CN112004825A - 细胞周期蛋白a1特异性t细胞受体及其用途 - Google Patents

细胞周期蛋白a1特异性t细胞受体及其用途 Download PDF

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CN112004825A
CN112004825A CN201980025483.1A CN201980025483A CN112004825A CN 112004825 A CN112004825 A CN 112004825A CN 201980025483 A CN201980025483 A CN 201980025483A CN 112004825 A CN112004825 A CN 112004825A
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amino acid
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acid sequence
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R·佩雷特
P·D·格林伯格
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Fred Hutchinson Cancer Center
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CN201980025483.1A 2018-02-12 2019-02-12 细胞周期蛋白a1特异性t细胞受体及其用途 Pending CN112004825A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862629648P 2018-02-12 2018-02-12
US62/629,648 2018-02-12
US201862630198P 2018-02-13 2018-02-13
US62/630,198 2018-02-13
US201862667207P 2018-05-04 2018-05-04
US62/667,207 2018-05-04
PCT/US2019/017708 WO2019157524A1 (en) 2018-02-12 2019-02-12 Cyclin a1 specific t cell receptors and uses thereof

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CN112004825A true CN112004825A (zh) 2020-11-27

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US (1) US12570712B2 (https=)
EP (1) EP3752525A1 (https=)
JP (2) JP2021512637A (https=)
CN (1) CN112004825A (https=)
AU (1) AU2019218397A1 (https=)
BR (1) BR112020016330A8 (https=)
CA (1) CA3090700A1 (https=)
IL (1) IL276556A (https=)
MX (1) MX2020008403A (https=)
SG (1) SG11202007660UA (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022156687A1 (en) * 2021-01-19 2022-07-28 Wuxi Biologics (Shanghai) Co., Ltd. Polypeptide complexes with improved stability and expression

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220095228A (ko) * 2019-11-06 2022-07-06 베이롤 칼리지 오브 메드신 암의 t 세포 치료를 위한 세포독성 효과기 기억 t 세포를 생산하는 방법
CN113321725B (zh) * 2020-02-28 2024-06-11 香雪生命科学技术（广东）有限公司 一种识别afp的t细胞受体
EP4168451A2 (en) 2020-06-22 2023-04-26 NGM Biopharmaceuticals, Inc. Lair-1-binding agents and methods of use thereof
CN113880953A (zh) * 2020-07-01 2022-01-04 华夏英泰（北京）生物技术有限公司 T细胞抗原受体、其多聚体复合物及其制备方法和应用
WO2022022696A1 (zh) * 2020-07-30 2022-02-03 香雪生命科学技术（广东）有限公司 一种识别afp的高亲和力tcr
MX2023012141A (es) * 2021-04-14 2023-11-28 Tscan Therapeutics Inc Peptidos inmunogenicos magec2, proteinas de union que reconocen peptidos inmunogenicos magec2, y usos de estos.
EP4731758A2 (en) * 2023-06-20 2026-04-29 The Methodist Hospital Antigen-specific t cell receptors and chimeric antigen receptors, and methods of use in immune signaling modulation for cancer immunotherapy
WO2025245169A1 (en) 2024-05-21 2025-11-27 Fred Hutchinson Cancer Center Immunotherapy cells equipped with a collagen-targeting payload

