CN111971307A - 用于预防移植物排斥的抗cd40抗体 - Google Patents

用于预防移植物排斥的抗cd40抗体 Download PDF

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Publication number
CN111971307A
CN111971307A CN201980024663.8A CN201980024663A CN111971307A CN 111971307 A CN111971307 A CN 111971307A CN 201980024663 A CN201980024663 A CN 201980024663A CN 111971307 A CN111971307 A CN 111971307A
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CN
China
Prior art keywords
antibody
seq
dose
cfz533
amino acid
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Pending
Application number
CN201980024663.8A
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English (en)
Chinese (zh)
Inventor
P·埃斯比
B·哈拉尔松
J·拉什
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Novartis AG
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Novartis AG
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Application filed by Novartis AG filed Critical Novartis AG
Publication of CN111971307A publication Critical patent/CN111971307A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980024663.8A 2018-04-13 2019-04-11 用于预防移植物排斥的抗cd40抗体 Pending CN111971307A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862657172P 2018-04-13 2018-04-13
US62/657,172 2018-04-13
EP18208332.9 2018-11-26
EP18208332 2018-11-26
PCT/IB2019/052976 WO2019198019A1 (en) 2018-04-13 2019-04-11 Anti-cd40 antibodies for use in prevention of graft rejection

Publications (1)

Publication Number Publication Date
CN111971307A true CN111971307A (zh) 2020-11-20

Family

ID=66542473

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980024663.8A Pending CN111971307A (zh) 2018-04-13 2019-04-11 用于预防移植物排斥的抗cd40抗体

Country Status (13)

Country Link
US (2) US11780927B2 (https=)
EP (1) EP3774913A1 (https=)
JP (2) JP6861301B2 (https=)
KR (1) KR20200143718A (https=)
CN (1) CN111971307A (https=)
AU (1) AU2019252858A1 (https=)
BR (1) BR112020020277A2 (https=)
CA (1) CA3094600A1 (https=)
CL (1) CL2020002622A1 (https=)
IL (1) IL277828A (https=)
MX (1) MX2020010722A (https=)
TW (1) TW201943731A (https=)
WO (1) WO2019198019A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020225736A1 (en) * 2019-05-08 2020-11-12 Novartis Ag Anti-cd40 antibodies for use in treatment of t1dm and insulitis
CN116234909A (zh) * 2020-08-21 2023-06-06 上海药明生物技术有限公司 Cd40激动剂抗体和使用方法
WO2022090194A1 (en) * 2020-10-26 2022-05-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for assessing the area under the curve of an immunosuppressant and associated method and systems
EP4402174A1 (en) * 2021-09-17 2024-07-24 Novartis AG Methods for prevention of graft rejection in xenotransplantation
WO2025117849A1 (en) * 2023-11-28 2025-06-05 Eledon Pharmaceuticals, Inc. Methods and compositions for prevention of transplant rejection
WO2025184603A2 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration
WO2025184567A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
WO2025235683A1 (en) * 2024-05-07 2025-11-13 Eledon Pharmaceuticals, Inc. Methods and compositions for prevention of transplant rejection
WO2025235670A1 (en) 2024-05-07 2025-11-13 Eledon Pharmaceuticals, Inc. Use of anti-cd40 ligand antibodies for immunosuppression in islet cell transplantation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
BRPI0417266B8 (pt) 2003-12-25 2021-05-25 Kyowa Hakko Kirin Co Ltd anticorpo monoclonal, seu uso e composição farmacêutica
CN101014386A (zh) * 2004-04-27 2007-08-08 诺华疫苗和诊断公司 拮抗性抗－cd40单克隆抗体及其使用方法
EP1854810A1 (en) 2006-05-09 2007-11-14 PanGenetics B.V. Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody
BR112012024713B1 (pt) 2010-03-31 2021-02-17 Boehringer Ingelheim International Gmbh anticorpo humanizado, seus usos e composição farmacêutica que o compreende
AR083847A1 (es) * 2010-11-15 2013-03-27 Novartis Ag Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
US11780977B2 (en) * 2020-08-10 2023-10-10 Dover Chemical Corporation Polymer compositions having an improved printable surface and related methods

Also Published As

Publication number Publication date
CL2020002622A1 (es) 2021-04-16
MX2020010722A (es) 2020-11-06
KR20200143718A (ko) 2020-12-24
JP2021113190A (ja) 2021-08-05
WO2019198019A1 (en) 2019-10-17
CA3094600A1 (en) 2019-10-17
JP2020519634A (ja) 2020-07-02
EP3774913A1 (en) 2021-02-17
US11780927B2 (en) 2023-10-10
US20240287198A1 (en) 2024-08-29
AU2019252858A1 (en) 2020-10-08
IL277828A (en) 2020-11-30
TW201943731A (zh) 2019-11-16
BR112020020277A2 (pt) 2021-01-19
US20210079107A1 (en) 2021-03-18
JP6861301B2 (ja) 2021-04-21

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