CN111803421A

CN111803421A - Moisturizing, whitening and skin-care cream

Info

Publication number: CN111803421A
Application number: CN202010810723.3A
Authority: CN
Inventors: 苏格格
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-08-13
Filing date: 2020-08-13
Publication date: 2020-10-23

Abstract

The invention discloses a moisturizing, whitening and skin-care cream. The moisturizing, whitening and skin-care cream comprises the following raw materials in parts by weight: 2-4 parts of a traditional Chinese medicine composition, 3-7 parts of glyceryl stearate, 0.1-1.5 parts of glyceryl monostearate, 2-6 parts of propylene glycol, 0.01-0.03 part of allantoin, 210.1-1 parts of steareth, 0.5-1 part of menthol, 0.01-0.05 part of methylparaben, 0.01-0.05 part of methylisothiazolinone and 70-80 parts of water. The mango leaf extract contained in the raw material traditional Chinese medicine composition can obviously inhibit the activity of tyrosinase and has a whitening effect. Meanwhile, the skin cream has obvious improvement effect on the increase of the skin moisture content and the reduction of the skin moisture loss, and has good moisturizing effect.

Description

Moisturizing, whitening and skin-care cream

Technical Field

The invention belongs to the field of cosmetics, and particularly relates to a moisturizing, whitening and skin-care cream.

Background

The cosmetic industry is one of the most popular industries at present, people pay more and more attention to the external image of the cosmetic along with the improvement of living standard, and meanwhile, the requirements on the safety and the function of the cosmetics are higher and higher. The rapid development of science and technology enables people to have a deeper understanding of many substances in nature, and people focus on natural Chinese herbal medicines gradually. The natural Chinese herbal medicine as the supplement of the functional components of the cosmetics becomes the mainstream of market development and is popular with consumers. The Chinese herbal medicine has obvious medicinal effect. Can be added into a cosmetic formula, has the functions of whitening, moisturizing, resisting oxidation, resisting allergy, resisting aging, protecting hair and the like, has good market prospect, and becomes a new development direction of the traditional Chinese medicine industry.

However, at present, research on cosmetics containing traditional Chinese medicine composition components with moisturizing and whitening effects is not deeply carried out, so that the development of the skin cream containing traditional Chinese medicine composition components with moisturizing and whitening effects has practical significance and wide market prospect.

Disclosure of Invention

In view of the above-mentioned drawbacks of the prior art, one of the technical problems to be solved by the present invention is to provide a moisturizing, whitening and skin-care cream.

In order to solve the technical problems, the invention adopts the technical scheme that:

the moisturizing, whitening and skin-care cream comprises the following raw materials:

traditional Chinese medicine composition, glyceryl stearate, glyceryl monostearate, propylene glycol, allantoin, steareth-21, menthol, methylparaben, methylisothiazolinone and water.

Preferably, the moisturizing and whitening skin cream comprises the following raw materials in parts by weight:

2-4 parts of a traditional Chinese medicine composition, 3-7 parts of glyceryl stearate, 0.1-1.5 parts of glyceryl monostearate, 2-6 parts of propylene glycol, 0.01-0.03 part of allantoin, 210.1-1 parts of steareth, 0.5-1 part of menthol, 0.01-0.05 part of methylparaben, 0.01-0.05 part of methylisothiazolinone and 70-80 parts of water.

The invention also discloses a preparation method of the moisturizing, whitening and skin-care cream, which comprises the following steps:

(1) mixing propylene glycol and steareth-21, uniformly stirring, adding water, heating to 80-90 ℃ under stirring, and heating for 10-15 min to form a water phase;

(2) mixing the traditional Chinese medicine composition, glyceryl stearate, glyceryl monostearate, allantoin and menthol, stirring uniformly, heating to 70-80 ℃, and heating for 10-15 min to form an oil phase;

(3) adding the oil phase in the step (2) into the water phase in the step (1), and stirring for 20-30 min;

(4) cooling to 45-55 ℃, adding methyl hydroxybenzoate and methylisothiazolinone, stirring for 5-10 min, and cooling to room temperature;

(5) after the inspection is qualified, filling, packaging and code spraying are carried out;

(6) and warehousing after the inspection is qualified.