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104080797A (zh) * 2011-11-11 2014-10-01 弗雷德哈钦森癌症研究中心 针对癌症的靶向细胞周期蛋白a1的t细胞免疫疗法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
US20020053092A1 (en) 1997-11-14 2002-05-02 Readhead Carol W. Nucleic acid constructs containing a cyclin A1 promoter, and kit
US6461813B2 (en) 1998-09-21 2002-10-08 Rigel Pharmaceuticals, Inc. Multiparameter FACS assays to detect alterations in cell cycle regulation
CN1560078B (zh) 1998-07-31 2011-06-22 株式会社国际癌症免疫研究所 基于癌抑制基因wt1的产物的癌抗原
WO2000023573A2 (en) 1998-10-20 2000-04-27 City Of Hope Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
WO2004024175A1 (ja) 2002-09-12 2004-03-25 Haruo Sugiyama 癌抗原ペプチド製剤
DE10244457A1 (de) 2002-09-24 2004-04-01 Johannes-Gutenberg-Universität Mainz Verfahren zur rationalen Mutagenese von alpha/beta T-Zell Rezeptoren und entsprechend mutierte MDM2-Protein spezifische alpha/beta T-Zell Rezeptoren
ES2556232T3 (es) 2004-03-31 2016-01-14 International Institute Of Cancer Immunology, Inc. Péptidos antigénicos del cáncer derivados de WT1
JP2008527001A (ja) 2005-01-13 2008-07-24 ザ ジョンズ ホプキンス ユニバーシティー 前立腺幹細胞抗原ワクチンおよびその使用
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
WO2008042814A2 (en) 2006-09-29 2008-04-10 California Institute Of Technology Mart-1 t cell receptors
EP2203746B1 (en) 2007-09-24 2013-03-06 Technion Research & Development Foundation Ltd. T cell subpopulations capable of treating cancer
EP2210903A1 (en) 2009-01-21 2010-07-28 Monoclonal Antibodies Therapeutics Anti-CD160 monoclonal antibodies and uses thereof
EP2258719A1 (en) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
US8362210B2 (en) 2010-01-19 2013-01-29 Xencor, Inc. Antibody variants with enhanced complement activity
US20130071414A1 (en) 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
JP6120848B2 (ja) 2011-08-15 2017-04-26 メディミューン，エルエルシー 抗ｂ７−ｈ４抗体およびその使用
CA2881981A1 (en) 2012-08-20 2014-02-27 Fred Hutchinson Cancer Research Center Method and compositions for cellular immunotherapy
AU2013361275B2 (en) 2012-12-19 2016-11-24 Amplimmune, Inc. Anti-human B7-H4 antibodies and their uses
JP6943760B2 (ja) 2014-09-12 2021-10-06 ジェネンテック， インコーポレイテッド 抗ｂ７−ｈ４抗体及び免疫複合体
JP2017531427A (ja) 2014-10-03 2017-10-26 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）抗体およびその使用法
US10317402B2 (en) 2014-12-03 2019-06-11 Verik Bio, Inc. Identification, selection and use of high curative potential T cell epitopes
AU2016242967B2 (en) 2015-04-01 2021-07-01 Adaptive Biotechnologies Corp. Method of identifying human compatible T cell receptors specific for an antigenic target
GB201511546D0 (en) 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
GB201516272D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201604494D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104080797A (zh) * 2011-11-11 2014-10-01 弗雷德哈钦森癌症研究中心 针对癌症的靶向细胞周期蛋白a1的t细胞免疫疗法
CN107011426A (zh) * 2011-11-11 2017-08-04 弗雷德哈钦森癌症研究中心 针对癌症的靶向细胞周期蛋白a1的t细胞免疫疗法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RACHEL PERRET ET AL: "Expanding the scope of WT1- and cyclin A1-specific TCR gene therapy for AML and other cancers", THE JOURNAL OF IMMUNOLOGY, vol. 196, pages 143, XP055591199 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022156687A1 (en) * 2021-01-19 2022-07-28 Wuxi Biologics (Shanghai) Co., Ltd. Polypeptide complexes with improved stability and expression

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MX2020008403A (es) 2020-09-25
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JP2023133505A (ja) 2023-09-22
US20200405762A1 (en) 2020-12-31
SG11202007660UA (en) 2020-09-29
CA3090700A1 (en) 2019-08-15
IL276556A (en) 2020-09-30
WO2019157524A1 (en) 2019-08-15
BR112020016330A8 (pt) 2023-04-18
US12570712B2 (en) 2026-03-10
BR112020016330A2 (pt) 2020-12-15
AU2019218397A1 (en) 2020-10-01

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