CN111956741B - 一种促进唾液分泌、减轻口腔干燥的植物组合物及其制备方法 - Google Patents
一种促进唾液分泌、减轻口腔干燥的植物组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种促进唾液分泌、减轻口腔干燥的植物组合物，所述植物组合物包含石斛、花椒、五味子和甘草。本发明的有益效果为：能有效促进唾液分泌、减轻口腔干燥症状。
Description
技术领域
本发明属于日用化工技术领域，具体涉及一种促进唾液分泌、减轻口腔干燥的植物组合物及其制备方法。
背景技术
唾液是人体自身分泌的一种生理物质，在我们日常生命活动中起着重要作用。唾液可以：
1、帮助我们吞咽食物，保持口腔湿润，使语言、咀嚼功能顺利进行；
2、唾液中含有的淀粉酶能够帮助食物消化；
3、唾液中含有的无机物和有机物，比如钠、钾、磷酸钙、蛋白质、葡萄糖等能平衡口腔内部酸碱度，帮助牙齿标点的珐琅质成熟和矿化，防治牙齿珐琅质受到侵害；
4、唾液的流动可清洁口腔内的食物残渣、细菌、脱落的上皮等，进而防止龋齿的发生；
5、唾液还有一定的抗菌作用，唾液中的溶菌酶能够起到杀菌作用，唾液是人体抵抗外来细菌的第一道屏障。
《本草纲目》记载：“人有病，则心肾不交，肾水不上，故津液干而真气耗也。”李时珍指出：“津液乃人之精气所化。”古代医学家认为“津”系“精”所化，精盈则肾水上升，化为津液，津液再予咽下，能润心，使心火免于过盛，水火相济，阴平阳秘谓之“自饮长生酒”。因此，古人常以吞咽津液达到祛病强身、益寿延年之效。
现代生活中，不少原因使得我们唾液分泌量减少，威胁着我们的口腔健康：精神紧张不安、年龄的增加，唾液腺功能减弱、放射性治疗、糖尿病、药物副作用、天气干燥、抽烟、喝酒等不健康的生活习惯都会导致唾液分泌减少。本发明组方可增加唾液分泌量、减轻口腔干燥症状。
发明内容
本发明的目的是提供一种促进唾液分泌、减轻口腔干燥的植物组合物。
本发明所采取的技术方案是：
一种促进唾液分泌、减轻口腔干燥的植物组合物，所述植物组合物包含石斛、花椒、五味子和甘草。
其中，石斛：石斛位于“九大仙草”之首，具有极高的药用价值；其化学成分主要为多糖类、石斛碱、氨基酸等，其性甘、微寒，益胃生津，滋阴清热。用于热病津伤，口干烦渴，胃阴不足，食少干呕，病后虚热不退，阴虚火旺，骨蒸劳热，目暗不明，筋骨痿软。铁皮石斛可下调TNF-α和IL-1β、调节T细胞亚群，缓解炎性细胞因子对唇腺的破坏，上调APQ5基因表达，增加唾液分泌。APQ5主要参与腺体的分泌及水分的转运，各种腺体腺泡细胞顶膜面均有分布；APQ5在腺泡细胞顶膜增加，通过信号通路传导，激活M3受体，促使胞质内Ca2+浓度升高，胞质内的APQ5向细胞顶膜进行转运，引起腺泡细胞水分的分泌增加，铁皮石斛多糖作为产品中的保湿剂，有利于口腔保湿，减少水分散失，进而缓解口干症状。
花椒：辛、温，温中止痛，杀虫止痒。用于脘腹冷痛，呕吐泄泻，虫积腹痛；外治湿疹，阴痒。花椒中的酰胺类物质可刺激唾液腺，使唾液分泌量即时增加。
五味子：酸、甘，温。固涩收敛，益气生津，补肾宁心。用于久咳虚喘，遗尿，尿频，遗精，久泻，盗汗，伤津口渴，气短脉虚，内热消渴，心悸失眠，肝炎；含有五味子素及维生素C、鞣质及少量糖类等。五味子中的有机酸类成分同样可以刺激唾液腺，使唾液分泌量即时增加。
甘草：甘、平，补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。
