CN111744012A - Externally-applied traditional Chinese medicine composition for treating rheumatic arthritis and preparation method thereof - Google Patents
Externally-applied traditional Chinese medicine composition for treating rheumatic arthritis and preparation method thereof Download PDFInfo
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- CN111744012A CN111744012A CN202010776517.5A CN202010776517A CN111744012A CN 111744012 A CN111744012 A CN 111744012A CN 202010776517 A CN202010776517 A CN 202010776517A CN 111744012 A CN111744012 A CN 111744012A
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Abstract
The invention discloses an external application traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof, wherein the external application traditional Chinese medicine composition comprises at least two layers of base cloth and external application materials, wherein a layer of heat conduction material is paved between every two adjacent layers of base cloth, and the external application materials are coated on the surface of the base cloth positioned at the uppermost layer; the external dressing is prepared from Notopterygii rhizoma, radix Angelicae Pubescentis, herba Girardiniae Palmatae, radix Gentianae Marcrophyllae, radix Clematidis, caulis Spatholobi, ramulus Cinnamomi, semen Persicae, Atractylodis rhizoma, radix Paeoniae Rubra, and radix Angelicae sinensis. The process design of the invention is reasonable, the component proportion is appropriate, the prepared traditional Chinese medicine composition needs to be used with auxiliary infrared rays, and heat can be generated through the infrared rays in the using process, so that the joint is hot-compressed, the efficacy of external dressing is improved, and meanwhile, the joint pain is relieved; the external application combines the functions of clearing heat, removing blood stasis, eliminating dampness, dispelling pathogenic wind, promoting blood circulation and invigorating kidney, and can be used for effectively treating diseases such as rheumatism or rheumatoid arthritis.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an externally applied traditional Chinese medicine composition for treating rheumatic arthritis and a preparation method thereof.
Background
Rheumatoid arthritis (rheumatoid arthritis) is a common acute or chronic inflammation of connective tissue. Generally, the rheumatic arthritis is one of the main manifestations of rheumatic fever, and is clinically characterized by joint and muscle wandering soreness, red swelling and pain. It is associated with group A type B hemolytic streptococcal infection, and cold, dampness and other factors can induce the disease. Although the incidence of rheumatic fever has declined significantly in recent decades, atypical rheumatic fever and chronic rheumatic arthritis are not uncommon.
At present, the traditional Chinese medicine is generally relieved by anti-inflammatory and analgesic medicines during treatment, but Western medicines mostly have strong side effects, harm to human health after long-term administration, and simultaneously have strong drug dependence and cannot radically cure diseases, so the invention discloses an external application traditional Chinese medicine composition for treating rheumatic arthritis and a preparation method thereof, and the rheumatic arthritis is fundamentally treated so as to solve the problem.
Disclosure of Invention
The invention aims to provide an externally applied traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof, and aims to solve the problems in the prior art.
In order to achieve the purpose, the invention provides the following technical scheme:
the externally applied traditional Chinese medicine composition for treating the rheumatoid arthritis comprises at least two layers of base cloth and an external dressing, wherein a heat conducting material is paved between the adjacent base cloth, and the external dressing is coated on the surface of the base cloth positioned on the uppermost layer.
According to a more optimized scheme, the external dressing comprises the following raw materials in parts by weight: by weight, 20-30 parts of notopterygium root, 40-50 parts of radix angelicae pubescentis, 10-15 parts of large scorpion grass, 15-20 parts of gentiana macrophylla, 20-30 parts of radix clematidis, 10-12 parts of caulis spatholobi, 6-8 parts of cassia twig, 20-30 parts of peach kernel, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of red paeony root and 30-40 parts of angelica.
In a preferred embodiment, the outer dressing further comprises: 10-12 parts of dendrobium, 6-8 parts of morinda officinalis, 8-10 parts of pseudo-ginseng, 8-10 parts of ginseng and 25-35 parts of rhizoma drynariae.
The invention discloses an external application traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof, wherein the external application traditional Chinese medicine composition comprises at least two layers of base cloth and external application materials, wherein a layer of heat conduction material is paved between every two adjacent layers of base cloth, and the external application materials are coated on the surface of the base cloth positioned at the uppermost layer; the external dressing is prepared from notopterygium root, radix angelicae pubescentis, scorpio grass, large-leaved gentian, radix clematidis, caulis spatholobi, cassia twig, peach kernel, bighead atractylodes rhizome, red paeony root, Chinese angelica and the like, and the pharmacological effects of the components are as follows:
notopterygium root: fragrant, slightly bitter and pungent; entering bladder and kidney meridians; dispelling cold, dispelling pathogenic wind, removing dampness, and relieving pain; can be used for treating wind-cold type common cold, headache, stiff neck, rheumatalgia, and soreness of shoulder and back.
