CN103417656A - Traditional Chinese medicine composition for treating thrombophlebitis - Google Patents
Traditional Chinese medicine composition for treating thrombophlebitis Download PDFInfo
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- CN103417656A CN103417656A CN2013103489231A CN201310348923A CN103417656A CN 103417656 A CN103417656 A CN 103417656A CN 2013103489231 A CN2013103489231 A CN 2013103489231A CN 201310348923 A CN201310348923 A CN 201310348923A CN 103417656 A CN103417656 A CN 103417656A
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Abstract
A traditional Chinese medicine composition for treating thrombophlebitis belongs to the field of medicines, and comprises the following raw materials by weight: astragalus 25-32 g, dangshen 12-17 g, angelica sinensis 13-17 g, ligusticum wallichii 14-16 g, spina gleditsiae 13-17 g, radix paeoniae rubra 14-17 g, radix aucklandiae 8-11 g, akebiaquinata 9-12 g, pangolin 7-11 g, rheum officinale 9-11 g, and honeysuckle stem 18-22g. Through the selection of the traditional Chinese medicines, characteristics of all the medicines are fully used, and all the medicines interact to relax tendons and activate collaterals, promote blood circulation to remove blood stasis, reduce phlegm and resolve masses, and the treatment effect on the thrombophlebitis is remarkable.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine, specifically relate to a kind of Chinese medicine composition that is used for the treatment of thrombophlebitis.
Background technology
Thrombophlebitis shows as superficial thrombophlebitis and deep venous thrombosis more, wherein in the majority with the latter.This sick frequently-occurring disease sharply, disease is seen limb swelling, pain, heating, the colour of skin is dark red or, with streak thing, not smooth for damp delay, congestion resistance numbness, venation obturation or blood fortune in fact, cold-damp is become silted up and hindered sering, strongly fragrant heat-transformation of a specified duration, damp and hot steaming, the contamination blood vessels of accumulateing, venation is obstructed and send out primary disease.
The multiple deep veins of lower limb of being born in of limb deep venous thrombosis, clinical more common, therapeutic effect is not ideal enough, often leaves over deep veins of lower limb obstruction or vein and does the film functional defect.Deep vein thrombosis of lower extremity originates from gastrocnemius venous plexus or bone vein mostly to the femoral vein section.After thrombosis, except minority melts voluntarily or is confined to happening part, major part extends to whole limb deep main venous trunk, if can not diagnose in time and process, develop into the thrombosis sequela more, long-time patient's live and work quality that affects, minority Complicated with Pulmonary infraction, cause very serious consequence.
Primary disease is multiple is born in puerperal, after wound and after operation.After operation, the sickness rate American-European countries of venous thrombosis is higher, and the sickness rate of China has rising trend in recent years.According to the literature, the above thrombosis of gastrocnemius venous plexus, lung infraction incidence rate be up to 50%, wherein 1/4 can be fatal.It is postoperative early stage that deep venous thrombosis betides various operation neutralizations mostly, and postoperative 5-9 days sends out the patient and accounts for 10%.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of thrombophlebitis, with solution, needs operative treatment thrombophlebitis and the bad problem of therapeutic effect.
To achieve these goals, the technical scheme that the present invention takes is: a kind of Chinese medicine composition for the treatment of thrombophlebitis, it is characterized in that, and this Chinese medicine composition is made by weight by following raw materials according:
In such scheme, the weight ratio of described raw material is:
In such scheme, described Ramulus Cinnamomi 10 grams, Caulis Spatholobi 30 grams, be applicable to the qi stagnation and blood stasis type patient.
In such scheme, described raw material also comprises Rhizoma Corydalis 10 grams, Fructus Toosendan 15 grams, is applicable to the patient that pain is serious.
In such scheme, prepared by described medicine by the following method:
A. first get the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spina Gleditsiae, Radix Paeoniae Rubra and clean after mixing the decocting that adds ten times and boil 3～4 hours, filter, leave and take medicinal liquid, medicinal residues are stand-by;
B. the Radix Aucklandiae, Caulis Akebiae, Squama Manis, Radix Et Rhizoma Rhei, Caulis Lonicerae are cleaned after mixing to the decocting that adds octuple and boiled 1～2 hour, filter, leave and take medicinal liquid, medicinal residues are stand-by;
C. the medicinal residues in step a and b are mixed, add the water of five times of its gross weight, decoct 1～2 hour, filter, leave and take medicinal liquid;
D. after the medicinal liquid in step a, b and c being mixed, take.
The present composition has the function of heat-clearing and toxic substances removing, disperse blood stasis and dredge collateral, inducing diuresis to remove edema, the clinical treatment thrombophlebitis has curative effect preferably, thromboangiitis obliterans is also had to certain preventive and therapeutic action, said composition toxicity is very little simultaneously, and clinical practice is safe and reliable.
Present composition preparation can suppress venothrombotic formation significantly.Hematological examination and antiinflammatory experimental result show, medicine can reduce plasma viscosity and the fibrinogen content of rat, extends plasma prothrombin time, improves plasma cortisol, reduce LPO content, the acute and chronic nonspecific inflammation of animal pattern is had to obvious antagonism.Results suggest Drug therapy TAO and anti-venothrombotic part mechanism are by the result of protection blood vessel endothelium and blood coagulation resisting function.In addition, thus still can make adrenal cortex function strengthen contributes to anti-inflammation detumescence; Can reduce lipid peroxidation, alleviate the infringement of anoxia to tissue.
Following experimental example and embodiment are for further illustrating the present invention.
The specific embodiment
Experiment material:
Medicine agent (not containing excipient) ，You Mou city peripheral angiopathy institute provides.
1. grind well with 1% sodium carboxymethyl cellulose (CMC-Na) suspension that is mixed with every milliliter of pastille 0.72g, 0.96g and tri-kinds of concentration of 1.44g.
2. the positive contrast medicine of FUFANG DANSHEN PIAN, the Huacheng Pharmaceutical Factory, Gaungzhou product.Be ground into fine powder after the desaccharide clothing, grind well with i%CMC-Na, be mixed with the suspension of 0.084g/ml.
3. sodium carboxymethyl cellulose (CMC-Na), Solution on Chemical Reagents in Shanghai packing factory.
4. lauric acid, Solution on Chemical Reagents in Shanghai purchasing and supply station packing factory provides.Be made into the solution of 10mg/ml with distilled water, with NaOH, be adjusted to PH8.0.
5. laboratory animal: the Wistar rat is provided by Chinese Academy of Medical Sciences's laboratory animal.
6. Medical comprehensive temperature measurer, Shanghai Medical Instrument and Meter Factory.
7.SJ-41 polygraph, Shanghai Medical Electric Instrument Factory.
8.NXE-1 the type cone and plate viscometer, Chengdu Instruement Factory.
9.PAM-2 the type platelet aggregation instrument, Changzhou instrument plant.
Experimental technique:
1.TAO the making of animal model:
Experiment is used the Wistar male rat, body weight 280-320g, ketamine intraperitoneal injection of anesthesia (100mg/kg), in the inboard cropping of right thigh,, with 75% alcohol disinfecting skin, the long skin of the about 1.5cm of longitudinal incision, separate femoral artery, use above it the bulldog clamp occlude blood, under bulldog clamp, direction femoral artery distal end injects 0.2ml lauric acid solution, after injection, with the ZT Rapid Medical Adhesive, seals pin hole, open bulldog clamp after 1 minute, and skin suture.Sham operated rats is injected the physiologic saline for substitute lauric acid solution of 0.2ml by femoral artery, other is the same.
2. experiment grouping: be divided into six groups,
A) sham operated rats: i%CMC-Na10mi/kg gavage;
B) model control group: i%CMC-Na10ml/kg gavage;
C) compound Salviae Miltiorrhizae group: make positive control, 0.84g/kg;
D) medicine low dose group: 9g/kg;
E) dosage group: 10g/kg in medicine;
F) medicine high dose group: 14.4g/kg.
Except sham operated rats, the 2-6 group all causes the TAO model, and respectively at first 1 hour gastric infusion of operation, be administered once later every day, continuous 2 weeks, treats observation.Get when experiment finishes that blood is made hemorheology and animal is measured and put to death to Platelet, intercept right lower extremity and do the pathology inspection.
3. observation item:
(1) overview: the TAO model group is injected sodium laurate solution after 5 minutes at femoral artery, and Ipsilateral foot claw loses color, and then the paleness purple, obfuscation, skin temperature reduces, and arteriopalmus weakens, the sufficient sole of the foot blackening of getting involved next day, and upwards development gradually, form gangrene.After one week, mummification can appear.Show as suffering limb after the minority animal surgery treating serious edema caused, erosion and inflammatory reaction, all rats all have limping and entrainment phenomenon, the struggle that suffering limb is touched.In two weeks, most rats occur that suffering limb gangrene part comes off, and pathological changes does not all appear in the lower limb of rats in sham-operated group.Be divided into the 0-5 level according to suffering limb swelling, gangrene and mummified lesion degree and scope, observe the classification situation of respectively organizing pathological changes, to judge therapeutic effect.
(2) hemorheology and Platelet are measured.
Rat the 15th day gastric infusion 1 hour after operation, with urethane anesthesia, open abdominal cavity, from abdominal aortic blood 4ml, with anticoagulant heparin (25u/ml), makes hemorheology and fibrinogen content and measure; Get blood 3ml, make Platelet with 3.8% sodium citrate anticoagulant and measure.
Determination of Blood Rheology: measure whole blood and plasma viscosity with NXE-1 type cone and plate viscometer, the high shearing of whole blood is 230S; Low-rate-of-shear is 11.5S; The shearing of blood plasma is 230S; Temperature is controlled at 25 ± 0.1 ℃. the mensuration of hematocrit: heparin anti-coagulating is injected in the Wen Qubo blood sedimentation tube, is placed in centrifuge, with 3000 rev/mins centrifugal 30 minutes, survey the hematocrit value.
Fibrinogen content is measured: with the biuret development process of saltouing.
Platelet is measured: anticoagulation is centrifugal 5 minutes with 1000 rev/mins, getting supernatant is and is rich in platelet blood plasma (PRP), then continue with 4000 rev/mins centrifugal 10 minutes, prepare platelet poor plasma (PPP) and adjust platelet count at 15-20 ten thousand/mm, by turbidimetry, at PAM-2 type platelet aggregation instrument, measure aggregation.
(3) pathological examination
After rat extracting blood, put to death, intercept whole right hind, fix with 10% formalin, use 10% nitric acid decalcification after three days, respectively at toes, ankle joint is upper and lower and four positions of thigh section, cross-section section, H, E dyeing, the section at four positions of each specimen is placed on a coverslip, respectively to the formation of cell infiltration, fibroplasia and the Intravascular Thrombus of the inner membrance of tremulous pulse, middle film and adventitia, machineization and understanding and considerate condition again etc. are carried out Microscopic observation and classification.
Embodiment 1: press column weight amount proportioning and weigh raw material:
Above-mentioned various medical material prepares medicine of the present invention by the following method: first get the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spina Gleditsiae, Radix Paeoniae Rubra and clean after mixing the decocting that adds ten times and boil 3～4 hours, filter, leave and take medicinal liquid, medicinal residues are stand-by; The Radix Aucklandiae, Caulis Akebiae, Squama Manis, Radix Et Rhizoma Rhei, Caulis Lonicerae are cleaned after mixing to the decocting that adds octuple again and boiled 1～2 hour, filter, leave and take medicinal liquid, medicinal residues are stand-by; Finally above-mentioned medicinal residues are mixed, add the water of five times of its gross weight, decoct 1～2 hour, filter, leave and take medicinal liquid, take with together with above-mentioned medicinal liquid, once a day.
Embodiment 2: press column weight amount proportioning and weigh raw material:
Above-mentioned various medical material prepares medicine of the present invention by the following method:
First get the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spina Gleditsiae, Radix Paeoniae Rubra and clean after mixing the decocting that adds ten times and boil 3～4 hours, filter, leave and take medicinal liquid, medicinal residues are stand-by; The Radix Aucklandiae, Caulis Akebiae, Squama Manis, Radix Et Rhizoma Rhei, Caulis Lonicerae are cleaned after mixing to the decocting that adds octuple again and boiled 1～2 hour, filter, leave and take medicinal liquid, medicinal residues are stand-by; Finally above-mentioned medicinal residues are mixed, add the water of five times of its gross weight, decoct 1～2 hour, filter, leave and take medicinal liquid, take with together with above-mentioned medicinal liquid, once a day.
Embodiment 3: press column weight amount proportioning and weigh raw material:
Above-mentioned various medical material prepares medicine of the present invention by the following method:
First get the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spina Gleditsiae, Radix Paeoniae Rubra and clean after mixing the decocting that adds ten times and boil 3～4 hours, filter, leave and take medicinal liquid, medicinal residues are stand-by; The Radix Aucklandiae, Caulis Akebiae, Squama Manis, Radix Et Rhizoma Rhei, Caulis Lonicerae are cleaned after mixing to the decocting that adds octuple again and boiled 1～2 hour, filter, leave and take medicinal liquid, medicinal residues are stand-by; Finally above-mentioned medicinal residues are mixed, add the water of five times of its gross weight, decoct 1～2 hour, filter, leave and take medicinal liquid, take with together with above-mentioned medicinal liquid, once a day.
Embodiment 4: press column weight amount proportioning and weigh raw material:
Above-mentioned various medical material prepares medicine of the present invention by the following method:
First get the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spina Gleditsiae, Radix Paeoniae Rubra and clean after mixing the decocting that adds ten times and boil 3～4 hours, filter, leave and take medicinal liquid, medicinal residues are stand-by; The Radix Aucklandiae, Caulis Akebiae, Squama Manis, Radix Et Rhizoma Rhei, Caulis Lonicerae, Ramulus Cinnamomi and Caulis Spatholobi are cleaned after mixing to the decocting that adds octuple again and boiled 1～2 hour, filter, leave and take medicinal liquid, medicinal residues are stand-by; Finally above-mentioned medicinal residues are mixed, add the water of five times of its gross weight, decoct 1～2 hour, filter, leave and take medicinal liquid, take with together with above-mentioned medicinal liquid, once a day.
Embodiment 5: press column weight amount proportioning and weigh raw material:
Above-mentioned various medical material prepares medicine of the present invention by the following method:
First get the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spina Gleditsiae, Radix Paeoniae Rubra and clean after mixing the decocting that adds ten times and boil 3～4 hours, filter, leave and take medicinal liquid, medicinal residues are stand-by; The Radix Aucklandiae, Caulis Akebiae, Squama Manis, Radix Et Rhizoma Rhei, Caulis Lonicerae, Rhizoma Corydalis and Fructus Toosendan are cleaned after mixing to the decocting that adds octuple again and boiled 1～2 hour, filter, leave and take medicinal liquid, medicinal residues are stand-by; Finally above-mentioned medicinal residues are mixed, add the water of five times of its gross weight, decoct 1～2 hour, filter, leave and take medicinal liquid, take with together with above-mentioned medicinal liquid, once a day.