四种作为药食同源的中药，安全可靠。
作为优选，所述植物组合物由以下重量组份的组分制成：石斛8～15份、花椒5～10份、五味子5～10份和甘草1～3份。
作为优选，所述植物组合物由以下重量组份的组分制成：石斛10份、花椒8份、五味子8份和甘草2份。
作为优选，所述石斛选自铁皮石斛，也可以选择其它可食用的石斛品种。
作为优选，所述植物组合物还包含多元醇、柠檬酸水溶液和乳酸链球菌。
多元醇作为溶剂、保湿剂；柠檬酸水溶液的质量百分比浓度为0.05％，为pH调节剂、溶剂；乳酸链球菌作为防腐剂使用。
本发明还提供了一种制备所述植物组合物的方法，包括以下步骤：
(1)称取石斛、花椒、五味子和甘草，加入水或乙醇提取，得提取液；
(2)将所述提取液过滤，收集滤液，浓缩至无醇味，得浸膏。
作为优选，所述步骤(1)中乙醇的体积百分比浓度为40％～95％。
作为优选，所述步骤(1)中乙醇的体积百分比浓度为50％或75％。
作为优选，所述步骤(1)中乙醇提取的次数为1～5次，每次所述提取的时间为1～5小时。
本发明的有益效果在于：
本发明中，重用石斛，生津清热，为君药。花椒促进唾液分泌，五味子益气生津，共为臣药。甘草清热，调和诸药，以缓和花椒、五味子辛温之性。诸药合用，共凑生津之功，能有效保持口腔湿润，缓解口腔干燥。
本发明中选取花椒、石斛、五味子、甘草，通过提取分离制备成可以添加在具有增加唾液分泌、减轻口干症状功效诉求的口腔用品或食品、保健品中的原料。
附图说明
图1为实施例1-5、阴性对照和阳性对照促进唾液分泌的效果图；
图2为实施例1、实施例6-7、阴性对照和阳性对照促进唾液分泌的效果图。
具体实施方式
为使本领域技术人员详细了解本发明的生产工艺和技术效果，下面以具体的生产实例来进一步介绍本发明的应用和技术效果。
实施例1
按重量份数，称取铁皮石斛10份、花椒8份、五味子8份和甘草2份，加入体积百分比浓度为50％的乙醇回流提取2小时，过滤，收集滤液，减压浓缩至无醇味，得浸膏(组方1)。
实施例2
省略花椒，其余完全按照实施例1的方式来进行(组方2)。
实施例3
省略铁皮石斛，其余完全按照实施例1的方式来进行(组方3)。
实施例4
省略甘草，其余完全按照实施例1的方式来进行(组方4)。
实施例5
省略五味子，其余完全按照实施例1的方式来进行(组方5)。
促唾液功效试验方法
邀请5～10位受试者，对其使用测试组方前后的静态唾液总流量(吐取法)进行测定。
阴性对照组：受试者在停止进食、饮水和吸烟后1h，取30g蒸馏水，漱口5～10s，受试者端坐于安静室内，不说话、不咀嚼、无吞咽动作，使唾液在口底聚集，受试者每隔60s将其吐入预先称好重量的烧杯中，收集5min，称唾液重量。
阳性对照组：受试者在停止进食、饮水和吸烟后1h，取0.05mol/L的枸橼酸水溶液30g，漱口5～10s，受试者端坐于安静室内，不说话、不咀嚼、无吞咽动作，使唾液在口底聚集，受试者每隔60s将其吐入预先称好重量的烧杯中，收集5min，称唾液重量。
实验组：受试者在停止进食、饮水和吸烟后1h，取粗浸膏配制成的5％样品溶液30g，漱口5～10s，受试者端坐于安静室内，不说话、不咀嚼、无吞咽动作，使唾液在口底聚集，受试者每隔60s将其吐入预先称好重量的烧杯中，收集5min，称唾液重量。
调查询问受试者，唾液分泌增加的感觉、溶液口感。
试验结果，见图1。
