CN111801108A - 局部皮肤护理组合物 - Google Patents
局部皮肤护理组合物 Download PDFInfo
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- CN111801108A CN111801108A CN201980016515.1A CN201980016515A CN111801108A CN 111801108 A CN111801108 A CN 111801108A CN 201980016515 A CN201980016515 A CN 201980016515A CN 111801108 A CN111801108 A CN 111801108A
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Abstract
本发明公开了组合物及其用于治疗人皮肤,特别是面部皮肤,以缓解化妆或皮肤病学皮肤病症的症状的用途。该组合物包含黑柳树皮提取物、猫爪藤提取物和血竭提取物。该组合物改善包括痤疮、酒渣鼻、瑕疵、皮炎、湿疹等皮肤病症。
Description
发明领域
本发明涉及包含一种或多种植物提取物的皮肤护理组合物。更具体地,本发明涉及包含黑柳树皮提取物、猫爪藤提取物和血竭提取物的皮肤护理组合物,及其用于改善某些皮肤病症的用途。
发明背景
痤疮是在青春期流行的皮肤疾病。其最常出现在患者的面部和躯干。痤疮的基本病变是粉刺或皮脂腺毛囊的“黑头”。在其最温和的形式时,仅存在少量粉刺,但在其严重的形式时,存在大量严重的、持久的粉刺。永久性疤痕经常是严重形式痤疮的后果。
痤疮本质上是由于青春期雄激素如睾酮的产生增加,其刺激皮脂腺以增加皮脂的产生。同时观察到毛囊导管的过度角质化,在皮脂腺毛囊中形成一种环境,该环境富含细菌菌群的营养物,并且其尤其促进类白喉厌氧细菌如丙酸杆菌(例如痤疮丙酸杆菌、颗粒丙酸杆菌(granulosnm)、贪婪丙酸杆菌)的繁殖。由于这些角质嵌塞中细菌的生长,毛囊破裂,引发该疾病的炎症阶段,其呈脓疱、丘疹、囊肿和结节形式。
通常使用的痤疮治疗是角质溶解剂如水杨酸或其衍生物,以去除死皮或过度角质化的皮肤,以及抗菌剂。各种方法已用于治疗痤疮,包括使用剥离剂、用于女性患者的激素疗法、抗菌疗法和普通外科皮肤磨削。
尽管已经使用的激素和抗菌药物的全身给药取得了一定的成功,但直到最近,还没有特别有效的局部治疗。因此,仍然需要供选择的温和的、“天然的”局部皮肤护理组合物,其改善包括痤疮、酒渣鼻、瑕疵、皮炎、湿疹等的皮肤病症,同时提供对皮肤外观和品质的优异改善。
发明概述
提出了局部皮肤护理组合物的各种实施方案。在一个实施方案中,本发明包括局部皮肤护理组合物,其包含黑柳树皮提取物、猫爪藤提取物和血竭提取物。一方面,该组合物包含约0.5重量%(wt%)至约10重量%的黑柳树皮提取物。另一方面,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物。另一方面,该组合物包含约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约7重量%的猫爪藤提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物是乳液、凝胶、乳膏、洗剂、精华液或溶液。另一方面,该组合物还包含以下中的至少一种:乳化剂、保湿剂、精油、遮光剂、药物活性剂、化妆品成分、甘油三酸酯、结构剂、抗氧化剂、防腐剂、树胶、多糖、聚合物、增稠剂、胶凝剂或维生素。另一方面,所述乳化剂是鲸蜡硬脂醇橄榄油酸酯或山梨坦橄榄油酸酯。另一方面,所述保湿剂是尿囊素。另一方面,所述精油是古巴香胶树(苦配巴香脂)树脂。另一方面,该组合物包含黑柳树皮提取物、猫爪藤提取物、血竭提取物、鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、古巴香胶树(苦配巴香脂)树脂、甘油、尿囊素、辛酸/癸酸甘油三酯、罗望子种子多糖、角叉菜(角叉菜胶)、疑拟香桃木(卡姆果)果实提取物、海茴香提取物、氢化植物油、圭亚那苦油楝种子油、巴西莓果油、互叶白千层(茶树)叶油、西番莲(百香果)种子油、巴西油桃木果油、生育酚、苯氧乙醇、乙基己基甘油和水。另一方面,该组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、约0.1重量%至约5重量%的鲸蜡硬脂醇橄榄油酸酯、约0.1重量%至约5重量%的山梨坦橄榄油酸酯、约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约3重量%的甘油、约0.1重量%至约5重量%的尿囊素、约0.1重量%至约5重量%的辛酸/癸酸甘油三酯、罗望子种子多糖、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约3重量%的海茴香提取物、约0.1重量%至约5重量%的氢化植物油、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约3重量%的互叶白千层(茶树)叶油、约0.1重量%至约5重量%的西番莲(百香果)种子油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油、约0.1重量%至约3重量%的生育酚、约0.1重量%至约1.0重量%的苯氧乙醇、约0.1重量%至约1.0重量%的乙基己基甘油和约10重量%至约90重量%的水。
在另一个实施方案中,本发明包括一种治疗皮肤病症的方法,该方法包括将包含黑柳树皮提取物、猫爪藤提取物和血竭提取物的组合物局部施用于有其需要的皮肤,其中将该组合物局部施用于有其需要的皮肤改善皮肤病症。一方面,皮肤病症选自皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物。另一方面,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物。另一方面,该组合物包含约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约7重量%的猫爪藤提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物是乳液、凝胶、乳膏、洗剂、精华液或溶液。另一方面,该方法进一步包括添加以下中的至少一种:乳化剂、保湿剂、精油、遮光剂、药物活性剂、化妆品成分、甘油三酸酯、结构剂、抗氧化剂、防腐剂、树胶、多糖、聚合物、增稠剂、胶凝剂或维生素。另一方面,所述乳化剂是鲸蜡硬脂醇橄榄油酸酯或山梨坦橄榄油酸酯。另一方面,所述保湿剂是尿囊素。另一方面,所述精油是古巴香胶树(苦配巴香脂)树脂。另一方面,该组合物包含黑柳树皮提取物、猫爪藤提取物、血竭提取物、鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、古巴香胶树(苦配巴香脂)树脂、甘油、尿囊素、辛酸/癸酸甘油三酯、罗望子种子多糖、角叉菜(角叉菜胶)、疑拟香桃木(卡姆果)果实提取物、海茴香提取物、氢化植物油、圭亚那苦油楝种子油、巴西莓果油、互叶白千层(茶树)叶油、西番莲(百香果)种子油、巴西油桃木果油、生育酚、苯氧乙醇、乙基己基甘油和水。另一方面,该组合物包含0.5重量%至约10重量%的黑柳树皮提取物,约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物,约0.1重量%至约5重量%的鲸蜡硬脂醇橄榄油酸酯、约0.1重量%至约5重量%的山梨坦橄榄油酸酯、约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约3重量%的甘油、约0.1重量%至约5重量%的尿囊素、约0.1重量%至约5重量%的辛酸/癸酸甘油三酯、罗望子种子多糖、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约3重量%的海茴香提取物、约0.1重量%至约5重量%的氢化植物油、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约3重量%的互叶白千层(茶树)叶油、约0.1重量%至约5重量%的西番莲(百香果)种子油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油、约0.1重量%至约3重量%的生育酚、约0.1重量%至约1.0重量%的苯氧乙醇、约0.1重量%至约1.0重量%的乙基己基甘油和约10重量%至约90重量%的水。
在另一个实施方案中,本发明包括一种试剂盒,该试剂盒包含设置于容器内的组合物,该组合物包含黑柳树皮提取物,猫爪藤提取物和血竭提取物。
在另一个实施方案中,本发明包括一种局部皮肤护理组合物,其包含约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。
在另一个实施方案中,本发明包括一种用于抑制或治疗中度至重度寻常痤疮的维持治疗方法(regime)/方案(regimen),其包括:首先向需要这样的治疗的受试者局部给予治疗有效量的第一局部皮肤护理组合物,持续1至14天的第一预定时间段,该组合物包含黑柳树皮提取物、猫爪藤提取物和血竭提取物;和在1至14天的第一预定时间段之后,将治疗有效量的第二局部皮肤护理组合物局部施用到需要这样的治疗的受试者的受影响的皮肤区域上,持续最长达8周的第二预定时间段,该组合物包含苦配巴香脂树脂、卡姆果果实提取物、苦油树种子油、阿萨伊果油、pequi果油。一方面,该局部皮肤护理组合物包含配制到可接受的局部载体中的约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,一天一次局部施用固定剂量组合。另一方面,所述可接受的局部载体包括乳液、凝胶、水凝胶、乳膏、洗剂、精华液或溶液。另一方面,第二局部皮肤护理组合物包含约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。
