CN111870656A

CN111870656A - Traditional Chinese medicine composition for enhancing immunity and preparation method and application thereof

Info

Publication number: CN111870656A
Application number: CN202010945393.9A
Authority: CN
Inventors: 唐敬波
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-09-10
Filing date: 2020-09-10
Publication date: 2020-11-03

Abstract

The invention provides a traditional Chinese medicine composition for enhancing immunity and a preparation method and application thereof. The traditional Chinese medicine composition for enhancing immunity comprises the following raw materials in parts by weight: 5-15 parts of pseudo-ginseng, 5-15 parts of salvia miltiorrhiza, 10-20 parts of kudzuvine root, 10-20 parts of dendrobium, 10-15 parts of American ginseng, 12-20 parts of astragalus membranaceus, 10-18 parts of radix ophiopogonis, 12-18 parts of rhodiola rosea, 10-20 parts of lucid ganoderma and 5-15 parts of prepared rehmannia root. The traditional Chinese medicine composition disclosed by the invention is reasonable in composition compatibility, simple in preparation process and has the remarkable effects of enhancing the immunity and the like.

Description

Traditional Chinese medicine composition for enhancing immunity and preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for enhancing immunity and a preparation method and application thereof.

Background

Immunity is the body's own defense mechanism, and is the body's ability to recognize and destroy any foreign body (virus, bacteria, etc.) that invades from the outside, to treat aged, damaged, dead, denatured self cells, and to recognize and treat mutant cells and virus-infected cells in the body. Most people with low immunity are easy to be infected or suffer from cancer, and generally have the manifestations of weak constitution, malnutrition, listlessness, fatigue, weakness, appetite reduction, sleep disorder and the like.

At present, there are some related researches on improving immunity by adopting a traditional Chinese medicine composition. For example, chinese patent application publication No. CN 110025742A discloses a Chinese medicinal composition for improving immunity, which comprises the following raw materials: licorice, poria cocos, sealwort, mulberry, ginseng, kudzu root, raspberry, wolfberry, momordica grosvenori, chrysanthemum, reed rhizome, purslane, houttuynia cordata, dandelion, chicory, endothelium corneum gigeriae galli, gardenia, platycodon grandiflorum, semen cassiae, semen brassicae, oyster, donkey-hide gelatin, Chinese yam, sterculia lychnophora and malt. The traditional Chinese medicine composition has the effects of greatly invigorating primordial qi, soothing nerves, promoting intelligence, nourishing liver and kidney, replenishing vital essence, improving eyesight, nourishing yin, enriching blood, nourishing yin, moistening lung, tonifying spleen, tonifying qi and the like, but the composition is complex and the preparation process is relatively complicated.

In view of this, the invention is particularly proposed.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for enhancing immunity, a preparation method and application thereof.

The traditional Chinese medicine composition for enhancing immunity provided by the invention comprises the following raw materials in parts by weight: 5-15 parts of pseudo-ginseng, 5-15 parts of salvia miltiorrhiza, 10-20 parts of kudzuvine root, 10-20 parts of dendrobium, 10-15 parts of American ginseng, 12-20 parts of astragalus membranaceus, 10-18 parts of radix ophiopogonis, 12-18 parts of rhodiola rosea, 10-20 parts of lucid ganoderma and 5-15 parts of prepared rehmannia root.

The effects of the raw materials are as follows:

pseudo-ginseng: has the effects of removing blood stasis, stopping bleeding, relieving swelling and relieving pain; it is mainly used for hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, thoracico-abdominal pain, traumatic injury and swelling and pain, etc. The pseudo-ginseng contains protopanaxadiol type saponin, protopanaxadiol type soap, saccharides, amino acid and the like, and has the functions of resisting aging, resisting fatigue and enhancing immunity; notoginseng radix polysaccharide A is effective component for promoting immunity, and can significantly increase phagocytic ability of phagocyte, enhance lysozyme content in serum, recover leukocyte of patients with low leucopenia, and regulate immunity.

Red sage root: has the effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle; it is mainly used for chest stuffiness and pains, abdominal and hypochondriac pain, abdominal mass accumulation, pain due to pyretic arthralgia, vexation and insomnia, menoxenia, dysmenorrhea and amenorrhea, and swelling and pain of pyocutaneous disease. Salvia miltiorrhiza can obviously improve the degree of phagocytosis and the degree of phagocytosis of macrophages, increase the conversion rate of lymphocytes in blood, and can directly resist rejection of humoral and cellular immunity, thereby enhancing immunity and organism immunity.