从图1可以看出，相对于阴性对照，各组方均有促进唾液分泌的效果；组方1,4,5促唾液分泌效果优于阳性对照；组方2/3分别减少花椒和铁皮石斛后，唾液分泌量明显低于其他3个组方，说明花椒、石斛为该组方中的重要药物；通过受试者调查，70％的受试者认为组方1口感最优。
实施例6
将实施例1中体积百分比浓度为50％的乙醇替换为水，其余完全按照实施例1的方式来进行。
实施例7
将实施例1中体积百分比浓度为50％的乙醇替换为体积百分比浓度为75％的乙醇，其余完全按照实施例1的方式来进行。
采用水提、50％醇提、75％醇提所得实施例1、实施例6和实施例7的样品促唾液分泌功效进行评估，选定提取溶剂。
试验方法同上，结果见图2。
从图2可以看出，75％乙醇、50％乙醇、水分别作为提取溶剂，相对于阴性对照，各样品均具有促进唾液分泌的效果，其中以50％乙醇提取的样品促唾液分泌效果最佳，故选定50％作为提取溶剂。
实施例8
按重量份数，取实施例1所得浸膏80份、多元醇18.45份、质量百分比浓度为0.05％的柠檬酸水溶液1.5份和乳酸链球菌0.05份。将多元醇加入浸膏中，混匀，得物料A；将乳酸链球菌加入柠檬酸水溶液中，混匀，得物料B；将物料A和物料B混匀，过滤，得产品1。
产品促唾液分泌作用的研究
试验方法
邀请20位受试者，对其使用测试组方前后的静态唾液总流量(吐取法)进行测定。
阴性对照组：受试者在停止进食、饮水和吸烟后1h，取30g蒸馏水，漱口5～10s，受试者端坐于安静室内，不说话、不咀嚼、无吞咽动作，使唾液在口底聚集，受试者每隔60s将其吐入预先称好重量的烧杯中，收集5min，称唾液重量。
实验组：受试者在停止进食、饮水和吸烟后1h，取样品配制成的5％样品(产品1)溶液30g，漱口5～10s，受试者端坐于安静室内，不说话、不咀嚼、无吞咽动作，使唾液在口底聚集，受试者每隔60s将其吐入预先称好重量的烧杯中，收集5min，称唾液重量。
两次样品间隔60min，且间隔期间禁止进食、饮水和吸烟。
调查询问受试者，唾液分泌增加的感觉，口腔湿润感和溶液口感。
试验结果如下：
样品促进唾液分泌结果
*备注：
唾液增加率％＝(M1-M0)/M0×100％促进唾液分泌
*备注
唾液增加率％≤5％：无促进唾液分泌效果
5％＜唾液增加率％＜30％：轻微促进唾液分泌
唾液增加率％≥30％：显著促进唾液分泌
从试验数据可以看出，75％的受试者均唾液分泌量增加，其中55％的受试者唾液分泌明显增加；通过受试者调查，20位受试者中有17位表示感觉唾液分泌增加，占比85％，说明该发明具有促进唾液分泌、减轻口腔干燥的作用。
实施例9
称取铁皮石斛10g、花椒8g、五味子8g、甘草2g，加560ml50％乙醇回流提取2h，300目筛网过滤，收集滤液；滤渣加420ml50％乙醇回流提取1.5h，300目筛网过滤，收集滤液；合并滤液，减压浓缩至无醇味，敞口浓缩至280g浸膏。浸膏冷却至60℃，加入天然澄清剂B相11.2g，搅匀，60℃保温90min，过程中每30min搅拌一次；保温结束，加入5.1g天然澄清剂A相，搅匀，放置30min后再次搅匀，静置过夜。加8.4g硅藻土至静置液中，搅拌分散均匀，用5μm滤膜正压过滤，收集滤液。敞口浓缩滤液至112g，加入25.8g丙二醇；另取0.07g乳酸链球菌素用0.05％柠檬酸水溶液2.1g溶解完全加入浸膏中，搅匀，用200目筛网过滤，即得。
实施例中用到的天然澄清剂为市售产品，天然澄清剂A相组份为海藻酸钠溶液，天然澄清剂B相为壳聚糖改性活性炭溶液。