Radix angelicae pubescentis: mild in nature, slightly bitter and pungent in flavor, entering liver, kidney and bladder meridians; it has effects in expelling pathogenic wind, removing dampness, relieving arthralgia, and relieving pain.
Herb of Daxiezhongzicao: bitter and pungent taste, cool in nature. Dispelling pathogenic wind, eliminating phlegm, promoting diuresis and removing toxic substances; can be widely used for treating rheumatic arthritis, rheumatoid arthritis and other diseases.
Chinese angelica: fragrant, sweet, pungent and slightly bitter. It enters liver, heart and spleen meridians; enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation; can be used for treating rheumatalgia and traumatic injury.
Clematis root: pungent and salty taste; entering bladder meridian; dispelling pathogenic wind, removing dampness, dredging collaterals and relieving pain; can be used for treating rheumatic arthralgia, numbness of limbs, and spasm of tendons and vessels.
Cassia twig: fragrant, sweet and slightly pungent; heart, lung, bladder meridian entered; inducing sweat to relieve muscles, warming and dredging channels, supporting yang to transform qi, and calming the adverse-rising energy; can be used for treating wind-cold type common cold, abdominal psychroalgia, amenorrhea due to blood cold, and arthralgia.
Large-leaved gentian, pungent and bitter in flavor and mild in nature; it enters stomach, gallbladder and liver meridians. Can dispel wind-damp, clear away damp-heat and relieve arthralgia; can be used for treating rheumatic arthralgia, muscular spasm, paralysis of hand and foot, and joint pain.
Caulis spatholobi: bitter, slightly sweet and warm in taste; entering liver meridian; can be used for promoting blood circulation, replenishing blood, relaxing muscles and tendons, and activating collaterals.
Peach kernel: mild in nature and bitter in taste; heart meridian, liver meridian, and lung meridian entered; can be used for promoting blood circulation and removing blood stasis, and is mainly used for treating traumatic injury and pain.
White atractylodes rhizome: slightly warm in nature, bitter and sweet in taste; spleen and stomach meridians entered; it has effects in invigorating qi, strengthening spleen, eliminating dampness, and promoting diuresis.
Red peony root: bitter taste and slightly cold nature; entering liver meridian; clearing heat and cooling blood, and removing blood stasis and relieving pain; it is used for treating traumatic injury, carbuncle, swelling, and pyocutaneous disease.
Dendrobe: sweet and slightly cold; entering stomach and kidney meridians; it has effects in invigorating stomach, promoting salivation, nourishing yin, and removing heat.
Morinda officinalis: pungent and sweet with mild temperature; entering kidney meridian; tonifying kidney and yang, dispelling wind and removing dampness; can be used for treating rheumatic arthralgia.
Pseudo-ginseng: sweet, slightly bitter and warm; heart, liver and spleen meridians entered; removing blood stasis, stopping bleeding, relieving swelling and pain; can be used for treating traumatic injury, and swelling and pain due to blood stasis.
Ginseng: sweet, slightly bitter and mild; it enters spleen, lung and heart meridians. Tonify primordial qi, recover pulse to stop collapse, tonify spleen and lung, promote fluid production, and induce tranquilization.
Rhizoma drynariae: bitter and warm; entering liver and kidney meridians; tonify kidney, activate blood, stop bleeding, continue the muscles and bones; can be used for treating lumbago due to kidney deficiency, traumatic injury, blood stasis, swelling and pain.
In the application, notopterygium root, radix angelicae pubescentis, gentiana macrophylla, clematis root and scorpio grass are used for cooperatively dispelling wind and removing dampness, and activating collaterals and relieving pain; angelica and cassia twig are used for activating blood circulation, promoting blood circulation, warming channels, dispelling cold and removing dampness; rhizoma drynariae, red paeony root and suberect spatholobus stem are used for activating blood and dissolving stasis, expanding the caliber of a blood vessel, accelerating blood flow, increasing blood flow volume, improving blood circulation, eliminating edema and improving pain; the bighead atractylodes rhizome and the peach kernel are used for supplementing qi and relieving pain, the functions of clearing heat, removing blood stasis and eliminating dampness, dispelling wind and activating blood circulation are combined with the function of tonifying kidney, and the traditional Chinese medicine composition can effectively treat diseases such as rheumatism or rheumatoid arthritis.
Because the high-incidence age of diseases such as rheumatism or rheumatoid arthritis is middle-aged, but medical consciousness of actual people is insufficient, patients who are treated by rheumatism and rheumatoid arthritis in general hospitals are mostly over fifty years old in some small towns, the formula is added with the ginseng, the pseudo-ginseng, the morinda officinalis and the dendrobium on the basis of the formula, the dendrobium, the ginseng and the pseudo-ginseng have the effects of tonifying the consumptive disease of five internal organs and slimming, tonifying the kidney and benefiting strength and strengthening the bones, and the morinda officinalis is used as an auxiliary material, so that the effects of replenishing essence and benefiting the marrow, strengthening the muscles and bones, strengthening the kidney and tonifying the kidney are achieved, the functions of the five internal organs are effectively conditioned, the foundation is strengthened, the muscles and the bones are strengthened, the self quality of the patients is effectively improved, and the using effect of the product is further improved.
According to an optimized scheme, the heat conducting material comprises residual medicine residues and mesoporous filling particles after the preparation of the external dressing, and the mass ratio of the medicine residues to the mesoporous filling particles is (3-4): 1.
according to an optimized scheme, the mesoporous filling particles are tungsten oxide and mesoporous silica composite particles.
In a preferred embodiment, the outer dressing further comprises: 20-30 parts of a hollow carrier and 35-60 parts of modified graphene oxide.
According to an optimized scheme, the modified graphene oxide is amino-functionalized graphene oxide, and the hollow carrier is mainly prepared by compounding polyacrylic acid, isopropanol, chloroauric acid trihydrate and ascorbic acid.
The traditional Chinese medicine composition prepared by the scheme is generally used in combination with infrared rays, residual medicine dregs of an external dressing are reserved after the external dressing is prepared, tungsten hexachloride is used as a raw material and is adsorbed into mesoporous silicon dioxide, mesoporous filling particles are prepared by adopting a hydrothermal sintering method, the mesoporous filling particles and the residual medicine dregs are mixed and are paved between adjacent base fabrics; tungsten oxide is a transition metal oxide, so that the tungsten oxide has a strong local surface plasma resonance effect under near-infrared light irradiation, local heat generation is caused, and the tungsten oxide has excellent photo-thermal conversion performance; when the traditional Chinese medicine composition is used in combination with infrared rays, the mesoporous filling particles can generate heat, so that joint pain can be relieved, the effect of external dressing can be stimulated, and the use effect of the external dressing is improved; meanwhile, as the residual dregs of the decoction can also have residual parts of traditional Chinese medicine components which are not extracted completely, the traditional Chinese medicine components can also have fine effects on joints under the action of the mesoporous filling particles, and the utilization of waste materials is improved.
The outer dressing is also added with a hollow carrier and modified graphene oxide, wherein the modified graphene oxide is amino functionalized graphene oxide, and the hollow carrier is mainly prepared by compounding polyacrylic acid, isopropanol, chloroauric acid trihydrate and ascorbic acid; polyacrylic acid, isopropanol and ammonia water react in an aqueous solution to generate polyacrylic acid nanospheres, and chloroauric acid and ascorbic acid are added to prepare the hollow nanogold carrier, wherein the carrier has excellent photo-thermal conversion performance; in the subsequent process, the traditional Chinese medicine components in the external dressing are treated firstly, the extracted extracting solution is loaded by using the hollow carrier, and the functionalized graphene oxide surface contains amino groups, so that the functionalized graphene oxide surface can be coated on the hollow carrier through electrostatic action, the medicine extracting solution loaded on the intermediate carrier is protected, volatilization is reduced, and meanwhile, the medicine extracting solution is prevented from contacting with the external environment, so that the service life of the product is prolonged; when the product is used, the graphene oxide lamella is vibrated and broken to be separated from the surface of the hollow carrier under the action of infrared rays under the synergistic action of the product and the infrared rays, and the hollow carrier generates heat under the action of the infrared rays, so that the release and the use effects of the medicine extracting solution are promoted.
When the infrared heating device is in actual use, the use parameters of infrared rays need to be adjusted, so that the scalding phenomenon of a patient is avoided.
According to a more optimized scheme, the preparation method of the externally applied traditional Chinese medicine composition for treating the rheumatoid arthritis comprises the following steps:
1) preparing an external dressing:
a) taking a polyacrylic acid aqueous solution and ammonia water, carrying out ultrasonic treatment, and slowly dropwise adding isopropanol to react to obtain a material A; taking the material A, continuously adding isopropanol and chloroauric acid trihydrate, stirring for reaction, adding ascorbic acid, continuously reacting, centrifugally washing, and drying to obtain a hollow carrier;
b) soaking Notopterygii rhizoma, radix Angelicae Pubescentis and herba Girardiniae Palmatae in 85% ethanol for 30-40min, ultrasonic extracting, cooling, filtering to obtain primary filtrate, extracting residue with methanol, filtering to obtain secondary filtrate, and mixing the primary filtrate and the secondary filtrate to obtain extractive solution A;
c) cleaning radix Gentianae Marcrophyllae, radix Clematidis, caulis Spatholobi, ramulus Cinnamomi, Ginseng radix, semen Persicae, Atractylodis rhizoma, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Drynariae, herba Dendrobii, radix Morindae officinalis and Notoginseng radix, drying, cutting, pulverizing, decocting in water, filtering, repeating the decocting operation for 2-3 times, and mixing filtrates to obtain extractive solution B;
d) mixing and stirring the extracting solution A and the extracting solution B, carrying out ultrasonic oscillation for 5-10min, adjusting the pH, adding a hollow carrier, continuing stirring, adding the modified graphene oxide, stirring, and concentrating to obtain an external dressing;
2) preparing a heat conducting material:
a) mixing and stirring tungsten hexachloride and propanol, adding silicon dioxide, vacuumizing, treating for 10-12h in a closed environment at the treatment temperature of 180 ℃ and 200 ℃, cooling, centrifugally washing, and vacuum drying to obtain mesoporous filling particles;
b) taking the filtered residue obtained in the step 2), and drying to obtain dregs; mixing the medicine residues and the mesoporous filling particles to obtain a heat conducting material;
3) and (3) spreading at least two layers of base cloth, uniformly laying a layer of heat-conducting material between adjacent base cloth, performing hot-pressing compounding to obtain a matrix, melting the external coating material, and uniformly coating the surface of the matrix to obtain a finished product.
The optimized scheme comprises the following steps:
1) preparing an external dressing:
a) taking a polyacrylic acid aqueous solution and ammonia water, carrying out ultrasonic treatment for 10-15min, then slowly dropwise adding isopropanol, and continuously stirring in the dropwise adding process to obtain a material A; taking the material A, continuously adding isopropanol and chloroauric acid trihydrate, stirring and reacting for 2-2.5h at 25-28 ℃, adding ascorbic acid, reacting for 1-1.2h, centrifuging, washing and drying to obtain a hollow carrier;
b) soaking Notopterygii rhizoma, radix Angelicae Pubescentis and herba Girardiniae Palmatae in 85% ethanol for 30-40min, ultrasonically extracting at 60-65 deg.C for 30-40min, cooling, filtering to obtain primary filtrate, extracting residue with methanol, filtering to obtain secondary filtrate, and mixing the primary filtrate and the secondary filtrate to obtain extractive solution A;
c) cleaning radix Gentianae Marcrophyllae, radix Clematidis, caulis Spatholobi, ramulus Cinnamomi, Ginseng radix, semen Persicae, Atractylodis rhizoma, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Drynariae, herba Dendrobii, radix Morindae officinalis and Notoginseng radix, drying, cutting, pulverizing, decocting in water for 1-2 hr, adding 4-7 times of water amount of raw materials, filtering, repeating the decocting operation for 2-3 times, and mixing filtrates to obtain extract B;
d) mixing and stirring the extract A and the extract B at 25-30 ℃ for 8-12min, carrying out ultrasonic oscillation for 5-10min, adjusting the pH, adding a hollow carrier, stirring for 2-4h, adding modified graphene oxide, continuing stirring for 2-3h, and concentrating to obtain an external dressing;
2) preparing a heat conducting material:
a) mixing and stirring tungsten hexachloride and propanol for 10-20min, adding silicon dioxide, vacuumizing for 10-20min, treating for 10-12h in a closed environment at the treatment temperature of 180-;
b) taking the filtered residue in the step 2), and drying at 50-60 ℃ to obtain medicinal residues; mixing the medicine residues and the mesoporous filling particles, and stirring for 10-20min to obtain a heat conducting material;
3) and (3) spreading at least two layers of base cloth, uniformly laying a layer of heat-conducting material between adjacent base cloth, performing hot-pressing compounding to obtain a matrix, melting the external coating material, and uniformly coating the surface of the matrix to obtain a finished product.
According to an optimized scheme, in the step 1), the preparation method of the modified graphene oxide comprises the following steps: mixing and stirring graphene oxide and absolute ethyl alcohol for 5-10min, carrying out ultrasonic treatment for 1-1.2h, adding triaminopropyltriethoxysilane, carrying out reflux reaction for 4-4.5h at the water bath temperature of 70-75 ℃, carrying out centrifugal separation, taking and washing a solid phase, and carrying out vacuum drying at the temperature of 90-100 ℃ to obtain the modified graphene oxide.