The traditional Chinese medicine composition comprises the following raw materials:

cortex Dictamni Radicis, cortex Magnolia officinalis, radix Sophorae Flavescentis, Glycyrrhrizae radix, bupleuri radix, Ganoderma, and folium Mangifera Indicae extract.

Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

5-10 parts of cortex dictamni, 2-6 parts of mangnolia officinalis, 4-10 parts of radix sophorae flavescentis, 2-8 parts of liquorice, 2-8 parts of radix bupleuri, 3-8 parts of lucid ganoderma and 0.5-1 part of mango leaf extract.

The preparation method of the mango leaf extract comprises the following steps:

s1, selecting fresh mango leaves without insects and diseases, cleaning, drying in a drying oven at 70-80 ℃, and crushing for later use;

s2, weighing dried and crushed mango leaves according to a solid-liquid ratio of 1: (10-30) g/mL of the extract is added into an ethanol solution with the mass fraction of 95%, and ultrasonic extraction is carried out for 30-60 min at the ultrasonic power of 300-500W to obtain a mango leaf extract;

s3, cooling the mango leaf extracting solution to 20-30 ℃, filtering with a filter cloth of 100-200 meshes, collecting filtrate, and removing the solvent through reduced pressure distillation to obtain the mango leaf extract.

Preferably, the preparation method of the mango leaf extract comprises the following steps:

s2, weighing dried and crushed mango leaves according to a solid-liquid ratio of 1: (10-30) g/mL of the extract is added into an ethanol solution with the mass fraction of 95%, then cyclodextrin is added, ultrasonic extraction is carried out for 30-60 min, and the ultrasonic power is 300-500W, so as to obtain mango leaf extract;

The ultrasonic extraction temperature is 30-60 ℃.

The addition amount of the cyclodextrin is 0.01-0.02 time of the weight of the mango leaves.

The cyclodextrin is one or a mixture of two or more of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin.

Preferably, the cyclodextrin is prepared from alpha-cyclodextrin and gamma-cyclodextrin according to the mass ratio of (1-3): (1-3).

The preparation method of the traditional Chinese medicine composition comprises the following steps:

step (1): weighing the cortex dictamni, the magnolia officinalis, the radix sophorae flavescentis, the liquorice, the radix bupleuri and the lucid ganoderma according to the weight part ratio, crushing and uniformly mixing;

step (2): adding the uniformly ground and mixed powder into water according to the solid-to-liquid ratio of 1 (50-100) g/mL, and extracting at 60-100 ℃ for 1-5 h to obtain an extracting solution;

and (3): cooling the extracting solution to 20-30 ℃, filtering through 100-200 mesh filter cloth, filtering out medicine residues, performing vacuum filtration, collecting filtrate, performing reduced pressure distillation to remove a solvent, adding the mango leaf extract, and uniformly mixing to obtain the traditional Chinese medicine composition.

The traditional Chinese medicine composition adopted by the invention comprises the following components;

cortex Dictamni Radicis is the dry root bark of Dictamni Radicis of Rutaceae, and has bitter and cold properties, and has effects of clearing heat, eliminating dampness, dispelling pathogenic wind and removing toxic substance. Cortex Dictamni Radicis contains chemical components such as flavonoids, coumarins, alkaloids, and sesquiterpenes.

The cortex Magnolia officinalis is dry bark, root bark and branch bark of Magnolia officinalis of Magnoliaceae, bitter, pungent and warm, and has effects of eliminating dampness and phlegm, and descending qi and relieving fullness. The magnolia bark contains various chemical components such as volatile oil, phenols, alkaloids and the like, wherein the phenols are the characteristic components of the magnolia bark, and comprise honokiol, magnolol, isoborol and the like.