在另一个实施方案中,本发明包括一种采用组合物治疗皮肤病症的方法,所述皮肤病症选自皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症,所述组合物包含配制到可接受的局部载体中的约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
在另一个实施方案中,本发明包括一种抗瑕疵和抗衰老的组合物,其包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。
还提出了一种通过将根据本发明的组合物局部施用于有其需要的皮肤来治疗皮肤病症的方法,其中将所述组合物局部施用于有其需要的皮肤改善皮肤病症。所述皮肤病症可以选自皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症。在另一个实施方案中,所述皮炎病症选自脂溢性皮炎、钱币状皮炎、接触性皮炎、特应性皮炎、剥脱性皮炎、口周皮炎和淤积性皮炎。
还提供了一种试剂盒,其包含设置于容器内的本发明的组合物。
附图简述
为了更全面地理解本发明的特征和优点,现在参考本发明的详细说明以及附图,并且在附图中:
图1A是显示使用本发明治疗之前的受试者的照片,而图1B是显示使用本发明治疗后的受试者的照片。
图2A是显示使用本发明治疗之前的受试者的照片,图2B是显示使用本发明初始治疗之后的受试者的照片,而图2C显示治疗21天后的受试者显示完全消除。
图3A是显示使用本发明治疗之前的受试者的照片,而图3B是显示使用本发明治疗后的受试者的照片。
图4A和4B显示本发明相对于现有行业标准治疗的比较例。图4A是显示使用本发明治疗之前的受试者的照片,其中受试者曾一直使用行业中常用的标准治疗,而图4B是显示使用本发明治疗后的受试者的照片,以及具有使用本发明消除皮肤病症的近视图的插图。
图5A和5B显示本发明相对于现有行业标准治疗的比较例。图5A是显示使用本发明治疗之前的受试者的照片,其中受试者曾一直使用行业中常用的标准治疗,而图5B是显示使用本发明治疗后的受试者的照片以及具有使用本发明消除皮肤病症的近视图的插图。
图6A和6B显示本发明相对于现有行业标准治疗的比较例。图6A是显示使用本发明治疗之前的受试者的照片,其中受试者曾一直使用行业中常用的标准治疗15年。比较起来,图6B是显示使用本发明治疗后的受试者的照片,以及具有使用本发明消除皮肤病症的近视图的插图。
发明详述
虽然下文详细讨论了本发明的各种实施方案的形成和使用,但是应当理解,本发明提供了许多可应用的创造性构思,这些构思可以在很多具体上下文中体现。本文讨论的具体实施方案仅是说明形成和使用本发明的具体方式,并不界定本发明的范围。
为了促进对本发明的理解,下文定义了许多术语。本文所定义的术语具有与本发明有关的领域的普通技术人员通常理解的含义。诸如“一(a)”、“一(an)”和“所述(the)”的术语不旨在仅指代单数实体,而是包括其中可用具体实例来说明的大类。本文的术语用于描述本发明的具体实施方案,但是除了权利要求中概述的以外,它们的使用不限制本发明。
如本文所用的,术语“局部施用”是指组合物施用或散布到皮肤表面或其他身体表面上。“局部皮肤组合物”包括适合用于在角质组织上局部施用的组合物。这样的组合物通常是在皮肤病学上可接受的,因为当施用于皮肤时,它们不具有不适当的毒性、不相容性、不稳定性、过敏反应等。本发明的局部皮肤护理组合物可具有选定的粘度,以避免在施用于皮肤后明显的滴落或聚集。
如本文所用的,术语“角质组织”包括被布置为哺乳动物的最外层保护覆盖物的含角蛋白的层,并且包括但不限于皮肤、毛发和指甲。
如本文所用的,术语“非挥发油”是指在常温或室温下不会蒸发的那些物质。
当在权利要求书和/或说明书中使用时,如本文所用的,术语“混合物(mixture)”、“混合(mix)”和“混合(mixing)”或这些术语的任何变型包括:搅拌、共混、分散、研磨、均质化和其他组合本发明的成分的类似方法。所公开的组合物的组分或成分的混合可以形成溶液。在其他实施方案中,混合物可以不形成溶液。成分/组分也可以作为未溶解的胶体悬浮液存在。
如本文所用的,术语“约”或“大约”被定义为接近于本领域普通技术人员所理解的,并且在一个非限制性实施方案中,所述术语被定义为在10%以内,优选在5以内%,更优选在1%以内,最优选在0.5%以内。
如本文所用的,术语“基本上”及其变型被定义为在很大程度上但并非必须完全是本领域普通技术人员所理解的规定内容,并且在一个非限制性实施方案中,基本上是指在10%以内、在5%以内、在1%以内或0.5%以内的范围。
如本文所用的,当在权利要求书和/或说明书中使用时,术语“抑制”或“减少”或这些术语的任何变型包括任何可测量的减少或完全抑制,以达到期望的结果。
如本文所用的,术语“有效量”是指有效产生减少、预防和/或改善皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和/或皮肤发炎的皮肤病症的预期效果的本发明的组合物和方法的量。尽管不是对本发明的限制,并且仅出于解释的目的,皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症可以是由细菌、环境状况、激素变化、年龄、阳光暴露、暴露于潮湿或干燥条件、对皮肤的急性或慢性损害、饮食及其组合引起的。
如本文所用的,术语“健康皮肤”或“正常皮肤”是指未损伤的皮肤,即没有视觉上明显的红斑、水肿、色素沉着过度、色素沉着不足或色素沉着不均匀、鳞屑形成、干燥症或水疱形成。在组织学上,健康皮肤或正常皮肤是指具有包括组织良好的基底层、棘层和颗粒层的形态外观的皮肤组织以及连贯的多层角质层。另外,正常或健康的表皮包括终末分化的复层鳞状上皮,其具有与下面的真皮组织的起伏连接。正常或健康皮肤通常不包括液体潴留、细胞浸润、任何细胞类型的过度增殖或增殖不足、肥大细胞脱颗粒、角化不全等迹象,并且意味着朗格汉斯细胞和真皮树突状细胞的正常树突化过程。这种外观在皮肤病学教科书,例如,HISTOPATHOLOGY OF THE SKIN,Lever和Schaumburg-Lever(编辑),J.B.Lippincott Company(1991)和TEXTBOOK OF DERMATOLOGY,Champion等人(编辑),第5版,BlackwellScientific Publications(1992年),特别是第3章“人体皮肤的解剖学和组织”;PHYSIOLOGY,BIOCHEMISTRY AND MOLECULAR BIOLOGY OF THE SKIN,第I和II卷,Goldsmith(编辑),Oxford Press(1991)中记载,相关部分通过引用并入本文。
在一个实施方案中,本发明的组合物可以是药学上或美容上优雅的。如本文所用的,术语“药学上优雅的”和/或“化妆上优雅的”描述具有在皮肤上感到愉悦的特别触觉特性的组合物(例如,不太水样或油腻的组合物,具有柔滑质地的组合物,不发粘或粘性的组合物等)。药学上或化妆上优雅的也可以涉及组合物的乳脂状或润滑性或组合物的保湿性。
本发明的组合物通常与基于预期的给予形式选择的并且与常规制药实践一致的合适的药用盐、缓冲液、稀释剂、增量剂、赋形剂和/或载体(在本文中统称为药学上可接受的载体或载体材料)混合给予。根据最佳的给予位置,可以配制组合物以提供例如最大和/或一致的剂量用于局部给予。尽管该组合物可以单独给药,但其通常将以稳定的盐形式与药学上可接受的载体混合提供。根据所选择的给予类型和/或给予位置,载体可以是固体或液体。
在以下一篇或多篇参考文献中描述了使用本发明制备有用剂型的技术和组合物。Anderson,Philip O.;Knoben,James E.;Troutman,William G编辑,Handbook ofClinical Drug Data,第十版,McGraw-Hill,2002;Pratt和Taylor编辑,Principles ofDrug Action,第三版,Churchill Livingston,纽约,1990年;Katzung编辑,Basic andClinical Pharmacology,第9版,McGraw Hill,20037ybg;Goodman和Gilman编辑,ThePharmacological Basis of Therapeutics,第十版,McGraw Hill,2001;Remington’sPharmaceutical Sciences,第20版,Lippincott Williams&Wilkins.,2000年;Martindale,The Extra Pharmacopoeia,第三十二版(The Pharmaceutical Press,伦敦,1999年);Remington:The Science and Practice of Pharmacy,Pharmaceutical Press,第22版(2012);所有这些都通过引用并入,以此类推,相关部分通过引用并入本文。
组合物可以以局部递送系统的形式给予,其可包含那些药用盐、缓冲液、稀释剂、增量剂、赋形剂和/或载体(在本文中统称为药学上可接受的载体或载体材料,通常用于局部给予)。一个这样的非限制性实例是脂质体递送系统,例如小的单层囊泡,大的单层囊泡和多层囊泡,无论带电荷的还是不带电荷的。脂质体可包括一种或多种:磷脂(例如胆固醇)、硬脂胺和/或卵磷脂、其混合物等。局部用组合物还可以连接到作为药物载体的一种或多种可溶的、可生物降解的、生物可接受的聚合物或作为前药,这样的聚合物可以包括:聚乙烯吡咯烷酮、吡喃共聚物、聚羟丙基甲基丙烯酰胺-苯酚、聚羟乙基天冬酰胺苯酚(polyhydroxyethylasparta-midephenol)或被棕榈酰基残基取代的聚环氧乙烷-聚赖氨酸、它们的混合物等。此外,可将组合物与一种或多种可生物降解的聚合物连接以实现组合物的受控释放,用于本发明的可生物降解的聚合物包括:聚乳酸、聚乙醇酸、聚乳酸和聚乙醇酸的共聚物、聚ε-己内酯、聚羟基丁酸、聚原酸酯、聚缩醛、聚二氢吡喃、聚氰基丙烯酸酯和水凝胶的交联或两亲嵌段共聚物,其混合物等。
在某些实施方案中,本发明克服了现有技术的已知问题,特别是需要避免包括过氧化苯甲酰、水杨酸、阿达帕林和/或视黄醇的严苛化学处理和/或剥离。因此,在某些实施方案中,本发明的组合物不含或基本上不含过氧化苯甲酰、水杨酸、阿达帕林和/或视黄醇。已知过氧化苯甲酰、水杨酸、阿达帕林和/或视黄醇具有明显的副作用,包括严重的皮肤刺激、过敏反应、甚至是与这样的过敏反应有关的喉咙发紧、呼吸问题或眼睛、面部、嘴唇或舌肿胀。
本发明是目前用于治疗痤疮、酒渣鼻、瑕疵、皮炎、湿疹和其他皮肤病症使用的组合物和成分的有效替代方案。
本发明的具体实施方案的以下实施例是用于说明本发明的目的,并不旨在限制本发明的范围。
一方面,所述局部皮肤护理组合物包含黑柳树皮提取物、猫爪藤提取物和血竭提取物。在一个实施方案中,该组合物包含总重量(wt%)的约0.5重量%至约10重量%的黑柳树皮提取物。在一个实施方案中,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物。在一个实施方案中,该组合物包含约0.2重量%至约8重量%的血竭提取物。如本文所用的,术语“重量百分比”或“重量%”是指组分相对于组合物的总重量的重量百分比。
在一个实施方案中,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约7重量%的猫爪藤提取物。在一个实施方案中,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约8重量%的血竭提取物。在一个实施方案中,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
在一个实施方案中,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
在一个实施方案中,该组合物可包含约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。
在一个实施方案中,该组合物包含黑柳树皮提取物、猫爪藤提取物、血竭提取物、鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、古巴香胶树(苦配巴香脂)树脂、甘油、尿囊素、辛酸/癸酸甘油三酯、罗望子种子多糖、角叉菜(角叉菜胶)、疑拟香桃木(卡姆果)果实提取物、海茴香提取物、氢化植物油、圭亚那苦油楝种子油、巴西莓果油、互叶白千层(茶树)叶油、西番莲(百香果)种子油、巴西油桃木果油、生育酚、苯氧乙醇、乙基己基甘油和水。
该组合物可包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、约0.1重量%至约5重量%的鲸蜡硬脂醇橄榄油酸酯、约0.1重量%至约5重量%的山梨坦橄榄油酸酯、约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约3重量%的甘油、约0.1重量%至约5重量%的尿囊素、约0.1重量%至约5重量%的辛酸/癸酸甘油三酯、罗望子种子多糖、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约3重量%的海茴香提取物、约0.1重量%至约5重量%的氢化植物油、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约3重量%的互叶白千层(茶树)叶油、约0.1重量%至约5重量%的西番莲(百香果)种子油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油、约0.1重量%至约3重量%的生育酚、约0.1重量%至约1.0重量%的苯氧乙醇、约0.1重量%至约1.0重量%的乙基己基甘油和约10重量%至约90重量%的水。
黑柳树皮提取物来自黑柳树(Salix nigra)的树皮。该提取物包含天然β羟基酸(BHA),并且被报道具有天然抗炎和防腐性质。这些BHA中的一种是天然形式的水杨酸,它是一种天然的去角质剂,并且由于其帮助皮肤脱落死细胞和清理毛孔的能力而被用于许多痤疮治疗;其也可以刺激新细胞的形成。柳树皮提取物还含有酚酸,如水杨苷、柳皮苷、fragilin、白杨苷、triandrin和vimalin,以及类黄酮、鞣质(没食子鞣质和儿茶素型鞣质)和矿物质,所有这些都使其有助于皮肤年轻化。
猫爪藤提取物源自绒毛钩藤(Uncaria tomentosa),该木质藤原产于南美和中美洲的热带丛林。猫爪藤这个名字源自植物叶子上的刺,其具有钩状形状,并且看起来像猫的爪子。发现猫爪藤具有强大的抗炎和抗氧化作用。在传统秘鲁医学中使用猫爪藤来治疗多种健康问题,尤其是消化不适和关节炎,以及治疗伤口、胃部问题和癌症。已记载,发现于猫爪藤的树皮和根中的羟吲哚生物碱刺激免疫系统,并具有各种不同的医用和愈合性质。最具免疫活性的生物碱被认为是异翅果定碱(isopteropodin)(异构体A),其增加体内的免疫反应,并起抗氧化剂的作用,以清除身体的自由基。猫爪藤中发现的化合物也可以起作用以杀死病毒、细菌和其他引起疾病的微生物。
血竭提取物是一种鲜红色的树脂,其是从许多不同的植物属的不同种获得的:巴豆属、龙血树属、黄藤属、省藤属和紫檀属。在一个实施方案中,血竭提取物获自海南龙血(Dracaena cambodiana)树。在另一个实施方案中,血竭提取物获自龙血巴豆(Crotonuechleri)树。当地的亚马逊土著人称这种植物性药材为“血竭”,因为其被砍割时从树渗出的红色汁液具有血的外观。如今,龙血树和黄藤树脂仍然经常作为血竭出售,而不同植物来源造成的区别很小或没有区别;然而,从黄藤获得的树脂已成为现代最常见的销售类型,通常是大树脂球的形式。自古以来,红色树脂就一直用作清漆、药物、熏香和染料。超过50项的临床研究已被报道和宣称因为血竭具有抗菌、消炎和抗微生物性质,因此其具有促进皮肤修复和用作抗菌剂的潜力。红色的汁液在皮肤上干燥并形成所谓的“第二皮肤”,该第二皮肤是一种隔离环境并同时加速再生的防护屏障。它还有助于减少发红的外观并改善皮肤的美观。
苦配巴香脂,一种从树的树干获得的油性油树脂,具有非常长的药用历史。在欧洲人到达南美之前,它已被土著人广泛使用,并且这些用途很快被欧洲人所接受。该树脂因其对抗胸部和泌尿生殖系统中的粘液的能力而特别受到重视。树脂和树皮都是止痛剂、抗酸剂、抗菌剂、抗真菌剂、抗炎剂、抗微生物剂、收敛剂、细胞抑制剂、缓和剂、消化剂、消毒剂、利尿剂、祛痰剂、轻度通便剂、驱虫剂和外伤药。从树干获得的树脂包含多种医学活性成分,包括30-90%的精油和不寻常的缩合鞣质。精油包含α-和β-石竹烯、倍半萜烯、树脂和萜烯酸。它改善消化,具有利尿和祛痰作用,并控制细菌感染。迄今为止进行的许多临床研究已经验证了苦配巴香脂的传统用途。例如,已表明它作为局部伤口愈合剂和抗炎剂非常有效。抗炎作用主要归因于倍半萜烯,特别是石竹烯,其也已显示出有效的止痛性质、针对指甲真菌的抗真菌性质和胃保护性质。树脂作为整体(特别是其二萜中的两种-黄脂酸和贝壳杉烯酸)已显示出对革兰氏阳性细菌的显著抗菌活性。该树脂外用用于治疗一系列皮肤问题,包括昆虫叮咬、湿疹、冻疮、溃疡和银屑病。
罗望子(Tamarind)种子多糖(TSP)是从罗望子树的种子获得的天然多糖聚合物,罗望子树是一种常绿植物,其在印度、非洲和整个远东地区非常普遍,在这些地方其主要作为食物种植。该果实包含含有高百分比的多糖的大种子,其具有积聚和保存重要的能量提供物质的功能。传统上,它用于腹痛、腹泻和痢疾、蠕虫感染、伤口愈合、疟疾和发烧、便秘、炎症、细胞毒性、淋病和眼病。它具有许多化学价值,并且富含植物化学物质,并且因此据报道该植物具有抗糖尿病活性、抗微生物活性、抗毒素活性(antivenomic activity)、抗氧化活性、抗疟疾活性、保肝活性、抗哮喘活性、通便活性和抗高血脂活性。
疑拟香桃木通常被称为卡姆果(camu camu)、卡姆果(Camu-Camu)、cacari或camocamo,是来自秘鲁和巴西的亚马逊雨林的一种小灌木丛河边树,其结出红色/紫色的樱桃样果实。高维生素C含量约为鲜重的2-3%,是果实的最重要性质。
海茴香(Crithmum maritimum)也被称为海蓬子、岩石海蓬子或海茴香(seafennel)。海茴香是一种可食用的野生植物。它见于不列颠和爱尔兰的南部和西部海岸、欧洲的地中海和西部海岸,包括加那利群岛、北非和黑海。该植物含有维生素C(抗坏血酸和脱氢抗坏血酸)、聚乙炔(包括法卡林醇和法卡林二醇)、类黄酮(地奥司明)、呋喃香豆素、果胶和矿物质锌、铁、镁、碘和硫酸盐。此外,从海茴香提取的精油含有物质乙酸香叶酯、莳萝油脑(dillapiole)、sabin、柠檬烯、百里酚甲基醚和γ萜品烯。