Kudzu root: has the effects of relieving muscles and fever, promoting eruption, promoting fluid production to quench thirst, invigorating yang and relieving diarrhea; it is mainly used for exterior syndrome fever, neck and back pain, measles without adequate eruption, fever thirst, yin deficiency with thirst, heat diarrhea and dysentery, spleen deficiency with diarrhea, etc. The kudzu root contains about 12% of flavonoids including more than 10 kinds of soybean (daidzin), daidzein, puerarin and the like, contains daucosterol, amino acid, coumarin and the like, has obvious function of enhancing phagocytosis of mouse macrophages, and has the function of resisting i-type allergy.

Dendrobe: has the effects of benefiting stomach, promoting fluid production, nourishing yin, clearing heat, etc.; it is mainly used for body fluid deficiency due to febrile disease, dry mouth with polydipsia, stomach yin deficiency, anorexia, retching, persistent asthenic fever after illness, hyperactivity of fire due to yin deficiency, bone steaming, overstrain, dim and unclear eyes, flaccidity of tendons and bones, etc. The active polysaccharide in herba Dendrobii has effects of resisting tumor, relieving inflammation, lowering blood pressure, reducing blood sugar, inhibiting lipid peroxidation, resisting aging, promoting health recovery, increasing leukocyte, assisting cancer treatment, and improving immunity.

American ginseng: has the effects of invigorating qi, nourishing yin, clearing away heat, promoting salivation, etc.; mainly used for treating deficiency of vital energy and yin, internal heat, cough, asthma, phlegm and blood, deficiency heat, vexation, tiredness, diabetes, dry mouth and dry throat; benefiting lung yin, clearing deficient fire, promoting fluid production to quench thirst; it is indicated for chronic cough due to lung deficiency, blood loss, dry throat, thirst, deficiency heat, restlessness and fatigue. The American ginseng contains a large amount of germanium and ginsenoside, can enhance the immune system, induce the proliferation of b lymphocytes, generate a large amount of antibodies, has the effects of resisting viruses and germs and the like, can tonify qi and promote the production of body fluid, and is particularly suitable for fatigue and shock caused by deficiency of both qi and yin.

Astragalus root: has effects in invigorating qi, consolidating superficial resistance, expelling toxic materials, expelling pus, promoting urination, and promoting granulation; it is mainly used for treating deficiency of vital energy, debilitation, chronic diarrhea, rectocele, spontaneous perspiration, edema, uterine prolapse, chronic nephritis proteinuria, diabetes, unhealed wound, etc. The astragalus contains a large amount of astragalus polysaccharides, which can promote cell regeneration, improve the activity of immune cells and improve the effect of immunocompetence.

Radix ophiopogonis: has effects in nourishing yin, moistening lung, invigorating stomach, promoting salivation, clearing away heart-fire, and relieving restlessness; it is mainly used for treating dry cough due to lung dryness, tuberculosis due to yin deficiency, sore throat, pharyngalgia, thirst due to body fluid consumption, diabetes due to internal heat, vexation, insomnia, and constipation due to intestinal dryness. The ophiopogonpolysaccharide in radix Ophiopogonis can increase the weight of spleen, increase the number of immunocytes, and improve immunity.

Rhodiola root: has the effects of benefiting qi, activating blood circulation, dredging collaterals, relieving asthma and the like; it is mainly used for qi deficiency and blood stasis, chest stuffiness and pain, apoplexy and hemiplegia, listlessness and asthma. The main chemical components of rhodiola comprise salidroside, tyrosol and rhodiola polysaccharide, and contain flavonoid, phenolic compounds, protein, fat, trace volatile oil, trace elements, amino acid and the like; research shows that the rhodiola has the effects of resisting anoxia, fatigue, aging and radiation, regulating nervous system, cardiovascular system, cerebrovascular system, immunity and the like.

Ganoderma lucidum: has effects of invigorating qi, tranquilizing mind, relieving cough and asthma; it can be used for treating restlessness of heart-mind, insomnia, palpitation due to fright, cough, asthma, excessive phlegm, and asthenia. The ganoderan in Ganoderma has antitumor, immunity enhancing, antiviral, antiaging, free radical scavenging, antithrombotic, and anticoagulant effects.

Prepared rehmannia root: has effects in nourishing yin, tonifying blood, replenishing essence, and replenishing marrow; can be used for treating deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, hectic fever due to yin deficiency, night sweat, nocturnal emission, internal heat, diabetes, blood deficiency, sallow complexion, cardiopalmus, severe palpitation, menoxenia, metrorrhagia, metrostaxis, hemorrhage, giddiness, tinnitus, and early white beard and hair. The polysaccharide in radix rehmanniae Preparata can enhance macrophage phagocytosis index, and has immunity enhancing effect.

Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 7-15 parts of pseudo-ginseng, 10-15 parts of salvia miltiorrhiza, 10-15 parts of kudzuvine root, 12-18 parts of dendrobium, 10-12 parts of American ginseng, 15-20 parts of astragalus membranaceus, 10-15 parts of radix ophiopogonis, 14-16 parts of rhodiola rosea, 12-20 parts of lucid ganoderma and 8-15 parts of prepared rehmannia root.

In one embodiment, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 11 parts of pseudo-ginseng, 12 parts of salvia miltiorrhiza, 12 parts of kudzuvine root, 15 parts of dendrobium, 11 parts of American ginseng, 18 parts of astragalus root, 12 parts of dwarf lilyturf tuber, 15 parts of rhodiola root, 16 parts of lucid ganoderma and 12 parts of prepared rehmannia root.

The traditional Chinese medicine composition disclosed by the invention is reasonable in formula, and can obtain a remarkable effect of enhancing the immunity through mutual cooperation and coordination among the components.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: mixing the raw materials according to the parts by weight, and adding water for water extraction. The water extraction can effectively extract the active ingredients in the raw materials, thereby being beneficial to improving the efficacy of the traditional Chinese medicine composition.

Further, before water extraction, the method can also comprise the following steps: each raw material was pulverized to 120 mesh. The method of pulverizing the raw materials is not particularly limited, and the raw materials may be pulverized separately or may be mixed and pulverized. The crushing step is beneficial to improving the water extraction effect, thereby releasing the active ingredients to the maximum extent.

The invention does not strictly limit the water extraction conditions; specifically, when water extraction is carried out, the weight ratio of water to the raw materials can be controlled to be (4-6): 1. in addition, the temperature of the water extraction can be 70-90 ℃, and the time of the water extraction can be 1.5-3 h.

Further, after water extraction, the method can also comprise the following steps: separating and concentrating the water extract.

The invention also provides application of the traditional Chinese medicine composition in preparation of a medicine or health-care product for enhancing immunity.

The application mode of the traditional Chinese medicine composition in preparing the medicine or health-care product for enhancing the immunity is not strictly limited; wherein the dosage form of the medicine or the health care product can be granules, tablets, pills, capsules, powder, oral liquid and the like.

The implementation of the invention has at least the following advantages:

1. the traditional Chinese medicine composition disclosed by the invention is reasonable in formula, and can obtain a remarkable effect of enhancing the immunity through mutual cooperation and coordination among all the components;

2. the preparation process of the invention has simple operation and good extraction effect, can release the active ingredients in the raw materials to the maximum extent, and is beneficial to improving the efficacy of the traditional Chinese medicine composition.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms also include the plural forms unless the context clearly dictates otherwise, and further, it is understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, devices, components, and/or combinations thereof.

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 11 parts of pseudo-ginseng, 12 parts of salvia miltiorrhiza, 12 parts of kudzuvine root, 15 parts of dendrobium, 11 parts of American ginseng, 18 parts of astragalus root, 12 parts of dwarf lilyturf tuber, 15 parts of rhodiola root, 16 parts of lucid ganoderma and 12 parts of prepared rehmannia root.

The preparation method of the traditional Chinese medicine composition for enhancing immunity of the embodiment comprises the following steps:

1) mixing the raw materials, and crushing to 120 meshes to obtain raw material powder;

2) mixing the raw material powder and water according to a mass ratio of 1: 5 mixing, heating to about 80 ℃, and extracting at 80 ℃ for 2h to obtain an aqueous extract;

3) carrying out solid-liquid separation on the aqueous extract, and concentrating an extracting solution obtained by separation to obtain an extract;

4) adding adjuvants into the extract, and making into pill with an amount of about 9g (about 6g of effective components).

Example 2

The traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 7 parts of pseudo-ginseng, 15 parts of salvia miltiorrhiza, 10 parts of kudzuvine root, 18 parts of dendrobium, 12 parts of American ginseng, 15 parts of astragalus, 15 parts of dwarf lilyturf tuber, 16 parts of rhodiola root, 20 parts of lucid ganoderma and 15 parts of prepared rehmannia root.