Radix Sophorae Flavescentis is the dried root of Sophora flavescens ait of Leguminosae, and is a good medicine for both oral administration and external use. Has good relieving effect on skin pruritus. The active ingredients of the radix sophorae flavescentis can balance skin grease secretion, dredge pores, remove toxins, repair damaged vascular nerve cells and restore the activity of the damaged vascular nerve cells; has the effects of removing acne, removing red blood streak, and caring skin, and can make skin compact, smooth, healthy and ruddy.

Glycyrrhrizae radix of Leguminosae family, including glycyrrhizin, licoflavone, glycyrrhizin, asparagine, mannitol, etc. The licoflavone is a good cosmetic active component, can reduce the formation of cell melanin, inhibit the activity of tyrosinase, has high antioxidant capacity, and can whiten skin and resist aging by adding the advanced cosmetic. The glycyrrhizin has the effects of inhibiting bacteria, resisting inflammation, treating wounds, effectively removing superoxide ions and alkyl free radicals, remarkably inhibiting liposome peroxide, and accelerating the absorption of components such as sun protection, whitening, conditioning, itching relieving, calming and the like by skin when being used together with other active components.

Radix bupleuri is dried root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae, and has effects of clearing away heat and toxic materials, diminishing inflammation, resisting bacteria, protecting liver and relieving pain. Radix bupleuri contains many chemical components, mainly including essential oil and saikosaponin. The saikosaponin can increase the proliferation activity of skin fibroblasts, promote the generation of skin hyaluronic acid and epidermal cell collagen, effectively improve and delay skin aging, enhance skin elasticity, reduce the generation of skin fine lines, and make the skin delicate, tender and elastic; can inhibit melanin generation, remove facial black speck, and can be used in speckle removing cosmetics.

Ganoderma is dry fruiting body of Ganoderma lucidum or Ganoderma sinense belonging to Polyporaceae, is rich in polysaccharide, triterpenes, proteins, alkaloids and trace elements, and has remarkable effects of resisting tumor, regulating immunity, resisting oxidation, reducing blood sugar, and protecting liver.

The folium Mangiferae Indicae is leaf of Mangifera Indicae of Anacardiaceae, contains ascorbic acid, tannin, mangiferin, and flavonoids, and the leaf extract can inhibit pyococcus and Escherichia coli, and can be used for treating heat stagnation abdominal pain, flatulence, infantile malnutrition, and ulcer. Mangiferin, also known as chinonin, is the main active ingredient of mango leaves. The inventor surprisingly finds that the mango leaf extract has an inhibiting effect on tyrosinase activity, so that the mango leaf extract is expected to be applied to cosmetics to achieve a whitening effect.

The inventor verifies through a large number of experiments that the inhibition rate of the obtained mango leaf extract on the tyrosinase activity is higher with the increase of the ultrasonic temperature, and the reason is that the dissolution rate of the effective components is higher with the higher ultrasonic temperature, and a better effect can be naturally obtained. However, when the ultrasonic temperature exceeds 60 ℃, the obtained mango leaf extract is prepared into a traditional Chinese medicine composition, and the inhibition rate of the tyrosinase activity is reduced. The inventor consults a large amount of data, and knows that the main component in mango leaves is mangiferin, and the stability of the mangiferin is damaged due to overhigh temperature, so that the properties of the mangiferin are changed, and the extraction amount of the active component mangiferin is reduced.

Furthermore, in order to solve the technical problem that the stability of mangiferin is damaged due to overhigh temperature in the extraction process, the cyclodextrin is added in the extraction process.

Cyclodextrins are cyclic oligosaccharides composed of D-glucose linked by alpha-l, 4-glycosidic bonds. The most common cyclodextrins are alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin, containing 6, 7, 8 alpha-D-glucose, respectively. Cyclodextrins are considered to be typical host molecules, the interaction of guest molecules with the hydrophobic cavity of the host facilitates the inclusion process, and the geometrical compatibility of the host and guest, the structure, charge and polarity of the guest, the reaction medium and temperature have a significant influence on the formation of inclusion compounds. The cyclodextrin has a ring-shaped three-dimensional structure, amphoteric molecules with hydrophobic inner cavities and hydrophilic outer cavities form a cone-shaped hydrophobic cavity, the mangiferin molecules and the cyclodextrin have weak intermolecular interaction force, enter the cavity and are wrapped by the cyclodextrin, and the mangiferin molecules are protected by the outer-layer cyclodextrin, so that the mangiferin extract is extracted at high temperature, the structural property of the mangiferin extract cannot be changed, and the content of active ingredients in mango leaves is remarkably improved.

A large number of experiments show that when the added cyclodextrin is a mixture of alpha-cyclodextrin and gamma-cyclodextrin, the mango leaf extract obtained by extraction is prepared into a traditional Chinese medicine composition, and the inhibition rate of the mango leaf extract on the tyrosinase activity is the highest. The reason for this is that the main active ingredient in mango leaves, in addition to mangiferin, has some other active ingredients, which also have an inhibitory effect on tyrosinase activity. The molecular size of the components is larger than that of mangiferin, so that the gamma-cyclodextrin with the largest cavity is needed to match to form a wrapping compound to stabilize the structure of the mangiferin.

The invention has the advantages of

(1) The moisturizing, whitening and skin-care cream disclosed by the invention has an obvious inhibition effect on the activity of tyrosinase and has a whitening effect.

(2) The moisturizing, whitening and skin-care cream disclosed by the invention has no irritation, no discomfort reaction such as allergy and the like to skin, has an obvious improvement effect on the increase of the moisture content of the skin and the reduction of the moisture loss of the skin, and has a good moisturizing effect.

(3) The invention solves the technical problem that the stability of mangiferin is damaged due to overhigh temperature in the extraction process, cyclodextrin is added in the extraction process, the cyclodextrin has a ring-shaped three-dimensional structure, amphoteric molecules with hydrophobic inner cavities and hydrophilic outer cavities form a cone-shaped hydrophobic cavity, intermolecular weak interaction force exists between the mangiferin molecules and the cyclodextrin, the mangiferin molecules enter the cavity and are wrapped by the cyclodextrin, and the mangiferin molecules are protected by the outer-layer cyclodextrin, so that the extraction is carried out at high temperature, the structural property of the mangiferin molecules cannot be changed, the content of effective components in mango leaves is remarkably improved, and the inhibition effect of the components of a traditional Chinese medicine composition on the activity of tyrosinase is further improved.

Detailed Description

In the examples, the sources of the raw materials are as follows:

cortex Dictamni Radicis, cortex Magnolia officinalis, radix Sophorae Flavescentis, Glycyrrhrizae radix, bupleuri radix, and Ganoderma are all purchased from Chinese medicinal materials group company, and meet 2005 edition standard of the Chinese people's republic of medicine dictionary.

Mango leaves: mature leaf of Tainong No. 1, Fujian.

Cyclodextrin: alpha-cyclodextrin; beta-cyclodextrin; gamma-cyclodextrin, food grade, is purchased from Zhiyuan Biotech limited, Binzhou, Shandong.

Betaine: CAS number; 107-43-7, available from Shanghai Allantin Biotechnology Ltd.

Propylene glycol: 1, 2-propanediol, CAS number; 57-55-6, available from Shanghai Aladdin Biotechnology Ltd.

Allantoin: CAS number; 97-59-6, available from Shanghai leaf Biotech, Inc.

Methyl hydroxybenzoate: CAS number; 99-76-3, available from Shanghai-derived leaf Biotech, Inc.

Glycerol stearate: CAS: 85666-92-8, available from Shanghai asking color New Material science and technology, Inc.

Glyceryl monostearate: CAS number; 123-94-4, available from Jiangsu Caesami Biotechnology Ltd.

Steareth-21: CAS number; 9005-00-9, available from Guangdong Wengjiang chemical reagents, Inc.

Example 1

The moisturizing, whitening and skin-care cream comprises the following raw materials in parts by weight:

3 parts of traditional Chinese medicine composition, 6 parts of glyceryl stearate, 1 part of glyceryl monostearate, 5 parts of propylene glycol, 0.02 part of allantoin, 211 parts of steareth-211 parts, 0.8 part of menthol, 0.01 part of methyl hydroxybenzoate, 0.01 part of methylisothiazolinone and 80 parts of water.

The preparation method of the moisturizing, whitening and skin-care cream comprises the following steps:

(1) mixing propylene glycol and steareth-21, stirring, adding water, heating to 85 deg.C under stirring, and heating for 15min to form water phase;

(2) mixing the Chinese medicinal composition, glyceryl stearate, glyceryl monostearate, allantoin, and menthol, stirring, heating to 75 deg.C, and heating for 15min to form oil phase;

(3) adding the oil phase in the step (2) into the water phase in the step (1), and stirring for 20 min;

(4) cooling to 50 deg.C, adding methyl hydroxybenzoate and methylisothiazolinone, stirring for 10min, and cooling to room temperature;

(6) and warehousing after the inspection is qualified.

The traditional Chinese medicine composition comprises the following raw materials in parts by weight:

6 parts of cortex dictamni, 5 parts of mangnolia officinalis, 5 parts of radix sophorae flavescentis, 4 parts of liquorice, 5 parts of radix bupleuri, 5 parts of lucid ganoderma and 0.5 part of mango leaf extract.

step (2): adding the uniformly ground powder into water according to the solid-to-liquid ratio of 1:50g/mL, and extracting at 80 ℃ for 2 hours to obtain an extracting solution;

and (3): cooling the extract to 25 ℃, filtering with 100-mesh filter cloth, filtering out residues, performing vacuum filtration, collecting filtrate, distilling under reduced pressure to remove solvent, adding mango leaf extract, and mixing to obtain the traditional Chinese medicine composition.

The preparation method of the mango leaf extract comprises the following steps:

s2, weighing dried and crushed mango leaves according to a solid-liquid ratio of 1: adding 10g/mL of the extract into 95% ethanol solution, and performing ultrasonic extraction at 40 ℃ for 30min with ultrasonic power of 300 to obtain mango leaf extract;

s3, cooling the mango leaf extracting solution to 25 ℃, filtering the mango leaf extracting solution by using a filter cloth of 100 meshes, collecting filtrate, and removing the solvent by reduced pressure distillation to obtain the mango leaf extract.

Example 2

Essentially the same as example 1, the only difference being:

the ultrasonic extraction temperature is 50 ℃.

Example 3

Essentially the same as example 1, the only difference being:

the ultrasonic extraction temperature is 60 ℃.

Example 4

(6) and warehousing after the inspection is qualified.

The preparation method of the mango leaf extract comprises the following steps:

s2, weighing dried and crushed mango leaves according to a solid-liquid ratio of 1: adding 10g/mL of the extract into 95% ethanol solution, adding cyclodextrin, wherein the addition amount of the cyclodextrin is 0.01 times of the weight of the mango leaves, and performing ultrasonic extraction at 60 ℃ for 30min with the ultrasonic power of 300W to obtain mango leaf extract;

The cyclodextrin is alpha-cyclodextrin.

Example 5

Essentially the same as example 4, the only difference being:

the cyclodextrin is beta-cyclodextrin.

Example 6

Essentially the same as example 4, the only difference being:

the cyclodextrin is gamma-cyclodextrin.

Example 7

Essentially the same as example 4, the only difference being:

the cyclodextrin is prepared from alpha-cyclodextrin and beta-cyclodextrin in a mass ratio of 3: 1 are mixed.

Example 8

Essentially the same as example 4, the only difference being:

the cyclodextrin is prepared from alpha-cyclodextrin and gamma-cyclodextrin according to a mass ratio of 3: 1 are mixed.