Compared with the prior art, the invention has the beneficial effects that:
the invention discloses an external application traditional Chinese medicine composition for treating rheumatic arthritis and a preparation method thereof, the process design is reasonable, the component proportion is proper, the prepared traditional Chinese medicine composition needs to be used by auxiliary infrared rays, and heat can be generated by the infrared rays in the using process, so that the joint is hot-compressed, the efficacy of an external dressing is improved, and meanwhile, the joint pain is relieved; the external application combines the functions of clearing heat, removing blood stasis, eliminating dampness, dispelling pathogenic wind, promoting blood circulation and invigorating kidney, and can be used for effectively treating diseases such as rheumatism or rheumatoid arthritis.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
s1: preparing an external dressing:
mixing and stirring graphene oxide and absolute ethyl alcohol for 5min, carrying out ultrasonic treatment for 1h, adding triaminopropyltriethoxysilane, carrying out reflux reaction for 4h at the water bath temperature of 70 ℃, carrying out centrifugal separation, taking and washing a solid phase, and carrying out vacuum drying at the temperature of 90 ℃ to obtain modified graphene oxide;
taking a polyacrylic acid aqueous solution and ammonia water, carrying out ultrasonic treatment for 10min, slowly dropwise adding isopropanol, and continuously stirring in the dropwise adding process to obtain a material A; taking the material A, continuously adding isopropanol and chloroauric acid trihydrate, stirring and reacting for 2 hours at 25 ℃, adding ascorbic acid, reacting for 1 hour, centrifuging, washing and drying to obtain a hollow carrier;
soaking Notopterygii rhizoma, radix Angelicae Pubescentis and herba Girardiniae Palmatae in 85% ethanol for 30min, ultrasonically extracting at 60 deg.C for 30min, cooling, filtering to obtain primary filtrate, extracting residue with methanol, filtering to obtain secondary filtrate, and mixing the primary filtrate and the secondary filtrate to obtain extractive solution A;
cleaning radix Gentianae Marcrophyllae, radix Clematidis, caulis Spatholobi, ramulus Cinnamomi, Ginseng radix, semen Persicae, Atractylodis rhizoma, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Drynariae, herba Dendrobii, radix Morindae officinalis and Notoginseng radix, drying, cutting, pulverizing, decocting in water for 1 hr, adding 4 times of water amount of the raw materials, filtering, repeating the decocting operation for 2 times, and mixing filtrates to obtain extractive solution B;
mixing and stirring the extract A and the extract B at 25 ℃ for 8min, ultrasonically oscillating for 5min, adjusting pH, adding a hollow carrier, stirring for 2h, adding the modified graphene oxide, continuously stirring for 2h, and concentrating to obtain an external dressing;
s2: preparing a heat conducting material:
mixing tungsten hexachloride and propanol, stirring for 10min, adding silicon dioxide, vacuumizing for 10min, treating for 10h in a closed environment at 180 ℃, cooling, centrifugally washing, and vacuum drying to obtain mesoporous filling particles;
taking the filtered residue obtained in the step S2, and drying at 50 ℃ to obtain medicine dregs; mixing the medicine residues and the mesoporous filling particles, and stirring for 10min to obtain a heat conducting material;
s3: and (3) spreading at least two layers of base cloth, uniformly laying a layer of heat-conducting material between adjacent base cloth, performing hot-pressing compounding to obtain a matrix, melting the external coating material, and uniformly coating the surface of the matrix to obtain a finished product.
In this embodiment, the external dressing comprises the following raw materials: by weight, 20 parts of notopterygium root, 40 parts of radix angelicae pubescentis, 10 parts of large scorpion grass, 15 parts of gentiana macrophylla, 20 parts of clematis root, 10 parts of suberect spatholobus stem, 6 parts of cassia twig, 20 parts of peach kernel, 10 parts of bighead atractylodes rhizome, 10 parts of red paeony root and 30 parts of Chinese angelica; 10 parts of dendrobium, 6 parts of morinda officinalis, 8 parts of pseudo-ginseng, 8 parts of ginseng, 25 parts of rhizoma drynariae, 20 parts of hollow carrier and 35 parts of modified graphene oxide.
Wherein the mass ratio of the medicine residues to the mesoporous filling particles is 3: 1.
example 2:
s1: preparing an external dressing:
mixing and stirring graphene oxide and absolute ethyl alcohol for 8min, carrying out ultrasonic treatment for 1.1h, adding triaminopropyltriethoxysilane, carrying out reflux reaction for 4.2h at 72 ℃ water bath temperature, carrying out centrifugal separation, taking and washing a solid phase, and carrying out vacuum drying at 95 ℃ to obtain modified graphene oxide;
taking a polyacrylic acid aqueous solution and ammonia water, carrying out ultrasonic treatment for 12min, slowly dropwise adding isopropanol, and continuously stirring in the dropwise adding process to obtain a material A; taking the material A, continuously adding isopropanol and chloroauric acid trihydrate, stirring and reacting for 2.3h at the temperature of 27 ℃, adding ascorbic acid, reacting for 1.1h, centrifugally washing, and drying to obtain a hollow carrier;
soaking Notopterygii rhizoma, radix Angelicae Pubescentis and herba Girardiniae Palmatae in 85% ethanol for 35min, ultrasonically extracting at 62 deg.C for 35min, cooling, filtering to obtain primary filtrate, extracting residue with methanol, filtering to obtain secondary filtrate, and mixing the primary filtrate and the secondary filtrate to obtain extractive solution A;
cleaning radix Gentianae Marcrophyllae, radix Clematidis, caulis Spatholobi, ramulus Cinnamomi, Ginseng radix, semen Persicae, Atractylodis rhizoma, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Drynariae, herba Dendrobii, radix Morindae officinalis and Notoginseng radix, drying, cutting, pulverizing, decocting in water for 1.5 hr, adding 6 times of water amount of the raw materials, filtering, repeating the decocting operation for 3 times, and mixing filtrates to obtain extract B;
mixing the extract A and the extract B at 28 deg.C, stirring for 10min, ultrasonically oscillating for 8min, adjusting pH, adding hollow carrier, stirring for 3 hr, adding modified graphene oxide, stirring for 2.5 hr, and concentrating to obtain an external dressing;
s2: preparing a heat conducting material:
mixing and stirring tungsten hexachloride and propanol for 15min, adding silicon dioxide, vacuumizing for 15min, treating for 11h in a closed environment at 190 ℃, cooling, centrifugally washing, and drying in vacuum to obtain mesoporous filling particles;
taking the filtered residue obtained in the step S2, and drying at 55 ℃ to obtain medicine residues; mixing the medicine residues and the mesoporous filling particles, and stirring for 15min to obtain a heat conducting material;
s3: and (3) spreading at least two layers of base cloth, uniformly laying a layer of heat-conducting material between adjacent base cloth, performing hot-pressing compounding to obtain a matrix, melting the external coating material, and uniformly coating the surface of the matrix to obtain a finished product.
In this embodiment, the external dressing comprises the following raw materials: by weight, 25 parts of notopterygium root, 45 parts of radix angelicae pubescentis, 13 parts of large scorpion grass, 18 parts of gentiana macrophylla, 25 parts of clematis root, 11 parts of suberect spatholobus stem, 7 parts of cassia twig, 25 parts of peach kernel, 13 parts of bighead atractylodes rhizome, 12 parts of red paeony root and 34 parts of Chinese angelica; 11 parts of dendrobium, 7 parts of morinda officinalis, 9 parts of pseudo-ginseng, 9 parts of ginseng, 30 parts of rhizoma drynariae, 25 parts of hollow carrier and 45 parts of modified graphene oxide.
Wherein the mass ratio of the medicine residues to the mesoporous filling particles is 3.5: 1.
example 3:
s1: preparing an external dressing:
mixing and stirring graphene oxide and absolute ethyl alcohol for 10min, carrying out ultrasonic treatment for 1.2h, adding triaminopropyltriethoxysilane, carrying out reflux reaction for 4.5h at the water bath temperature of 75 ℃, carrying out centrifugal separation, taking and washing a solid phase, and carrying out vacuum drying at the temperature of 100 ℃ to obtain modified graphene oxide;
taking a polyacrylic acid aqueous solution and ammonia water, carrying out ultrasonic treatment for 15min, slowly dropwise adding isopropanol, and continuously stirring in the dropwise adding process to obtain a material A; taking the material A, continuously adding isopropanol and chloroauric acid trihydrate, stirring and reacting for 2.5h at 28 ℃, adding ascorbic acid, reacting for 1.2h, centrifugally washing, and drying to obtain a hollow carrier;
soaking Notopterygii rhizoma, radix Angelicae Pubescentis and herba Girardiniae Palmatae in 85% ethanol for 40min, ultrasonically extracting at 65 deg.C for 40min, cooling, filtering to obtain primary filtrate, extracting residue with methanol repeatedly, filtering to obtain secondary filtrate, and mixing the primary filtrate and the secondary filtrate to obtain extractive solution A;
cleaning radix Gentianae Marcrophyllae, radix Clematidis, caulis Spatholobi, ramulus Cinnamomi, Ginseng radix, semen Persicae, Atractylodis rhizoma, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Drynariae, herba Dendrobii, radix Morindae officinalis and Notoginseng radix, drying, cutting, pulverizing, decocting in water for 2 hr, adding water 7 times of the raw materials, filtering, repeating the decocting operation for 3 times, and mixing filtrates to obtain extractive solution B;
mixing and stirring the extract A and the extract B at 30 ℃ for 12min, carrying out ultrasonic oscillation for 10min, adjusting the pH, adding a hollow carrier, stirring for 4h, adding the modified graphene oxide, continuing stirring for 3h, and concentrating to obtain an external dressing;
s2: preparing a heat conducting material:
mixing and stirring tungsten hexachloride and propanol for 20min, adding silicon dioxide, vacuumizing for 20min, treating for 12h in a closed environment at the treatment temperature of 200 ℃, cooling, centrifugally washing, and drying in vacuum to obtain mesoporous filling particles;
taking the filtered residue obtained in the step S2, and drying at 60 ℃ to obtain medicine dregs; mixing the medicine residues and the mesoporous filling particles, and stirring for 20min to obtain a heat conducting material;
s3: and (3) spreading at least two layers of base cloth, uniformly laying a layer of heat-conducting material between adjacent base cloth, performing hot-pressing compounding to obtain a matrix, melting the external coating material, and uniformly coating the surface of the matrix to obtain a finished product.
In this embodiment, the external dressing comprises the following raw materials: by weight, 30 parts of notopterygium root, 50 parts of radix angelicae pubescentis, 15 parts of scorpio grass, 20 parts of gentiana macrophylla, 30 parts of clematis root, 12 parts of suberect spatholobus stem, 8 parts of cassia twig, 30 parts of peach kernel, 15 parts of bighead atractylodes rhizome, 15 parts of red paeony root and 40 parts of Chinese angelica; 12 parts of dendrobium, 8 parts of morinda officinalis, 10 parts of pseudo-ginseng, 10 parts of ginseng, 35 parts of rhizoma drynariae, 30 parts of hollow carrier and 60 parts of modified graphene oxide.
Wherein the mass ratio of the medicine residues to the mesoporous filling particles is 4: 1.
and (4) conclusion: the embodiments 1 to 3 are the traditional Chinese medicine composition prepared according to the scheme disclosed by the invention, when the composition is used in an auxiliary manner with infrared rays, the composition can effectively treat diseases such as rheumatic arthritis, rheumatoid arthritis and the like, the effective rate can reach 95%, the curative effect is good, and the curative effect of radical treatment can be achieved.
The traditional Chinese medicine composition prepared in the embodiment 1 is used as a patch, the patch is used for two times a day, two weeks are a treatment course, and after the patch is used for one treatment course, a patient with slight symptoms is basically cured without recurrence; the symptoms of severe patients are obviously improved, the pain is reduced, and the patients basically recover after continuous use for three courses of treatment.
Typical cases are:
1. wangzhi, female, age 52, with symptoms of joint and muscle wandering soreness, pain, and inability to move freely; after 2 days using the Chinese medicinal composition prepared in the embodiment 2, symptoms gradually lighten and the pain feeling reduces; after one treatment course, the joint moves freely, and no obvious recurrence phenomenon is caused subsequently.
2. Wu-Chi, a female aged 48 years old, with leg rheumatoid arthritis and pain in the knees, and in severe cases, the female cannot walk out of bed, and with the traditional Chinese medicine composition prepared in the embodiment 3, symptoms are relieved after 1 week, pain is greatly reduced after 2 treatment courses, normal life is not affected, and no obvious recurrence phenomenon is caused in the follow-up.
3. Plum, male, age 44, suffering from rheumatoid arthritis, finger deformity, and bony prominence, affecting normal life; after 1 week using the Chinese medicinal composition prepared in this example 1, the symptoms gradually relieved, the pain feeling reduced, and the bony prominences subsided; after one treatment course, the joint moves freely, and no obvious recurrence phenomenon is caused subsequently.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Claims (10)
1. An externally applied traditional Chinese medicine composition for treating rheumatic arthritis is characterized in that: the traditional Chinese medicine composition comprises at least two layers of base cloth and an external dressing, wherein a heat conducting material is paved between the adjacent base cloth, and the external dressing is coated on the surface of the base cloth positioned on the uppermost layer.
2. The externally applied traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 1, which is characterized in that: the outer dressing comprises the following raw materials in parts by weight: by weight, 20-30 parts of notopterygium root, 40-50 parts of radix angelicae pubescentis, 10-15 parts of large scorpion grass, 15-20 parts of gentiana macrophylla, 20-30 parts of radix clematidis, 10-12 parts of caulis spatholobi, 6-8 parts of cassia twig, 20-30 parts of peach kernel, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of red paeony root and 30-40 parts of angelica.
3. The externally applied traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 1, which is characterized in that: the outer dressing further comprises: 10-12 parts of dendrobium, 6-8 parts of morinda officinalis, 8-10 parts of pseudo-ginseng, 8-10 parts of ginseng and 25-35 parts of rhizoma drynariae.
4. The externally applied traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 1, which is characterized in that: the heat conducting material comprises residual medicine residues and mesoporous filling particles after the preparation of the external dressing, and the mass ratio of the medicine residues to the mesoporous filling particles is (3-4): 1.
5. the externally applied traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 4, which is characterized in that: the mesoporous filling particles are tungsten oxide and mesoporous silicon dioxide composite particles.
6. The externally applied traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 1, which is characterized in that: the outer dressing further comprises: 20-30 parts of a hollow carrier and 35-60 parts of modified graphene oxide.
7. The externally applied traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 6, which is characterized in that: the modified graphene oxide is amino-functionalized graphene oxide, and the hollow carrier is mainly prepared by compounding polyacrylic acid, isopropanol, chloroauric acid trihydrate and ascorbic acid.
