CN111868083B - 因子h增强抗体及其用途 - Google Patents

因子h增强抗体及其用途 Download PDF

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Publication number
CN111868083B
CN111868083B CN201980019128.3A CN201980019128A CN111868083B CN 111868083 B CN111868083 B CN 111868083B CN 201980019128 A CN201980019128 A CN 201980019128A CN 111868083 B CN111868083 B CN 111868083B
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China
Prior art keywords
sequence
seq
antibody
light chain
heavy chain
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CN201980019128.3A
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English (en)
Chinese (zh)
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CN111868083A (zh
Inventor
塔卡·威廉·库依普斯
黛安娜·武泰
玛利亚·克莱尔·布劳威尔
理查德·本杰明·普维
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Stichting Sanquin Bloedvoorziening
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Stichting Sanquin Bloedvoorziening
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201980019128.3A 2018-01-15 2019-01-15 因子h增强抗体及其用途 Active CN111868083B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18151726 2018-01-15
EP18151726.9 2018-01-15
PCT/NL2019/050018 WO2019139481A1 (en) 2018-01-15 2019-01-15 Factor h potentiating antibodies and uses thereof

Publications (2)

Publication Number Publication Date
CN111868083A CN111868083A (zh) 2020-10-30
CN111868083B true CN111868083B (zh) 2025-02-11

Family

ID=60972152

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980019128.3A Active CN111868083B (zh) 2018-01-15 2019-01-15 因子h增强抗体及其用途

Country Status (11)

Country Link
US (2) US11377487B2 (https=)
EP (1) EP3740502A1 (https=)
JP (2) JP7471224B2 (https=)
KR (2) KR102896085B1 (https=)
CN (1) CN111868083B (https=)
AU (1) AU2019206207B2 (https=)
BR (1) BR112020014399A2 (https=)
CA (1) CA3088507A1 (https=)
IL (1) IL276008A (https=)
MX (1) MX2020007555A (https=)
WO (1) WO2019139481A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102896085B1 (ko) * 2018-01-15 2025-12-08 스티흐팅 산퀸 불드포르지닝 인자 h 강화 항체 및 이의 사용
TWI851771B (zh) * 2019-07-17 2024-08-11 美商雙子治療子公司 因子ｈ增強抗體及其用途
CN114560941B (zh) * 2020-11-27 2024-01-16 广东东阳光药业股份有限公司 Cldn18.2的抗体及其应用
US20250121090A1 (en) * 2021-07-30 2025-04-17 R.P. Scherer Technologies, Llc Antibody-Drug Conjugates and Methods of Use Thereof
CN116355860A (zh) * 2021-12-28 2023-06-30 四川远大蜀阳药业有限责任公司 分泌抗h因子抗体的杂交瘤细胞株、抗h因子抗体及其应用
CN116041521B (zh) * 2022-03-21 2023-11-03 南京蓬勃生物科技有限公司 靶向Siglec-15的单克隆抗体及其应用
NL2032398B1 (en) * 2022-07-06 2024-01-23 Academisch Ziekenhuis Leiden Bispecific antibody and uses thereof
CN118878671B (zh) * 2024-07-04 2025-09-30 南京农业大学 抗兽疫链球菌SzM蛋白的猪源化单克隆抗体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016028150A1 (en) * 2014-08-20 2016-02-25 Stichting Sanquin Bloedvoorziening Factor h potentiating antibodies and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508287A (ja) * 2009-10-14 2013-03-07 ヤンセン バイオテツク，インコーポレーテツド 抗体を親和性成熟する方法
CA2780221A1 (en) * 2009-11-04 2011-05-12 Fabrus Llc Methods for affinity maturation-based antibody optimization
KR102485788B1 (ko) * 2014-08-27 2023-01-09 메모리얼 슬로안 케터링 캔서 센터 항체, 조성물 및 용도
KR102896085B1 (ko) * 2018-01-15 2025-12-08 스티흐팅 산퀸 불드포르지닝 인자 h 강화 항체 및 이의 사용
TWI851771B (zh) * 2019-07-17 2024-08-11 美商雙子治療子公司 因子ｈ增強抗體及其用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016028150A1 (en) * 2014-08-20 2016-02-25 Stichting Sanquin Bloedvoorziening Factor h potentiating antibodies and uses thereof
CN107074939A (zh) * 2014-08-20 2017-08-18 桑昆血液供给基金会 H因子增强抗体及其用途

Also Published As

Publication number Publication date
US11377487B2 (en) 2022-07-05
JP2023089191A (ja) 2023-06-27
WO2019139481A1 (en) 2019-07-18
KR20200110688A (ko) 2020-09-24
US20220356235A1 (en) 2022-11-10
KR102896085B1 (ko) 2025-12-08
JP7471224B2 (ja) 2024-04-19
AU2019206207A1 (en) 2020-08-13
JP2021510523A (ja) 2021-04-30
EP3740502A1 (en) 2020-11-25
IL276008A (en) 2020-08-31
CA3088507A1 (en) 2019-07-18
MX2020007555A (es) 2021-01-15
US20210054059A1 (en) 2021-02-25
KR20250171487A (ko) 2025-12-08
CN111868083A (zh) 2020-10-30
BR112020014399A2 (pt) 2020-12-29
AU2019206207B2 (en) 2025-04-10

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