CN111939198B - Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and preparation method and application thereof Download PDFInfo
- Publication number
- CN111939198B CN111939198B CN202011030375.4A CN202011030375A CN111939198B CN 111939198 B CN111939198 B CN 111939198B CN 202011030375 A CN202011030375 A CN 202011030375A CN 111939198 B CN111939198 B CN 111939198B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- medicine composition
- blood stasis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 20-50 parts of angelica tail, 20-50 parts of ligusticum wallichii, 20-50 parts of caulis spatholobi, 20-50 parts of pubescent holly root, 20-50 parts of longhairy antenoron herb, 20-50 parts of rheum officinale, 20-50 parts of costustoot, 20-50 parts of tinospora sinensis and 20-50 parts of radix paeoniae rubra. The traditional Chinese medicine composition provided by the invention can enable a human body to absorb effective components of the traditional Chinese medicine composition through skin, so that the effects of promoting blood circulation to remove blood stasis and inducing diuresis to alleviate edema are fully exerted, and the aim of safely eliminating edema of lower limbs of CKD patients with blood stasis is fulfilled.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and a preparation method and application thereof.
Background
Chronic Kidney Disease (CKD) is a common disease, frequently encountered disease. The study on the etiology, pathology, treatment and prevention of CKD and its complications is a hot topic in the research on kidney diseases at present.
Edema is one of the most common symptoms of kidney diseases, usually occurs in the face and lower limbs, and may progress to generalized edema in severe cases. Edema of the lower limb reduces blood circulation in the swollen area, increasing the risk of localized skin ulceration and infection. Also, CKD can lead to resistance to diuretic therapy. Therefore, conventional dose diuretic therapy is often not helpful for the patient, while a large dose of diuretic may exacerbate renal ischemia, resulting in the occurrence of renal injury. At this time, it becomes extremely important to seek a safer and more effective method for treating edema.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for promoting blood circulation and removing blood stasis, and a preparation method and application thereof. The traditional Chinese medicine composition provided by the invention can enable a human body to absorb effective components of the traditional Chinese medicine composition through skin, so that the effects of promoting blood circulation to remove blood stasis and inducing diuresis to alleviate edema are fully exerted, and the aim of safely eliminating edema of lower limbs of CKD patients with blood stasis is fulfilled.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention provides a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis, which comprises the following raw materials in parts by mass: 20-50 parts of angelica tail, 20-50 parts of ligusticum wallichii, 20-50 parts of caulis spatholobi, 20-50 parts of pubescent holly root, 20-50 parts of longhairy antenoron herb, 20-50 parts of rheum officinale, 20-50 parts of costustoot, 20-50 parts of tinospora sinensis and 20-50 parts of radix paeoniae rubra.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by mass: 30 parts of angelica tail, 30 parts of ligusticum wallichii, 30 parts of caulis spatholobi, 30 parts of pubescent holly root, 30 parts of longhairy antenoron herb, 30 parts of rheum officinale, 30 parts of costustoot, 30 parts of tinospora sinensis and 30 parts of radix paeoniae rubra.
Preferably, the dosage form of the traditional Chinese medicine composition comprises external powder.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: mixing the raw materials of the traditional Chinese medicine composition, preparing raw material particles with the particle size of 74-106 mu m, and grinding the raw material particles into traditional Chinese medicine composition powder with the particle size of 10-50 mu m.
The invention also provides application of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method in preparing a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis.
Preferably, the use method of the traditional Chinese medicine composition comprises the steps of soaking the traditional Chinese medicine composition in hot water to obtain a foot bath solution; the temperature of the hot water is 45-55 ℃; the Chinese medicinal composition is soaked in hot water for 10-30 min.
Preferably, the mass volume ratio of the traditional Chinese medicine composition to hot water is (180-450) g: (300) and (mL).
