CN111902428A - 一种双特异性抗体及其用途 - Google Patents
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Abstract
本发明提供了一种双特异性抗体及其用途。所述双特异性抗体包含第一蛋白功能区和第二蛋白功能区，其中，第一蛋白功能区靶向TIM‑3，其对应的靶向TIM‑3的TIM‑3全长抗体与猕猴(Macaca)TIM‑3有弱结合活性，与狨猴(Marmoset)和人TIM‑3有强结合活性并能够激活人NK细胞对肿瘤细胞的杀伤作用。所述的双特异性抗体保留单个TIM‑3抗体所具有的激活PBMC(NK)杀伤肿瘤细胞的活性，同时保持另一个蛋白功能区的原有活性，并能够达到和两个分子联用相当或者更好激活T淋巴细胞的活性。
Description
PCT国内申请，说明书已公开。
Claims (16)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810720048 | 2018-07-03 | ||
| CN2018107200488 | 2018-07-03 | ||
| PCT/CN2019/093548 WO2020007240A1 (zh) | 2018-07-03 | 2019-06-28 | 一种双特异性抗体及其用途 |
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| CN111902428A true CN111902428A (zh) | 2020-11-06 |
| CN111902428B CN111902428B (zh) | 2023-11-10 |
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| CN201980019463.3A Active CN111902428B (zh) | 2018-07-03 | 2019-06-28 | 一种双特异性抗体及其用途 |
| CN201910576333.1A Active CN110669135B (zh) | 2018-07-03 | 2019-06-28 | 一种双特异性抗体及其用途 |
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| US (1) | US20210269521A1 (zh) |
| EP (1) | EP3819313A4 (zh) |
| JP (1) | JP7352973B2 (zh) |
| CN (2) | CN111902428B (zh) |
| WO (1) | WO2020007240A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111518214B (zh) * | 2019-02-03 | 2023-09-22 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的双特异性抗体及其制备方法和应用 |
| CN113150150B (zh) * | 2020-02-24 | 2023-08-11 | 苏州恒康生命科学有限公司 | Tim3结合分子及其应用 |
| CN113698478A (zh) * | 2020-05-21 | 2021-11-26 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其稳定制剂 |
| WO2022002038A1 (zh) * | 2020-06-30 | 2022-01-06 | 和铂医药(上海)有限责任公司 | 免疫细胞衔接器多特异性结合蛋白及其制备和应用 |
| CN111748040B (zh) * | 2020-07-31 | 2021-09-28 | 杭州皓阳生物技术有限公司 | 多价抗体及其制备方法 |
| CN113603779B (zh) * | 2021-08-18 | 2023-06-02 | 深圳市元谷生物科技有限公司 | 一种结合人淋巴细胞活化基因3(lag-3)的抗体及其用途 |
| CN115246885B (zh) * | 2022-06-30 | 2023-10-24 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体及其应用 |
Citations (5)
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| WO2016015685A1 (zh) * | 2014-07-30 | 2016-02-04 | 珠海市丽珠单抗生物技术有限公司 | 抗pd-1抗体及其应用 |
| WO2016071448A1 (en) * | 2014-11-06 | 2016-05-12 | F. Hoffmann-La Roche Ag | Anti-tim3 antibodies and methods of use |
| WO2017055404A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
| WO2017087547A1 (en) * | 2015-11-17 | 2017-05-26 | Oncomed Pharmaceuticals, Inc. | Pd-l1-binding agents and uses thereof |
| CN108948193A (zh) * | 2017-05-18 | 2018-12-07 | 珠海市丽珠单抗生物技术有限公司 | 针对tim-3的抗体分子,抗原结合片段及其医药用途 |
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| TW201840336A (zh) | 2011-08-01 | 2018-11-16 | 美商建南德克公司 | 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法 |
| JOP20200096A1 (ar) * | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| US10465014B2 (en) * | 2016-03-04 | 2019-11-05 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | PDL-1 antibody, pharmaceutical composition thereof, and uses thereof |
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| JOP20190133A1 (ar) * | 2016-12-08 | 2019-06-02 | Innovent Biologics Suzhou Co Ltd | أجسام مضادة لـ Tim-3 لمزجها بأجسام مضادة لـ PD-1 |
| CN106986939B (zh) * | 2017-03-27 | 2019-06-07 | 顺昊细胞生物技术（天津）股份有限公司 | 抗pd-1和tem-8双特异性抗体及其应用 |
| US20220281997A1 (en) * | 2019-09-27 | 2022-09-08 | Nanjing GenScript Biotech Co., Ltd. | Anti-VHH Domain Antibodies and Use Thereof |
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2019
- 2019-06-28 WO PCT/CN2019/093548 patent/WO2020007240A1/zh unknown
- 2019-06-28 JP JP2020573186A patent/JP7352973B2/ja active Active
- 2019-06-28 CN CN201980019463.3A patent/CN111902428B/zh active Active
- 2019-06-28 CN CN201910576333.1A patent/CN110669135B/zh active Active
- 2019-06-28 EP EP19831370.2A patent/EP3819313A4/en active Pending
- 2019-06-28 US US17/254,862 patent/US20210269521A1/en active Pending
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| WO2016015685A1 (zh) * | 2014-07-30 | 2016-02-04 | 珠海市丽珠单抗生物技术有限公司 | 抗pd-1抗体及其应用 |
| WO2016071448A1 (en) * | 2014-11-06 | 2016-05-12 | F. Hoffmann-La Roche Ag | Anti-tim3 antibodies and methods of use |
| WO2017055404A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
| WO2017087547A1 (en) * | 2015-11-17 | 2017-05-26 | Oncomed Pharmaceuticals, Inc. | Pd-l1-binding agents and uses thereof |
| CN108948193A (zh) * | 2017-05-18 | 2018-12-07 | 珠海市丽珠单抗生物技术有限公司 | 针对tim-3的抗体分子,抗原结合片段及其医药用途 |
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| CN110669135A (zh) | 2020-01-10 |
| JP2021530207A (ja) | 2021-11-11 |
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| EP3819313A4 (en) | 2021-09-01 |
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| JP7352973B2 (ja) | 2023-09-29 |
| CN110669135B (zh) | 2022-11-11 |
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