Example 9

Essentially the same as example 4, the only difference being:

the cyclodextrin is prepared from beta-cyclodextrin and gamma-cyclodextrin according to a mass ratio of 3: 1 are mixed.

Comparative example 1

(6) and warehousing after the inspection is qualified.

6 parts of cortex dictamni, 5 parts of mangnolia officinalis, 5 parts of radix sophorae flavescentis, 4 parts of liquorice, 5 parts of radix bupleuri and 5 parts of lucid ganoderma.

and (3): cooling the extractive solution to 25 deg.C, filtering with 100 mesh filter cloth, filtering to obtain residue, vacuum filtering, collecting filtrate, and distilling under reduced pressure to remove solvent to obtain the Chinese medicinal composition.

Test example 1

Whitening performance test of moisturizing, whitening and skin-care cream

Tyrosinase activity inhibition assay

Solutions of the moisturizing, whitening and skin-care creams of examples 1 to 9 and comparative example 1 at a concentration of 0.2mg/mL were prepared using 0.2mol/L Phosphate Buffered Saline (PBS) having a pH of 6.8 as a solvent.

0.9mL of each of the moisturizing, whitening and skin-caring creams prepared in examples 1 to 9 and comparative example 1, which had a concentration of 0.2mg/mL, was added with 1mL of L-tyrosine (0.3mol) and 1mL of Phosphate Buffered Saline (PBS) having a pH of 6.8, and the mixture was preheated in a constant-temperature water bath at 37 ℃ for 10 minutes, then 0.01mL of an aqueous solution of tyrosinase (1.0mg/mL, mcllains buffer) was added thereto, the mixture was thoroughly stirred, and after a reaction at 37 ℃ for 15 minutes, absorbance at 475nm was measured (D1). In addition, the same reaction was carried out using the above phosphate buffer solution in place of the 0.2mg/mL solution prepared in the moisturizing, whitening and skin care creams of examples 1 to 10 and comparative example 1, and the absorbance (D2) was measured. For control, absorbance was measured without addition of the sample solution and tyrosinase (D3). The tyrosinase activity inhibition rate was calculated by the following formula.

Tyrosinase activity inhibition rate (%) (D2-D1)/(D2-D3) × 100

The results are shown in table 1:

table 1: tyrosinase activity inhibition rate test result table

Test results show that the moisturizing, whitening and skin-care cream has an inhibiting effect on tyrosinase activity.

Comparing examples 1-3 with comparative example 1, the moisturizing, whitening and skin-care creams of examples 1-3 contain mango leaf extract, and have a significantly better inhibiting effect on tyrosinase activity than comparative example 1. Comparing examples 1-3, it can be seen that the obtained mango leaf extract is prepared into a moisturizing and whitening skin cream with the increase of the ultrasonic temperature, the higher the inhibition rate of the mango leaf extract on the tyrosinase activity is, and when the ultrasonic temperature is 60 ℃, the obtained mango leaf extract is prepared into a moisturizing and whitening skin cream with the decrease of the inhibition rate on the tyrosinase activity. The reason is that the mangiferin is the main component in the mango leaves, and the stability of the mangiferin is damaged due to overhigh temperature, so that the properties of the mangiferin are changed, and the extraction amount of the active component mangiferin is reduced.

Further, comparative examples 3 to 6; in the embodiments 4-6, cyclodextrin is added in the extraction process, and the obtained mango leaf extract is prepared into a traditional Chinese medicine composition, so that the tyrosinase activity inhibition rate is obviously improved compared with that in the embodiment 3. The reason is that the cyclodextrin has a ring-shaped three-dimensional structure, amphiphilic molecules with a hydrophobic inner cavity and a hydrophilic outer cavity form a cone-shaped hydrophobic cavity, the mangiferin molecules and the cyclodextrin have weak intermolecular interaction force, enter the cavity and are wrapped by the cyclodextrin, and the mangiferin molecules are protected by the outer-layer cyclodextrin, so that the mangiferin extract is extracted at high temperature, the structural property of the mangiferin extract cannot be changed, and the content of effective components in mango leaves is remarkably improved.

