CN111870597A - Compound preparation easy to realize industrialization and used for treating chicken respiratory tract mixed infection and preparation method thereof - Google Patents
Compound preparation easy to realize industrialization and used for treating chicken respiratory tract mixed infection and preparation method thereof Download PDFInfo
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- CN111870597A CN111870597A CN202010607132.6A CN202010607132A CN111870597A CN 111870597 A CN111870597 A CN 111870597A CN 202010607132 A CN202010607132 A CN 202010607132A CN 111870597 A CN111870597 A CN 111870597A
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- hydrochloride
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- respiratory tract
- compound preparation
- mixed infection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Abstract
The invention discloses a compound preparation for treating chicken respiratory tract mixed infection and a preparation method thereof, wherein each 100Kg of the preparation is prepared from 5Kg of arbidol hydrochloride, 8Kg of doxycycline hydrochloride, 2Kg of sodium alginate and 85Kg of anhydrous glucose. The compound preparation is prepared by adding the flavoring agent and the cosolvent into the arbidol hydrochloride and the doxycycline hydrochloride, plays the role of coordinating antibacterial action and antiviral action of the arbidol hydrochloride and the doxycycline hydrochloride, has good palatability, and has better prevention and treatment effects on respiratory tract mixed infection caused by chicken bacteria and viruses; meanwhile, the production process is simple, expensive equipment and professional technicians with high requirements are not needed, the energy consumption is low, the environment is protected, the total cost is low, the industrialization is easy to realize, and the medicine can be popularized and used more greatly.
Description
Technical Field
The invention belongs to the field of veterinary drug application, and particularly relates to a compound preparation for treating chicken respiratory tract mixed infection, which is easy to realize industrialization, and a preparation method thereof.
Background
The mixed infection of respiratory bacteria and virus of chicken is mainly manifested by nasal discharge, asthma, cough, hemoptysis mucus, pulmonary congestion in severe cases, dyspnea, slow development of young poultry infected with the disease, low feed conversion rate, egg laying reduction of laying poultry, and high mortality rate. Recent research shows that the respiratory tract infection of the chicken is difficult to prevent and treat by a method for treating a single pathogen, the disease is more common and extensive, the harm to the chicken industry is greatest, and the loss is also the most serious. In recent years, the disease is more and more serious, the treatment difficulty and the treatment cost are more and more, so that the research, the application and the clinical application of a preparation for treating and preventing the respiratory tract bacterial and viral mixed infection of the chicken are urgent and necessary.
Disclosure of Invention
The invention provides a compound preparation for treating chicken respiratory tract mixed infection and a preparation method thereof, which are easy to realize industrialization, wherein the compound preparation is prepared by adding corrective and cosolvent into arbidol hydrochloride and doxycycline hydrochloride, and the coordination effect of the antibacterial and antiviral effects of the arbidol hydrochloride and doxycycline hydrochloride is exerted, so that the compound preparation has good palatability and has better prevention and treatment effects on the chicken respiratory tract mixed infection caused by bacteria and viruses; meanwhile, the production process is simple, expensive equipment and professional technicians with high requirements are not needed, the energy consumption is low, the environment is protected, the total cost is low, the industrialization is easy to realize, and the medicine can be popularized and used more greatly.
The specific technical scheme provided by the invention is as follows:
every 100g of the compound preparation is prepared from 3-8 g of arbidol hydrochloride, 3-10 g of doxycycline hydrochloride, 2-10 g of flavoring agent and 72.0-91.0 g of cosolvent;
the flavoring agent is one or two of sodium alginate and mannitol;
the cosolvent is one or two of anhydrous glucose or soluble starch.
Every 100g of the compound preparation is prepared from 4-7 g of arbidol hydrochloride, 5-8 g of doxycycline hydrochloride, 4-7 g of flavoring agent and 78.0-85.0 g of cosolvent;
the flavoring agent is one or two of sodium alginate and mannitol;
the cosolvent is one or two of anhydrous glucose or soluble starch.
Every 100g of the compound preparation is prepared from 6g of arbidol hydrochloride, 7g of doxycycline hydrochloride, 5g of flavoring agent and 82.0g of cosolvent;
the flavoring agent is one or two of sodium alginate and mannitol;
the cosolvent is one or two of anhydrous glucose or soluble starch.
The flavoring agent is preferably mannitol; the cosolvent is preferably anhydrous glucose, so that the prepared compound preparation has good cosolvent and palatability.
The medicines and equipment used in the invention are all commercial products, and the medicines are all solid powder.
