CN111868070A - 一种多肽的纯化方法 - Google Patents
一种多肽的纯化方法 Download PDFInfo
- Publication number
- CN111868070A CN111868070A CN201980019263.8A CN201980019263A CN111868070A CN 111868070 A CN111868070 A CN 111868070A CN 201980019263 A CN201980019263 A CN 201980019263A CN 111868070 A CN111868070 A CN 111868070A
- Authority
- CN
- China
- Prior art keywords
- mobile phase
- salt
- solution
- phosphate
- acetonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
Abstract
本申请公开了利用色谱技术对式(I)化合物进行纯化的方法。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810460715 | 2018-05-15 | ||
| CN2018104607153 | 2018-05-15 | ||
| PCT/CN2019/085576 WO2019218881A1 (zh) | 2018-05-15 | 2019-05-05 | 一种多肽的纯化方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111868070A true CN111868070A (zh) | 2020-10-30 |
Family
ID=68539412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980019263.8A Pending CN111868070A (zh) | 2018-05-15 | 2019-05-05 | 一种多肽的纯化方法 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN111868070A (zh) |
| WO (1) | WO2019218881A1 (zh) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3521301B1 (en) * | 2016-09-27 | 2024-03-06 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Polyamide compound and use thereof |
-
2019
- 2019-05-05 WO PCT/CN2019/085576 patent/WO2019218881A1/zh active Application Filing
- 2019-05-05 CN CN201980019263.8A patent/CN111868070A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019218881A1 (zh) | 2019-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Oyler et al. | Hydrophilic interaction chromatography on amino-silica phases complements reversed-phase high-performance liquid chromatography and capillary electrophoresis for peptide analysis | |
| CN103980351A (zh) | 加压素、加压素鞣酸盐的制备方法 | |
| CN108101959B (zh) | 一种制备高纯度多肽或其类似物的方法 | |
| CN106226427A (zh) | 一种超临界流体色谱法快速拆分阿雷地平外消旋体的方法 | |
| TWI488862B (zh) | Separation and Purification of Cyclohexyl Compounds and Their Salts | |
| CN111868070A (zh) | 一种多肽的纯化方法 | |
| CN114369142A (zh) | 一种纯化醋酸去氨加压素的方法 | |
| CN109467591B (zh) | 一种西曲瑞克的纯化方法 | |
| CN107759667B (zh) | 一种西曲瑞克的分离纯化方法 | |
| CN110927279B (zh) | 一种盐酸咪达普利有关物质的分离方法 | |
| CN103965291B (zh) | 奥曲肽、奥曲肽醋酸盐的制备方法 | |
| Westerink et al. | Do neuroleptics prevent the penetration of dopamine agonists into the brain? | |
| CN110194758B (zh) | 一种从关木通中分离纯化马兜铃酸类化合物的方法 | |
| CN109406685B (zh) | 一种分离卡非佐米和其异构体的高效液相色谱方法 | |
| YOSHIMI et al. | Importance of hydrolysis of amino acid moiety in water-soluble prodrugs of disodium cromoglycate for increased oral bioavailability | |
| CN113624898B (zh) | 一种手性镇痛类多肽药物的纯化方法 | |
| EP0167936A2 (en) | Use of actinonin as an immunopotentiator | |
| CN115636859A (zh) | 一种从杨梅叶中同时分离纯化两种没食子酰基化杨梅苷的方法及用途 | |
| CN111170945B (zh) | 黄蘑菇中天然抗氧化氨基酸衍生物的分离工艺及其应用 | |
| JPS6267025A (ja) | 医薬組成物およびその製造方法 | |
| CN101486702B (zh) | 一种艾拉莫德类似物及其分离方法 | |
| CN112279895A (zh) | 一种化学合成酸性多肽的制备方法 | |
| JP2007509945A (ja) | 逆相分取クロマトグラフィーによるフェンタニルの分離および精製のための産業用の方法 | |
| JP4373510B2 (ja) | １８β，１９β−ジアセチルオキシ−１８α，１９α−エポキシ−３，１３（１６），１４−クレロダトリエン−２−オン（エスクレンチンＡ）および１８β，１９β−ジアセチルオキシ−１８α，１９α−エポキシ−３，１２，１４−クレロダトリエン−２β−イソバレリルオキシ−６β，７α−ジオール（エスクレンチンＢ）、それらの製法ならびに医薬の製造におけるそれらの使用 | |
| CN115850383A (zh) | 一种雷扎芬净纯化方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |