CN111902428A - 一种双特异性抗体及其用途 - Google Patents

一种双特异性抗体及其用途 Download PDF

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CN111902428A
CN111902428A CN201980019463.3A CN201980019463A CN111902428A CN 111902428 A CN111902428 A CN 111902428A CN 201980019463 A CN201980019463 A CN 201980019463A CN 111902428 A CN111902428 A CN 111902428A
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antibody
heavy chain
seq
chain variable
tim
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CN111902428B (zh
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刘佳建
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Shanghai Jianxin Biomedical Technology Co ltd
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Abstract

本发明提供了一种双特异性抗体及其用途。所述双特异性抗体包含第一蛋白功能区和第二蛋白功能区,其中,第一蛋白功能区靶向TIM‑3,其对应的靶向TIM‑3的TIM‑3全长抗体与猕猴(Macaca)TIM‑3有弱结合活性,与狨猴(Marmoset)和人TIM‑3有强结合活性并能够激活人NK细胞对肿瘤细胞的杀伤作用。所述的双特异性抗体保留单个TIM‑3抗体所具有的激活PBMC(NK)杀伤肿瘤细胞的活性,同时保持另一个蛋白功能区的原有活性,并能够达到和两个分子联用相当或者更好激活T淋巴细胞的活性。

Description

PCT国内申请,说明书已公开。

Claims (16)

  1. PCT国内申请,权利要求书已公开。
CN201980019463.3A 2018-07-03 2019-06-28 一种双特异性抗体及其用途 Active CN111902428B (zh)

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CN111518214B (zh) * 2019-02-03 2023-09-22 上海健信生物医药科技有限公司 靶向cldn18.2的双特异性抗体及其制备方法和应用
CN113150150B (zh) * 2020-02-24 2023-08-11 苏州恒康生命科学有限公司 Tim3结合分子及其应用
CN113698478A (zh) * 2020-05-21 2021-11-26 迈威(上海)生物科技股份有限公司 抗α-溶血素的抗体及其稳定制剂
WO2022002038A1 (zh) * 2020-06-30 2022-01-06 和铂医药(上海)有限责任公司 免疫细胞衔接器多特异性结合蛋白及其制备和应用
CN111748040B (zh) * 2020-07-31 2021-09-28 杭州皓阳生物技术有限公司 多价抗体及其制备方法
CN113603779B (zh) * 2021-08-18 2023-06-02 深圳市元谷生物科技有限公司 一种结合人淋巴细胞活化基因3(lag-3)的抗体及其用途
CN115246885B (zh) * 2022-06-30 2023-10-24 盛禾(中国)生物制药有限公司 一种双特异性抗体及其应用

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EP3819313A1 (en) 2021-05-12
CN110669135A (zh) 2020-01-10
JP2021530207A (ja) 2021-11-11
WO2020007240A1 (zh) 2020-01-09
EP3819313A4 (en) 2021-09-01
US20210269521A1 (en) 2021-09-02
CN111902428B (zh) 2023-11-10
JP7352973B2 (ja) 2023-09-29
CN110669135B (zh) 2022-11-11

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