The preparation method of the compound preparation comprises the following specific steps:
weighing the abidol hydrochloride, the doxycycline hydrochloride and the flavoring agent according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, mixing the cosolvent with the mixture in an equivalent incremental mode for 30-40 min, and finally subpackaging to obtain the compound preparation. The compound preparation is light yellow powder, has good water solubility, can be administered by drinking water, and is convenient to take.
The compound preparation is prepared by adding the flavoring agent and the cosolvent into the arbidol hydrochloride and the doxycycline hydrochloride, plays the synergistic action of the antibacterial action and the antiviral action of the arbidol hydrochloride and the doxycycline hydrochloride, has good palatability, and has better prevention and treatment effects on respiratory tract mixed infection caused by chicken bacteria and viruses; meanwhile, the production process is simple, expensive equipment and professional technicians with high requirements are not needed, the energy consumption is low, the environment is protected, the total cost is low, the industrialization is easy to realize, and the medicine can be popularized and used more greatly.
Detailed Description
Example 1
Every 100Kg of the compound preparation for treating the chicken respiratory tract mixed infection is prepared by the following raw materials of 5Kg of arbidol hydrochloride, 8Kg of doxycycline hydrochloride, 2Kg of sodium alginate and 85Kg of anhydrous glucose.
The preparation method of the compound preparation comprises the following specific steps:
weighing the abidol hydrochloride, the doxycycline hydrochloride and the sodium alginate according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, mixing the anhydrous glucose with the mixture in an equivalent incremental mode for 30-40 min, and finally subpackaging to obtain yellow powder.
Example 2
Every 100Kg of the compound preparation for treating the chicken respiratory tract mixed infection is prepared by 3Kg of arbidol hydrochloride, 4Kg of doxycycline hydrochloride, 2Kg of sodium alginate, 2Kg of mannitol and 87Kg of soluble starch.
The preparation method of the compound preparation comprises the following specific steps:
weighing the abidol hydrochloride, the doxycycline hydrochloride, the sodium alginate and the mannitol according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, mixing the soluble starch with the mixture in an equivalent incremental manner for 30-40 min, and finally subpackaging to obtain yellow powder.
Example 3
Every 100Kg of the compound preparation for treating the chicken respiratory tract mixed infection is prepared by 6Kg of arbidol hydrochloride, 7Kg of doxycycline hydrochloride, 5Kg of mannitol and 82Kg of anhydrous glucose.
The preparation method of the compound preparation comprises the following specific steps:
weighing the abidol hydrochloride, the doxycycline hydrochloride and the mannitol according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, then mixing the anhydrous glucose with the mixture in an equivalent incremental manner for 30-40 min, and finally subpackaging to obtain yellow powder.
Example 4
Every 100Kg of the compound preparation for treating the chicken respiratory tract mixed infection is prepared by 8Kg of arbidol hydrochloride, 10 Kg of doxycycline hydrochloride, 5Kg of sodium alginate, 5Kg of mannitol and 72Kg of anhydrous glucose.
The preparation method of the compound preparation comprises the following specific steps:
weighing the abidol hydrochloride, the doxycycline hydrochloride, the sodium alginate and the mannitol according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, then mixing the anhydrous glucose with the mixture in an equivalent incremental mode for 30-40 min, and finally subpackaging to obtain yellow powder.
Example 5
Every 100Kg of the compound preparation for treating the chicken respiratory tract mixed infection is prepared by 7Kg of arbidol hydrochloride, 5Kg of doxycycline hydrochloride, 4Kg of sodium alginate, 6Kg of mannitol and 78Kg of soluble starch.
The preparation method of the compound preparation comprises the following specific steps:
weighing the abidol hydrochloride, the doxycycline hydrochloride, the sodium alginate and the mannitol according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, mixing the soluble starch with the mixture in an equivalent incremental manner for 30-40 min, and finally subpackaging to obtain yellow powder.
Example 6
Every 100Kg of the compound preparation for treating the chicken respiratory tract mixed infection is prepared by 3Kg of arbidol hydrochloride, 3Kg of doxycycline hydrochloride, 3Kg of sodium alginate, 40Kg of soluble starch and 51Kg of anhydrous glucose.
The preparation method of the compound preparation comprises the following specific steps:
weighing the abidol hydrochloride, the doxycycline hydrochloride and the sodium alginate according to the formula proportion, uniformly mixing by using a three-dimensional motion mixer, mixing the soluble starch and the anhydrous glucose with the mixture in an equivalent incremental mode for 30-40 min, and finally subpackaging to obtain yellow powder.