圭亚那苦油楝,也称为苦油树,在巴西和其他包括亚马逊雨林的国家中用于大众医药。实际上,苦油树的所有部分都得到了利用,包括用于治疗发炎和感染的种子油。圭亚那苦油楝的药用性质已经归因于柠檬苦素类化合物的存在,柠檬苦素类化合物是四降三萜类化合物。从圭亚那苦油楝种子获得的油含有不同的四降三萜类化合物,包括6α-乙酰氧基葛杜宁、7-脱乙酰氧基-7-氧杂葛杜宁和刺槐毒素、葛杜宁和安哥拉紫檀酸甲酯(methyl-angolensate)。种子油和这部分四降三萜类化合物表现出明显的抗炎和抗过敏性质。
由于其报道的高抗氧化剂水平,巴西莓(阿萨伊)已经被称赞具有广泛的健康促进和治疗好处。在巴西的许多地方,巴西莓具有用作药用植物和作为主食的历史。根据传统,它已用于治疗发烧、皮肤并发症、消化障碍和寄生虫感染。巴西莓在巴西也具有重要的经济意义。这是基于相对高的多酚含量,而多酚又与多种抗氧化、抗炎、抗增殖和心脏保护性质有关。
互叶白千层叶油,也称为茶树油或白千层油,是使用最广泛和研究最广泛的精油之一。在白千层油声称的所有性质中,其抗微生物活性受到了最多的关注。最早报道的推测利用该性质的互叶白千层植物的使用是新南威尔士州北部的邦加隆(Bundjalung)土著居民的传统用途。吸入捣碎的“茶树”叶以治疗咳嗽和感冒,或将其撒在伤口上,然后涂上药膏。此外,浸泡茶树叶以制备输注液来治疗喉咙痛或皮肤病。当代数据表明,白千层油的广谱活性包括抗菌、抗真菌、抗病毒和抗原生动物活性。
巴西油桃木,被称为pequi,是一种可食用的水果,在巴西某些地区,尤其是在巴西中西部地区受欢迎。可以从pequi果实的中果皮内的坚果/种子提取pequi精油。在巴西,该精油通常包含在传统的洗发水和保湿剂中,但它也开始在国际市场上获得发展。此外,由于生育酚和维生素A的抗氧化性质,pequi中高含量的这些化合物意味着皮肤和头发得到保护。消耗pequi可防止皮肤出现瑕疵,改善疤痕愈合,为皮肤添加丰富的光泽并防止过早衰老的迹象。根据传统,它也已被用于治疗湿疹和皮肤损伤。
本领域普通技术人员将能够通过使用本领域已知的任何合适方法从相应植物的部分分离出以上确定的任何一种提取物。在一个非限制性实施例中,植物(或植物的任何部分,如叶、茎、树皮、根、果实、花或花蕾、种子、种子荚、树液、整株植物等)可通过产生植物泥的机械手段被破坏。然后将植物泥加工成基本上不含杂质或不期望的固体。然后可以将植物泥倒入浅容器中,并迅速暴露于低温下,即例如在-20℃或更低的温度下急速冷冻,优选在真空下以除去水分(冻干)。然后可以将所得的提取物用于本发明的组合物。
在其他方面,水基、醇基或油基提取技术或其组合可用于整株植物或其任何部分(例如,叶、茎、树皮、根、果实、花或花蕾、种子、种子荚、树液、整株植物等)以产生提取物。在这样的过程中,将所需的植物部分或整个植物压碎(例如,搅拌器),然后使其经受期望的溶剂(例如水、醇、水/醇或油基溶剂)以获得期望的提取物。然后可以将提取物以液体形式存储、冻干或经受进一步的处理技术(例如加热,冷却等)。提取过程对于提取领域的普通技术人员来说是众所周知的(例如,浸渍、浸泡、渗滤、消化、煎煮、热连续提取、水醇提取、逆流提取、微波辅助提取、超声提取、超临界流体提取、环保冷媒提取(phytonic extract)(例如,使用氢氟碳溶剂)。
在一些实施方案中,该组合物被配制成局部皮肤组合物。该组合物可以是洗剂、乳膏、凝胶、乳液(例如水包油、油包水、水包硅氧烷、硅氧烷包水、水包油包水、水包油,油包水包油、硅氧烷包水包油等)、溶液(例如水溶液或水醇溶液)、无水碱(例如唇膏或粉)、软膏、乳状物、糊、气溶胶、固体形式,眼部啫喱等。组合物可以呈粉末形式(例如,干燥的、冻干的、颗粒状的等)。该组合物可以具有用于植物、植物部分或其提取物的皮肤病学可接受的溶媒或载体。所述组合物可以进一步包含保湿剂、抗氧化剂、结构剂或增稠剂和/或乳化剂(这些成分中的每一个的实例在下文提供)。该组合物可以进一步包含含硅氧烷的化合物和/或遮光剂。本发明的组合物还可包含以下附加成分中的任何一种、其任何组合或全部:水、防腐剂,含硅氧烷的化合物、精油、结构剂、维生素、药物成分或抗氧化剂、或这样的成分的任何组合或这样的成分的混合物。在某些方面,该组合物可以包括至少两种、三种、四种、五种、六种、七种、八种、九种、十种或所有在先前句子中确定的这些附加成分。这些附加成分的非限制性实例在整个说明书中被确定并且通过引用并入本部分。这样的成分的量按组合物的重量或体积计可以为0.0001%至99.9%,或者如本说明书的其他部分所公开的在其之间的任何整数或范围内,其通过引用并入本段。
在一些实施方案中,组合物可以进一步包含一种或多种乳化剂。乳化剂可以降低相之间的界面张力,并改善制剂和乳液的稳定性。乳化剂可包括非离子型乳化剂、阴离子型乳化剂、阳离子型乳化剂、两性离子型乳化剂或其组合。乳化剂的非限制性实例包括甘油的酯、丙二醇的酯、聚乙二醇的脂肪酸酯、聚丙二醇的脂肪酸酯、山梨醇的酯、脱水山梨糖醇酐的酯、羧酸共聚物、葡萄糖的酯和醚、乙氧基化醚、乙氧基化醇、烷基磷酸酯、聚氧乙烯脂肪醚磷酸酯、脂肪酸酰胺、酰基乳酸酯、皂、TEA硬脂酸酯、DEA油醇聚醚-3磷酸酯、聚乙二醇20脱水山梨醇单月桂酸酯(聚山梨酸酯20)、聚乙二醇5大豆甾醇、硬脂醇聚醚-2、硬脂醇聚醚-20、硬脂醇聚醚-21、鲸蜡硬脂醇聚醚-20。PPG-2甲基葡萄糖醚二硬脂酸酯、鲸蜡醇聚醚10、聚山梨酸酯80、鲸蜡醇磷酸酯、鲸蜡醇磷酸酯钾、二乙醇胺鲸蜡醇磷酸酯、聚山梨酸酯60、硬脂酸甘油酯、PEG-100硬脂酸酯及其混合物。在一个实施方案中,非离子型乳化剂是鲸蜡硬脂醇橄榄油酸酯或山梨坦橄榄油酸酯。在另一个实施方案中,乳化剂以约0.1重量%至约4.0重量%的量存在。
在一个实施方案中,该组合物还包含保湿剂。可以用于本发明的组合物的保湿剂的非限制性实例包括氨基酸、硫酸软骨素、双甘油、赤藓糖醇、果糖、葡萄糖、甘油、甘油聚合物、二醇、1,2,6-己三醇、蜂蜜、透明质酸、氢化蜂蜜、氢化淀粉水解产物、肌醇、乳糖醇、麦芽糖醇、麦芽糖、甘露醇、天然保湿因子、PEG-15丁二醇、聚甘油山梨糖醇、吡咯烷酮羧酸盐、PCA钾、丙二醇、葡糖醛酸钠、PCA钠、山梨糖醇、蔗糖、海藻糖、尿素和木糖醇。在一个实施方案中,保湿剂是甘油。在另一个实施方案中,保湿剂以约0.5重量%至约6.0重量%的量存在。
其他实例包括乙酰化羊毛脂、乙酰化羊毛脂醇、丙氨酸、藻类提取物、库拉索芦荟、库拉索芦荟提取物、库拉索芦荟凝胶、药蜀葵提取物、杏(prunus armeniaca)核仁油、精氨酸、精氨酸天冬氨酸盐、山金车提取物、天冬氨酸、鳄梨(persea gratissima)油、屏障鞘脂、丁醇、蜂蜡、山嵛醇、β-谷甾醇、桦树(betula alba)树皮提取物、琉璃苣(boragoofficinalis)提取物、假叶树(ruscus aculeatus)提取物、丁二醇、金盏花提取物、金盏花油、小烛树(euphorbia cerifera)蜡、菜籽油、辛酸/癸酸甘油三酯、小豆蔻(elettariacardamomum)油、巴西棕榈(copernicia cerifera)蜡、胡萝卜(daucus carota sativa)油、蓖麻(ricinus communis)油、神经酰胺、地蜡、鲸蜡硬脂醇聚醚-5、鲸蜡硬脂醇聚醚-12、鲸蜡硬脂醇聚醚-20、鲸蜡硬脂基辛酸酯、鲸蜡醇聚醚-20、鲸蜡醇聚醚-24、乙酸鲸蜡酯、辛酸鲸蜡酯、棕榈酸鲸蜡酯、洋甘菊(anthemis nobilis)油、胆固醇、胆固醇酯、羟基硬脂酸胆固醇酯、柠檬酸、鼠尾草(salvia sclarea)油、可可(theobroma cacao)脂、椰油醇辛酸酯/癸酸酯、椰子(cocos nucifera)油、胶原蛋白、胶原蛋白氨基酸、玉米(zea mays)油、脂肪酸、油酸癸酯、聚二甲基硅氧烷共聚多元醇、聚二甲基硅氧烷醇、己二酸二辛酯、琥珀酸二辛酯、二季戊四基六辛酯/六癸酸酯、DNA、赤藓糖醇、乙氧基二甘醇、亚油酸乙酯、蓝桉油、月见草(oenothera biennis)油、脂肪酸、斑点老鹳草油、葡萄糖胺、葡萄糖谷氨酸酯、谷氨酸、甘油聚醚-26、甘油(glycerin)、甘油(glycerol)、二硬脂酸甘油酯、羟基硬脂酸甘油酯、月桂酸甘油酯、亚油酸甘油酯、肉豆蔻酸甘油酯、油酸甘油酯、硬脂酸甘油酯、硬脂酸甘油酯SE、甘氨酸、硬脂酸乙二醇酯、硬脂酸乙二醇酯SE、糖胺聚糖、葡萄(vitis vinifera)籽油、榛子(corylus americana)坚果油、榛子(corylus avellana)坚果油、己二醇、透明质酸、杂交红花(carthamus tinctorius)油、氢化蓖麻油、氢化椰油甘油酯、氢化椰子油、氢化羊毛脂、氢化卵磷脂、氢化棕榈甘油酯、氢化棕榈仁油、氢化大豆油、氢化牛脂酸甘油酯、氢化植物油、水解胶原蛋白、水解弹性蛋白、水解糖胺聚糖、水解角蛋白、水解大豆蛋白、羟基化羊毛脂、羟基脯氨酸、异鲸蜡醇硬脂酸酯、异鲸蜡醇硬脂酰基硬脂酸酯、油酸异癸酯、异硬脂酸异丙酯、羊毛脂酸异丙酯、肉豆蔻酸异丙酯、棕榈酸异丙酯、硬脂酸异丙酯、异硬脂酰胺DEA、异硬脂酸、乳酸异硬脂酸酯、新戊酸异硬脂酸酯、茉莉(jasminum officinale)油、荷荷巴(buxuschinensis)油、海带、石栗(aleurites moluccana)坚果油、乳酰胺MEA、羊毛脂醇聚醚-16、羊毛脂醇聚醚-10乙酸酯、羊毛脂、羊毛脂酸、羊毛脂醇、羊毛脂油、羊毛脂蜡、熏衣草(lavandula angustifolia)油、卵磷脂、柠檬(citrus medica limonum)油、亚油酸、亚麻酸、澳洲坚果坚果油、麦芽糖醇、母菊(chamomilla recutita)油、甲基葡萄糖倍半硬脂酸酯、甲基硅烷醇PCA、矿物油、貂油、黄褐色被孢霉油、乳酸肉豆蔻酯、肉豆蔻酸肉豆蔻酯、丙酸肉豆蔻酯、新戊二醇二辛酸酯/二癸酸酯、辛基十二烷醇、肉豆蔻酸辛基十二烷酯、辛基十二醇硬脂酰基硬脂酸酯、羟基硬脂酸辛酯、棕榈酸辛酯、水杨酸辛酯、硬脂酸辛酯、油酸、橄榄(olea europaea)油、橙(citrus aurantium dulcis)油、棕榈(elaeis guineensis)油、棕榈酸、泛硫乙胺、泛醇、泛醇基乙基醚、石蜡、PCA、桃(prunus persica)核油、花生(arachis hypogaea)油。
保湿剂的其他非限制性实例可包括PEG-8C12-18酯、PEG-15椰油胺、PEG-150二硬脂酸酯、PEG-60异硬脂酸甘油酯、PEG-5硬脂酸甘油酯、PEG-30硬脂酸甘油酯、PEG-7氢化蓖麻油、PEG-40氢化蓖麻油、PEG-60氢化蓖麻油、PEG-20甲基葡萄糖倍半硬脂酸酯、PEG40脱水山梨醇全油酸酯、PEG-5大豆甾醇、PEG-10大豆甾醇、PEG-2硬脂酸酯、PEG-8硬脂酸酯、PEG-20硬脂酸酯、PEG-32硬脂酸酯、PEG40硬脂酸酯、PEG-50硬脂酸酯、PEG-100硬脂酸酯、PEG-150硬脂酸酯、十五内酯、薄荷(mentha piperita)油、凡士林、磷脂、聚氨基糖缩合物、聚甘油-3二异硬脂酸酯、聚季铵盐24、聚山梨酸酯20、聚山梨酸酯40、聚山梨酸酯60、聚山梨酸酯80、聚山梨酸酯85、肉豆蔻酸钾、棕榈酸钾、丙二醇、丙二醇二辛酸酯/二癸酸酯、丙二醇二辛酸酯、丙二醇二壬酸酯、丙二醇月桂酸酯、丙二醇硬脂酸酯、丙二醇硬脂酸酯SE、PVP、吡哆素二棕榈酸酯、视黄醇、棕榈酸视黄酯、大米(oryza sativa)糠油、RNA、迷迭香(rosmarinusofficinalis)油、玫瑰油、红花(carthamus tinctorius)油、鼠尾草(salvia officinalis)油、檀香(santalum album)油、丝氨酸、血清蛋白、芝麻(sesamum indicum)油、乳木果油(butyrospermum parkii)、蚕丝粉、硫酸软骨素钠、透明质酸钠、乳酸钠、棕榈酸钠、PCA钠、聚谷氨酸钠、可溶性胶原蛋白、脱水山梨糖醇月桂酸酯、脱水山梨糖醇油酸酯、脱水山梨糖醇棕榈酸酯、脱水山梨糖醇倍半油酸酯、脱水山梨糖醇硬脂酸酯、山梨糖醇、大豆(glycinesoja)油、鞘脂、角鲨烷、角鲨烯、硬脂酰胺MEA-硬脂酸酯、硬脂酸、硬脂氧基聚二甲基硅氧烷、硬脂氧基三甲基硅烷、硬脂醇、硬脂醇甘草次酸酯、硬脂醇庚酸酯、硬脂醇硬脂酸酯、向日葵(helianthus annuus)籽油、甜杏仁(prunus amygdalusdulcis)油、合成蜂蜡、生育酚、生育酚乙酸酯、生育酚亚油酸酯、山萮酸甲酯(tribehenin)、新戊酸十三烷基酯、硬脂酸十三烷基酯、三乙醇胺、三硬脂精、尿素、植物油、水、蜡、小麦(triticum vulgare)胚芽油和依兰依兰(cananga odorata)油。在一个实施方案中,保湿剂可以是尿囊素。在另一个实施方案中,保湿剂在组合物中的存在量为约0.5重量%至约6.0重量%。
在一些实施方案中,该组合物可以进一步包含增稠剂。增稠剂,包括稠化剂或胶凝剂,包括可增加组合物的粘度的物质。增稠剂包括可以增加组合物的粘度而基本上不改变组合物中的活性成分的功效的那些。增稠剂还可增加本发明的组合物的稳定性。在本发明的某些方面,增稠剂包括氢化聚异丁烯或三羟基硬脂精,或两者的混合物。
可以在本发明的上下文中使用的另外的增稠剂的非限制性实例包括羧酸聚合物、交联的聚丙烯酸酯聚合物、聚丙烯酰胺聚合物、多糖和树胶。羧酸聚合物的实例包括含有一种或多种衍生自丙烯酸、取代的丙烯酸、以及这些丙烯酸和取代的丙烯酸的盐和酯的单体的交联化合物,其中交联剂包含两个或更多个碳-碳双键并且衍生自多元醇(参见CTFA国际化妆品成分词典,第四版,1991,第12和80页)。市售的羧酸聚合物的实例包括卡波姆,其为与蔗糖或季戊四醇的烯丙基醚交联的丙烯酸的均聚物(例如,来自B.F.Goodrich的CarbopolTM 900系列)。交联聚丙烯酸酯聚合物的非限制性实例包括阳离子和非离子聚合物。
聚丙烯酰胺聚合物(包括取代的支链或非支链聚合物的非离子聚丙烯酰胺聚合物)的非限制性实例包括聚丙烯酰胺、异链烷烃和月桂醇聚醚-7、丙烯酰胺和取代的丙烯酰胺与丙烯酸和取代的丙烯酸的多嵌段共聚物。
多糖的非限制性实例包括纤维素、羧甲基羟乙基纤维素、乙酸丙酸纤维素羧酸酯、羟乙基纤维素、羟乙基乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、甲基羟乙基纤维素、微晶纤维素、纤维素硫酸钠及其混合物。另一个实例是烷基取代的纤维素,其中纤维素聚合物的羟基基团被羟烷基化(优选羟乙基化或羟丙基化)以形成羟烷基化纤维素,然后将其通过醚键用C10-C30直链或支链烷基基团进一步改性。通常,这些聚合物是C10-C30直链或支链醇与羟基烷基纤维素的醚。其他有用的多糖包括硬葡聚糖(scleroglucan),其包含(1-3)连接的葡萄糖单元的线性链,每三个单元具有(1-6)连接的葡萄糖。
可以用于本发明的组合物的树胶的非限制性实例包括阿拉伯胶、琼脂、藻胶、藻酸、藻酸铵、支链淀粉、藻酸钙、角叉菜胶钙、肉碱、角叉菜胶、糊精、明胶、结冷胶、瓜尔胶、瓜尔胶羟丙基三甲基氯化铵(guar hydroxypropyltrimonium chloride)、锂蒙脱石、透明质酸、水合硅石、羟丙基壳聚糖、羟丙基瓜尔胶、刺梧桐树胶(karaya gum)、海带、刺槐豆胶、纳豆胶、藻酸钾、角叉菜胶钾、藻酸丙二醇酯、小核菌胶、羧甲基葡聚糖钠、角叉菜胶钠、黄芪胶、黄原胶及其混合物。在一个实施方案中,增稠剂是角叉菜(Chondrus crispus)(角叉菜胶)提取物。在另一个实施方案中,增稠剂在组合物中存在的量为约0.1重量%至约4.5重量%。
在一些实施方案中,组合物还包含精油。精油包括源自草本植物、花卉、树木和其他植物的油。这样的油通常以微小液滴的形式存在于植物细胞之间,并且可以通过本领域技术人员已知的几种方法(例如,蒸汽蒸馏、吸香(即使用脂肪进行提取)、浸渍、溶剂提取或机械压榨)进行提取。当这些类型的油暴露于空气时,它们倾向于蒸发(即,挥发性油)。结果,许多精油是无色的,但是随着年限的增长,它们会氧化并变得更深。精油不溶于水,而可溶于醇、醚、不挥发油(植物)和其他有机溶剂。在精油中发现的典型物理特征包括从约160℃至240℃变化的沸点和范围为约0.759至约1.096的密度。
精油通常由发现该油的植物来命名。例如,玫瑰油或薄荷油分别源自玫瑰或薄荷植物。可用于本发明的上下文中的精油的非限制性实例包括芝麻油、澳洲坚果油、茶树油、月见草油、西班牙鼠尾草油、西班牙迷迭香油、芫荽油、百里香油、多香果浆果油、玫瑰油、大茴香油、香脂油、佛手柑油、玫瑰木油、雪松油、洋甘菊油、鼠尾草油、快乐鼠尾草油、丁香油、柏树油、桉树油、小茴香油、海茴香油、乳香油、天竺葵油、姜油、葡萄柚油、茉莉油、杜松油、薰衣草油、柠檬油、柠檬草油、酸橙油、橘子油、马郁兰油、没药油、橙花油、橙油、广藿香油、辣椒油、黑胡椒油、橙叶油、松树油、玫瑰精油、迷迭香油、檀香油、留兰香油、甘松油、香根草油、冬青油或依兰依兰。在本发明的上下文内,本领域技术人员已知的其他精油也被认为是有用的。在一个实施方案中,精油可以是古巴香胶树(苦配巴香脂)树脂。在另一个实施方案中,精油组分存在的量为约0.1重量%至约2.5重量%。
在一些实施方案中,组合物可以进一步包含防腐剂。防腐剂的非限制性实例可包括季铵防腐剂,如聚季铵盐1和苯扎卤铵(例如,苯扎氯铵(“BAC”)和苯扎溴铵)、对羟基苯甲酸酯(例如,对羟基苯甲酸甲酯和对羟基苯甲酸丙酯)、苯氧乙醇,乙基己基甘油苄醇、氯丁醇、苯酚、山梨酸、硫柳汞或其组合。在一些实施方案中,组合物中的防腐剂是苯氧乙醇。在一些实施方案中,组合物中的防腐剂是乙基己基甘油。在另一个实施方案中,防腐剂组分存在的量为约0.1重量%至约1.0重量%。
在一些实施方案中,组合物还可包含抗氧化剂。可用于本发明的组合物的抗氧化剂的非限制性实例包括乙酰半胱氨酸、抗坏血酸多肽、抗坏血酸二棕榈酸酯、抗坏血酸基甲基硅烷醇果胶酸酯、抗坏血酸棕榈酸酯、抗坏血酸硬脂酸酯、BHA、BHT、叔丁基氢醌、半胱氨酸、半胱氨酸HCl、二戊基氢醌(diamyihydroquinone)、二叔丁基氢醌、二鲸蜡醇硫代二丙酸酯、二油基生育酚基甲基硅烷醇、抗坏血酸硫酸二钠、二硬脂醇硫代二丙酸酯、双十三醇硫代二丙酸酯、没食子酸十二烷醇酯、异抗坏血酸、抗坏血酸酯、阿魏酸乙酯、阿魏酸、没食子酸酯、氢醌、巯基乙酸异辛酯、曲酸、抗坏血酸镁、抗坏血酸磷酸镁、甲基硅烷醇抗坏血酸酯、天然植物抗氧化剂如绿茶或葡萄籽提取物、去甲二氢愈创木酸、没食子酸辛酯、苯硫基乙醇酸、抗坏血酸基生育酚基磷酸钾、亚硫酸钾、没食子酸丙酯、醌、迷迭香酸、抗坏血酸钠、亚硫酸氢钠、异抗坏血酸钠、焦亚硫酸钠、亚硫酸钠、超氧化物歧化酶、硫代乙醇酸钠、山梨醇缩糠醛、硫代二甘醇、硫二甘醇酰胺、硫代二乙醇酸、巯基乙酸、硫代乳酸、硫代水杨酸、生育酚聚醚-5、生育酚聚醚-10、生育酚聚醚-12、生育酚聚醚-18、生育酚聚醚-50、生育酚、托可索仑(tocophersolan)、乙酸生育酚酯、亚油酸生育酚酯、烟酸生育酚酯、琥珀酸生育酚酯和亚磷酸三(壬基苯基)酯。在一个实施方案中,抗氧化剂是生育酚。在另一个实施方案中,抗氧化剂组分存在的量为约0.1重量%至约10重量%。
在一些实施方案中,组合物还可包含结构剂。在某些方面,结构剂有助于为组合物提供流变特性,从而有助于组合物的稳定性。在其他方面,结构剂也可以用作乳化剂或表面活性剂。结构剂的非限制性实例包括硬脂酸、棕榈酸、硬脂醇、鲸蜡醇、山嵛醇、硬脂酸、棕榈酸、具有平均约1至约21个环氧乙烷单元的硬脂醇的聚乙二醇醚、具有平均约1个至约5个环氧乙烷单元的鲸蜡醇的聚乙二醇醚及其混合物。
