CN105056154A - Traditional Chinese medicine compound gel dispersible patch for curing rheumatic arthralgia - Google Patents
Traditional Chinese medicine compound gel dispersible patch for curing rheumatic arthralgia Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine compound gel dispersible patch for curing rheumatic arthralgia, mainly being prepared from traditional Chinese medicines such as notoginseng, angelica, rhizoma drynariae, torricellia angulata, garden balsam stem, radix paeoniae alba and ligusticum. The medicines are synergistically matched, are in mutual promotion and mutual assistance, and jointly realize the effects of removing wind and dampness, promoting blood circulation to remove blood stasis, and relieving swelling and pain. The traditional Chinese medicine compound gel dispersible patch is little in toxic and side effects in comparison to western medicines, has the effects of removing wind and dampness, promoting blood circulation to remove blood stasis, and relieving swelling and pain as the medicines are in synergistic interaction, is very convenient to carry and use as the gel dispersible patch form is adopted, has the advantages of flexibly adjusting the application area according to the area size of a hurt affected part, remarkably improving the application purposiveness of the affected part, and adopts menthol and a propylene glycol transdermal absorption accelerant which can promote the absorption of the medicines and keep skin humidity and have the functions of cooling and refreshing to relieve pain.
Description
Technical field
The present invention relates to a kind of Traditional Chinese medicine compound gel decentralized patch for the treatment of rheumatic arthralgia, belong to compound Chinese medicinal preparation technical field.
Background technology
Rheumatism is trembled with fear as one group of primary symptom extremely common clinical syndrome with arthralgia, anemophobia.Rheumatism is the abbreviation of rheumatism, and general reference affects BJM and surrounding soft tissue thereof, as synovial bursa, tendon, fascia, blood vessel, nerve etc. organize disease greatly.Rheumatic arthralgia is a kind of to organize numb pain for the rheumatism cardinal symptom of performance, and mostly have arthropathy and symptom, probability can up to 70% ~ 80%, and its remarkable symptom is that arthralgia is even out of shape, upper limb or numbness of lower limbs, trick spasm and pain etc.Along with modern's growth in the living standard and the pursuit higher to Happiness Index, the alleviation of rheumatic arthralgia and treatment have become the medical care problem that a lot of patient urgently expects to solve.
At present, the Therapeutic Method of rheumatic arthralgia mainly contains Chinese medicine, Western medicine etc., Chinese medicine aspect, and have oral Chinese medicine decoction etc. at present, complicated component, complex operation, uses inconvenience, and because decoction taste is strong, is difficult to stand for a lot of patient; And other conventional formulation types such as pill are also faced with similar problem.The treatment of Western medicine aspect is main mainly with hormone therapy, has multiple injection, capsule, tablet etc., containing a large amount of hormone medicines, has larger side effect, comparatively large to human injury, unsuitable life-time service.
summary of the invention:
In order to solve the deficiency of current rheumatic arthralgia treatment, the invention provides a kind of Traditional Chinese medicine compound gel decentralized patch for the treatment of rheumatic arthralgia, clinical effectiveness is obvious.
Invention further provides a kind of preparation technology treating the Traditional Chinese medicine compound gel decentralized patch of rheumatic arthralgia, technical process is simple, utilize menthol as Percutaneous absorption enhancer, with propylene glycol synergism, itself also there is while keeping good humidity and promotion drug absorption the effect of cool pain-alleviating.
The object of this invention is to provide a kind of Traditional Chinese medicine compound gel decentralized patch for the treatment of rheumatic arthralgia, it is characterized in that by following medicine by weight mark ratio form:
Radix Notoginseng 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 15 parts, Cortex torricelliae tiliifoliae 10 ~ 15 parts, Herba speranskiae tuberculatae 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Rhizoma Ligustici 5 ~ 10 parts, the Cortex Eucommiae 5 ~ 10 parts, 5 ~ 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 5 ~ 10 parts, Fructus Viticis 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Rhizoma Chuanxiong 5 ~ 10 parts, scalds Rhizoma Cibotii 5 ~ 10 parts, Radix Fissistigmatis Oldhamii 5 ~ 10 parts, crosses mountain breeze 5 ~ 10 parts, Rhizoma Atractylodis 1 ~ 5 part, 1 ~ 5 part, Flos Carthami, Rhizoma Et Radix Notopterygii 1 ~ 5 part, Herba Asari 1 ~ 5 part, 1 ~ 5 part, Rhizoma Curcumae Longae, Oletum Trogopterori 1 ~ 5 part, Radix Aconiti 1 ~ 5 part, Radix Angelicae Pubescentis 1 ~ 5 part.
A kind of compound Chinese medicinal preparation for the treatment of rheumatic arthralgia of the present invention, its optimum ratio is:
Radix Notoginseng 18 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Drynariae 13 parts, Cortex torricelliae tiliifoliae 11 parts, Herba speranskiae tuberculatae 12 parts, the Radix Paeoniae Alba 14 parts, Rhizoma Ligustici 8 parts, the Cortex Eucommiae 7 parts, 7 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 8 parts, Fructus Viticis 9 parts, Radix Saposhnikoviae 9 parts, Rhizoma Chuanxiong 7 parts, scalds Rhizoma Cibotii 9 parts, Radix Fissistigmatis Oldhamii 8 parts, crosses mountain breeze 7 parts, Rhizoma Atractylodis 3 parts, 4 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 4 parts, Herba Asari 2 parts, 5 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 2 parts, Radix Aconiti 3 parts, Radix Angelicae Pubescentis 4 parts.
A kind of Traditional Chinese medicine compound gel decentralized patch for the treatment of rheumatic arthralgia of the present invention, the key step of its preparation technology comprises:
1) Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Drynariae, Cortex torricelliae tiliifoliae, Herba speranskiae tuberculatae, the Radix Paeoniae Alba, Rhizoma Ligustici, the Cortex Eucommiae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Saposhnikoviae, Rhizoma Chuanxiong, scalds Rhizoma Cibotii, Radix Fissistigmatis Oldhamii, cross mountain breeze, Rhizoma Atractylodis, Flos Carthami, Rhizoma Et Radix Notopterygii, Herba Asari, Rhizoma Curcumae Longae, Oletum Trogopterori, Radix Aconiti, Radix Angelicae Pubescentis is pulverized and is added 8-10 times of soak by water for after coarse powder in medicinal pulverizer, time is 2 ~ 3 hours, filtering extracting liquid, and medicinal residues 8 ~ 10 times of water that add water decoct 2 ~ 3 hours again, merges medicinal liquid.Subsequently medicinal liquid is placed in scrapper thin film evaporator to concentrate, until concentration of liquid medicine is the extractum of water content 15% ~ 20%, namely obtains the water extract extracta spissa of said medicine.
2) the Chinese medical concrete agent upper step obtained, triacetin, DuroTak87-2888 polyacrylate binder, menthol, propylene glycol is mixed and made into uniform solution according to the ratio of 18:9:70:1:2, utilize coating-drying-film mulching integrated machine, pressure sensitive adhesive dissolution homogeneity, elder generation coats that (dry weight is about 6mg/cm
-- 2) on the anti-stick substrate of polyester crossed through silicone-treated, and carry out drying, subsequently thickness 15 micron polyethylene backing film layer is pressed on the dry adhesive surface of the stickiness matrix containing Chinese medical concrete, carries out die-cut according to the specification of 6cm × 10cm.
[usage and dosage]:be affixed on rheumatic arthralgia affected part, size that can be suitable according to affected part area cutting.Within every 24 hours, change once.
[indication]:be applicable to the rheumatic arthritis controlled caused by anemofrigid-damp arthralgia, trick spasm and pain, numb limbs and tense tendons also can be used for acute and chronic soreness of waist and knee joint, traumatic injury, dampens symptoms such as spraining.
pharmacological property of the present invention is as follows:
Radix Notoginseng, dissipating blood stasis stops blooding, subduing swelling and relieving pain; Radix Angelicae Sinensis, enriches blood and invigorates blood circulation, menstruction regulating and pain relieving; Rhizoma Drynariae, the kidney invigorating bone strengthening, continues and hinders pain relieving; Cortex torricelliae tiliifoliae, blood circulation promoting and blood stasis dispelling, synthetism, expelling wind and removing dampness; Herba speranskiae tuberculatae, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and dampness, promoting blood circulation and stopping pain, softening the hard mass disappears painful abdominal mass; The Radix Paeoniae Alba, nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant; Rhizoma Ligustici, expelling wind and dampness, dispersing cold for relieving pain, antiinflammatory is dispeled the wind; The Cortex Eucommiae, invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to remove obstruction in the collateral; Radix Glycyrrhizae, QI invigorating strengthening the spleen and middle emergency, coordinating the actions of various ingredients in a prescription; The Radix Angelicae Dahuricae, expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifies sensible, detumescence and apocenosis; Fructus Viticis, dispelling wind and heat pathogens, cool pain-alleviating, eliminates rheumatic arthralgia; Radix Saposhnikoviae, expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic; Rhizoma Chuanxiong, blood-activating and qi-promoting, wind-expelling pain-stopping; Scald Rhizoma Cibotii, invigorating the liver and kidney, strong spinal column, wind-damp dispelling; Radix Fissistigmatis Oldhamii, expelling wind and removing dampness, promoting blood circulation and stopping pain; Cross mountain breeze, heat-clearing and toxic substances removing; Dampness removing pain relieving; Rhizoma Atractylodis, drying damp and strengthening spleen, expelling wind and removing dampness; Flos Carthami, latus rectum of invigorating blood circulation, eliminating stasis to stop pain; Rhizoma Et Radix Notopterygii, dispersing wind-cold; Victory is wet to relieve the pain; Herba Asari, cold expelling wind-expelling pain-stopping; Rhizoma Curcumae Longae, removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia; Oletum Trogopterori, promoting blood circulation, eliminating stasis to stop pain, hemostasis by removing blood stasis; Radix Aconiti, expelling wind and cold, antalgic; Radix Angelicae Pubescentis, expelling wind and dampness, dispersing cold for relieving pain.The present invention is according to theory of Chinese medical science basis, utilizes said medicine to work in coordination with compatibility, the mutual reinforcement between mutual-assistance, common row expelling wind and dampness, blood circulation promoting and blood stasis dispelling, effect of reducing swelling and alleviating pain.
good effect of the present invention is:effective ingredient of the present invention is Chinese medicine extract, compare Western medicine toxic and side effects little, all medicine Synergistics, there is expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, effect of reducing swelling and alleviating pain, adopts gel dispersion type patch carry and use all very convenient, according to grieved affected part size flexible medication area, and the purposiveness of the medication of patient part can be significantly improved.The menthol adopted and propylene glycol Percutaneous absorption enhancer not only can promote the absorption of medicine, can also keep the humidity of skin, have the effect of cool pain-alleviating simultaneously.
detailed description of the invention:
For making the present invention easier to understand, below in conjunction with specific embodiment, set forth the present invention further.These embodiments are only not used in for illustration of the present invention and limit the scope of the invention.
embodiment 1:
prescription:radix Notoginseng 18kg, Radix Angelicae Sinensis 15kg, Rhizoma Drynariae 13kg, Cortex torricelliae tiliifoliae 11kg, Herba speranskiae tuberculatae 12kg, Radix Paeoniae Alba 14kg, Rhizoma Ligustici 8kg, Cortex Eucommiae 7kg, Radix Glycyrrhizae 7kg, Radix Angelicae Dahuricae 8kg, Fructus Viticis 9kg, Radix Saposhnikoviae 9kg, Rhizoma Chuanxiong 7kg, scalds Rhizoma Cibotii 9kg, Radix Fissistigmatis Oldhamii 8kg, crosses mountain breeze 7kg, Rhizoma Atractylodis 3kg, Flos Carthami 4kg, Rhizoma Et Radix Notopterygii 4kg, Herba Asari 2kg, Rhizoma Curcumae Longae 5kg, Oletum Trogopterori 2kg, Radix Aconiti 3kg, Radix Angelicae Pubescentis 4kg.
1) Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Drynariae, Cortex torricelliae tiliifoliae, Herba speranskiae tuberculatae, the Radix Paeoniae Alba, Rhizoma Ligustici, the Cortex Eucommiae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Saposhnikoviae, Rhizoma Chuanxiong, scalds Rhizoma Cibotii, Radix Fissistigmatis Oldhamii, cross mountain breeze, Rhizoma Atractylodis, Flos Carthami, Rhizoma Et Radix Notopterygii, Herba Asari, Rhizoma Curcumae Longae, Oletum Trogopterori, Radix Aconiti, Radix Angelicae Pubescentis is pulverized and is added 8-10 times of soak by water for after coarse powder in medicinal pulverizer, time is 2 ~ 3 hours, filtering extracting liquid, and medicinal residues 8 ~ 10 times of water that add water decoct 2 ~ 3 hours again, merges medicinal liquid.Subsequently medicinal liquid is placed in scrapper thin film evaporator to concentrate, until concentration of liquid medicine is the extractum of water content 15% ~ 20%, namely obtains the water extract extracta spissa of said medicine.
2) the Chinese medical concrete agent upper step obtained, triacetin, DuroTak87-2888 polyacrylate binder, menthol, propylene glycol is mixed and made into uniform solution according to the ratio of 18:9:70:1:2, utilize coating-drying-film mulching integrated machine, pressure sensitive adhesive dissolution homogeneity, elder generation coats that (dry weight is about 6mg/cm
-- 2) on the anti-stick substrate of polyester crossed through silicone-treated, and carry out drying, subsequently thickness 15 micron polyethylene backing film layer is pressed on the dry adhesive surface of the stickiness matrix containing Chinese medical concrete, carries out die-cut according to the specification of 6cm × 10cm.
embodiment 2:
prescription:radix Notoginseng 20kg, Radix Angelicae Sinensis 20kg, Rhizoma Drynariae 15kg, Cortex torricelliae tiliifoliae 15kg, Herba speranskiae tuberculatae 15kg, Radix Paeoniae Alba 15kg, Rhizoma Ligustici 10kg, Cortex Eucommiae 10kg, Radix Glycyrrhizae 10kg, Radix Angelicae Dahuricae 10kg, Fructus Viticis 10kg, Radix Saposhnikoviae 10kg, Rhizoma Chuanxiong 10kg, scalds Rhizoma Cibotii 10kg, Radix Fissistigmatis Oldhamii 10kg, crosses mountain breeze 10kg, Rhizoma Atractylodis 5kg, Flos Carthami 5kg, Rhizoma Et Radix Notopterygii 5kg, Herba Asari 5kg, Rhizoma Curcumae Longae 5kg, Oletum Trogopterori 5kg, Radix Aconiti 5kg, Radix Angelicae Pubescentis 5kg.
1) Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Drynariae, Cortex torricelliae tiliifoliae, Herba speranskiae tuberculatae, the Radix Paeoniae Alba, Rhizoma Ligustici, the Cortex Eucommiae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Saposhnikoviae, Rhizoma Chuanxiong, scalds Rhizoma Cibotii, Radix Fissistigmatis Oldhamii, cross mountain breeze, Rhizoma Atractylodis, Flos Carthami, Rhizoma Et Radix Notopterygii, Herba Asari, Rhizoma Curcumae Longae, Oletum Trogopterori, Radix Aconiti, Radix Angelicae Pubescentis is pulverized and is added 8-10 times of soak by water for after coarse powder in medicinal pulverizer, time is 2 ~ 3 hours, filtering extracting liquid, and medicinal residues 8 ~ 10 times of water that add water decoct 2 ~ 3 hours again, merges medicinal liquid.Subsequently medicinal liquid is placed in scrapper thin film evaporator to concentrate, until concentration of liquid medicine is the extractum of water content 15% ~ 20%, namely obtains the water extract extracta spissa of said medicine.
2) the Chinese medical concrete agent upper step obtained, triacetin, DuroTak87-2888 polyacrylate binder, menthol, propylene glycol is mixed and made into uniform solution according to the ratio of 18:9:70:1:2, utilize coating-drying-film mulching integrated machine, pressure sensitive adhesive dissolution homogeneity, elder generation coats that (dry weight is about 6mg/cm
-- 2) on the anti-stick substrate of polyester crossed through silicone-treated, and carry out drying, subsequently thickness 15 micron polyethylene backing film layer is pressed on the dry adhesive surface of the stickiness matrix containing Chinese medical concrete, carries out die-cut according to the specification of 6cm × 10cm.
embodiment 3:
prescription:radix Notoginseng 10kg, Radix Angelicae Sinensis 10kg, Rhizoma Drynariae 10kg, Cortex torricelliae tiliifoliae 10kg, Herba speranskiae tuberculatae 10kg, Radix Paeoniae Alba 10kg, Rhizoma Ligustici 5kg, Cortex Eucommiae 5kg, Radix Glycyrrhizae 5kg, Radix Angelicae Dahuricae 5kg, Fructus Viticis 5kg, Radix Saposhnikoviae 5kg, Rhizoma Chuanxiong 5kg, scalds Rhizoma Cibotii 5kg, Radix Fissistigmatis Oldhamii 5kg, crosses mountain breeze 5kg, Rhizoma Atractylodis 1kg, Flos Carthami 1kg, Rhizoma Et Radix Notopterygii 1kg, Herba Asari 1kg, Rhizoma Curcumae Longae 1kg, Oletum Trogopterori 1kg, Radix Aconiti 1kg, Radix Angelicae Pubescentis 1kg.
1) Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Drynariae, Cortex torricelliae tiliifoliae, Herba speranskiae tuberculatae, the Radix Paeoniae Alba, Rhizoma Ligustici, the Cortex Eucommiae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Saposhnikoviae, Rhizoma Chuanxiong, scalds Rhizoma Cibotii, Radix Fissistigmatis Oldhamii, cross mountain breeze, Rhizoma Atractylodis, Flos Carthami, Rhizoma Et Radix Notopterygii, Herba Asari, Rhizoma Curcumae Longae, Oletum Trogopterori, Radix Aconiti, Radix Angelicae Pubescentis is pulverized and is added 8-10 times of soak by water for after coarse powder in medicinal pulverizer, time is 2 ~ 3 hours, filtering extracting liquid, and medicinal residues 8 ~ 10 times of water that add water decoct 2 ~ 3 hours again, merges medicinal liquid.Subsequently medicinal liquid is placed in scrapper thin film evaporator to concentrate, until concentration of liquid medicine is the extractum of water content 15% ~ 20%, namely obtains the water extract extracta spissa of said medicine.
2) the Chinese medical concrete agent upper step obtained, triacetin, DuroTak87-2888 polyacrylate binder, menthol, propylene glycol is mixed and made into uniform solution according to the ratio of 18:9:70:1:2, utilize coating-drying-film mulching integrated machine, pressure sensitive adhesive dissolution homogeneity, elder generation coats that (dry weight is about 6mg/cm
-- 2) on the anti-stick substrate of polyester crossed through silicone-treated, and carry out drying, subsequently thickness 15 micron polyethylene backing film layer is pressed on the dry adhesive surface of the stickiness matrix containing Chinese medical concrete, carries out die-cut according to the specification of 6cm × 10cm.
curative effect of the present invention proves as follows:
Patient 60 example on probation, wherein male 30 example, women 30 example, is rheumatic arthralgia patient, patient is divided into 3 groups, on average often organizes 20 examples.After being cleaned at the rheumatic arthralgia position of patient, use this product to be affixed on rheumatalgia position in right amount, each medication continues 24 hours, treats 3 days respectively, one week, two weeks, and observe therapeutic effect according to group.Each group of experimental result is in table 1.
using method:
First dry clean for affected part with warm water, use this product to be affixed on rheumatalgia position in right amount, each medication continues 24 hours.
Table 1 Chinese herbs paste therapeutic effect of the present invention and untoward reaction
| Grouping | Treatment time | Pain relief rate % | Untoward reaction |
| First group (20 people) | 3 days | 50 | Nothing |
| Second group (20 people) | One week | 80 | Nothing |
| 3rd group (20 people) | Two weeks | 90 | Nothing |
Conclusion: can be found out by table 1, Chinese herbs paste of the present invention uses 3 days, and pain relief rate is 50%, and use one week, pain relief rate is 80%, continuously uses two weeks, and pain relief rate up to 90%, and is often organized and do not found untoward reaction.
Claims (3)
1. treat a Traditional Chinese medicine compound gel decentralized patch for rheumatic arthralgia, it is characterized in that being made up of by ratio of weight and the number of copies following medicine:
Radix Notoginseng 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 15 parts, Cortex torricelliae tiliifoliae 10 ~ 15 parts, Herba speranskiae tuberculatae 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Rhizoma Ligustici 5 ~ 10 parts, the Cortex Eucommiae 5 ~ 10 parts, 5 ~ 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 5 ~ 10 parts, Fructus Viticis 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Rhizoma Chuanxiong 5 ~ 10 parts, scald Rhizoma Cibotii 5 ~ 10 parts, Radix Fissistigmatis Oldhamii 5 ~ 10 parts, cross mountain breeze 5 ~ 10 parts, Rhizoma Atractylodis 0 ~ 5 part, 0 ~ 5 part, Flos Carthami, Rhizoma Et Radix Notopterygii 0 ~ 5 part, Herba Asari 0 ~ 5 part, 0 ~ 5 part, Rhizoma Curcumae Longae, Oletum Trogopterori 0 ~ 5 part, Radix Aconiti 0 ~ 5 part, artificial Moschus 0 ~ 5 part, Radix Angelicae Pubescentis 0 ~ 5 part.
2. a kind of compound Chinese medicinal preparation for the treatment of rheumatic arthralgia according to claim 1, its optimum ratio is:
Radix Notoginseng 18 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Drynariae 13 parts, Cortex torricelliae tiliifoliae 11 parts, Herba speranskiae tuberculatae 12 parts, the Radix Paeoniae Alba 14 parts, Rhizoma Ligustici 8 parts, the Cortex Eucommiae 7 parts, 7 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 8 parts, Fructus Viticis 9 parts, Radix Saposhnikoviae 9 parts, Rhizoma Chuanxiong 7 parts, scald Rhizoma Cibotii 9 parts, Radix Fissistigmatis Oldhamii 8 parts, cross mountain breeze 7 parts, Rhizoma Atractylodis 3 parts, 4 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 4 parts, Herba Asari 2 parts, 5 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 2 parts, Radix Aconiti 3 parts, artificial Moschus 4 parts, Radix Angelicae Pubescentis 4 parts.
3. a kind of Traditional Chinese medicine compound gel decentralized patch for the treatment of rheumatic arthralgia described in claim 1 or 2, the key step of its preparation technology comprises:
1) Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Drynariae, Cortex torricelliae tiliifoliae, Herba speranskiae tuberculatae, the Radix Paeoniae Alba, Rhizoma Ligustici, the Cortex Eucommiae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Saposhnikoviae, Rhizoma Chuanxiong, scalds Rhizoma Cibotii, Radix Fissistigmatis Oldhamii, cross mountain breeze, Rhizoma Atractylodis, Flos Carthami, Rhizoma Et Radix Notopterygii, Herba Asari, Rhizoma Curcumae Longae, Oletum Trogopterori, Radix Aconiti, artificial Moschus, Radix Angelicae Pubescentis is pulverized and is added 8-10 times of soak by water for after coarse powder in medicinal pulverizer, time is 2 ~ 3 hours, filtering extracting liquid, and medicinal residues 8 ~ 10 times of water that add water decoct 2 ~ 3 hours again, merges medicinal liquid; Subsequently medicinal liquid is placed in scrapper thin film evaporator to concentrate, until concentration of liquid medicine is the extractum of water content 15% ~ 20%, namely obtains the water extract extracta spissa of said medicine;
2) Chinese medical concrete agent step 1) obtained, triacetin, DuroTak87-2888 polyacrylate binder, menthol, propylene glycol is mixed and made into uniform solution according to the ratio of 18:9:70:1:2, utilize coating-drying-film mulching integrated machine, pressure sensitive adhesive dissolution homogeneity, elder generation coats that (dry weight is about 6mg/cm
-- 2) on the anti-stick substrate of polyester crossed through silicone-treated, and carry out drying, subsequently thickness 15 micron polyethylene backing film layer is pressed on the dry adhesive surface of the stickiness matrix containing Chinese medical concrete, carries out die-cut according to the specification of 6cm × 10cm, to obtain final product.
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| CN105412206A (en) * | 2015-12-29 | 2016-03-23 | 刘书玲 | Traditional Chinese medicine preparation with relaxing tendon and dissipating hard mass effects |
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| CN107951868A (en) * | 2017-12-27 | 2018-04-24 | 山东宏济堂制药集团股份有限公司 | A kind of muskone patch and its preparation method and application |
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Application publication date: 20151118 |
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