CN115624585A - Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing rheumatic arthritis - Google Patents
Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing rheumatic arthritis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating or preventing rheumatic arthritis, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 10-40 parts of angelica sinensis, 10-30 parts of radix linderae, 10-30 parts of notopterygium root, 10-30 parts of radix angelicae pubescentis, 10-30 parts of pericarpium citri reticulatae viride, 10-30 parts of radix angelicae, 10-30 parts of radix clematidis, 10-30 parts of cinnamon, 10-30 parts of star anise, 10-20 parts of radix sileris, 10-20 parts of akebia stem, 10-20 parts of fructus aurantii, 10-20 parts of safflower and 5-15 parts of liquorice. The traditional Chinese medicine composition can effectively solve the problem that the rheumatic arthritis cannot be fundamentally treated by the existing western medicines.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating or preventing rheumatic arthritis and a traditional Chinese medicine preparation.
Background
Rheumatic arthritis belongs to allergic diseases, is one of main manifestations of rheumatic fever, mostly starts with acute fever and joint pain, is typically mild or moderate fever, wandering polyarthritis, mostly involves large joints such as knee, ankle, shoulder, elbow, wrist and the like, is usually transferred from one joint to another joint, has red, swollen, scorching and severe pain at local parts, is also commonly suffered by a plurality of joints of partial patients, is only related to joint pain but not other inflammation manifestations of atypical patients, is generally subsided in 2-4 weeks, does not have sequelae, but is frequently recurrent. If the rheumatic activity affects the heart, myocarditis may occur, even leaving behind heart valve lesions.
In the treatment of the rheumatic arthritis, the western medicines such as aspirin, sertraline, naproxen or other non-hormone anti-inflammatory medicines are mostly used for treating the rheumatic arthritis, but most western medicines only can play a role in relieving pain, and the aim of treating the rheumatic arthritis cannot be fundamentally fulfilled.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating or preventing rheumatic arthritis, and the traditional Chinese medicine composition can effectively solve the problem that the rheumatic arthritis cannot be fundamentally treated by the existing western medicines.
In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problem is as follows:
a traditional Chinese medicine composition for treating or preventing rheumatic arthritis comprises the following components in parts by weight: 10-40 parts of angelica sinensis, 10-30 parts of radix linderae, 10-30 parts of notopterygium root, 10-30 parts of radix angelicae pubescentis, 10-30 parts of pericarpium citri reticulatae viride, 10-30 parts of radix angelicae, 10-30 parts of radix clematidis, 10-30 parts of cinnamon, 10-30 parts of star anise, 10-20 parts of radix sileris, 10-20 parts of akebia stem, 10-20 parts of fructus aurantii, 10-20 parts of safflower and 5-15 parts of liquorice.
Further, the paint comprises the following components in parts by weight: 25-35 parts of angelica, 20-30 parts of radix linderae, 15-25 parts of notopterygium root, 15-25 parts of radix angelicae pubescentis, 15-25 parts of pericarpium citri reticulatae viride, 15-25 parts of angelica dahurica, 15-25 parts of radix clematidis, 15-25 parts of cinnamon, 15-25 parts of star anise, 13-18 parts of radix sileris, 13-18 parts of akebia stem, 13-18 parts of fructus aurantii, 13-18 parts of safflower and 8-12 parts of liquorice.
Further, the paint comprises the following components in parts by weight: 30 parts of angelica, 25 parts of radix linderae, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae, 20 parts of radix clematidis, 20 parts of cinnamon, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of safflower and 10 parts of liquorice.
A traditional Chinese medicine preparation for treating or preventing rheumatic arthritis is prepared by adopting the traditional Chinese medicine composition.
Further, the Chinese medicinal preparation is an external preparation.
Further, the external preparation is a plaster, a liniment or a spray.
Further, the preparation method of the external preparation comprises the following steps: soaking the above Chinese medicinal materials in cold water in casserole until the liquid surface is about 2cm above the decoction pieces, soaking for 30min, boiling rapidly with strong fire, maintaining with slow fire for about 15-20 min, filtering to obtain decoction, decocting with water for 2 times, mixing the decoctions obtained in 3 times, and mixing with adjuvants to obtain external preparation.