最后应说明的是，以上实施例仅用以说明而非限制本发明的技术方案，尽管参照上述实施例对本发明进行了详细说明，本领域技术人员应当理解，依然可以对本发明进行修改或者等同替换，而不脱离本发明的精神和范围的任何修改或局部替换，其均应涵盖在本发明的权利要求范围中。
Claims (8)
1.一种促进唾液分泌、减轻口腔干燥的植物组合物，其特征在于，所述植物组合物由以下重量组份的组分制成：石斛8～15份、花椒5～10份、五味子5～10份和甘草1～3份。
2.根据权利要求1所述的一种促进唾液分泌、减轻口腔干燥的植物组合物，其特征在于，所述植物组合物由以下重量组份的组分制成：石斛10份、花椒8份、五味子8份和甘草2份。
3.根据权利要求1-2任一项所述的一种促进唾液分泌、减轻口腔干燥的植物组合物，其特征在于，所述石斛选自铁皮石斛。
4.根据权利要求1-2任一项所述的一种促进唾液分泌、减轻口腔干燥的植物组合物，其特征在于，所述植物组合物还包含多元醇、柠檬酸水溶液和乳酸链球菌。
5.一种制备权利要求1-2任一项所述植物组合物的方法，其特征在于：包括以下步骤：
(1)称取石斛、花椒、五味子和甘草，加入水或乙醇提取，得提取液；
(2)将所述提取液过滤，收集滤液，浓缩至无醇味，得浸膏。
6.根据权利要求5制备所述植物组合物的方法，其特征在于：所述步骤(1)中乙醇的体积百分比浓度为40％～95％。
7.根据权利要求6制备所述植物组合物的方法，其特征在于：所述步骤(1)中乙醇的体积百分比浓度为50％或75％。
8.根据权利要求5制备所述植物组合物的方法，其特征在于：所述步骤(1)中乙醇提取的次数为1～5次，每次所述提取的时间为1～5小时。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083638A (zh) * | 2014-06-28 | 2014-10-08 | 蚌埠火鹤制药有限公司 | 一种治疗唾液分泌不足的中药茶饮 |
| CN107660715A (zh) * | 2017-11-16 | 2018-02-06 | 宁夏万升实业有限责任公司 | 一种中老年人滋补配方 |
| CN107927678A (zh) * | 2017-11-16 | 2018-04-20 | 宁夏万升实业有限责任公司 | 一种补益配方 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083638A (zh) * | 2014-06-28 | 2014-10-08 | 蚌埠火鹤制药有限公司 | 一种治疗唾液分泌不足的中药茶饮 |
| CN107660715A (zh) * | 2017-11-16 | 2018-02-06 | 宁夏万升实业有限责任公司 | 一种中老年人滋补配方 |
| CN107927678A (zh) * | 2017-11-16 | 2018-04-20 | 宁夏万升实业有限责任公司 | 一种补益配方 |
Non-Patent Citations (2)
| Title |
|---|
| 口臭治验三则;韩月红等;《中国民间疗法》;20020128(第01期);第6页左栏第1段 * |
| 铁皮枫斗胶囊的药理作用研究;王立明等;《中国现代应用药学》;20020831(第04期);第262-264页 * |
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