2) mixing the raw material powder and water according to a mass ratio of 1: 6 mixing, heating to about 90 ℃, and extracting at 90 ℃ for 1.5h to obtain an aqueous extract;

Example 3

The traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 15 parts of pseudo-ginseng, 10 parts of salvia miltiorrhiza, 15 parts of kudzuvine root, 12 parts of dendrobium, 10 parts of American ginseng, 20 parts of astragalus mongholicus, 10 parts of radix ophiopogonis, 14 parts of rhodiola rosea, 12 parts of lucid ganoderma and 8 parts of prepared rehmannia root.

2) mixing the raw material powder and water according to a mass ratio of 1: 4 mixing, heating to about 70 ℃, and extracting at 70 ℃ for 3 hours to obtain an aqueous extract;

Comparative example 1

The traditional Chinese medicine composition for enhancing immunity in the comparison example comprises the following raw materials in parts by weight: 12 parts of salvia miltiorrhiza, 12 parts of kudzuvine root, 15 parts of dendrobium, 16 parts of American ginseng, 24 parts of astragalus, 12 parts of dwarf lilyturf tuber, 15 parts of rhodiola rosea, 16 parts of lucid ganoderma and 12 parts of prepared rehmannia root.

The traditional Chinese medicine composition is prepared into pills by the method of example 1, and each pill is about 9g (about 6g of active ingredients).

Comparative example 2

The traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 11 parts of pseudo-ginseng, 12 parts of salvia miltiorrhiza, 12 parts of poria cocos, 15 parts of bighead atractylodes rhizome, 11 parts of American ginseng, 18 parts of angelica sinensis, 12 parts of radix ophiopogonis, 15 parts of rhodiola rosea, 16 parts of lucid ganoderma and 12 parts of prepared rehmannia root.

Test examples

Selecting 40 people with low immunity with symptoms of limb weakness, deficiency of qi and blood, emaciation and the like, randomly dividing into five groups, wherein each group comprises 8 people, the five groups respectively take the pills of the embodiments 1-3 and the comparative examples 1-2 for 3 times every day, each pill is taken for 1 month continuously, then scoring is carried out according to the effect, the scoring grade is 1-10, the total scoring of each group is counted, and the average scoring (the average scoring is the total scoring/8) is calculated.

The evaluation results are shown in Table 1.

TABLE 1 Effect scores for the Chinese medicinal compositions

Chinese medicinal composition	Total score (points)	Average score (score)
			Example 1	68	8.50
Example 1	64	8.00
			Example 1	66	8.25
Comparative example 1	54	6.75
			Comparative example 2	50	6.25

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. The traditional Chinese medicine composition for enhancing immunity is characterized by comprising the following raw materials in parts by weight: 5-15 parts of pseudo-ginseng, 5-15 parts of salvia miltiorrhiza, 10-20 parts of kudzuvine root, 10-20 parts of dendrobium, 10-15 parts of American ginseng, 12-20 parts of astragalus membranaceus, 10-18 parts of radix ophiopogonis, 12-18 parts of rhodiola rosea, 10-20 parts of lucid ganoderma and 5-15 parts of prepared rehmannia root.

2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 7-15 parts of pseudo-ginseng, 10-15 parts of salvia miltiorrhiza, 10-15 parts of kudzuvine root, 12-18 parts of dendrobium, 10-12 parts of American ginseng, 15-20 parts of astragalus membranaceus, 10-15 parts of radix ophiopogonis, 14-16 parts of rhodiola rosea, 12-20 parts of lucid ganoderma and 8-15 parts of prepared rehmannia root.

3. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 11 parts of pseudo-ginseng, 12 parts of salvia miltiorrhiza, 12 parts of kudzuvine root, 15 parts of dendrobium, 11 parts of American ginseng, 18 parts of astragalus root, 12 parts of dwarf lilyturf tuber, 15 parts of rhodiola root, 16 parts of lucid ganoderma and 12 parts of prepared rehmannia root.

4. A method for preparing the Chinese medicinal composition of any one of claims 1 to 3, which comprises: mixing the raw materials according to the parts by weight, and adding water for water extraction.

5. The method of claim 4, further comprising, prior to the water extraction: each raw material was pulverized to 120 mesh.

6. The preparation method according to claim 4, wherein the weight ratio of water to raw materials is controlled to be (4-6): 1.

7. the method according to claim 4, wherein the temperature of the water extraction is 70-90 ℃ and the time of the extraction is 1.5-3 h.

8. The method of claim 4, further comprising, after the water extraction: separating and concentrating the water extract.

9. Use of the Chinese medicinal composition of any one of claims 1 to 3 in the preparation of a medicament or health product for enhancing immunity.

10. The use of claim 9, wherein the pharmaceutical or nutraceutical formulation is in the form of granules, tablets, pills, capsules, powders or oral liquids.