The beneficial effects produced by the invention are as follows:
in the formula, the angelica sinensis is sweet and pungent in property and warm in nature and good in moving blood, is good at activating blood and stimulating menstrual flow to relieve pain on one hand, has better effects on the aspects of rheumatic arthralgia, traumatic injury, carbuncle, cellulitis, sore and ulcer and the like on the other hand, is good at enriching blood and moistening dryness, can enable blood vessels to be full and better dispel blocked pathogenic qi, moisten and nourish old injury; the combined use of radix linderae and radix linderae can promote qi circulation, dispel cold and alleviate pain, and the compatibility of Chinese angelica and radix linderae can treat arthralgia from qi and blood, mainly activate blood and promote qi circulation, dredge vessels and alleviate pain, and assisted by warming and nourishing blood, eliminate pathogenic factors and treat both manifestation and root cause of disease and nourishing blood and strengthen body resistance, and can be used as monarch drug in the prescription. The notopterygium root, the radix angelicae pubescentis, the pericarpium citri reticulatae viride and the notopterygium root are used as ministers to activate and regulate the wind-cold-dampness arthralgia of the whole body, so that the effects of dispelling wind, removing dampness, eliminating arthralgia and relieving pain are exerted; pericarpium Citri Reticulatae viride has the effects of breaking qi and promoting circulation of qi, one of them can moisten qi and promote blood circulation, and the other can relieve pain, the other can help the combined spicebush root to promote qi circulation and dissipate stagnation, and relieve swelling and pain. Radix angelicae dahuricae is used for dispelling cold, dispelling wind, relieving pain, eliminating dampness, reducing swelling and expelling pus; radix clematidis is used for dispelling wind and eliminating dampness, and relaxing tendons and activating collaterals; cinnamon and star anise are used as adjuvants to dispel cold and relieve pain, and warm and dredge channels; wind-proof, wind-dispelling and dampness-eliminating are assisted; the akebia stem is used for dredging collaterals and inducing diuresis to alleviate edema; the bitter orange is added to strengthen the effects of promoting qi circulation and relieving pain; safflower is used as adjuvant for promoting blood circulation, removing blood stasis, relieving swelling and alleviating pain. The adjuvant drugs are matched, so that the intention of treating pain arthralgia and relieving pain by monarch and ministerial drugs is enhanced, and symptoms such as swelling, numbness, muscular spasm and the like caused by arthralgia and pain can be relieved. The liquorice is used for harmonizing the medicines and coordinating the efficacy of the medicines; the formula contains a plurality of fragrant medicines, and the contained fragrant components can also play a role in promoting skin penetration in external preparations and can also be used as guiding medicines in the formula.
The medicines of the whole formula are compatible, the main method is to activate blood, promote qi circulation and relieve pain, and the effects of relieving symptoms and pain and quickly relieving pain and obstruction of qi are achieved; with the assistance of wind-dispelling and dampness-removing herbs, qi-moving and nodulation-dissipating herbs, it can also treat diseases and eliminate the pain caused by this disease. Treat both manifestation and root cause of disease, and has better treatment effect on rheumatic arthritis; meanwhile, the medicine has the functions of promoting blood circulation, promoting qi circulation and relieving pain, and has the functions of relieving and treating old injury caused by long-term treatment failure, joint discomfort, waist and leg pain, numbness and the like caused by rheumatism obstruction.
Detailed Description
Example 1
A traditional Chinese medicine composition for treating or preventing rheumatic arthritis comprises the following components in parts by weight: 20 parts of angelica sinensis, 30 parts of radix linderae, 15 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of pericarpium citri reticulatae viride, 15 parts of radix angelicae, 15 parts of radix clematidis, 15 parts of cinnamon, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 20 parts of fructus aurantii, 10 parts of safflower and 5 parts of liquorice.
The method for preparing the external preparation by adopting the traditional Chinese medicine composition comprises the following steps: soaking the above Chinese medicinal materials in cold water in casserole for 30min until the liquid surface is about 2cm above the decoction pieces, boiling rapidly with strong fire, maintaining with slow fire for about 20min, filtering to obtain decoction, decocting with water for 2 times, mixing decoctions obtained by 3 times of decoction, adding adjuvants, and making into plaster.
Example 2
A traditional Chinese medicine composition for treating or preventing rheumatic arthritis comprises the following components in parts by weight: 40 parts of angelica, 20 parts of radix linderae, 20 parts of notopterygium root, 30 parts of radix angelicae pubescentis, 10 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae, 20 parts of radix clematidis, 15 parts of cinnamon, 15 parts of star anise, 20 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 20 parts of safflower and 10 parts of liquorice.
The preparation method is the same as example 1.
Example 3
A traditional Chinese medicine composition for treating or preventing rheumatoid arthritis comprises the following components in parts by weight: 30 parts of angelica, 25 parts of radix linderae, 17 parts of notopterygium root, 16 parts of radix angelicae pubescentis, 18 parts of pericarpium citri reticulatae viride, 22 parts of radix angelicae, 25 parts of radix clematidis, 25 parts of cinnamon, 17 parts of star anise, 17 parts of radix sileris, 18 parts of akebia stem, 13 parts of fructus aurantii, 15 parts of safflower and 12 parts of liquorice.