Test example for Effect of treating Chicken respiratory tract bacterial and viral Mixed infection
Test example 1
6000 broiler chickens are bred in a chicken farm in Lin \26384inWeifang city, rhinorrhea, cough, asthma with respiratory rale appear at 15 days of age, the body temperature is raised, the feed intake is reduced, then breeding personnel adopt antibiotics to treat for 2 days, the disease condition is not improved, death occurs after 72 hours of disease occurrence, the death rate is 1.7%, the death rate is 2.6% after 96 hours, the anatomical manifestation is that mucus is inflamed in trachea and air sac, pulmonary edema has hydrops, and tissue separation pathogenic microorganisms are determined as mixed type infection of bacteria, mycoplasma and virus.
The subsequent treatment with the preparation prepared in the invention example 3, drinking water administration is carried out according to the formula proportion of 0.06mg/kg of arbidol hydrochloride and 0.07mg/kg of doxycycline hydrochloride, and the continuous use is carried out for 5 days, and the results show that the death rate of the chicken flocks is reduced to 0.6% on the administration day 2, the chicken flocks do not die and the feed intake is increased on the day 4, the feed intake of the chicken flocks is normal on the day five, no death and no respiratory infection symptoms exist, and the tissue organs are found to be recovered to be normal through anatomy.
Test example 2
12000 layers of Weifang Anqiu city are bred, respiratory tract diseases appear at the age of 32 days, the Weifang Anqiu city is diagnosed as mixed type infection of bacteria and virus, breeding personnel adopt antibiotics and antiviral traditional Chinese medicines for treatment for 5 days, the state of an illness is not improved, and the mortality rate is up to 2.9%.
The preparation prepared in the embodiment 3 of the invention is used for treatment, drinking water administration is carried out according to the formula proportion of 0.06mg/kg of arbidol hydrochloride and 0.07mg/kg of doxycycline hydrochloride, and the continuous use is carried out for 6 days, and the result shows that the mortality rate of chickens on the 3 rd day after administration is reduced to 0.7%, and the mortality rate of chickens on the 4 th day after administration is reduced to 0.03%; no death and increased feed intake of the chicken flocks occur on the 5 th day, the feed intake of the chicken flocks is normal, no death and no respiratory infection symptoms occur on the 6 th day, and the tissues and organs are found to be recovered to be normal through dissection.
Test example 3
Weifang Gaomi, 5000 layers of laying hens are bred by a certain farmer in Gaomi city, respiratory diseases appear at the age of 37 days, the farmer adopts antibiotics and antiviral traditional Chinese medicines to treat the respiratory diseases for 5 days, the state of the disease is not improved, the disease is dead, and the infection is diagnosed as respiratory bacteria and virus mixed type infection through dissection.
Through communication with the householder, 1000 sick chickens with obvious respiratory symptoms but no death in the chicken farm were selected for the following tests: 1000 chickens were divided equally into 10 groups of 100 chickens each. Wherein the 1 st to 6 th groups are respectively treated by the compound preparation prepared in the embodiment 1 to 6; group 7 is treatment with abidol hydrochloride and doxycycline hydrochloride; group 8 treatments with only Arbidol hydrochloride material; group 9 treatment with doxycycline hydrochloride alone; continuously treating the groups 1-9 for 6 days according to the set test conditions; group 10 was a control group, which was not treated with drug, and only the test equivalent of water was given.
From the test results, the preparation disclosed by the invention has a better treatment effect on the mixed infection of respiratory bacteria and viruses of the chicken, and the effect is obviously higher than that of a single medicament. Furthermore, the main drug doses (0.06 mg/kg of arbidol hydrochloride and 0.07mg/kg of doxycycline hydrochloride) contained in the 3 rd group of compound preparation in the test are less than the drug doses (0.08 mg/kg of arbidol hydrochloride and 0.1mg/kg of doxycycline hydrochloride) in the 7 th group of main combination mode, and the cure rate of the 3 rd group (99%) is obviously higher than that of the 7 th group (87%) from the therapeutic effect.
Claims (2)
1. Every 100Kg of the compound preparation for treating the chicken respiratory tract mixed infection is prepared by the following raw materials of 5Kg of arbidol hydrochloride, 8Kg of doxycycline hydrochloride, 2Kg of sodium alginate and 85Kg of anhydrous glucose.
