CN111825743A - 对可冷诱导的rna结合蛋白活性进行抑制的肽 - Google Patents

对可冷诱导的rna结合蛋白活性进行抑制的肽 Download PDF

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CN111825743A
CN111825743A CN202010358115.3A CN202010358115A CN111825743A CN 111825743 A CN111825743 A CN 111825743A CN 202010358115 A CN202010358115 A CN 202010358115A CN 111825743 A CN111825743 A CN 111825743A
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cirp
peptide
gly
pharmaceutically acceptable
acceptable salt
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王平
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Feinstein Institutes for Medical Research
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CN202010358115.3A 2013-09-24 2014-09-24 对可冷诱导的rna结合蛋白活性进行抑制的肽 Pending CN111825743A (zh)

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US (1) US9957295B2 (https=)
EP (1) EP3049438B1 (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113616776A (zh) * 2021-08-20 2021-11-09 兰州大学第二医院 一种阻断剂c23在制备治疗心肌梗死的药物中的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3049438B1 (en) 2013-09-24 2018-07-25 The Feinstein Institute for Medical Research Peptides inhibiting cold-inducible rna binding protein activity
EP3280256A4 (en) * 2015-04-06 2018-12-12 University of Maryland, Baltimore Small molecule inhibitors of tlr2 signaling
KR101745520B1 (ko) 2015-05-29 2017-06-12 아주대학교산학협력단 신규한 tlr4 길항제
CN108864311A (zh) * 2018-08-03 2018-11-23 中国人民解放军第四军医大学 一种抑制md2与cirp蛋白结合的短肽及其应用
US11001608B2 (en) 2019-07-11 2021-05-11 King Faisal University Arid5a peptide inhibitors
CN114705848B (zh) * 2022-04-07 2022-10-25 中国中医科学院中药研究所 Ctrp3与ctrp15作为生物标志物在制备早期诊断自发性脑出血产品中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102458465A (zh) * 2009-04-13 2012-05-16 范因斯坦医学研究院 通过抑制冷诱导rna结合蛋白(cirp)治疗炎性疾病

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172124A (en) 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
AU665025B2 (en) 1991-09-23 1995-12-14 Cambridge Antibody Technology Limited Production of chimeric antibodies - a combinatorial approach
DE614989T1 (de) 1993-02-17 1995-09-28 Morphosys Proteinoptimierung Verfahren für in vivo Selektion von Ligandenbindende Proteine.
US5919661A (en) 1997-08-25 1999-07-06 Incyte Pharmaceuticals, Inc. Polynucleotides encoding cytokine inducible regulatory protein
JPH11199507A (ja) 1998-01-09 1999-07-27 Chugai Pharmaceut Co Ltd 脳疾患及び神経疾患治療薬
WO2001009387A1 (en) 1999-07-29 2001-02-08 Northeastern University Isolation of novel hemapoietic genes by representational difference analysis
US6610713B2 (en) 2000-05-23 2003-08-26 North Shore - Long Island Jewish Research Institute Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US7317077B2 (en) 2001-11-16 2008-01-08 Nymox Pharmaceutical Corporation Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
EP1781267A4 (en) 2004-05-17 2009-03-11 Combinatorx Inc METHOD AND REAGENTS FOR THE TREATMENT OF INFAMOUS DISEASES
CA2675954A1 (en) * 2007-01-18 2008-07-24 Plant Bioscience Limited (Pbl) Methods and compositions for modulating the mirna pathway
WO2009090287A1 (es) * 2008-01-17 2009-07-23 Fundació Institut de Recerca de L'Hospital Universitari Vall d'Hebron Compuestos antitumorales basados en cirp
JP2012503673A (ja) * 2008-09-25 2012-02-09 ティッシュ リジェネレーション システムズ インコーポレイテッド ミネラルコーティングされたマイクロスフェア
US20140193412A1 (en) 2013-01-10 2014-07-10 The Feinstein Institute For Medical Research Treatment of cutaneous wounds by inhibiting cold shock proteins
EP3049438B1 (en) 2013-09-24 2018-07-25 The Feinstein Institute for Medical Research Peptides inhibiting cold-inducible rna binding protein activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102458465A (zh) * 2009-04-13 2012-05-16 范因斯坦医学研究院 通过抑制冷诱导rna结合蛋白(cirp)治疗炎性疾病

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOSEPH T. MCGINN MD ET AL: "Cold-inducible RNA-binding protein-derived peptide C23 attenuates inflammation and tissue injury in a murine model of intestinal ischemia-reperfusion", SURGERY *
XIAOLING QIANG ET AL: "Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis", NATURE MEDICINE *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113616776A (zh) * 2021-08-20 2021-11-09 兰州大学第二医院 一种阻断剂c23在制备治疗心肌梗死的药物中的应用

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