Furthermore, in comparative examples 7-9, the effect of (alpha, beta, gamma) cyclodextrin compounding with different cavity sizes on the extraction effect is examined. Tests show that when the cyclodextrin is a mixture of alpha-cyclodextrin and gamma-cyclodextrin in example 8, the mango leaf extract obtained by extraction is prepared into the moisturizing, whitening and skin-care cream, and the inhibition rate of the mango leaf extract on the tyrosinase activity is highest. The reason for this is that the main active ingredient in mango leaves contains, in addition to mangiferin, other ingredients, which also have an inhibitory effect on tyrosinase activity. The molecular size of the components is larger than that of mangiferin, so that the gamma-cyclodextrin with the largest cavity is needed to match to form a wrapping compound to stabilize the structure of the mangiferin.

Test example 2:

test of moisturizing Effect

Skin stratum corneum hydration test: the working principle is that the capacitor is used as an instrument probe, and as water is a substance with the largest dielectric constant on the skin, when the moisture content of the skin changes, the capacitance value of the skin also changes, so that the moisture content on the surface of the skin can be analyzed by measuring the capacitance value of the skin. The instrument used was Corneometer CM 825. The change of the moisture content of the stratum corneum is measured by measuring the change of the capacitance value of the stratum corneum of the skin before and after the product is used, so that the moisture content of the stratum corneum of the skin cream is evaluated quantitatively, the change of the moisture content of the skin can be sensitively reflected, the reproducibility is good, and the method is one of the commonly used methods for evaluating the efficacy of the skin cream at present.

The experimental method comprises the following steps: marking out 3X 3cm on the bent side of the left and right forearms of the person to be tested²The method comprises the steps of uniformly coating 0.1g of anti-moisturizing whitening skin cream in each square centimeter in a square experiment area with the left arm as a testing area of a moisturizing product, taking a corresponding symmetrical area of the right arm as a blank control, testing and detecting the moisture content of each test part by using a Corneometer CM825, and repeating for 5 times respectively to obtain an average value. The hydration rate was calculated by the formula (1).

Hydration rate ═ (test value-blank value)/blank value × 100% formula (1)

Table 2: moisturizing effect test result table

The moisture-preserving whitening skin cream has the advantages that the moisture content increase rate of the skin is more than 24.1% through tests, and the moisture-preserving whitening skin cream has a good moisture-preserving effect. The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims

1. The moisturizing, whitening and skin-care cream is characterized by comprising the following raw materials:

2. The moisturizing, whitening and skin-care cream as claimed in claim 1, is characterized by comprising the following raw materials in parts by weight:

3. The moisturizing, whitening and skin-care cream as claimed in claim 2, wherein the preparation method of the moisturizing, whitening and skin-care cream comprises the following steps:

(6) and warehousing after the inspection is qualified.

4. The moisturizing, whitening and skin-care cream as claimed in claim 2, wherein the traditional Chinese medicine composition comprises the following raw materials:

5. The moisturizing, whitening and skin-care cream as claimed in claim 4, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

6. The moisturizing, whitening and skin-care cream as claimed in claim 4 or 5, wherein the preparation method of the mango leaf extract comprises the following steps:

7. The moisturizing and whitening skin cream according to claim 6, wherein the preparation method of the mango leaf extract comprises the following steps:

8. The moisturizing, whitening and skin-care cream according to claim 6 or 7, characterized in that the ultrasonic extraction temperature is 30-60 ℃.

9. The moisturizing, whitening and skin-care cream as claimed in claim 7, wherein the cyclodextrin is added in an amount of 0.01-0.02 times of the weight of the mango leaves.

10. The moisturizing, whitening and skin-care cream as claimed in claim 7, wherein the cyclodextrin is one or a mixture of two or more of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin.