CN108619464B

CN108619464B - Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method and application thereof

Info

Publication number: CN108619464B
Application number: CN201810942092.3A
Authority: CN
Inventors: 陈楚翁
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-08-17
Filing date: 2018-08-17
Publication date: 2021-03-16
Anticipated expiration: 2038-08-17
Also published as: CN108619464A

Abstract

The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis, a preparation method and application thereof. The traditional Chinese medicine composition for treating rheumatoid arthritis comprises the following raw materials in parts by weight: 20-30 parts of astragalus membranaceus, 5-15 parts of codonopsis pilosula, 5-15 parts of angelica sinensis, 2-8 parts of ligusticum wallichii, 5-15 parts of bighead atractylodes rhizome, 10-20 parts of golden cypress, 5-15 parts of poria cocos, 10-30 parts of caulis spatholobi, 5-15 parts of pawpaw, 5-15 parts of trichosanthes root, 2-7 parts of akebiaquinata, 2-7 parts of stiff silkworm, 5-15 parts of ground beetle, 2-7 parts of prepared monkshood, 2-6 parts of gentiana macrophylla, 5-15 parts of rhizoma cyperi, 5-15 parts of earthworm, 10-30 parts of corydalis tuber, 5-15 parts of root of kudzu vine, 5-15 parts of curcuma longa, 5-15 parts of ramulus mori, 5-15 parts of eucommia ulmoides, 5-15 parts of cassia. The invention achieves the effects of regulating qi and blood, dredging the channels and collaterals, improving the immunity and radically treating rheumatoid arthritis through the synergistic effect of the raw materials; the medicine of the invention can not cause gastrointestinal irritation, does not influence the normal diet of patients, and is not easy to relapse after healing.

Description

Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method and application thereof

Technical Field

The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for treating rheumatoid arthritis, a preparation method and application thereof.

Background

Rheumatoid arthritis is a systemic and autoimmune disease mainly and slowly caused by arthropathy, redness, swelling and pain of joint stiffness, and mainly manifested by small joints such as fingers and back spine and large joints such as hip joint and knee joint with obvious symptoms of joint stiffness, deformity and dysfunction. The traditional Chinese medicine considers that the qi and blood circulation is influenced by the deficiency of the original qi, the decline of the immunity, the deficiency of the liver and the kidney and the invasion of wind-cold-dampness evil into the body, so that the joint and the skin of the whole body are painful, then the cartilage is destroyed, the joint clearance is narrowed, and the qi and blood stasis, the circulation disorder and the channels and collaterals are blocked and painful. In treatment, the traditional Chinese medicine composition has the effects of regulating qi and blood, dredging channels and collaterals, removing rheumatism and blood stasis inside and outside bones, tonifying liver and kidney and improving immunity, thereby achieving the purpose of eradicating rheumatoid diseases. With the continuous development of Chinese medicine and pharmacy, the traditional Chinese medicine for treating rheumatoid arthritis has the advantages of excellent curative effect, quick response, small toxic and side effect and the like. However, the existing medicines easily cause gastrointestinal stimulation, cause the diet reduction of patients, cause malnutrition, and reduce the immunity of the patients, thereby being difficult to thoroughly cure the rheumatoid arthritis.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating rheumatoid arthritis, a preparation method and application thereof, and aims to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

a traditional Chinese medicine composition for treating rheumatoid arthritis comprises the following raw materials in parts by weight: 20-30 parts of astragalus membranaceus, 5-15 parts of codonopsis pilosula, 5-15 parts of angelica sinensis, 2-8 parts of ligusticum wallichii, 5-15 parts of bighead atractylodes rhizome, 10-20 parts of golden cypress, 5-15 parts of poria cocos, 10-30 parts of caulis spatholobi, 5-15 parts of pawpaw, 5-15 parts of trichosanthes root, 2-7 parts of akebiaquinata, 2-7 parts of stiff silkworm, 5-15 parts of ground beetle, 2-7 parts of prepared monkshood, 2-6 parts of gentiana macrophylla, 5-15 parts of rhizoma cyperi, 5-15 parts of earthworm, 10-30 parts of corydalis tuber, 5-15 parts of root of kudzu vine, 5-15 parts of curcuma longa, 5-15 parts of ramulus mori, 5-15 parts of eucommia ulmoides, 5-15 parts of cassia.

As a further scheme of the invention: the composite material comprises the following raw materials in parts by weight: 25 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 10 parts of angelica sinensis, 5 parts of ligusticum wallichii, 10 parts of bighead atractylodes rhizome, 15 parts of phellodendron, 10 parts of poria cocos, 20 parts of caulis spatholobi, 10 parts of pawpaw, 10 parts of trichosanthes root, 5 parts of akebiaquinata, 5 parts of stiff silkworm, 10 parts of ground beetle, 5 parts of prepared monkshood, 5 parts of gentiana macrophylla, 10 parts of rhizoma cyperi, 10 parts of earthworm, 20 parts of corydalis tuber, 10 parts of radix puerariae, 10 parts of curcuma longa, 10 parts of mulberry twig, 10 parts of eucommia ulmoides, 10.

A preparation method of a traditional Chinese medicine composition for treating rheumatoid arthritis comprises the following steps:

(1) weighing radix astragali, radix Codonopsis, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, Atractylodis rhizoma, cortex Phellodendri, Poria, caulis Spatholobi, fructus Chaenomelis, Trichosanthis radix, caulis Akebiae, Bombyx Batryticatus, Eupolyphaga Seu Steleophaga, radix Aconiti Preparata, radix Gentianae Marcrophyllae, rhizoma Cyperi, Lumbricus, rhizoma corydalis, radix Puerariae, Curcuma rhizome, ramulus Mori, Eucommiae cortex, ramulus Cinnamomi, Achyranthis radix and rhizoma Atractylodis according to the above formula for use;

(2) mixing the above materials, pouring into a container, soaking in water for 20-40min, and soaking Myrrha in water;

(3) boiling with strong fire, then decocting with slow fire for 20-30min, turning off the fire, pouring out the liquid medicine a, putting the dregs of a decoction into a container, adding 100 plus 150 parts of water, decocting for 20-40min again, pouring out the liquid medicine b, and mixing the liquid medicine b with the liquid medicine a to obtain the finished product.

As a further scheme of the invention: and (2) mixing the raw materials, pouring the mixture into a container, adding water, and soaking for 30min to immerse the medicine in the water.

As a further scheme of the invention: and (3) boiling with strong fire, then decocting with slow fire for 25min, turning off the fire, pouring out the liquid medicine a, putting the dregs of a decoction into a container, adding 120 parts of water, decocting for 30min again, pouring out the liquid medicine b, and mixing the liquid medicine b with the liquid medicine a to obtain a finished product.

An application of a Chinese medicinal composition for treating rheumatoid arthritis in preparing a medicament for treating rheumatoid arthritis is provided.

Compared with the prior art, the invention has the beneficial effects that:

the traditional Chinese medicine composition is prepared by decocting more than twenty Chinese herbal medicines together, can effectively play the role of each raw material, and achieves the effects of regulating qi and blood, eliminating qi stagnation and blood stasis, dredging channels and collaterals, improving immunity and radically treating rheumatoid arthritis through the synergistic effect of the raw materials; the medicine of the invention can not cause gastrointestinal irritation, does not influence the normal diet of patients, and is not easy to relapse after healing.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

Example 1

A traditional Chinese medicine composition for treating rheumatoid arthritis comprises the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 5 parts of codonopsis pilosula, 5 parts of angelica sinensis, 2 parts of ligusticum wallichii, 5 parts of bighead atractylodes rhizome, 10 parts of golden cypress, 5 parts of poria cocos, 10 parts of caulis spatholobi, 5 parts of pawpaw, 5 parts of trichosanthes root, 2 parts of akebiaquinata, 2 parts of stiff silkworm, 5 parts of ground beetle, 2 parts of prepared monkshood, 2 parts of gentiana macrophylla, 5 parts of rhizoma cyperi, 5 parts of lumbricus, 10 parts of rhizoma corydalis, 5 parts of radix puerariae, 5 parts of curcuma longa, 5 parts of ramulus mori, 5 parts of eucommia ulmoides.