The invention provides a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis, which comprises the following raw materials in parts by mass: 20-50 parts of angelica tail, 20-50 parts of ligusticum wallichii, 20-50 parts of caulis spatholobi, 20-50 parts of pubescent holly root, 20-50 parts of longhairy antenoron herb, 20-50 parts of rheum officinale, 20-50 parts of costustoot, 20-50 parts of tinospora sinensis and 20-50 parts of radix paeoniae rubra. The Chinese angelica root and the szechuan lovage rhizome are taken as monarch drugs, and the Chinese angelica root directly enters the blood system, so that the Chinese angelica root and the szechuan lovage rhizome can promote blood circulation to remove meridian obstruction, remove blood stasis and promote diuresis; chuan Xiong is pungent, warm, fragrant and dry, and walking without guarding, it can disperse, go up to the vertex, enter the blood system, go down to the blood sea, and is known as "qi-medicine in blood". In traditional Chinese medicine, qi is the commander of blood and blood is the mother of qi, and qi is the motive force for generating and moving blood, and blood is the generation basis and carrier of qi. Chuan Xiong and Dang Gui Tail are the monarch drugs, and have the action of activating blood and qi. The traditional Chinese medicine composition provided by the invention uses caulis spatholobi, pubescent holly root, longhairy antenoron herb and red peony root as ministerial drugs, and combines the effects of monarch drugs of angelica tail and ligusticum wallichii on promoting qi and blood circulation and removing blood stasis and inducing diuresis, wherein the caulis spatholobi also promotes blood circulation and enriches blood, so that the formula cannot be closed and a cardamom is kept, and pneumatic blood is not broken; pubescent holly root, Glechomae herba and radix Paeoniae Rubra have effects of clearing heat and toxic materials, cooling blood and promoting blood circulation, and can be used for treating blood heat syndrome and clearing heat stasis in blood. The caulis tinosporae sinensis dispels wind and relieves pain, and the rhubarb is used as adjuvant drug to disperse wind and remove pathogenic factors. Finally, mu Xiang is used as a guiding drug for harmonizing the actions of the other drugs and regulating the middle-jiao to remove food stagnation. The whole formula is combined to play the effects of activating blood and promoting qi, inducing diuresis to alleviate edema, clearing heat and cooling blood, and can effectively treat blood stasis type edema. The embodiment shows that the CKD patient can effectively control the weight and reduce the leg circumference after adding the traditional Chinese medicine composition provided by the invention, thereby achieving the effects of inducing diuresis and reducing edema.
Detailed Description
The invention provides a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis, which comprises the following raw materials in parts by mass: 20-50 parts of angelica tail, 20-50 parts of ligusticum wallichii, 20-50 parts of caulis spatholobi, 20-50 parts of pubescent holly root, 20-50 parts of longhairy antenoron herb, 20-50 parts of rheum officinale, 20-50 parts of costustoot, 20-50 parts of tinospora sinensis and 20-50 parts of radix paeoniae rubra.
The traditional Chinese medicine composition comprises 20-50 parts of angelica tails, preferably 40-50 parts of angelica tails and most preferably 50 parts of angelica tails. In the invention, the angelica tail directly enters the blood system to play the roles of activating blood circulation to remove meridian obstruction, removing blood stasis and promoting diuresis.
The raw materials of the traditional Chinese medicine composition comprise 20-50 parts of ligusticum wallichii, preferably 40-50 parts, and most preferably 50 parts. In the invention, the angelica tail and the ligusticum wallichii are used as monarch drugs in the traditional Chinese medicine composition, and the effects of activating blood and promoting qi are achieved.
The traditional Chinese medicine composition comprises 20-50 parts of caulis spatholobi, preferably 20-30 parts of caulis spatholobi, and most preferably 30 parts of caulis spatholobi. In the invention, the caulis spatholobi has the effects of activating blood and enriching blood in the traditional Chinese medicine composition, so that the traditional Chinese medicine composition provided by the invention does not cause the situation that a door is closed and the situation that pneumatic blood is broken does not exist.
The raw materials of the traditional Chinese medicine composition comprise 20-50 parts of pubescent holly root, preferably 20-30 parts, and most preferably 30 parts.
The traditional Chinese medicine composition comprises 20-50 parts of longhairy antenoron herb, more preferably 20-30 parts of longhairy antenoron herb, and most preferably 30 parts of longhairy antenoron herb.
The raw materials of the traditional Chinese medicine composition comprise 20-50 parts of radix paeoniae rubra, more preferably 20-30 parts, and most preferably 30 parts.
In the invention, the pubescent holly root, the longhairy antenoron herb and the red peony root have the effects of clearing away heat and toxic materials, cooling blood and activating blood circulation in the traditional Chinese medicine composition, and are specially used for treating blood heat syndrome and clearing heat stasis in blood. The caulis Spatholobi, radix Ilicis Pubescentis, Glechomae herba and radix Paeoniae Rubra are used as ministerial drugs, and have effects of activating qi-flowing, promoting blood circulation, removing blood stasis and promoting diuresis by combining with radix Angelicae sinensis and rhizoma Ligustici Chuanxiong.
The traditional Chinese medicine composition comprises 20-50 parts of rheum officinale, preferably 20-30 parts of rheum officinale, and preferably 20 parts of rheum officinale.
The traditional Chinese medicine composition comprises 20-50 parts of tinospora sinensis, preferably 20-30 parts of tinospora sinensis and preferably 20 parts of tinospora sinensis.
In the invention, the tinospora sinensis and the rheum officinale are used as adjuvant drugs, wherein the tinospora sinensis plays a role in dispelling wind and relieving pain in the invention, and the rheum officinale plays a role in guiding drugs downwards, so that the combination of the tinospora sinensis and the rheum officinale can disperse wind to remove pathogenic factors and get out of the way.
The raw materials of the traditional Chinese medicine composition comprise 20-50 parts of elecampane, and most preferably 20 parts of elecampane. In the invention, the costustoot is used as a messenger drug in the traditional Chinese medicine composition, and has the effects of harmonizing the drugs, regulating the middle-jiao and removing food stagnation.
The source of the above raw materials is not particularly limited in the present invention, and conventional commercially available products known to those skilled in the art may be used. The above materials are added or removed according to the symptoms of patients. For patients with symptoms of soreness of waist and knees, cold hands and feet, radix Aconiti lateralis Preparata 20 parts, cortex Cinnamomi 10 parts, and Achyranthis radix 15 parts can be added for warming kidney, regulating qi-flowing, inducing diuresis, and relieving swelling. For example, for the combined symptoms of anorexia, loose stool, mental fatigue and hypodynamia, 15 parts of prepared aconite root and 30 parts of astragalus root can be added to tonify qi and strengthen yang.
The dosage form of the traditional Chinese medicine composition provided by the invention preferably comprises external powder.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: mixing the raw materials of the traditional Chinese medicine composition, preparing raw material particles with the particle size of 74-106 mu m, and grinding the raw material particles into traditional Chinese medicine composition powder with the particle size of 10-50 mu m, and further preferably 20 mu m. The invention combines the grinding technology of ultrafine particles, grinds the raw materials of the traditional Chinese medicine composition into micron (mum) -level particles, can effectively release effective substances, thereby leading a patient to absorb effective components through the skin to the greatest extent, achieving the effects of promoting blood circulation by removing blood stasis, inducing diuresis to alleviate edema and achieving the technical effect of safely eliminating the edema of the lower limbs of the CKD patient with blood stasis syndrome.
The invention also provides application of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method in preparing a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis.
In the present invention, the method of using the Chinese medicinal composition preferably comprises soaking the Chinese medicinal composition in hot water to obtain a footbath solution; the temperature of the hot water is 45-55 ℃; the Chinese medicinal composition is soaked in hot water for 10min, and the medicinal effect of the raw materials can be released by using the method for soaking the composition in the hot water. In the present invention, the method for the patient to use the footbath solution preferably comprises a footbath method comprising: pouring the foot-bath solution into an electric foot-bath basin, adding water until the foot-bath solution submerges 6-8 cm above the external malleolus of a patient, turning on a power switch, adjusting the temperature of the water to 40-45 ℃, and preferably selecting the time for foot-bath of the patient for 30 min. The using method provided by the invention has the advantages of comfortable and noninvasive process and rare adverse reactions, so that the compliance of patients is high, and the patients are willing to cooperate with treatment.
In the invention, the mass-to-volume ratio of the traditional Chinese medicine composition to hot water is preferably (180-450) g to 300mL, and more preferably (250-350) g to 300 mL. The traditional Chinese medicine composition provided by the invention preferably contains 180-450 g of raw materials of the traditional Chinese medicine composition in each dose, and the price of the traditional Chinese medicine composition is reduced to 1/3-1/2 compared with other low-molecular dextran injections or low-molecular heparin calcium injections for treating edema of CKD patients by about 50 yuan RMB.
For further illustration of the present invention, the following examples are provided to describe the Chinese medicinal composition and powder for promoting blood circulation to remove blood stasis, and the preparation method and application thereof in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
Preparing the following materials in parts by mass: 30 parts of angelica tail, 30 parts of ligusticum wallichii, 30 parts of caulis spatholobi, 30 parts of pubescent holly root, 30 parts of longhairy antenoron herb, 30 parts of rheum officinale, 30 parts of costustoot, 30 parts of tinospora sinensis and 30 parts of radix paeoniae rubra.