Claims (5)
1. a Chinese medicine composition for the treatment of thrombophlebitis, is characterized in that, this Chinese medicine composition is made by weight by following raw materials according:
2. a kind of Chinese medicine composition for the treatment of thrombophlebitis as claimed in claim 1, it is characterized in that: the weight ratio of described raw material is:
3. a kind of Chinese medicine composition for the treatment of thrombophlebitis as claimed in claim 2, is characterized in that: described Ramulus Cinnamomi 10 grams, Caulis Spatholobi 30 grams.
4. a kind of Chinese medicine composition for the treatment of thrombophlebitis as claimed in claim 2, it is characterized in that: described raw material also comprises Rhizoma Corydalis 10 grams, Fructus Toosendan 15 grams.
5. a kind of Chinese medicine composition for the treatment of thrombophlebitis as claimed in claim 2, it is characterized in that: prepared by described medicine by the following method:
A. first get the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Spina Gleditsiae, Radix Paeoniae Rubra and clean after mixing the decocting that adds ten times and boil 3～4 hours, filter, leave and take medicinal liquid, medicinal residues are stand-by;
B. the Radix Aucklandiae, Caulis Akebiae, Squama Manis, Radix Et Rhizoma Rhei, Caulis Lonicerae are cleaned after mixing to the decocting that adds octuple and boiled 1～2 hour, filter, leave and take medicinal liquid, medicinal residues are stand-by;
C. the medicinal residues in step a and b are mixed, add the water of five times of its gross weight, decoct 1～2 hour, filter, leave and take medicinal liquid;
D. after the medicinal liquid in step a, b and c being mixed, take.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656390A (en) * | 2013-12-26 | 2014-03-26 | 张治成 | Traditional Chinese medicine ointment for treating lower-limb superficial thrombophlebitis |
| CN103961617A (en) * | 2014-05-30 | 2014-08-06 | 济南高达信息技术有限公司 | External ointment for treating venous inflammation |
| CN104027658A (en) * | 2014-07-09 | 2014-09-10 | 胡枫 | Heat removing and blood cooling beverage for heat-toxin gangrene and preparation method thereof |
| CN105596814A (en) * | 2015-11-16 | 2016-05-25 | 孙绪连 | Traditional Chinese medicine smoked lotion for treating thrombophlebitis |
| CN106822849A (en) * | 2017-03-30 | 2017-06-13 | 蒋世芬 | The medicine of thrombophlebitis |
| CN106853132A (en) * | 2017-02-20 | 2017-06-16 | 成都富豪斯生物科技有限公司 | A kind of decoction medicine for treating thrombophlebitis and preparation method thereof |
| CN111939198A (en) * | 2020-09-27 | 2020-11-17 | 广州中医药大学第一附属医院 | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and preparation method and application thereof |
-
2013
- 2013-08-06 CN CN2013103489231A patent/CN103417656A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656390A (en) * | 2013-12-26 | 2014-03-26 | 张治成 | Traditional Chinese medicine ointment for treating lower-limb superficial thrombophlebitis |
| CN103961617A (en) * | 2014-05-30 | 2014-08-06 | 济南高达信息技术有限公司 | External ointment for treating venous inflammation |
| CN104027658A (en) * | 2014-07-09 | 2014-09-10 | 胡枫 | Heat removing and blood cooling beverage for heat-toxin gangrene and preparation method thereof |
| CN105596814A (en) * | 2015-11-16 | 2016-05-25 | 孙绪连 | Traditional Chinese medicine smoked lotion for treating thrombophlebitis |
| CN106853132A (en) * | 2017-02-20 | 2017-06-16 | 成都富豪斯生物科技有限公司 | A kind of decoction medicine for treating thrombophlebitis and preparation method thereof |
| CN106822849A (en) * | 2017-03-30 | 2017-06-13 | 蒋世芬 | The medicine of thrombophlebitis |
| CN111939198A (en) * | 2020-09-27 | 2020-11-17 | 广州中医药大学第一附属医院 | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and preparation method and application thereof |
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