(2) mixing the above materials, pouring into a container, soaking in water for 20min, and soaking Myrrha in water;

(3) decocting with strong fire, decocting with slow fire for 20min, stopping fire, pouring out liquid medicine a, placing the residue in a container, adding 100 parts of water, decocting for 20min, pouring out liquid medicine b, and mixing liquid medicine b and liquid medicine a to obtain the final product.

Example 2

A traditional Chinese medicine composition for treating rheumatoid arthritis comprises the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 15 parts of codonopsis pilosula, 15 parts of angelica sinensis, 8 parts of ligusticum wallichii, 15 parts of bighead atractylodes rhizome, 20 parts of golden cypress, 15 parts of poria cocos, 30 parts of caulis spatholobi, 15 parts of pawpaw, 15 parts of trichosanthes root, 7 parts of akebiaquinata, 7 parts of stiff silkworm, 15 parts of ground beetle, 7 parts of prepared monkshood, 6 parts of gentiana macrophylla, 15 parts of rhizoma cyperi, 15 parts of earthworm, 30 parts of rhizoma corydalis, 15 parts of radix puerariae, 15 parts of turmeric, 15 parts of ramulus mori, 15 parts of eucommia ulmoides, 15 parts of cassia.

(2) mixing the above materials, pouring into a container, soaking in water for 40min, and soaking Myrrha in water;

(3) decocting with strong fire, decocting with slow fire for 30min, stopping heating, pouring out liquid medicine a, placing the residue in a container, adding 150 parts of water, decocting for 40min, pouring out liquid medicine b, and mixing liquid medicine b and liquid medicine a to obtain the final product.

Example 3

A traditional Chinese medicine composition for treating rheumatoid arthritis comprises the following raw materials in parts by weight: 25 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 10 parts of angelica sinensis, 5 parts of ligusticum wallichii, 10 parts of bighead atractylodes rhizome, 15 parts of phellodendron, 10 parts of poria cocos, 20 parts of caulis spatholobi, 10 parts of pawpaw, 10 parts of trichosanthes root, 5 parts of akebiaquinata, 5 parts of stiff silkworm, 10 parts of ground beetle, 5 parts of prepared monkshood, 5 parts of gentiana macrophylla, 10 parts of rhizoma cyperi, 10 parts of earthworm, 20 parts of corydalis tuber, 10 parts of radix puerariae, 10 parts of curcuma longa, 10 parts of mulberry twig, 10 parts of eucommia ulmoides, 10.

(2) mixing the above materials, pouring into a container, adding water, soaking for 30min, and soaking the medicine in water.

(3) Decocting with strong fire, decocting with slow fire for 25min, turning off fire, pouring out liquid medicine a, placing the residue in a container, adding 120 parts of water, decocting for 30min, pouring out liquid medicine b, and mixing liquid medicine b and liquid medicine a to obtain the final product.

The use method of the medicine comprises the following steps: the medicine is taken after meals, 200 ml and 300ml are taken each time, and 1 month is a treatment course. Patients with mild rheumatoid arthritis can be cured after 1-3 treatment courses generally, and patients with severe rheumatoid arthritis can be cured after 5-8 treatment courses generally. The medicine is stopped for 5 days between each treatment course.

Examples of the experiments

120 patients with rheumatoid arthritis were selected, and each patient took the Chinese medicinal composition prepared in example 3 of the present invention. The use method of the medicine comprises the following steps: the medicine is taken after meals, 200 ml of medicine is taken each time, and 1 month is a treatment course. The medicine is stopped for 5 days between each treatment course.

The curative effect standard is as follows:

and (3) curing: symptoms of patients with mild rheumatoid arthritis disappear after 1 course of treatment; the symptoms of the patient with severe rheumatoid arthritis disappear after 5 courses of treatment.

The method has the following advantages: the symptoms of patients with mild rheumatoid arthritis disappear after 3 courses of treatment; the symptoms of the patient with severe rheumatoid arthritis disappear after 8 courses of treatment.

And (4) invalidation: after 1 treatment course, no obvious change of symptoms occurs.

The treatment results are as follows: 98 cases are cured, 21 cases are effective, and 1 case is ineffective; of these, 1 patient who was not effective had severe diabetes, no medication, and 21 patients who were effective had intermittent medication. The invention has the advantages of 81.7 percent of cure rate, 17.5 percent of effective rate and 0.8 percent of ineffective rate. The total effective rate is 99.2%. In addition, no gastrointestinal stimulation reaction occurs in the treatment process, and the appetite of the patient is not influenced.

Typical cases are: the disease is characterized in that the disease is caused by rheumatoid arthritis for more than 6 years, the life cannot be controlled, medical seeking of multiple parties is ineffective, the diagnosis is carried out in 2016 and 4 months, and the index of the rheumatoid factor is up to 1483 through the test result of a hospital. After the traditional Chinese medicine composition prepared in the embodiment 3 of the invention is taken for one month, the rheumatoid factor index is reduced by 200, and the symptoms are relieved; after the medicine is continuously taken for two months, the index of the rheumatoid factor is reduced by 300, the fingers can move, and the legs can walk slowly; after continuing to take the medicine for 3 months, the rheumatoid factor index is 198; after the medicine is continuously taken for one month, the rheumatoid factor index disappears, reaches the normal range, the uric acid index is 540, and the value is reduced to 402; continuously consolidation for one month. The medicine is taken for 8 months in total, and the rheumatoid arthritis is cured after the last examination, the medicine can work normally, and the disease does not recur until two years.

The theoretical basis of the invention is as follows:

astragalus root: sweet and warm. It enters lung, spleen, liver and kidney meridians. Invigorating qi and consolidating superficial resistance, invigorating spleen and replenishing middle-jiao, and is a middle-jiao and qi-replenishing drug, applied to spleen qi deficiency syndrome and qi sinking syndrome of middle-jiao, yang-ascending and collapse-elevating syndrome, lung qi deficiency syndrome, reinforcing defensive qi and consolidating superficial resistance, qi deficiency spontaneous perspiration syndrome, detoxification and granulation promoting, qi and blood deficiency, edema caused by qi deficiency and water dampness failure and dysuria.

Codonopsis pilosula: sweet and neutral. It enters spleen and lung meridians. Tonify middle energizer and qi, and spleen-lung qi, and treat dizziness and blurred vision.

Chinese angelica: sweet, pungent and warm, entering liver and heart, spleen meridian, tonifying blood and regulating menstruation, promoting blood circulation to relieve pain, loosening bowel to relieve constipation, and is used for treating blood deficiency.

Ligusticum wallichii: pungent and warm, entering liver, gallbladder and pericardium meridian, activating blood and promoting qi circulation, and blood-qi-tonifying herbs, dispelling wind and relieving pain, and can be used for treating blood stasis, headache, rheumatic arthralgia and numbness of limbs.

White atractylodes rhizome: sweet, bitter and warm, spleen and stomach channel entering, spleen strengthening and qi benefiting, spleen and stomach weakness, dampness eliminating and diuresis inducing, spleen dysfunction, water retention due to water-damp retention, edema, dysuresia, exterior syndrome consolidating and sweating checking, spontaneous sweating caused by lung weakness, exogenous cold, miscarriage prevention, spleen deficiency and qi weakness, fetal irritability and the like.

Phellodendron bark: bitter and cold herbs enter kidney, bladder and large intestine meridians, and are indicated for clearing heat and drying dampness, purging fire and removing toxicity, bone-steaming and fatigue-heat, clearing stomach fire, yellow gallbladder, leukorrhagia stranguria and prostatitis.

Tuckahoe, poria cocos: sweet, bland, neutral, enter heart, spleen, stomach and lung meridians, induce diuresis and drain dampness, invigorate spleen and calm heart, and it is indicated for edema due to cold-heat, deficiency and excess, diarrhea due to spleen deficiency and dampness.

Caulis spatholobi: bitter, slightly sweet and warm, entering liver and kidney channels, promoting blood circulation and enriching blood, regulating menstruation and activating collaterals, and treating symptoms such as rheumatism and arthralgia, numbness of hands and feet, paralysis of limbs, phlegm and blood deficiency and sallow complexion.

Pawpaw: sour and warm, entering liver and spleen channels, relaxing tendons and activating collaterals, resolving dampness and harmonizing stomach, promoting digestion and promoting fluid production to quench thirst, and is applied to rheumatism, leg twitching, beriberi edema and the like.

Trichosanthes root: sweet, slightly bitter and cold, entering lung and stomach meridians, clearing heat and purging fire, promoting the production of body fluid to quench thirst, relieving swelling and expelling pus, treating internal heat, polydipsia, thirst, dry throat and other symptoms.

B, wood through: bitter, cold and toxic, entering heart, small intestine and bladder meridians, inducing diuresis for treating stranguria, dredging meridians and promoting lactation, and can be used for dredging all vessels, inducing diuresis and dredging collaterals.

Stiff silkworm: wei, pungent and even, enter liver, lung and stomach meridians, extinguish wind and stop convulsions, dispel wind and alleviate pain, resolve phlegm and dissipate nodulation, and indicated for convulsions and convulsions due to fright, apoplexy, facial distortion, wind-heat headache, conjunctival congestion, etc.

Ground beetle: cold, with little toxicity, entering liver meridian, breaking blood and resolving stasis, reuniting tendons and bones, it is the key herb for traumatic injury, swelling and pain due to blood stasis in joints and joint injury.

Radix aconiti preparata: pungent, bitter and hot with strong toxicity, entering heart, spleen, liver and kidney channels, dispelling wind and removing dampness, warming channels and relieving pain, and applied to treating wind-cold-dampness stasis in bones, arthralgia-syndrome and toxic material, the preparation is necessary.

Large-leaved gentian: bitter, pungent and slightly cold herbs enter stomach, liver and gallbladder meridians to dispel wind-damp-heat, so it is indicated for syndrome of bone-steaming tidal-heat and dampness-heavy.

Rhizoma cyperi: pungent, slightly sweet, slightly bitter and even, entering liver meridian and triple energizer meridian, governing liver and relieving superficiality, regulating menstruation and relieving pain, regulating qi and regulating middle energizer, and is used for treating arthralgia syndrome due to stagnation of liver-qi.

Earthworm: cold, entering liver, tablet, bladder channel and high fever, and is applied to the symptoms of blockage of meridians, unsmooth blood vessels and adverse limb joints caused by various reasons.

Rhizoma corydalis: pungent, bitter and warm herbs enter liver, tablet and heart meridians, activate blood and resolve stasis, move qi and alleviate pain, and are indicated for pain due to blood stasis and qi stagnation.

Kudzu root: sweet, pungent and cool, entering spleen and kidney meridians, expelling pathogenic factors from muscles and skin, bringing about fluid production to quench thirst, lifting yang and sinking, and treating exterior syndrome with fever due to external contraction, internal heat, diabetes, spleen deficiency and diarrhea.

Turmeric: pungent, bitter and warm herbs enter liver and spleen meridians, activate blood and move qi, warm meridians and alleviate pain, and qi stagnation and blood stasis, wind-damp arthralgia and shoulder joint channels-leading herbs are used.

Mulberry twig: bitter and flat, dispelling wind and removing dampness, and relaxing joints, and applying the drugs for inducing channels in the upper limbs and numbness of the shoulder and fingers.

Eucommia ulmoides: sweet and warm, entering liver and kidney meridians, tonifying liver and kidney, strengthening tendons and bones, preventing abortion, and treating soreness and pain of waist and knees, atrophy-flaccidity of lower limbs, impotence, frequent micturition, etc.

Cassia twig: pungent, sweet and warm. It enters heart, lung and bladder meridians. Has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, supporting yang, regulating qi, and lowering qi. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm and fluid retention, edema and palpitation.

Achyranthes root: bitter, sweet, sour and neutral, entering liver and kidney meridians, activating blood and dredging collaterals and benefiting liver and kidney, strengthening tendons and bones, inducing fire and blood downward, inducing diuresis and treating stranguria, and treating soreness and pain of waist and knees, flaccidity and weakness of lower limbs, flaming-up of fire heat, hyperactivity of fire due to yin deficiency and the like.

Rhizoma atractylodis: pungent, bitter and warm, entering spleen, stomach and liver meridians, drying dampness and strengthening spleen, dispelling wind and cold, and applying to symptoms such as arthroncus, dampness and dryness, rheumatic arthralgia and the like.

The invention follows the theory of traditional Chinese medicine, and is divided into monarch, minister, assistant and guide channels. Wherein, the astragalus root is the monarch, and the radix codonopsitis is matched with the white atractylodes rhizome, and the white atractylodes rhizome has the functions of strengthening the middle-jiao and replenishing qi, the angelica and the suberect spatholobus stem are added for enriching the blood, promoting the blood circulation, regulating menstruation, the twotooth achyranthes root and the Szechuan lovage rhizome are added for promoting the blood circulation and removing the blood stasis. The Chinese medicinal composition has the effects of improving the immunologic function, clearing kidney fire, promoting the production of body fluid, inducing diuresis and clearing channels, removing dampness and stasis of channels and collaterals in bones by using radix aconiti, removing rheumatic fever and swelling pain by using radix gentianae macrophyllae, removing stiff silkworm by clearing channels and eliminating, promoting blood circulation and dredging collaterals by using lumbricus and ground beetles, repairing articular bone tips, clearing damp heat and relieving swelling by using rhizoma atractylodis, and removing blood stasis by using meridian-guiding medicaments of radix puerariae, curcuma longa, eucommia ulmoides, ramulus mori, cassia twig and pawpaw by using rhizoma cyperi and rhizoma corydalis, and can promote blood circulation and regulate qi, eliminate qi stagnation and blood stasis, promote qi circulation and remove channels and rheumatoid arthritis.

Although the preferred embodiments of the present patent have been described in detail, the present patent is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present patent within the knowledge of those skilled in the art.

Claims

1. A traditional Chinese medicine composition for treating rheumatoid arthritis is characterized by comprising the following raw materials in parts by weight: 25 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 10 parts of angelica sinensis, 5 parts of ligusticum wallichii, 10 parts of bighead atractylodes rhizome, 15 parts of phellodendron, 10 parts of poria cocos, 20 parts of caulis spatholobi, 10 parts of pawpaw, 10 parts of trichosanthes root, 5 parts of akebiaquinata, 5 parts of stiff silkworm, 10 parts of ground beetle, 5 parts of prepared monkshood, 5 parts of gentiana macrophylla, 10 parts of rhizoma cyperi, 10 parts of earthworm, 20 parts of corydalis tuber, 10 parts of radix puerariae, 10 parts of curcuma longa, 10 parts of mulberry twig, 10 parts of eucommia ulmoides, 10.

2. A method for preparing the traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 1, which is characterized by comprising the following steps:

3. The preparation method of the Chinese medicinal composition for treating rheumatoid arthritis according to claim 2, wherein the raw materials in the step (2) are mixed and poured into a container, and the container is soaked in water for 30min, so that the medicine is immersed in the water.

4. The preparation method of the traditional Chinese medicine composition for treating rheumatoid arthritis according to claim 2, wherein the decoction in the step (3) is performed by boiling with strong fire, then decocting with slow fire for 25min, then turning off the fire, pouring out the liquid medicine a, then putting the dregs of a decoction into a container, adding 120 parts of water, decocting again for 30min, pouring out the liquid medicine b, and mixing the liquid medicine b with the liquid medicine a to obtain the finished product.

5. The use of the Chinese medicinal composition for treating rheumatoid arthritis according to claim 1 in the preparation of a medicament for treating rheumatoid arthritis.