2. A process for preparing a compound formulation as claimed in claim 1, wherein: the method comprises the following specific steps:
weighing the abidol hydrochloride, the doxycycline hydrochloride and the sodium alginate according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, mixing the anhydrous glucose with the mixture in an equivalent incremental mode for 30-40 min, and finally subpackaging to obtain yellow powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010607132.6A CN111870597A (en) | 2016-07-29 | 2016-07-29 | Compound preparation easy to realize industrialization and used for treating chicken respiratory tract mixed infection and preparation method thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610624322.2A CN106236758B (en) | 2016-07-29 | 2016-07-29 | Compound preparation for treating chicken respiratory tract bacterial and virus mixed infection and preparation method thereof |
| CN202010607132.6A CN111870597A (en) | 2016-07-29 | 2016-07-29 | Compound preparation easy to realize industrialization and used for treating chicken respiratory tract mixed infection and preparation method thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610624322.2A Division CN106236758B (en) | 2016-07-29 | 2016-07-29 | Compound preparation for treating chicken respiratory tract bacterial and virus mixed infection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111870597A true CN111870597A (en) | 2020-11-03 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010607658.4A Withdrawn CN112315957A (en) | 2016-07-29 | 2016-07-29 | Compound preparation for preventing and treating chicken respiratory tract mixed infection and preparation method thereof |
| CN201610624322.2A Active CN106236758B (en) | 2016-07-29 | 2016-07-29 | Compound preparation for treating chicken respiratory tract bacterial and virus mixed infection and preparation method thereof |
| CN202010607132.6A Pending CN111870597A (en) | 2016-07-29 | 2016-07-29 | Compound preparation easy to realize industrialization and used for treating chicken respiratory tract mixed infection and preparation method thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010607658.4A Withdrawn CN112315957A (en) | 2016-07-29 | 2016-07-29 | Compound preparation for preventing and treating chicken respiratory tract mixed infection and preparation method thereof |
| CN201610624322.2A Active CN106236758B (en) | 2016-07-29 | 2016-07-29 | Compound preparation for treating chicken respiratory tract bacterial and virus mixed infection and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742720A (en) * | 2005-09-20 | 2006-03-08 | 江苏吴中苏药医药开发有限责任公司 | Arbidol preparation and preparing method |
| CN102000030A (en) * | 2010-11-08 | 2011-04-06 | 东北制药（沈阳）科技发展有限公司 | Arbidol dry suspension and preparation method thereof |
| WO2011100528A2 (en) * | 2010-02-12 | 2011-08-18 | Emory University | Compositions and uses of lectins |
| CN105250223A (en) * | 2015-11-06 | 2016-01-20 | 石家庄四药有限公司 | Dry suspension containing Arbidol and salt thereof as well as preparation method of dry suspension |
| CN105614161A (en) * | 2015-12-27 | 2016-06-01 | 陈洪福 | Feed for fishes and shrimps and preparation method of feed |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813909B (en) * | 2012-08-02 | 2014-10-22 | 青岛绿曼生物工程有限公司 | Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof |
-
2016
- 2016-07-29 CN CN202010607658.4A patent/CN112315957A/en not_active Withdrawn
- 2016-07-29 CN CN201610624322.2A patent/CN106236758B/en active Active
- 2016-07-29 CN CN202010607132.6A patent/CN111870597A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742720A (en) * | 2005-09-20 | 2006-03-08 | 江苏吴中苏药医药开发有限责任公司 | Arbidol preparation and preparing method |
| WO2011100528A2 (en) * | 2010-02-12 | 2011-08-18 | Emory University | Compositions and uses of lectins |
| CN102000030A (en) * | 2010-11-08 | 2011-04-06 | 东北制药（沈阳）科技发展有限公司 | Arbidol dry suspension and preparation method thereof |
| CN105250223A (en) * | 2015-11-06 | 2016-01-20 | 石家庄四药有限公司 | Dry suspension containing Arbidol and salt thereof as well as preparation method of dry suspension |
| CN105614161A (en) * | 2015-12-27 | 2016-06-01 | 陈洪福 | Feed for fishes and shrimps and preparation method of feed |
Non-Patent Citations (3)
| Title |
|---|
| 中央农业广播电视学校组编: "《农业政策与农村法规》", 30 November 2005 * |
| 朱云芬等: "阿比多尔可作为家禽呼吸道疾病的广谱药", 《中国家禽》 * |
| 邓翠芬等: "强力霉素对鸡大肠杆菌病的临床治疗效果", 《中国畜禽种业》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112315957A (en) | 2021-02-05 |
| CN106236758A (en) | 2016-12-21 |
| CN106236758B (en) | 2020-07-28 |
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Application publication date: 20201103 |