen Biotech, Inc. Gamma delta t cells and uses thereof
JP7701908B2 (ja) 2019-08-16 2025-07-02 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 抗ｃｄ３８キメラ抗原受容体を発現する制御性ｔ細胞
US20230051885A1 (en) 2019-12-18 2023-02-16 H. Lee Moffitt Cancer Center And Research Institute Inc. Systems and Methods for Producing Efficacious Regulatory T Cells
EP4093767A1 (en) 2020-01-22 2022-11-30 H. Lee Moffitt Cancer Center & Research Institute, Inc. Bi-specific chimeric antigen receptor t cells targeting cd83 and interleukin 6 receptor
WO2023122643A1 (en) 2021-12-22 2023-06-29 Regents Of The University Of Minnesota Cd83 and allo- and autoimmune conditions
JP2024102735A (ja) 2023-01-19 2024-07-31 セイコーエプソン株式会社 頭部装着型表示装置及び光学ユニット

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103906766A (zh) * 2011-07-01 2014-07-02 弗·哈夫曼-拉罗切有限公司 抗cd83激动剂抗体用于治疗自身免疫疾病的用途
CN105531289A (zh) * 2013-02-01 2016-04-27 全氏生物有限公司 抗cd83抗体及其用途
WO2016126608A1 (en) * 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
WO2017149515A1 (en) * 2016-03-04 2017-09-08 Novartis Ag Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ZENAN L. CHANG等: "Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 13, no. 161, 20 May 2015 (2015-05-20), pages 1 - 16 *
刘宙;杨伟明;赵洪远;王超宇;邬江华;: "CD83、CD1a标记肿瘤浸润性树突状细胞在大肠癌中的表达及其临床意义", 西安交通大学学报(医学版), vol. 32, no. 01, 31 January 2011 (2011-01-31), pages 124 - 127 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119331093A (zh) * 2024-11-04 2025-01-21 武汉伊莱瑞特生物科技股份有限公司 一种抗CD30的兔源Fab抗体及其制备方法和应用

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US20210032336A1 (en) 2021-02-04
MA51917A (fr) 2021-06-02
KR20200130324A (ko) 2020-11-18
WO2019165156A1 (en) 2019-08-29
JP2021513857A (ja) 2021-06-03
MX2020008803A (es) 2021-01-15
SG11202007755YA (en) 2020-09-29
US12492254B2 (en) 2025-12-09
PH12020500632A1 (en) 2021-05-10
AU2019226101A1 (en) 2020-09-17
IL276836A (en) 2020-10-29
CA3092220A1 (en) 2019-08-29
ZA202005837B (en) 2023-02-22
JP7358369B2 (ja) 2023-10-10
EP3755722A4 (en) 2021-11-24
BR112020017015A2 (pt) 2020-12-15

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