CN111989098A - 用于治疗肌肉疾病的化合物和组合物 - Google Patents
用于治疗肌肉疾病的化合物和组合物 Download PDFInfo
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- CN111989098A CN111989098A CN201980026811.XA CN201980026811A CN111989098A CN 111989098 A CN111989098 A CN 111989098A CN 201980026811 A CN201980026811 A CN 201980026811A CN 111989098 A CN111989098 A CN 111989098A
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- epicatechin
- bone
- muscle
- follistatin
- weakening
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
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- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
Landscapes
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US15/900,533 US20180193306A1 (en) | 2012-03-23 | 2018-02-20 | Compounds and compositions for the treatment of muscular disorders and bone disorders |
US15/900,533 | 2018-02-20 | ||
PCT/US2019/018730 WO2019164914A1 (fr) | 2018-02-20 | 2019-02-20 | Composés et compositions pour le traitement de troubles musculaires |
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CN111989098A true CN111989098A (zh) | 2020-11-24 |
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EP (1) | EP3755319A4 (fr) |
JP (1) | JP2021514380A (fr) |
CN (1) | CN111989098A (fr) |
AU (1) | AU2019224003A1 (fr) |
BR (1) | BR112020016923A2 (fr) |
CA (1) | CA3091892A1 (fr) |
IL (1) | IL276786A (fr) |
WO (1) | WO2019164914A1 (fr) |
Cited By (1)
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US11918570B2 (en) | 2020-04-13 | 2024-03-05 | The Research Foundation For The State University Of New York | Method of treatment for prevention of glucocorticoid toxicity and/or enhancement of muscle regeneration via neutrophil elastase inhibition |
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US10052316B2 (en) | 2011-06-06 | 2018-08-21 | Cardero Therapeutics, Inc. | Methods and compositions for treatment of mitochondrial toxicity |
US10898465B2 (en) | 2016-06-21 | 2021-01-26 | Epirium Bio Inc. | Utility of (+) epicatechin and their analogs |
WO2024036225A1 (fr) * | 2022-08-10 | 2024-02-15 | Epirium Bio Inc. | Épicatéchine pour l'inhibition de la toxicité du glutamate |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1739498A (zh) * | 2005-09-05 | 2006-03-01 | 中山大学 | (-)-表没食子儿茶素没食子酸酯-钙络合物固体分散体及其制备方法与应用 |
CN104837369A (zh) * | 2012-10-04 | 2015-08-12 | 雅培制药有限公司 | 用于增强EGCg对减缓骨骼肌损失的作用的方法 |
CN107206040A (zh) * | 2014-06-16 | 2017-09-26 | 尤尼根公司 | 用于管理或改进骨病症、软骨病症或二者的组合物和方法 |
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PL374966A1 (en) * | 2002-02-21 | 2005-11-14 | Wyeth | Follistatin domain containing proteins |
JP2004161669A (ja) * | 2002-11-13 | 2004-06-10 | Ito En Ltd | 骨形成促進剤 |
WO2008155397A2 (fr) * | 2007-06-20 | 2008-12-24 | Galapagos N.V. | Cibles et composés moléculaires utiles dans le traitement de maladies dégénératives des os et des articulations, et procédés pour les identifier |
KR101760758B1 (ko) * | 2008-05-14 | 2017-07-24 | 애그리컬쳐 빅토리아 서비스 피티와이 엘티디 | 질병 및 장애를 치료하기 위한 안지오게닌 또는 안지오게닌 아고니스트의 이용 |
JP2010095474A (ja) * | 2008-10-17 | 2010-04-30 | Ito En Ltd | カルシウム吸収促進組成物及びカルシウム吸収促進飲食物 |
KR101096574B1 (ko) * | 2008-12-12 | 2011-12-20 | 에이치 엘 지노믹스(주) | 유럽종 포도의 씨 추출물을 함유하는 골다공증 예방 또는 치료용 약학 조성물 |
JP2011006355A (ja) * | 2009-06-25 | 2011-01-13 | Ito En Ltd | 骨密度改善組成物及び飲食物 |
JP2013051920A (ja) * | 2011-09-05 | 2013-03-21 | Ishikawa Prefectural Public Univ Corp | 骨密度強化補助食品 |
EP3884937A1 (fr) * | 2012-03-23 | 2021-09-29 | Cardero Therapeutics, Inc. | Composés et compositions pour le traitement d'affections musculaires |
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- 2019-02-20 JP JP2020544632A patent/JP2021514380A/ja active Pending
- 2019-02-20 EP EP19756654.0A patent/EP3755319A4/fr not_active Withdrawn
- 2019-02-20 AU AU2019224003A patent/AU2019224003A1/en active Pending
- 2019-02-20 CA CA3091892A patent/CA3091892A1/fr active Pending
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CN1739498A (zh) * | 2005-09-05 | 2006-03-01 | 中山大学 | (-)-表没食子儿茶素没食子酸酯-钙络合物固体分散体及其制备方法与应用 |
CN104837369A (zh) * | 2012-10-04 | 2015-08-12 | 雅培制药有限公司 | 用于增强EGCg对减缓骨骼肌损失的作用的方法 |
CN107206040A (zh) * | 2014-06-16 | 2017-09-26 | 尤尼根公司 | 用于管理或改进骨病症、软骨病症或二者的组合物和方法 |
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US11918570B2 (en) | 2020-04-13 | 2024-03-05 | The Research Foundation For The State University Of New York | Method of treatment for prevention of glucocorticoid toxicity and/or enhancement of muscle regeneration via neutrophil elastase inhibition |
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WO2019164914A1 (fr) | 2019-08-29 |
BR112020016923A2 (pt) | 2020-12-15 |
EP3755319A1 (fr) | 2020-12-30 |
AU2019224003A1 (en) | 2020-10-08 |
JP2021514380A (ja) | 2021-06-10 |
CA3091892A1 (fr) | 2019-08-29 |
EP3755319A4 (fr) | 2021-12-01 |
IL276786A (en) | 2020-10-29 |
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