CN111918859A - 稠合三环γ-氨基酸衍生物的盐的晶型及制备和应用 - Google Patents
稠合三环γ-氨基酸衍生物的盐的晶型及制备和应用 Download PDFInfo
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- CN111918859A CN111918859A CN201980022314.2A CN201980022314A CN111918859A CN 111918859 A CN111918859 A CN 111918859A CN 201980022314 A CN201980022314 A CN 201980022314A CN 111918859 A CN111918859 A CN 111918859A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
提供稠合三环γ‑氨基酸衍生物的盐和/或晶型及制备和应用。所述如式(I)所示，其中，Y选自马来酸、富马酸、氢卤酸(优选为氢溴酸和盐酸)、硫酸、磷酸、L‑酒石酸、柠檬酸、L‑苹果酸、马尿酸、D‑葡萄糖醛酸、乙醇酸、粘酸、琥珀酸、乳酸、乳清酸、帕莫酸、丙二酸、龙胆酸、草酸、戊二酸或糖精
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018107493351 | 2018-07-12 | ||
| CN201810749335 | 2018-07-12 | ||
| PCT/CN2019/095857 WO2020011258A1 (zh) | 2018-07-12 | 2019-07-12 | 稠合三环γ-氨基酸衍生物的盐的晶型及制备和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111918859A true CN111918859A (zh) | 2020-11-10 |
| CN111918859B CN111918859B (zh) | 2023-06-30 |
Family
ID=69143189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980022314.2A Active CN111918859B (zh) | 2018-07-12 | 2019-07-12 | 稠合三环γ-氨基酸衍生物的盐的晶型及制备和应用 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN111918859B (zh) |
| TW (1) | TW202019871A (zh) |
| WO (1) | WO2020011258A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4183771A4 (en) * | 2020-07-20 | 2024-04-24 | Sichuan Haisco Pharmaceutical Co., Ltd. | SUSTAINED RELEASE PHARMACEUTICAL FORMULATION OF A CONDENSED TRICYCLIC T-AMINO ACID DERIVATIVE AND METHOD OF MANUFACTURING THE SAME |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1720219A (zh) * | 2001-04-19 | 2006-01-11 | 沃纳-兰伯特公司 | 稠合二环或三环氨基酸 |
| CN101878193A (zh) * | 2007-09-28 | 2010-11-03 | 第一三共株式会社 | 双环γ-氨基酸衍生物 |
| WO2017114225A1 (zh) * | 2015-12-31 | 2017-07-06 | 四川海思科制药有限公司 | 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用 |
| CN106928080A (zh) * | 2015-12-31 | 2017-07-07 | 四川海思科制药有限公司 | 稠合环γ‑氨基酸衍生物及其制备方法和在医药上的应用 |
| WO2018050046A1 (zh) * | 2016-09-14 | 2018-03-22 | 四川海思科制药有限公司 | 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用 |
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2019
- 2019-07-12 WO PCT/CN2019/095857 patent/WO2020011258A1/zh active Application Filing
- 2019-07-12 TW TW108124671A patent/TW202019871A/zh unknown
- 2019-07-12 CN CN201980022314.2A patent/CN111918859B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1720219A (zh) * | 2001-04-19 | 2006-01-11 | 沃纳-兰伯特公司 | 稠合二环或三环氨基酸 |
| CN101878193A (zh) * | 2007-09-28 | 2010-11-03 | 第一三共株式会社 | 双环γ-氨基酸衍生物 |
| WO2017114225A1 (zh) * | 2015-12-31 | 2017-07-06 | 四川海思科制药有限公司 | 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用 |
| CN106928080A (zh) * | 2015-12-31 | 2017-07-07 | 四川海思科制药有限公司 | 稠合环γ‑氨基酸衍生物及其制备方法和在医药上的应用 |
| WO2018050046A1 (zh) * | 2016-09-14 | 2018-03-22 | 四川海思科制药有限公司 | 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用 |
Non-Patent Citations (1)
| Title |
|---|
| PETER YATES等: "DECOMFOSITJON OF l-DIAZO-3-(2,2,3-TRIMETHYLCYCLOPENT-3-ENYL)PROPAN-2-ONE.A NOVEL SVNTHESIS AND REARRANGEMENT OF A TRICYCLO[3.2.1.0]OCTAN-4-ONE", 《TETRAHEDRON LETTERS》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020011258A1 (zh) | 2020-01-16 |
| TW202019871A (zh) | 2020-06-01 |
| CN111918859B (zh) | 2023-06-30 |
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| PB01 | Publication | ||
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| GR01 | Patent grant | ||
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