CN101590210B - Chinese medicinal composition for treating cerebraledema and preparation method thereof - Google Patents
Chinese medicinal composition for treating cerebraledema and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating apoplexy and a preparation method thereof and belongs to the field of Chinese medicaments. The Chinese medicinal composition of the invention comprises the following raw materials in portion by weight: agaric 9-12, Indian buead 9-12, larger head atractylodes rhizome 9-12, oriental waterplantain rhizome 12-15, cassia bark 3-6, stiff silkworm 6-9, cicada slough 6-9, turmeric 1-3, rhubarb 2-4, hiraute shiny bugleweed herb 12-15, plantain seed 5-9, and leech 2-4. With the characteristics of regulating the ascending and descending of qi dynamic and disinhibiting water by bland percolation, the Chinese medicinal composition can effectively correct pathologic factors of oedema in the central nervous system and treat stroke caused by abnormal circulation of qi and blood in brain. The Chinese medicinal composition of the invention is safe in clinic use, avoids any adverse reaction in patients after use, effectively protects the functions of the kidney of the patient with cerebral apoplexy and avoids any adverse reaction generating in patients stopping using the medicament.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of treating apoplexy, the invention still further relates to the method for preparing of this Chinese medicine composition, belong to the field of Chinese medicines.
Background technology
Cerebrovascular mainly refers to vasospasm, the obturation that the cerebral arteries system injury causes or breaks, and causes the brain local circulation and the dysfunction of development.Be commonly referred to as ACVD or apoplexy, clinical ischemic and the hemorrhagic two big classes of being divided into.Along with the progress in epoch, variation has taken place in epiphytotics spectrum of disease.According to present statistics, China's town and country apoplexy annual morbidity is about 120-180/10 ten thousand, and annual death rate is about 60-120/10 ten thousand, and relapse rate is 41%.Have a strong impact on patient's daily life.Apoplexy becomes China's commonly encountered diseases frequently-occurring disease.Wherein, the dehydration therapy of acute stage is particularly crucial.Think that generally a kind of ideal dehydrant should have following characteristics: 1. effect is rapid, and it is lasting to reduce intracranial hypertension, convenient in application; 2. medicine does not get into the brain cell gap, to avoid " knock-on " phenomenon; 3. fast can the discharge through kidney of medicine ability has good diuresis; 4. metabolism rapidly in body, non-toxic reaction.But present various drug application does not all reach requirement.
China successive dynasties physician has deep understanding to apoplexy.Huangdi's Internal Classics is many, and the double pathogenesis of stating of its symptom of opinion is cured holy Zhang Zhongjing the opinion of apoplexy is controlled to hit diseases such as servant, coma, and principle-method-recipe-medicines is had, and establishes one's own system.Gold dollar four everybody, set forth one's views with endogenous cause of ill, innovation is respectively arranged, emphasize particularly on different fields.Qing Dynasty last years of a dynasty or reign, well-known doctor's Wang Qingren, Tang Rongchuan, Zhang Bailong, Zhang Shanlei, Zhang Xichun carries forward Gu Yi, merges new knowledge, knows thick marrow clearly, and is evident in efficacy, plays a disease and rescues severely, and it is much to benefit mankind.Under the present classical instruction of Chinese Medicine theory, design a distinctive tcm prescription, in the hope of further improving improvement aspect the curative effect of treating cerebral edema at present.
WULING SAN is the prescription of the holy Zhang Zhongjing of doctor; For the representative prescription of QI invigorating dehumidifying, be the side commonly used in the classical prescription, comprise Polyporus, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi; Famous doctor of successive dynasties family affirms that to its curative effect the modern times have report with this side's treatment hydrocephalus good efficacy to be arranged.Go up and down to loose is the representative prescription of treatment epidemic febrile disease; Comprise Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei; After Qing Dynasty Yang Li mountain " typhoid fever pestilence bar is distinguished " elucidated, transferred three warmers with this square tube modern times, and plus-minus back various miscellaneous diseases of treatment such as fire stagnation, expectorant coagulate, the card of wet resistance, the stagnation of QI, blood stasis all has good effect; It is widely used, and is total pathogenic characteristic with disorder of movement of QI.Auxilliary week of Pu in modern age, Zhao Shaoqin, the time ease people face the card application gains in depth of comprehension arranged more.
Zhang Shanlei is famous traditional Chinese medical science scholar in China's modern age, writes " annotate in the apoplexy school ", explains apoplexy in conjunction with a meaning and the single proposition of stannum " QI and blood is towards a brain " theory of " blood stagnating in the upper part of the body makes people's emotional syncope " in " interior warp ".Receive the appreciation of doctor families such as Lu Yuanlei, Jiang Chunhua.Tang Rongchuan thinks in " treatise on blood trouble ": harness the river promptly to control blood; Control blood promptly to harness the river, blood stasis is the stagnation of QI then, the then wet resistance of the stagnation of QI, and the deep viscous of pathogenic warmth is prone to strongly fragrant and heat-transformation exhausts that further Liver and kidney is Kidney-Yin, and damp is positioned at the top, mountain peak, the yin subjugating yang position, difficulty has outlet, recurs so the course of disease is continuous and is prone to.To these pathogenesis, this prescription of design closes the effect that WULING SAN is played the QI invigorating dampness eliminating to alleviate water retention altogether with Rhizoma Curcumae Longae, and Radix Et Rhizoma Rhei gives damp with outlet, and share Herba Lycopi, the turbid diuretic of Semen Plantaginisization.Bombyx Batryticatus, Periostracum Cicadae, Hirudo merit are entered arbitrarily network, and abnormal smells from the patient is empty clearly, blood circulation promoting and blood stasis dispelling, each sweet in the mouth of we is slow to be main, and the paralytic belongs to old age more, the spleen renal function a little less than, so it is shared to close mannitol with we, protect the human righteousness, play good effect altogether.
Summary of the invention
One of the object of the invention is that to go up and down with the property of medicine of Chinese medicine be basic prescription, unifies to come prescription with Treatise on Febrile Diseases mutually with the epidemic febrile disease opinion, the Chinese medicine composition of the treatment cerebral edema that a kind of good effect, instant effect are provided, has no side effect;
Two of the object of the invention provides a kind of method for preparing above-mentioned Chinese medicine composition.
The present invention seeks to realize through following technical scheme:
A kind of Chinese medicine composition of treating cerebral edema comprises by following each crude drug and forming:
Polyporus, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Alismatis, Cortex Cinnamomi, Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Herba Lycopi, Semen Plantaginis, Hirudo.
Preferably, the weight portion of each crude drug is:
Polyporus 9-12 part, Poria 9-12 part, Rhizoma Atractylodis Macrocephalae 9-12 part, Rhizoma Alismatis 12-15 part, Cortex Cinnamomi 3-6 part, Bombyx Batryticatus 6-9 part, Periostracum Cicadae 6-9 part, Rhizoma Curcumae Longae 1-3 part, Radix Et Rhizoma Rhei 2-4 part, Herba Lycopi 12-15 part, Semen Plantaginis 5-9 part, Hirudo 2-4 part.
Further preferred, the weight portion of each crude drug is:
10 parts of Polyporus, 10 parts in Poria, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Alismatis, 3 parts of Cortex Cinnamomis, 6 parts of Bombyx Batryticatus, 6 parts of Periostracum Cicadaes, 1 part in Rhizoma Curcumae Longae, 3 parts of Radix Et Rhizoma Rhei, 15 parts of Herba Lycopi, 5 parts of Semen Plantaginiss, 3 parts of Hirudos.
The compatibility foundation of Chinese medicine composition of the present invention:
According to YANG QI deficiency, blood stagnant in cerebral venation syndrome, the pathogenesis of retention of water-damp in the body is worked out the QI invigorating warming YANG, the principle of treatment of collateral dredging diuretic, with Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae is a monarch drug in the side, to play supplementing QI to induce diuresis, the effect that Wen Huashui is wet.Through saying: light taste which can promote urination belonging to YANG.Polyporus, the sweet light regulating fluid apssage of Poria, again because of the first warming YANG of QI invigorating palpus, the first QI invigorating of warming YANG palpus is so with the Cortex Cinnamomi warming YANG and invigorating QI, Cortex Cinnamomi and Polyporus, Poria are ministerial drug.Hirudo has very high medical value, and through all being used as medicine with drying, hirudin and protein are for going into the high medicine of network blood circulation and promoting silt, so use on a small quantity.Radix Et Rhizoma Rhei has the effect of blood circulation and promoting silt tissue regeneration promoting, Herba Lycopi's inducing diuresis to remove edema, action temperature with, the Semen Plantaginis promoting diuresis to eliminate dampness and promoting QI circulation be adjuvant drug altogether, with reach the stasis of blood go new life purpose.Bombyx Batryticatus, Periostracum Cicadae all rise floating article, and the pure edema caused by disorder of QI of walking rises the gas of sending out the clear sun of three warmers.The Rhizoma Curcumae Longae dredging QI between the upper and lower, the mediation mechanism of qi is thought messenger drug.Full side's monarch, in perfect order, both closed ancient method, new meaning is arranged again.