Uniformly mixing 30g of angelica sinensis tails, 30g of ligusticum wallichii, 30g of caulis spatholobi, 30g of pubescent holly roots, 30g of longhairy antenoron herbs, 30g of rheum officinale, 30g of elecampane, 30g of tinospora sinensis and 30g of radix paeoniae rubra, grinding the raw materials of the traditional Chinese medicine composition into traditional Chinese medicine powder by a crusher in sequence, grinding the traditional Chinese medicine powder into particles with the particle size of 74-106 mu m by using a common crusher, and grinding the particles into the traditional Chinese medicine composition with the particle size of 20 mu m by using an ultrafine crusher.
Soaking 250g of the Chinese medicinal composition in 300mL of 50 deg.C water for 10min to obtain foot bath solution.
Example 2
Preparing the following materials in parts by mass: 50 parts of angelica tail, 50 parts of ligusticum wallichii, 30 parts of caulis spatholobi, 30 parts of pubescent holly root, 30 parts of longtube ground ivy herb, 20 parts of rheum officinale, 20 parts of costustoot, 20 parts of tinospora sinensis and 30 parts of radix paeoniae rubra.
Taking 50g of angelica sinensis tails, 50g of ligusticum wallichii, 30g of caulis spatholobi, 30g of pubescent holly roots, 30g of longhairy antenoron herbs, 20g of rheum officinale, 20g of elecampane, 20g of tinospora sinensis and 30g of radix paeoniae rubra, uniformly mixing, grinding the raw materials of the traditional Chinese medicine composition into traditional Chinese medicine powder by a crusher in sequence, grinding the traditional Chinese medicine powder into particles with the particle size of 74-106 mu m by using a common crusher, and grinding the particles into the traditional Chinese medicine composition with the particle size of 20 mu m by using an ultra-micro crusher.
Soaking 280g of the Chinese medicinal composition in 300mL of 50 deg.C water for 20min to obtain foot bath solution.
Example 3
Preparing the following materials in parts by mass: 50 parts of angelica tail, 50 parts of ligusticum wallichii, 30 parts of caulis spatholobi, 30 parts of pubescent holly root, 30 parts of longtube ground ivy herb, 20 parts of rheum officinale, 20 parts of costustoot, 20 parts of tinospora sinensis, 30 parts of radix paeoniae rubra, 20 parts of prepared monkshood, 10 parts of cinnamon and 15 parts of achyranthes bidentata.
Uniformly mixing 50g of angelica sinensis tails, 50g of ligusticum wallichii, 30g of caulis spatholobi, 30g of pubescent holly roots, 30g of longhairy antenoron herbs, 20g of rheum officinale, 20g of elecampane, 20g of tinospora sinensis, 30g of radix paeoniae rubra, 20g of prepared monkshood, 10g of cinnamon and 15g of radix achyranthis bidentatae, grinding the raw materials of the traditional Chinese medicine composition into traditional Chinese medicine powder by a crusher in sequence, grinding the traditional Chinese medicine powder into particles with the particle size of 74-106 micrometers by using a common crusher, and grinding the particles into the traditional Chinese medicine composition with the particle size of 30 micrometers by using a superfine crusher.
Soaking 300g of the Chinese medicinal composition in 300mL of 50 deg.C water for 30min to obtain foot bath solution.
Application example 1
1. Case selection
(1) Diagnostic criteria: 1. western diagnostic criteria (chronic kidney disease): firstly, the onset of the disease is slow, the course of the disease is longer than 6 months, and the renal function is normal or slightly reduced (eGFR is more than or equal to 80mL/min/1.73m 2); ② with or without different degrees of proteinuria (quantitative urine protein > lg/24h), hematuria, edema and hypertension; acute attack can be induced by respiratory tract infection and the like in the course of disease, and the manifestations similar to acute nephritis appear.
(2) Traditional Chinese medicine syndrome differentiation standard (blood stasis syndrome): soreness and weakness of waist and knees, dizziness and tinnitus and dark and gloomy complexion; secondly, the face color is very dark, the skin is scaly, and the mouth, lip, paws and nails are purple and dark; ③ or subcutaneous purpura, or tiny blood veins of skin like thread, or abdomen green muscle exposed, or lower limb green muscle distending pain; fourthly, common amenorrhea of women; the tongue is purple or pale or has ecchymosis and petechia, and the pulse is thready and unsmooth or deep and unsmooth.
(3) Inclusion criteria were: the patient is aged 20-60 years old, accords with the diagnosis standard of Chronic Kidney Disease (CKD), has the manifestation of edema of lower limbs before being assembled, is dialectically determined as a blood stasis syndrome according to the dialectical standard of western medicine and Chinese medicine combination society of 2013 Kidney disease professional Committee 'practical guideline for Western diagnosis of kidney disease and dialectical typing' and has no operation trauma, skin infection and wound history within nearly 3 months; at present, the condition of the patient is stable, the vital signs are stable, the heart function is I grade when the patient is taken, and sequela such as paralysis of limbs, unfavorable speech and the like is avoided; informed consent was given and voluntarily enrolled in the trial.
(4) Exclusion criteria: at present, the patients with serious cardiovascular diseases, sequelae of cerebral infarction or cerebral hemorrhage, COPD (chronic obstructive pulmonary disease), myasthenia gravis, angle-closure glaucoma, blood system diseases, mental system diseases or other systemic diseases cannot be matched with the testers; poor compliance or bad medical attitude; severe hearing or vision loss, or extremely low cultural degree, which cannot be matched with the testers.
(5) Exit criteria: serious complications occur; the patient insists on requiring withdrawal; the occurrence of a malignant adverse event; patients were lost or not on treatment in the central clinic or ward.
2. Case grouping
(1) The source of the patient is as follows: patients who are hospitalized in two disease areas of a first subsidiary hospital, a nephrology department and a residence department of Guangzhou Chinese medicine university, from 10 months to 2019 months in 2018 and meet the selection of the cases are selected.
(2) Grouping: 52 patients were collected and randomized into trial and control groups of 26 patients each.
3. Method of treatment
(1) Basic treatment: 52 patients were given adequate medication and adequate EPO, iron therapy in an effort to correct their secondary hyperparathyroidism and calcium phosphorus metabolic disorders, while all patients were advised to follow a low phosphorus and low fat diet with strict control of water intake, blood pressure and blood glucose levels. No drugs such as diuretics which have an effect on the test were used during the test. If the condition requires the application of a diuretic, the case is rejected.
(2) Test groups: the treatment with the traditional Chinese medicine composition provided in example 1 was administered on a basic treatment basis, the treatment method being: pouring the foot-bath solution provided by the embodiment 1 into an electric foot-bath basin, adding water to required scales, turning on a power switch, adjusting the temperature of the water to 40-45 ℃, preferably enabling the patient to perform foot bath for 30min, and enabling the patient in the test group to perform foot bath for 1-2 times per week. It is not suitable for foot inflammation, sores and abscess, chilblain or superficial skin ulceration. The experiment was carried out for 3 weeks.
(3) Control group: no additional treatment was done on the basis of the basic treatment.
4. Observation indexes are as follows: changes in body weight and changes in leg circumference were measured and recorded for all patients before and after treatment, and detailed results are shown in tables 1 and 2.
TABLE 1 variation of leg circumference, body weight and urine volume before and after treatment in the test group of patients
TABLE 2 variation of leg circumference and body weight of control patients before and after treatment
As can be seen from the comparison between table 1 and table 2, the leg circumference difference and the weight difference before and after treatment of the patients in the test group are significantly lower than those of the control group (i.e., the lower limb edema and weight loss of the test group are more significant), which indicates that the traditional Chinese medicine composition provided in example 1 can effectively treat the lower limb edema symptom of CKD patients and is beneficial to weight loss of the patients.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (7)
1. An external traditional Chinese medicine composition for treating chronic kidney disease lower limb edema and promoting blood circulation to remove blood stasis is characterized by comprising the following raw materials in parts by mass: 20-50 parts of angelica tail, 20-50 parts of ligusticum wallichii, 20-50 parts of caulis spatholobi, 20-50 parts of pubescent holly root, 20-50 parts of longhairy antenoron herb, 20-50 parts of rheum officinale, 20-50 parts of costustoot, 20-50 parts of tinospora sinensis and 20-50 parts of radix paeoniae rubra.
2. The external traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by mass: 30 parts of angelica tail, 30 parts of ligusticum wallichii, 30 parts of caulis spatholobi, 30 parts of pubescent holly root, 30 parts of longhairy antenoron herb, 30 parts of rheum officinale, 30 parts of costustoot, 30 parts of tinospora sinensis and 30 parts of radix paeoniae rubra.