The preparation method is the same as example 1.
Example 4
A traditional Chinese medicine composition for treating or preventing rheumatic arthritis comprises the following components in parts by weight: 30 parts of angelica, 25 parts of radix linderae, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae dahuricae, 20 parts of radix clematidis, 20 parts of cinnamon, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of safflower and 10 parts of liquorice.
The preparation method is the same as that of example 1.
Comparative example 1
A traditional Chinese medicine composition for treating or preventing rheumatoid arthritis comprises the following components in parts by weight: 30 parts of salvia miltiorrhiza, 25 parts of radix linderae, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae, 20 parts of radix clematidis, 20 parts of cinnamon, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of safflower and 10 parts of liquorice.
The preparation method is the same as example 1.
Comparative example 2
A traditional Chinese medicine composition for treating or preventing rheumatoid arthritis comprises the following components in parts by weight: 30 parts of angelica, 25 parts of radix linderae, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of immature bitter orange, 20 parts of angelica dahurica, 20 parts of radix clematidis, 20 parts of cinnamon, 20 parts of star anise, 15 parts of divaricate saposhnikovia root, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of safflower and 10 parts of liquorice.
The preparation method is the same as example 1.
Comparative example 3
A traditional Chinese medicine composition for treating or preventing rheumatoid arthritis comprises the following components in parts by weight: 30 parts of angelica, 25 parts of radix linderae, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae, 20 parts of radix clematidis, 20 parts of cinnamon, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of radix paeoniae rubra and 10 parts of liquorice.
The preparation method is the same as example 1.
Comparative example 4
A traditional Chinese medicine composition for treating or preventing rheumatoid arthritis comprises the following components in parts by weight: 30 parts of angelica, 25 parts of radix linderae, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae dahuricae, 20 parts of erythrina bark, 20 parts of cinnamon, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of safflower and 10 parts of liquorice.
The preparation method is the same as that of example 1.
Comparative example 5
A traditional Chinese medicine composition for treating or preventing rheumatoid arthritis comprises the following components in parts by weight: 30 parts of angelica, 25 parts of radix linderae, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae, 20 parts of radix clematidis, 20 parts of galangal, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of safflower and 10 parts of liquorice.
The preparation method is the same as that of example 1.
Comparative example 6
A traditional Chinese medicine composition for treating or preventing rheumatic arthritis comprises the following components in parts by weight: 8 parts of angelica, 8 parts of radix linderae, 35 parts of notopterygium root, 35 parts of radix angelicae pubescentis, 30 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae, 35 parts of radix clematidis, 20 parts of cinnamon, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of safflower and 10 parts of liquorice.
The preparation method is the same as that of example 1.
Test examples
1. Clinical data
1.1, collecting the patients who are diagnosed with rheumatoid arthritis and are in the attack stage in 2020-2022 clinical years, counting 200 persons, the age is 30-50 years, the average age is 43.5 years, dividing the patients into 10 groups randomly, each group has 20 persons, each group has comparability, using the plaster of examples 1-4 and comparative examples 1-6 for each group of patients, one time per day, observing the pain condition of the patients after use, continuously using for 4 days, recording the treatment condition of the patients, and the concrete result is shown in Table 1.
1.2, standard of treatment
The method has the following advantages: the pain degree of the patient is reduced;
and (4) invalidation: the pain degree of the patient has no obvious change;
and (3) curing: the pain degree of the patient completely disappears;
effective rate = (effective number of people + cured number)/total number of people 100%
1.3 therapeutic results
Table 1: statistics of treatment conditions
As can be seen from the data in the table above, the treatment effect of the traditional Chinese medicine preparation in the examples 1-4 on rheumatoid arthritis is obviously better than that of the traditional Chinese medicine composition in the comparative examples 1-6, the symptoms of the patients are obviously relieved after the traditional Chinese medicine preparation in the examples 1-4 is used, the symptoms of the patients are relieved more obviously along with the increase of the use time, and the symptoms of most patients completely disappear after the traditional Chinese medicine preparation is continuously used for 4 days.
Comparing the traditional Chinese medicine composition in the comparative example 1 with the traditional Chinese medicine composition in the example 4, the radix angelicae sinensis is replaced by the salvia miltiorrhiza with similar effects, and the treatment effect in the comparative example 1 shows that the treatment effect of the replaced composition is obviously poor, so that the fact that the monarch drug in the replaced composition is changed can be inferred, the main treatment principle of the drug is changed, and the interaction among the medicinal materials is weakened or disappeared, so that the treatment effect is poor.
Comparing the traditional Chinese medicine composition in the comparative example 2 with the traditional Chinese medicine composition in the example 4, immature bitter orange with similar effect is used for replacing green tangerine orange peel, and the treatment effect of the replaced composition is obviously poor as can be seen from the treatment effect in the comparative example 2, so that the synergistic effect between the immature bitter orange and the combined spicebush root and the like disappears, and the treatment effect is poor.
Comparing the comparative example 3 with the traditional Chinese medicine composition in the example 4, the red peony root with similar action is used for replacing the safflower, and the treatment effect in the comparative example 3 shows that the treatment effect of the replaced composition is poor, so that the interaction relationship between the safflower and other medicines can be inferred, and the interaction relationship disappears after the replacement.
Comparing the traditional Chinese medicine composition in the comparative example 4 with the traditional Chinese medicine composition in the example 4, the erythrina bark with similar effect is used for replacing the clematis root, and the treatment effect in the comparative example 4 shows that the treatment effect of the replaced composition is poor, so that the fact that the clematis root and other medicines have interaction relationship can be inferred, and the interaction relationship disappears after replacement.
Comparing the comparative example 5 with the traditional Chinese medicine composition in the example 4, the galangal with similar effect is used for replacing the cinnamon, and the treatment effect in the comparative example 5 shows that the treatment effect of the replaced composition is poor, so that the interactive relation between the cinnamon and other medicines can be inferred, and the interactive relation disappears after replacement.
Comparing the comparative example 6 with the traditional Chinese medicine composition in the example 4, the dosage of the medicines in the formula is changed, which is equivalent to the adjustment of the assistant and guide relationship in the composition, and the treatment effect of the traditional Chinese medicine composition after the dosage proportion is changed can be seen through the treatment effect in the comparative example 6, so that the treatment effect of the traditional Chinese medicine composition is poor, and the dosage of the medicines in the composition is proved to be important for treatment.
In conclusion, the analysis shows that the medicinal materials of the Chinese medicinal composition have interaction relationship, the composition can play a treatment role as a whole, and the whole treatment effect of the composition can be changed after the medicinal materials are changed. In addition, the traditional Chinese medicine composition has a certain treatment effect on arthralgia caused by traumatic injury.
Claims (6)
1. The traditional Chinese medicine composition for treating or preventing the rheumatic arthritis is characterized by comprising the following components in parts by weight: 10-40 parts of angelica sinensis, 10-30 parts of radix linderae, 10-30 parts of notopterygium root, 10-30 parts of radix angelicae pubescentis, 10-30 parts of pericarpium citri reticulatae viride, 10-30 parts of radix angelicae, 10-30 parts of radix clematidis, 10-30 parts of cinnamon, 10-30 parts of star anise, 10-20 parts of radix sileris, 10-20 parts of akebia stem, 10-20 parts of fructus aurantii, 10-20 parts of safflower and 5-15 parts of liquorice.
2. The traditional Chinese medicine composition for treating or preventing rheumatoid arthritis according to claim 1, which comprises the following components in parts by weight: 25-35 parts of angelica sinensis, 20-30 parts of radix linderae, 15-25 parts of notopterygium root, 15-25 parts of radix angelicae pubescentis, 15-25 parts of pericarpium citri reticulatae viride, 15-25 parts of radix angelicae, 15-25 parts of radix clematidis, 15-25 parts of cinnamon, 15-25 parts of star anise, 13-18 parts of radix sileris, 13-18 parts of akebiaquinata, 13-18 parts of fructus aurantii, 13-18 parts of safflower and 8-12 parts of liquorice.
3. The traditional Chinese medicine composition for treating or preventing rheumatoid arthritis according to claim 1, which comprises the following components in parts by weight: 30 parts of angelica, 25 parts of radix linderae, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of pericarpium citri reticulatae viride, 20 parts of radix angelicae dahuricae, 20 parts of radix clematidis, 20 parts of cinnamon, 20 parts of star anise, 15 parts of radix sileris, 15 parts of akebia stem, 15 parts of fructus aurantii, 15 parts of safflower and 10 parts of liquorice.
4. A Chinese medicinal preparation for treating or preventing rheumatoid arthritis, which is prepared from the Chinese medicinal composition of any one of claims 1 to 3.
5. The traditional Chinese medicine preparation for treating or preventing rheumatoid arthritis according to claim 4, wherein the traditional Chinese medicine preparation is an external preparation.
6. The Chinese medicinal preparation for treating or preventing rheumatoid arthritis according to claim 5, wherein the external preparation is a patch, a liniment or a spray.
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