Each used crude drug of the present invention can be bought at pharmacy and obtain.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form; For example disintegrating agent, lubricant, adhesive etc.; Method of Chinese medicinal with routine is prepared into any suitable clinical preparation; Can be capsule, pill, powder, granule, tablet, oral liquid or drop pill etc. for example, be preferably capsule.
A kind of method for preparing of Chinese medicine composition of the present invention: after each crude drug of the present invention taken by weighing by said weight portion proportioning, pulverize, sieve (for example can be the 500-800 mesh sieve) promptly gets.Certainly, after also can each crude drug being pulverized, add required adjuvant or the excipient of preparations shaping, be prepared into capsule, pill, powder, granule, tablet, oral liquid or drop pill etc.
Preferably, a kind of method for preparing Chinese medicine composition of the present invention may further comprise the steps:
(1) takes by weighing each crude drug by said weight portion;
(2) Cortex Cinnamomi is extracted volatile oil, adopt the colloid mill homogeneous technology with volatile oil with betacyclodextrin (enclose of β-CD), after the clathrate cold drying, pulverizing, subsequent use;
(3) will extract Cortex Cinnamomi medicinal residues and Polyporus, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Herba Lycopi, Semen Plantaginis one behind the volatile oil and reinstate drinking water and extract, with the aqueous extract spray drying, subsequent use;
(4) Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei are used the 30-95% ethanol extraction, with the ethanol extract spray drying, subsequent use;
(5) Hirudo is pulverized back and step (2), (3) and (4) resulting product mix homogeneously, add the pharmaceutical preparation auxiliary materials and mixing and process the preparation semi-finished product, process the preparation finished product through preparations shaping technology again.
Chinese medicine composition compatibility of the present invention is reasonable, has the characteristics of regulating functional activities of qi up-down, promoting diuresis with drugs of tasteless flavour, can effectively correct the edema pathological factor among the central nervous system, and treatment brain QI and blood can not normally follow the apoplexy due to the row.Chinese medicine composition of the present invention is clinical safe in utilization, and the patient uses the no any untoward reaction in back and can effectively protect the kidney function of using the mannitol patient, does not also produce any untoward reaction behind the medicine of the present invention of stopping using.
The specific embodiment
Below in conjunction with embodiment the present invention is described further, it should be understood that these embodiment only are used for the purpose of illustration, never limit protection scope of the present invention.
The preparation of embodiment 1 hard capsule
(1) takes by weighing each raw material decoction pieces by following weight: Polyporus 1000g, Poria 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Alismatis 1500g, Cortex Cinnamomi 300g, Bombyx Batryticatus 600g, Periostracum Cicadae 600g, Rhizoma Curcumae Longae 100g, Radix Et Rhizoma Rhei 300g, Herba Lycopi 1500g Semen Plantaginis 500g, Hirudo 300g;
(2) Cortex Cinnamomi is extracted volatile oil; After getting 20% the ethanol mixing that adds 3 times of amounts of beta-schardinger dextrin-behind the beta-schardinger dextrin-of 10 times of amounts of Cortex Cinnamomi volatile oil again; Carried out enclose in 15 minutes with the colloid mill homogenizing; With 24 hours after-filtration of the homogenizing fluid cold preservation behind the enclose, the clathrate after the filtration is dried the back pulverizing under 40 ℃ of temperature, subsequent use;
(3) will extract Cortex Cinnamomi medicinal residues and Polyporus, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Herba Lycopi, Semen Plantaginis one behind the volatile oil reinstates drinking water and extracts secondary; Add for the first time water weight and be 2 times of said medicine gross weight; Decocted 3 hours, and added for the second time water weight and be 4 times of said medicine gross weight, decocted 1 hour; Twice decoction liquor merged, filter, filtrating is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃ Celsius), and spray drying prepares fine powder, and is subsequent use;
(4) Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei are used 50% ethanol extraction, ethanol adding weight is 4 times of said medicine gross weight, decocts 3 times; The each decoction 2 hours; Merge decoction liquor, filter, filtrating is concentrated into the clear paste of relative density 1.30-1.35 (55 ℃ Celsius); Spray drying prepares fine powder, and is subsequent use;
(5) Hirudo powder is broken into behind the fine powder and step (2), (3) and (4) resulting product mix homogeneously, adds dextrin, Flos Chrysanthemi total glycosides is an amount of, mixing adds ethanol and processes granule in right amount, and cold drying is subsequent use;
(6) dried particles with preparation in (5) carries out granulate, is prepared into single-size, and is subsequent use;
(7) with the single-size of preparation in (6), be filled in the hard capsule case with the automatic filling machine of capsule, subsequent use;
(8) hard capsule in (7) is polished or seals, promptly get.
The preparation of embodiment 2 powders
Take by weighing each crude drug by following weight: Polyporus 900g, Poria 900g, Rhizoma Atractylodis Macrocephalae 900g, Rhizoma Alismatis 1200g, Cortex Cinnamomi 300g, Bombyx Batryticatus 600g, Periostracum Cicadae 600g, Rhizoma Curcumae Longae 100g, Radix Et Rhizoma Rhei 400g, Herba Lycopi 1200g, Semen Plantaginis 500g, Hirudo 200g; After above-mentioned each crude drug pulverizing, cross 800 mesh sieves, promptly get.
The preparation of embodiment 3 granules
(1) takes by weighing each raw material by following weight: Polyporus 1200g, Poria 1200g, Rhizoma Atractylodis Macrocephalae 1200g, Rhizoma Alismatis 1500g, Cortex Cinnamomi 600g, Bombyx Batryticatus 900g, Periostracum Cicadae 900g, Rhizoma Curcumae Longae 300g, Radix Et Rhizoma Rhei 400g, Herba Lycopi 1500g, Semen Plantaginis 900g, Hirudo 400g;
(2) Cortex Cinnamomi is extracted volatile oil, volatile oil is encapsulated the back pulverize, subsequent use;
The Cortex Cinnamomi medicinal residues that (3) will extract behind the volatile oil are used the water extraction secondary with Polyporus, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Alismatis, Herba Lycopi, Semen Plantaginis; Add for the first time water weight and be 2 times of said medicine gross weight; Decocted 3 hours; Add for the second time water weight and be 4 times of said medicine gross weight, decocted 1 hour; Decoction liquor is merged, filter, filtrating is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃ Celsius); Merge clear paste twice, spray drying, subsequent use;
(4) Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei are used 50% ethanol extraction, ethanol adding weight is 4 times of said medicine gross weight, decocts 3 times; The each decoction 2 hours; Merge decoction liquor, filter, filtrating is concentrated into the clear paste of relative density 1.30-1.35 (55 ℃ Celsius); Spray drying prepares fine powder, and is subsequent use;
(5) Hirudo is pulverized back and step (2), (3) and (4) resulting product mix homogeneously, adding dextrin, Flos Chrysanthemi total glycosides are an amount of, and mixing adds ethanol and processes granule in right amount, after the cold drying, and granulate, packing promptly gets.
Test Example 1 traditional Chinese medicine composition for treating apoplexy clinical observation on the therapeutic effect test of the present invention
One, case is selected:
Source of disease derives from the department of neurology inpatient; All meet nineteen ninety-five the 4th cerebrovascular academic conference in the whole nation; And existing tentative tcm diagnosis standard (" apoplexy diagnosis curative effect determinate standard " that State Administration of Traditional Chinese Medicine's encephalopathy acute disease scientific research cooperative groups is worked out); With comatose patient and with the depleted patient of serious organ function, get rid of this research.Apoplexy is the 6th meeting of standard reference national encephalopathy cooperative groups in 1993 " the apoplexy tcm diagnosis efficacy assessment standard " that pass through by stages: in around acute stage.
Two, trial drug
Capsule-up-down diuretic capsule that the embodiment of the invention 1 is prepared; The conventional fluid infusion medicine of mannitol and department of neurology.
Three, Therapeutic Method
Be divided into simple Neurology Department conventional therapy group (A group) at random, share up-down diuretic Capsules group (B group).
The dosage of A group: one bottle of mannitol 250ML, two bottles of every days first three day, then four day every day one bottle of 250ML, stop using in the back.
The dosage of B group: oral up-down diuretic capsule on A group basis, one time 3,3 times on the one, 15 days is a course of treatment, treats 2 courses of treatment altogether.
Four: criterion of therapeutical effect is judged: the apoplexy criterion of therapeutical effect is judged:
Integration * 100% before [(integration before the treatment-treatment back integration)] ÷ treatment is represented with percent
Be almost recovered: >=85%; Produce effects: >=50%; Effectively: >=20%; Invalid:＜20%; Dead.
Table 1: each group treatment Comparison of therapeutic
Contrast P＜0.05 before and after each group treatment, complication is meant: the renal failure that occurs in the therapeutic process, hematuria.
Table 2: Barthel index evaluation before and after each group treatment
Contrast P＜0.05 before and after each group treatment.
Table 3: neurologic impairment integration before and after each group treatment (x ± S)
Contrast P＜0.05 before and after each group treatment.
Conclusion: mannitol share up-down diuretic Capsules group (B group) and compares with mannitol group (A group); Syndrome integration, neurological functional deficit, obvious improve (P＜0.05) of Barthel index reached more than 60 minutes before and after the treatment, the prompting patient uses mannitol, and to share up-down diuretic Capsules group therapeutic scheme curative effect good.Pharmaceutical composition of the present invention meets the characteristics that ideal dehydrant should have: 1. effect is rapid, and it is lasting to reduce intracranial hypertension, convenient in application; 2. medicine does not get into the brain cell gap, to avoid " knock-on " phenomenon; 3. fast can the discharge through kidney of medicine ability has good diuresis; 4. metabolism rapidly in body, non-toxic reaction.But present various drug application does not all reach requirement.And the independent effect of pharmaceutical composition of the present invention is promptly gentle and lasting, share the back effect rapidly with mannitol, reduces intracranial hypertension; Convenient in application is the effect of mannitol, and Chinese medicine composition of the present invention has the effect that alleviates cerebral edema, and the mannitol medicine can be discharged through kidney rapidly, and good diuresis is arranged; Metabolism rapidly in body, non-toxic reaction, and it is lasting to reduce intracranial hypertension.
Safety: mannitol share none complication of up-down diuretic Capsules group.Therapeutic method of traditional Chinese and western medicine is more obvious than single group western medical treatment effect after the prompting acute apoplexy.And up-down diuretic Capsules group has the effect of protection kidney.
Claims (3)
1. Chinese medicine composition of treating apoplexy, the weight portion of each crude drug is: Polyporus 9-12 part, Poria 9-12 part, Rhizoma Atractylodis Macrocephalae 9-12 part, Rhizoma Alismatis 12-15 part, Cortex Cinnamomi 3-6 part, Bombyx Batryticatus 6-9 part, Periostracum Cicadae 6-9 part, Rhizoma Curcumae Longae 1-3 part, Radix Et Rhizoma Rhei 2-4 part, Herba Lycopi 12-15 part, Semen Plantaginis 5-9 part, Hirudo 2-4 part;
It is characterized in that said Chinese medicine composition prepares according to following steps:
(1) takes by weighing each crude drug by said weight portion;
(2) Cortex Cinnamomi is extracted volatile oil, volatile oil is encapsulated the back pulverize, subsequent use;
The Cortex Cinnamomi medicinal residues that (3) will extract behind the volatile oil are used water extraction with Polyporus, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Herba Lycopi, Semen Plantaginis, and are with the aqueous extract spray drying, subsequent use;
(4) Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei are used 50% ethanol extraction, with the ethanol extract spray drying, subsequent use;
(5) Hirudo is pulverized back and step (2), (3) and (4) resulting product mix homogeneously, add the pharmaceutical preparation auxiliary materials and mixing and process the preparation semi-finished product, process the preparation finished product through preparations shaping technology again.
2. according to the Chinese medicine composition of the said treatment apoplexy of claim 1; It is characterized in that the weight portion of each crude drug is: 10 parts of Polyporus, 10 parts in Poria, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Alismatis, 3 parts of Cortex Cinnamomis, 6 parts of Bombyx Batryticatus, 6 parts of Periostracum Cicadaes, 1 part in Rhizoma Curcumae Longae, 3 parts of Radix Et Rhizoma Rhei, 15 parts of Herba Lycopi, 5 parts of Semen Plantaginiss, 3 parts of Hirudos.
3. claim 1 or 2 described Chinese medicine compositions are treated the purposes in the apoplexy medicine in preparation.
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| CN102698156B (en) * | 2012-06-25 | 2013-12-04 | 李良 | Glabrous greenbrier rhizome Chinese medicinal decoction for treating edema and preparation method thereof |
| CN104771525A (en) * | 2014-01-15 | 2015-07-15 | 周辉 | Traditional Chinese medicine composition for treating vertebral artery stenting postoperation and preparing method thereof |
| CN104138573A (en) * | 2014-07-08 | 2014-11-12 | 济南高达信息技术有限公司 | Traditional Chinese medicinal decoction for treating hydrocephalus |
| CN105770690A (en) * | 2016-03-11 | 2016-07-20 | 王德亮 | Medicament for treating hydrocephalus and preparation method thereof |
| CN108392600A (en) * | 2018-05-29 | 2018-08-14 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | A kind of Chinese medicinal formulae for treating apoplexy |
| CN116270943B (en) * | 2023-03-21 | 2024-01-26 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Chinese herbal compound preparation for treating ischemic cerebral apoplexy and preparation method thereof |
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