8. A preparation method of an externally applied traditional Chinese medicine composition for treating rheumatic arthritis is characterized by comprising the following steps: the method comprises the following steps:
preparing an external dressing:
taking a polyacrylic acid aqueous solution and ammonia water, carrying out ultrasonic treatment, and slowly dropwise adding isopropanol to react to obtain a material A; taking the material A, continuously adding isopropanol and chloroauric acid trihydrate, stirring for reaction, adding ascorbic acid, continuously reacting, centrifugally washing, and drying to obtain a hollow carrier;
soaking Notopterygii rhizoma, radix Angelicae Pubescentis and herba Girardiniae Palmatae in 85% ethanol for 30-40min, ultrasonic extracting, cooling, filtering to obtain primary filtrate, extracting residue with methanol, filtering to obtain secondary filtrate, and mixing the primary filtrate and the secondary filtrate to obtain extractive solution A;
cleaning radix Gentianae Marcrophyllae, radix Clematidis, caulis Spatholobi, ramulus Cinnamomi, Ginseng radix, semen Persicae, Atractylodis rhizoma, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Drynariae, herba Dendrobii, radix Morindae officinalis and Notoginseng radix, drying, cutting, pulverizing, decocting in water, filtering, repeating the decocting operation for 2-3 times, and mixing filtrates to obtain extractive solution B;
mixing and stirring the extracting solution A and the extracting solution B, carrying out ultrasonic oscillation for 5-10min, adjusting the pH, adding a hollow carrier, continuing stirring, adding the modified graphene oxide, stirring, and concentrating to obtain an external dressing;
preparing a heat conducting material:
mixing and stirring tungsten hexachloride and propanol, adding silicon dioxide, vacuumizing, treating for 10-12h in a closed environment at the treatment temperature of 180 ℃ and 200 ℃, cooling, centrifugally washing, and vacuum drying to obtain mesoporous filling particles;
taking the filtered residue obtained in the step 2), and drying to obtain dregs; mixing the medicine residues and the mesoporous filling particles to obtain a heat conducting material;
and (3) spreading at least two layers of base cloth, uniformly laying a layer of heat-conducting material between adjacent base cloth, performing hot-pressing compounding to obtain a matrix, melting the external coating material, and uniformly coating the surface of the matrix to obtain a finished product.
9. The preparation method of the externally applied traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 8 is characterized in that: the method comprises the following steps:
preparing an external dressing:
taking a polyacrylic acid aqueous solution and ammonia water, carrying out ultrasonic treatment for 10-15min, then slowly dropwise adding isopropanol, and continuously stirring in the dropwise adding process to obtain a material A; taking the material A, continuously adding isopropanol and chloroauric acid trihydrate, stirring and reacting for 2-2.5h at 25-28 ℃, adding ascorbic acid, reacting for 1-1.2h, centrifuging, washing and drying to obtain a hollow carrier;
soaking Notopterygii rhizoma, radix Angelicae Pubescentis and herba Girardiniae Palmatae in 85% ethanol for 30-40min, ultrasonically extracting at 60-65 deg.C for 30-40min, cooling, filtering to obtain primary filtrate, extracting residue with methanol, filtering to obtain secondary filtrate, and mixing the primary filtrate and the secondary filtrate to obtain extractive solution A;
cleaning radix Gentianae Marcrophyllae, radix Clematidis, caulis Spatholobi, ramulus Cinnamomi, Ginseng radix, semen Persicae, Atractylodis rhizoma, radix Paeoniae Rubra, radix Angelicae sinensis, rhizoma Drynariae, herba Dendrobii, radix Morindae officinalis and Notoginseng radix, drying, cutting, pulverizing, decocting in water for 1-2 hr, adding 4-7 times of water amount of raw materials, filtering, repeating the decocting operation for 2-3 times, and mixing filtrates to obtain extract B;
mixing and stirring the extract A and the extract B at 25-30 ℃ for 8-12min, carrying out ultrasonic oscillation for 5-10min, adjusting the pH, adding a hollow carrier, stirring for 2-4h, adding modified graphene oxide, continuing stirring for 2-3h, and concentrating to obtain an external dressing;
preparing a heat conducting material:
mixing and stirring tungsten hexachloride and propanol for 10-20min, adding silicon dioxide, vacuumizing for 10-20min, treating for 10-12h in a closed environment at the treatment temperature of 180-;
taking the filtered residue in the step 2), and drying at 50-60 ℃ to obtain medicinal residues; mixing the medicine residues and the mesoporous filling particles, and stirring for 10-20min to obtain a heat conducting material;
and (3) spreading at least two layers of base cloth, uniformly laying a layer of heat-conducting material between adjacent base cloth, performing hot-pressing compounding to obtain a matrix, melting the external coating material, and uniformly coating the surface of the matrix to obtain a finished product.
10. The preparation method of the externally applied traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 8 is characterized in that: in the step 1), the preparation method of the modified graphene oxide comprises the following steps: mixing and stirring graphene oxide and absolute ethyl alcohol for 5-10min, carrying out ultrasonic treatment for 1-1.2h, adding triaminopropyltriethoxysilane, carrying out reflux reaction for 4-4.5h at the water bath temperature of 70-75 ℃, carrying out centrifugal separation, taking and washing a solid phase, and carrying out vacuum drying at the temperature of 90-100 ℃ to obtain the modified graphene oxide.
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