3. The topical Chinese medicinal composition of claim 1 or 2, wherein the dosage form of the Chinese medicinal composition comprises a topical powder.
4. A method for preparing the topical Chinese medicinal composition of any one of claims 1 to 3, comprising the steps of: mixing the raw materials of the traditional Chinese medicine composition, preparing raw material particles with the particle size of 74-106 mu m, and grinding the raw material particles into traditional Chinese medicine composition powder with the particle size of 10-50 mu m.
5. The use of the topical Chinese medicinal composition of any one of claims 1 to 3 or the topical Chinese medicinal composition prepared by the preparation method of claim 4 in preparing a medicament for promoting blood circulation and removing blood stasis for treating chronic kidney disease lower limb edema.
6. The use of claim 5, wherein the method of using the composition comprises soaking the composition in hot water to obtain a footbath solution; the temperature of the hot water is 45-55 ℃; the Chinese medicinal composition is soaked in hot water for 10-30 min.
7. The use of claim 5, wherein the mass-to-volume ratio of the traditional Chinese medicine composition to hot water is (180-450) g:300 mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011030375.4A CN111939198B (en) | 2020-09-27 | 2020-09-27 | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011030375.4A CN111939198B (en) | 2020-09-27 | 2020-09-27 | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111939198A CN111939198A (en) | 2020-11-17 |
| CN111939198B true CN111939198B (en) | 2022-04-19 |
Family
ID=73356278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011030375.4A Active CN111939198B (en) | 2020-09-27 | 2020-09-27 | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111939198B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417656A (en) * | 2013-08-06 | 2013-12-04 | 王新程 | Traditional Chinese medicine composition for treating thrombophlebitis |
-
2020
- 2020-09-27 CN CN202011030375.4A patent/CN111939198B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN111939198A (en) | 2020-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103083451B (en) | Traditional Chinese medical ointment for treating shoulder-hand syndrome as well as preparation method thereof | |
| CN106421663A (en) | Medicine composition for treating rheumatoid bone disease and preparation method thereof | |
| CN108553633A (en) | A kind of Dressed plaster and preparation method thereof for treating rheumatism and neck-shoulder pain, lumbago and leg pain | |
| CN110721219A (en) | Traditional Chinese medicine for treating allergic rhinitis | |
| CN107854683A (en) | A kind of plaster for treating damp and hot numbness type knee osteoarthritis | |
| CN101940739A (en) | Traditional Chinese medicine for treating gout | |
| CN111939198B (en) | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and preparation method and application thereof | |
| CN105326926B (en) | A kind of external medicine preparation that treating muscles along the regular meridians disease, preparation method and application | |
| CN101632756B (en) | Traditional Chinese medicine for treating malignant tumours and preparation method thereof | |
| CN103191330A (en) | Traditional Chinese medicine used for treating swelling of limbs of hemiplegic patient | |
| CN109865046B (en) | External plaster for treating postpartum body pain and preparation method thereof | |
| CN111744012A (en) | Externally-applied traditional Chinese medicine composition for treating rheumatic arthritis and preparation method thereof | |
| CN101757465B (en) | Traditional Chinese medicine capsule for treating cervical spondylosis, lumbar disc herniation, cervicodynia and lumbodynia | |
| CN105311210A (en) | Pharmaceutical composition for treating rheumatoid bone diseases | |
| CN112076271B (en) | Traditional Chinese medicine composition for clearing heat and promoting diuresis and preparation method and application thereof | |
| CN115998800B (en) | Traditional Chinese medicine composition and preparation method and application method thereof | |
| CN108567926B (en) | Traditional Chinese medicine composition for treating blood stasis collateral blocking type autoimmune hepatitis and preparation method thereof | |
| CN101983676A (en) | Medicament for treating gynecological blood stasis and qi stagnation | |
| CN104758604A (en) | Traditional Chinese medicinal capsule preparation for recovery of hemiplegia | |
| CN105617214A (en) | Traditional Chinese medicine composition for treating scabies | |
| CN117427127A (en) | Traditional Chinese medicine composition for treating peripheral arthralgia | |
| CN116270942A (en) | Plaster and preparation method thereof | |
| CN116850225A (en) | Traditional Chinese medicine preparation for treating gynecological abnormal uterine bleeding and preparation method thereof | |
| CN115381910A (en) | Plaster for treating hyperosteogeny of cervical vertebra and lumbar vertebra | |
| CN115624585A (en) | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing rheumatic arthritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |