CN111875582A - 一种喹啉异羟肟酸衍生物及其制备方法和应用 - Google Patents
一种喹啉异羟肟酸衍生物及其制备方法和应用 Download PDFInfo
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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CN112225737A (zh) * | 2020-12-11 | 2021-01-15 | 北京鑫开元医药科技有限公司 | 具有hdac抑制活性的化合物、制备方法、组合物及用途 |
CN113321651A (zh) * | 2021-06-22 | 2021-08-31 | 四川省医学科学院·四川省人民医院 | 吡唑并吡啶异羟肟酸类化合物、其制备方法及其应用 |
CN115160294A (zh) * | 2022-06-27 | 2022-10-11 | 中山大学 | 一种G9a/GLP共价抑制剂及其制备方法及应用 |
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WO2014196328A1 (ja) * | 2013-06-04 | 2014-12-11 | 日本理化学工業株式会社 | ヒドロキサム酸誘導体またはその塩 |
CN106916101A (zh) * | 2017-02-15 | 2017-07-04 | 聚缘(上海)生物科技有限公司 | Nampt/hdac双靶点抑制剂及其制备方法 |
CN111116469A (zh) * | 2019-12-27 | 2020-05-08 | 北京鑫开元医药科技有限公司 | 一种hdac抑制剂、制备方法、药物组合物及其用途 |
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WO2014196328A1 (ja) * | 2013-06-04 | 2014-12-11 | 日本理化学工業株式会社 | ヒドロキサム酸誘導体またはその塩 |
CN106916101A (zh) * | 2017-02-15 | 2017-07-04 | 聚缘(上海)生物科技有限公司 | Nampt/hdac双靶点抑制剂及其制备方法 |
CN111116469A (zh) * | 2019-12-27 | 2020-05-08 | 北京鑫开元医药科技有限公司 | 一种hdac抑制剂、制备方法、药物组合物及其用途 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112225737A (zh) * | 2020-12-11 | 2021-01-15 | 北京鑫开元医药科技有限公司 | 具有hdac抑制活性的化合物、制备方法、组合物及用途 |
CN112225737B (zh) * | 2020-12-11 | 2021-04-09 | 北京鑫开元医药科技有限公司 | 具有hdac抑制活性的化合物、制备方法、组合物及用途 |
CN113321651A (zh) * | 2021-06-22 | 2021-08-31 | 四川省医学科学院·四川省人民医院 | 吡唑并吡啶异羟肟酸类化合物、其制备方法及其应用 |
CN115160294A (zh) * | 2022-06-27 | 2022-10-11 | 中山大学 | 一种G9a/GLP共价抑制剂及其制备方法及应用 |
CN115160294B (zh) * | 2022-06-27 | 2023-09-29 | 中山大学 | 一种G9a/GLP共价抑制剂及其制备方法及应用 |
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