在一些实施方案中,组合物可以另外包含甘油三酸酯。非限制性实例包括短、中和长链甘油三酸酯。在某些方面,甘油三酸酯是中链甘油三酸酯(例如,辛酸/癸酸甘油三酯)。
在一些实施方案中,组合物还可包含UV吸收剂。可以与本发明的组合物组合使用的UV吸收剂包括化学和物理防晒剂。可以使用的化学防晒剂的非限制性实例包括对氨基苯甲酸(PABA)、PABA酯(PABA甘油酯、PABA戊基二甲酯和PABA辛基二甲酯)、PABA丁酯、PABA乙酯、PABA乙基二羟丙酯、二苯甲酮(氧苯酮、磺异苯酮、二苯甲酮和二苯甲酮1至12)、肉桂酸酯(甲氧基肉桂酸辛酯、对甲氧基肉桂酸异戊酯、甲氧基肉桂酸辛酯、西诺沙酯(cinoxate)、肉桂酸二异丙基甲酯、DEA-甲氧基肉桂酸酯、二异丙基肉桂酸乙酯、甘油辛酸酯二甲氧基肉桂酸酯和甲氧基肉桂酸乙酯)、肉桂酸酯、水杨酸酯(甲基水杨醇(homomethylsalicylate)、水杨酸苄酯、水杨酸乙二醇酯、水杨酸异丙基苄酯等)、邻氨基苯甲酸酯、尿刊酸乙酯、胡莫柳酯(homosalate)、水杨酸辛酯(octisalate)、二苯甲酰甲烷衍生物(如阿伏苯宗)、奥克立林(octocrylene)、辛基三嗪酮、二没食子酰基三油酸酯、氨基苯甲酸甘油酯、指甲花醌与二羟基丙酮、乙基己基三嗪酮、二辛基丁酰胺基三嗪酮、亚苄基丙二酸酯聚硅氧烷、对苯二亚甲基二樟脑磺酸、苯基二苯并咪唑四磺酸二钠、二乙基氨基羟基苯甲酰基己基苯甲酸酯、双二乙基氨基羟基苯甲酰基苯甲酸酯、双苯并噁唑基苯基乙基己基亚氨基三嗪、甲酚曲唑三硅氧烷、亚甲基双苯并三唑基四甲基丁基苯酚和双乙基己氧基苯酚甲氧基苯基三嗪、4-甲基亚苄基樟脑和4-甲氧基肉桂酸异戊酯。物理防晒剂的非限制性实例包括高岭土、滑石粉、凡士林和金属氧化物(例如二氧化钛和氧化锌)。
在一些实施方案中,组合物还可包含化妆品成分。可以使用the CTFAInternational Cosmetic Ingredient Dictionary and Handbook(2004年和2008年)中描述的许多种非限制性化妆品成分。化妆品成分的非限制性实例包括香料(人造的和天然的)、染料和颜色成分(例如,蓝色1、蓝色1色淀、红色40、二氧化钛、D&C蓝色4号、D&C绿色5号、D&C橙色4号、D&C红色17号、D&C红色33号、D&C紫色2号、D&C黄色10号和D&C黄色11号)、吸附剂、润滑剂、溶剂、保湿剂(包括例如润肤剂、湿润剂、成膜剂、阻塞剂和影响皮肤的自然保湿机制的试剂)、防水剂、UV吸收剂(物理和化学吸收剂,如对氨基苯甲酸(“PABA”)和相应的PABA衍生物、二氧化钛、氧化锌等)、精油、维生素(例如维生素A、B、C、D、E和K)、微量金属(例如锌、钙和硒)、抗刺激剂(例如甾体和非甾体抗炎剂)、植物提取物(例如芦荟、洋甘菊、黄瓜提取物、银杏、人参和迷迭香)、抗微生物剂、抗氧化剂(例如BHT和生育酚)、螯合剂(例如EDTA二钠和EDTA四钠)、防腐剂(例如,对羟基苯甲酸甲酯和对羟基苯甲酸丙酯)、pH调节剂(例如氢氧化钠和柠檬酸)、吸收剂(例如淀粉辛烯基琥珀酸铝、高岭土、玉米淀粉、燕麦淀粉、环糊精、滑石粉和沸石)、皮肤漂白和亮白剂(例如氢醌和烟酰胺乳酸盐)、湿润剂(例如山梨糖醇、尿素和甘露醇)、去角质剂、防水剂(例如硬脂酸氢氧化镁/铝)、皮肤调理剂(例如芦荟提取物、尿囊素、没药醇、神经酰胺、二甲硅氧烷、透明质酸和甘草酸二钾)。
在一些实施方案中,组合物可以进一步包含药物活性剂。所述药物活性剂的非限制性实例包括抗痤疮剂、用于治疗酒渣鼻的药剂、镇痛剂、麻醉剂、肛门直肠药、抗组胺剂、包括非甾体抗炎药的抗炎剂、抗生素、抗真菌剂、抗病毒剂、抗微生物剂、抗癌活性物质、抗疥螨剂、灭虱剂、抗肿瘤剂、止汗剂、止痒剂、抗银屑病药、抗皮脂溢剂、生物活性蛋白和多肽、烧伤治疗剂、烧灼剂、脱色剂、脱毛剂、尿布疹治疗剂、酶、毛发生长促进剂、包括DFMO及其盐和类似物的毛发生长抑制剂、止血剂、去角质剂、口腔溃疡治疗剂、唇疱疹治疗剂、牙齿和牙周治疗剂、光敏活性物质、皮肤保护剂/屏障剂、包括激素和皮质类固醇的甾体、晒伤治疗剂、遮光剂、透皮活性物质、鼻活性物质、阴道活性物质、疣治疗剂、伤口治疗剂、伤口愈合剂等。
本文还提出了通过将本发明的组合物局部施用于有其需要的皮肤来治疗皮肤病症的方法,其中将所述组合物局部施用于有其需要的皮肤治疗或改善皮肤病症。所述组合物可以施用于细纹或皱纹,干燥、脱皮或发痒的皮肤,发炎的皮肤和贯穿本申请公开的其他与皮肤相关的障碍。皮肤病症的非限制性实例包括皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎(包括但不限于脂溢性皮炎、钱币状皮炎、接触性皮炎、特应性皮炎、剥脱性皮炎、口周皮炎和淤滞性皮炎),银屑病、毛囊炎、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤、皮肤发炎的皮肤病症等。在某些非限制性方面,皮肤病症可以由暴露于UV光、年龄、辐射、长期日光暴露、环境污染物、空气污染、风、寒冷、热、化学物质、疾病病理、吸烟或缺乏营养引起。皮肤可以是面部皮肤或非面部皮肤(例如,手臂、腿、手、胸部、背部、脚等)。该方法可以进一步包括识别需要皮肤治疗的人。该人可以是男性或女性。该人的年龄可以是至少1、2、3、4、5、6、7、8、9、10、15、20、25、30、35、40、45、50、55、60、65、70、75、80、85、90、95或更高的年龄,或可从其中得到的任何范围。
实施例1
采用本发明的组合物治疗具有痤疮和皮肤瑕疵病史的23岁女性。在该实施例中,所述组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。图1A是按照使用本发明进行至少14天的治疗方法治疗之前,而图1B是按照使用本发明进行治疗至少14天的治疗方法治疗之后。图1A清楚地显示了整个脸颊区域遍布的痤疮和其他瑕疵。图1B显示了整个图1A所示的同一脸颊区域的痤疮和其他瑕疵完全消除。
实施例2
采用本发明的组合物治疗具有痤疮和皮肤瑕疵病史的29岁女性。在该实施例中,受试者使用本发明的两步法,其中第一组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物、以及约0.2重量%至约8重量%的血竭提取物。第二组合物包含0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。该组合物在本文中也称为SkinKick。图2A是之前的照片。图2B显示了治疗3天后的皮肤,其中皮肤不再广泛发红并恶化(如图21所见),而图2C显示了按照使用本发明进行治疗21天的治疗方法治疗后的皮肤。图2A清楚地显示了整个面部区域遍布的痤疮和其他瑕疵,并且还包括明显的脂溢性皮炎。图2B显示了采用本发明开始治疗后3天的面部,其中脂溢性皮炎已被减轻或消除。21天后,图2C显示了整个图2A和2C中所示的同一区域的痤疮和其他瑕疵完全消除。受试者将该组合物描述为“瓶中的自尊”。当她决定采用本发明的两步法时,该受试者曾一直在处理恶化的皮肤和瑕疵。该受试者注意到,仅三天后,她的皮肤就显著稳定下来,并且她的瑕疵正在清除。到第21天,受试者的皮肤清洁、更新和发光。受试者感到她“感到有动力和挺拔”。至于她的病症,受试者进一步陈述:“两天内,我的红肿程度下降。SkinKick彻底改变了我的皮肤。其确实改变了状况!”。
比较例3
采用本发明的组合物治疗具有痤疮和皮肤瑕疵病史、有小面积的脂溢性皮炎和/或过敏反应的39岁女性。以前,该受试者曾一直使用行业内广泛使用的包含过氧化苯甲酰和水杨酸的组合物三年。该比较组合物包括三步抗痤疮试剂盒,该试剂盒包含清洁剂、爽肤水和洗剂。受试者先前使用的每种组合物都包括活性剂,例如过氧化苯甲酰和水杨酸。在该实施例中,受试者使用的组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。图3A是以前的采用由清洁剂、爽肤水和洗剂(过氧化苯甲酰和水杨酸)组成的现有技术三步抗痤疮试剂盒治疗3年后的照片。比较起来,图3B是采用本发明治疗后的照片。图3A清楚地显示整个脸颊区域遍布的痤疮和其他瑕疵。图3B显示整个图3A所示的面部区域的痤疮和其他瑕疵完全消除。图3B还包括显示近视图的插图,其清楚地显示痤疮和其他瑕疵完全消除。
比较例1
采用本发明的组合物治疗具有痤疮和皮肤瑕疵的病史、具有小面积的脂溢性皮炎和/或过敏反应的19岁女性。之前,该受试者曾一直使用行业内广泛使用的包含过氧化苯甲酰和水杨酸的组合物至少3年。该比较组合物包括三步抗痤疮试剂盒,该试剂盒包含清洁剂、爽肤水和洗剂。受试者先前使用的每种组合物包含活性剂,如过氧化苯甲酰和水杨酸。在该实施例中,受试者使用的组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。图4A是以前的采用由清洁剂、爽肤水和洗剂(过氧化苯甲酰和水杨酸)组成的现有技术的三步抗痤疮试剂盒治疗3年后的照片。比较起来,图4B是采用本发明治疗后的照片。图4A清楚地显示整个脸颊区域遍布的痤疮和其他瑕疵。图4B显示整个图4A所示的面部区域的痤疮和其他瑕疵完全消除。图4B还包括显示近视图的插图,其清楚地显示痤疮和其他瑕疵完全消除。受试者陈述:“对于任何想要使其皮肤变得更好的人:继续阅读……我发现这种新的护肤品,它已经彻底改善我的面貌!它将其清理,使其变得如此柔软,并增亮了我的皮肤,并且在第一天我就看到了效果!最后我相信护肤品!我认为每个人都需要尽快拥有它。真的对该产品不能更爱了!”
比较例2
采用本发明的组合物治疗具有痤疮和皮肤瑕疵病史、有小面积脂溢性皮炎和/或过敏反应的15岁女性。以前,该受试者曾一直使用行业内广泛使用的包含过氧化苯甲酰和水杨酸的组合物至少3年。该比较组合物包括三步抗痤疮试剂盒,该试剂盒包含清洁剂、爽肤水和洗剂。受试者先前使用的每种组合物包含活性剂,如过氧化苯甲酰和水杨酸。在该实施例中,受试者使用的组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。图5A是以前的使用由清洁剂、爽肤水和洗剂(过氧化苯甲酰和水杨酸)组成的现有技术三步抗痤疮试剂盒治疗3年后的照片。比较起来,图5B是采用本发明治疗仅3天后的照片。图5A清楚地显示整个脸颊区域遍布痤疮和其他瑕疵。图5B显示整个图5A所示的面部区域的痤疮和其他瑕疵完全消除。图5B还包括一个显示近视图的插图,其清楚地显示仅3天内痤疮和其他瑕疵几乎完全消除。该受试者的父母陈述:“我们喜欢这个产品!在我们尝试了所有其他的之后,我开始让我的女儿使用该产品,并踏上了使用青春痘特效药的危险之路。如果没有至少先尝试一下SkinKick,我根本无法使她治愈。我们很高兴我们做到了!与其他某些人不同,这不是一夜之间发生的,但它确实发生了。几个月内,她的皮肤完全清理了。真是太神奇了,生活在改变。她可以自信地行走,而不会躲在只突出瑕疵的妆容后面。参加体育运动一直是一个问题,因为汗水只会使情况恶化,但现在再不是问题。由于她已经看到使用它的成功,所以我开始自己使用清洁和面部精华素。我的皮肤看起来和感觉都很棒!洁面乳中含有适量的磨砂膏,不会使我的皮肤感觉有砂砾和粗糙,而清洁效果很好。面部精华素是针对我的细纹和皱纹的理想产品。我注意到了一个很大的不同,因为我的妆容不再陷入深层的皱纹线中,并且变得更加光滑。我将该产品强烈推荐给从受困于持续瑕疵和发红或偶尔爆发的青少年到像我这样的希望使皮肤看起来更年轻的更好的日常生活的成年人”。
比较例3
采用本发明的组合物治疗具有痤疮和皮肤瑕疵病史的女性受试者。之前,在过去的15年,该受试者曾一直使用行业中广泛使用的包含过氧化苯甲酰和水杨酸的组合物。该比较组合物包括三步抗痤疮试剂盒,该试剂盒包含清洁剂、爽肤水和洗剂。受试者先前使用的每种组合物都包含活性剂,例如过氧化苯甲酰和水杨酸。在该实施例中,受试者使用的组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。图6A是以前的采用由清洁剂、爽肤水和洗剂(过氧化苯甲酰和水杨酸)组成的现有技术三步抗痤疮试剂盒治疗3年后的照片。比较起来,图6B是在采用本发明治疗仅3天后的照片。图6A清楚地显示整个脸颊区域遍布的痤疮和其他瑕疵。图6B显示在图6所示的整个面部区域的痤疮和其他瑕疵完全消除。图6B还包括一个显示近视图的插图,其清楚地显示仅三天后痤疮和其他瑕疵几乎完全消除。
也考虑将试剂盒用于本发明的某些方面。例如,本发明的组合物可以包含在试剂盒中。试剂盒可包括容器。容器可包括瓶、金属管、层压管、塑料管、分配器、阻隔容器、包装、隔间或其他类型的容器,如将组合物或期望的瓶、分配器或包装保留在其中的注塑或吹塑塑料容器。试剂盒和/或容器可在其表面上包含标记。标记例如可以是单词、短语、缩写、图片或符号。
容器可以分配预定量的组合物。在其他实施方案中,可以挤压容器(例如,金属管、层压管或塑料管)以分配所需量的组合物。该组合物可以作为液体、流体或半固体形式分配。容器可以具有泵或挤压机构。试剂盒还可包括用于使用试剂盒和/或组合物的说明书。说明书可包括有关如何施用、使用和维护组合物的说明。
在一个实施方案中,本发明包括一种局部皮肤护理组合物,其基本上由黑柳树皮提取物、猫爪藤提取物和血竭提取物组成。在另一个实施方案中,本发明包括一种局部皮肤护理组合物,其由黑柳树皮提取物、猫爪藤提取物和血竭提取物组成。一方面,该组合物包含约0.5重量%(wt%)至约10重量%的黑柳树皮提取物。另一方面,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物。另一方面,该组合物包含约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约7重量%的猫爪藤提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物是乳液、凝胶、乳膏、洗剂、精华液或溶液。另一方面,该组合物还包含以下至少一种:乳化剂、保湿剂、精油、遮光剂、药物活性剂、化妆品成分、甘油三酸酯、结构剂、抗氧化剂、防腐剂、树胶、多糖、聚合物、增稠剂、胶凝剂或维生素。另一方面,该乳化剂是鲸蜡硬脂醇橄榄油酸酯或山梨坦橄榄油酸酯。另一方面,所述保湿剂是尿囊素。另一方面,所述精油是古巴香胶树(苦配巴香脂)树脂。另一方面,该组合物包含黑柳树皮提取物、猫爪藤提取物、血竭提取物、鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、古巴香胶树(苦配巴香脂)树脂、甘油、尿囊素、辛酸/癸酸甘油三酯、罗望子种子多糖、角叉菜(角叉菜胶)、疑拟香桃木(卡姆果)果实提取物、海茴香提取物、氢化植物油、圭亚那苦油楝种子油、巴西莓果油、互叶白千层(茶树)叶油、西番莲(百香果)种子油、巴西油桃木果油、生育酚、苯氧乙醇、乙基己基甘油和水。另一方面,该组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、约0.1重量%至约5重量%的鲸蜡硬脂醇橄榄油酸酯、约0.1重量%至约5重量%的山梨坦橄榄油酸酯、约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约3重量%的甘油、约0.1重量%至约5重量%的尿囊素、约0.1重量%至约5重量%的辛酸/癸酸甘油三酯、罗望子种子多糖、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约3重量%的海茴香提取物、约0.1重量%至约5重量%的氢化植物油、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约3重量%的互叶白千层(茶树)叶油、约0.1重量%至约5重量%的西番莲(百香果)种子油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油、约0.1重量%至约3重量%的生育酚、约0.1重量%至约1.0重量%的苯氧乙醇、约0.1重量%至约1.0重量%的乙基己基甘油和约10重量%至约90重量%的水。
在另一个实施方案中,本发明包括一种治疗皮肤病症的方法,该方法主要由将包含黑柳树皮提取物、猫爪藤提取物和血竭提取物的组合物局部施用于有其需要的皮肤组成,其中将该组合物局部施用于有其需要的皮肤改善皮肤病症。在另一个实施方案中,本发明包括一种治疗皮肤病症的方法,该方法由将包含黑柳树皮提取物、猫爪藤提取物和血竭提取物的组合物局部施用于有其需要的皮肤组成,其中将该组合物局部施用于有其需要的皮肤改善皮肤病症。一方面,所述皮肤病症选自皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物。另一方面,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物。另一方面,该组合物包含约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约7重量%的猫爪藤提取物。另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物包含约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。在另一方面,该组合物包含约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,该组合物是乳液、凝胶、乳膏、洗剂、精华液或溶液。另一方面,该方法进一步包括添加以下中的至少一种:乳化剂、保湿剂、精油、遮光剂、药物活性剂、化妆品成分、甘油三酸酯、结构剂、抗氧化剂、防腐剂、树胶、多糖、聚合物、增稠剂、胶凝剂或维生素。另一方面,该乳化剂是鲸蜡硬脂醇橄榄油酸酯或山梨坦橄榄油酸酯。另一方面,所述保湿剂是尿囊素。另一方面,所述精油是古巴香胶树(苦配巴香脂)树脂。在另一方面,该组合物包含黑柳树皮提取物、猫爪藤提取物、血竭提取物、鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、古巴香胶树(苦配巴香脂)树脂、甘油、尿囊素、辛酸/癸酸甘油三酯、罗望子种子多糖、角叉菜(角叉菜胶)、疑拟香桃木(卡姆果)果实提取物、海茴香提取物、氢化植物油、圭亚那苦油楝种子油、巴西莓果油、互叶白千层(茶树)叶油、西番莲(百香果)种子油、巴西油桃木果油、生育酚、苯氧乙醇、乙基己基甘油和水。另一方面,该组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、约0.1重量%至约5重量%的鲸蜡硬脂醇橄榄油酸酯、约0.1重量%至约5重量%的山梨坦橄榄油酸酯、约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约3重量%的甘油、约0.1重量%至约5重量%的尿囊素、约0.1重量%至约5重量%的辛酸/癸酸甘油三酯、罗望子种子多糖、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约3重量%的海茴香提取物、约0.1重量%至约5重量%的氢化植物油、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约3重量%的互叶白千层(茶树)叶油、约0.1重量%至约5重量%的西番莲(百香果)种子油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油、约0.1重量%至约3重量%的生育酚、约0.1重量%至约1.0重量%的苯氧乙醇、约0.1重量%至约1.0重量%的乙基己基甘油和约10重量%至约90重量%的水。
在另一个实施方案中,本发明包括一种试剂盒,该试剂盒包含基本上由设置于容器内的黑柳树皮提取物、猫爪藤提取物和血竭提取物组成的组合物。在另一个实施方案中,本发明包括一种试剂盒,该试剂盒包含由设置于容器内的黑柳树皮提取物、猫爪藤提取物和血竭提取物组成的组合物。
在另一个实施方案中,本发明包括一种局部皮肤护理组合物,其基本上由约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油组成。在另一个实施方案中,本发明包括一种局部皮肤护理组合物,该皮肤护理组合物由约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油组成。
在另一个实施方案中,本发明包括一种用于抑制或治疗中度至重度寻常痤疮的维持治疗方法(regime)/方案(regimen),其主要由以下组成:首先向需要这样的治疗的受试者局部给予治疗有效量的第一局部皮肤护理组合物,持续1至14天的第一预定时间段,该组合物包含黑柳树皮提取物、猫爪藤提取物和血竭提取物;和在1至14天的第一预定时间段之后,将治疗有效量的第二局部皮肤护理组合物局部施用到需要这样的治疗的受试者的受影响的皮肤区域,持续最长达8周的第二预定时间段,该组合物包含苦配巴香脂树脂、卡姆果果实提取物、苦油树种子油、阿萨伊果油、pequi果油。一方面,该局部皮肤护理组合物包含配制到可接受的局部载体中的约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。另一方面,每天局部施用一次固定剂量组合。另一方面,所述可接受的局部载体包括乳液、凝胶、水凝胶、乳膏、洗剂、精华液或溶液。另一方面,所述第二局部皮肤护理组合物包含约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。
在另一个实施方案中,本发明包括一种采用组合物治疗皮肤病症的方法,所述皮肤病症选自皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症,所述组合物基本上由配制到可接受的局部载体中的约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物组成。在另一个实施方案中,本发明包括一种采用组合物治疗皮肤病症的方法,所述皮肤病症选自皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症,所述组合物由配制到可接受的局部载体中的约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物组成。
在另一个实施方案中,本发明包括一种抗瑕疵和抗衰老组合物,其基本上由0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油组成。在另一个实施方案中,本发明包括一种抗瑕疵和抗衰老组合物,其由0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油组成。
还考虑了包含本发明的组合物的产品。在非限制性方面,所述产品可以是化妆品。化妆品可以是在本说明书的其他部分中描述的那些,或者是本领域技术人员已知的那些。所述产品的非限制性实例包括保湿剂、乳膏、洗剂、皮肤柔软剂、粉底、晚霜、口红、清洁剂、爽肤水、防晒剂、面膜或抗衰老产品。
组合物及其使用方法可以“包括”整个说明书中公开的任何成分,或“基本上由其组成”或“由其组成”。为了本发明的目的,过渡短语“基本上由……组成”的使用包括在组合物中包含不实质影响黑柳树皮提取物、猫爪藤提取物和血竭提取物的组合的多种有益性质的另外成分的组合物。一个这样的实例是包含对组合中确定的任何一种成分具有有害作用(例如,降低功效或稳定性)的成分,或对组合物的活性没有影响的成分,如惰性赋形剂、稳定剂、缓冲剂、增稠剂、防腐剂、香料等。当使用过渡短语“由……组成”时,仅指包含所列成分,即黑柳树皮提取物、猫爪藤提取物和血竭提取物的组合物。
预期就本发明的任何方法或组合物而言,都可以实现本说明书中讨论的任何实施方案,反之亦然。此外,本发明的组合物可用于实现本发明的方法。
当在权利要求和/或说明书中与术语“包含(comprising)”结合使用时,词语“一(a)”或“一(an)”的使用可以意指“一”,但也可以与“一或多”、“至少一”和“一或多于一”的含义一致。
如本说明书和权利要求(多项权利要求)中所使用的,词语“包含(comprising)”(以及包含的任何形式,例如“包含(comprise)”和“包含(comprises)”)、“具有(having)”(以及具有的任何形式,例如“具有(have)”和“具有(has)”)、“包括(including)”(以及包括的任何形式,例如“包括(includes)”和“包括(include)”)或“含有(containing)”(以及含有的任何形式,例如“含有(contains)”和“含有(contain)”)是包含性的或开放式的,且不排除其他未引用的要素或方法步骤。
按照下文的详细描述,本发明的其他目的、特征和优点将变得明显。然而,应该理解的是,详细说明和实施例虽然显示本发明的具体实施方案,但是仅以示例的方式给出。另外,预期根据该详细描述,在本发明的精神和范围内的改变和修改对于本领域技术人员而言将变得显而易见。
Claims (40)
1.一种局部皮肤护理组合物,其包含黑柳树皮提取物、猫爪藤提取物和血竭提取物。
2.权利要求1所述的组合物,其中所述组合物包含约0.5重量%至约10重量%的黑柳树皮提取物。
3.权利要求1所述的组合物,其中所述组合物包含约0.2重量%至约7重量%的猫爪藤提取物。
4.权利要求1所述的组合物,其中所述组合物包含约0.2重量%至约8重量%的血竭提取物。
5.权利要求1所述的组合物,其中所述组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约7重量%的猫爪藤提取物。
6.权利要求1所述的组合物,其中所述组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约8重量%的血竭提取物。
7.权利要求1所述的组合物,其中所述组合物包含约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
8.权利要求1所述的组合物,其中所述组合物包含约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
9.权利要求1所述的组合物,其中所述组合物是乳液、凝胶、乳膏、洗剂、精华液或溶液。
10.权利要求1所述的组合物,其进一步包含以下中的至少一种:乳化剂、保湿剂、精油、遮光剂、药物活性剂、化妆品成分、甘油三酸酯、结构剂、抗氧化剂、防腐剂、树胶、多糖、聚合物、增稠剂、胶凝剂或维生素。
11.权利要求10所述的组合物,其中所述乳化剂是鲸蜡硬脂醇橄榄油酸酯或山梨坦橄榄油酸酯。
12.权利要求10所述的组合物,其中所述保湿剂是尿囊素。
13.权利要求10所述的组合物,其中,所述精油是古巴香胶树(苦配巴香脂)树脂。
14.权利要求1所述的组合物,其中所述组合物包含黑柳树皮提取物、猫爪藤提取物、血竭提取物、鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、古巴香胶树(苦配巴香脂)树脂、甘油、尿囊素、辛酸/癸酸甘油三酯、罗望子种子多糖、角叉菜(角叉菜胶)、疑拟香桃木(卡姆果)果实提取物、海茴香提取物、氢化植物油、圭亚那苦油楝种子油、巴西莓果油、互叶白千层(茶树)叶油、西番莲(百香果)种子油、巴西油桃木果油、生育酚、苯氧乙醇、乙基己基甘油和水。
15.权利要求1所述的组合物,其中所述组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、约0.1重量%至约5重量%的鲸蜡硬脂醇橄榄油酸酯、约0.1重量%至约5重量%的山梨坦橄榄油酸酯、约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约3重量%的甘油、约0.1重量%至约5重量%的尿囊素、约0.1重量%至约5重量%的辛酸/癸酸甘油三酯、罗望子种子多糖、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约3重量%的海茴香提取物、约0.1重量%至约5重量%的氢化植物油、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约3重量%的互叶白千层(茶树)叶油、约0.1重量%至约5重量%的西番莲(百香果)种子油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油、约0.1重量%至约3重量%的生育酚、约0.1重量%至约1.0重量%的苯氧乙醇、约0.1重量%至约1.0重量%的乙基己基甘油和约10重量%至约90重量%的水。
16.一种治疗皮肤病症的方法,其包括将权利要求1所述的组合物局部施用于有其需要的皮肤,其中将所述组合物局部施用于有其需要的皮肤改善皮肤病症。
17.权利要求16所述的方法,其中所述皮肤病症选自皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症。
18.权利要求16所述的方法,其中所述组合物包含约0.5重量%至约10重量%的黑柳树皮提取物。
19.权利要求16所述的方法,其中所述组合物包含约0.2重量%至约7重量%的猫爪藤提取物。
20.权利要求16所述的方法,其中所述组合物包含约0.2重量%至约8重量%的血竭提取物。
21.权利要求16所述的方法,其中所述组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约7重量%的猫爪藤提取物。
22.权利要求16所述的方法,其中所述组合物包含约0.5重量%至约10重量%的黑柳树皮提取物和约0.2重量%至约8重量%的血竭提取物。
23.权利要求16所述的方法,其中所述组合物包含约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
24.权利要求16所述的方法,其中所述组合物包含约0.5重量%至约10重量%的黑柳树皮提取物,约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
25.权利要求16所述的方法,其中所述组合物是乳液、凝胶、乳膏、洗剂、精华液或溶液。
26.权利要求16所述的方法,还包括加入以下中的至少一种:乳化剂、保湿剂、精油、遮光剂、药物活性剂、化妆品成分、甘油三酸酯、结构剂、抗氧化剂、防腐剂、树胶、多糖、聚合物、增稠剂、胶凝剂或维生素。
27.权利要求26所述的方法,其中所述乳化剂是鲸蜡硬脂醇橄榄油酸酯或山梨坦橄榄油酸酯。
28.权利要求26所述的方法,其中所述保湿剂是尿囊素。
29.权利要求26所述的方法,其中所述精油是古巴香胶树(苦配巴香脂)树脂。
30.权利要求16所述的方法,其中所述组合物包含黑柳树皮提取物、猫爪藤提取物、血竭提取物、鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、古巴香胶树(苦配巴香脂)树脂、甘油、尿囊素、辛酸/癸酸甘油三酯、罗望子种子多糖、角叉菜(角叉菜胶)、疑拟香桃木(卡姆果)果实提取物、海茴香提取物、氢化植物油、圭亚那苦油楝种子油、巴西莓果油、互叶白千层(茶树)叶油、西番莲(百香果)种子油、巴西油桃木果油、生育酚、苯氧乙醇、乙基己基甘油和水。
31.权利要求16所述的方法,其中所述组合物包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、约0.1重量%至约5重量%的鲸蜡硬脂醇橄榄油酸酯、约0.1重量%至约5重量%的山梨坦橄榄油酸酯、约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约3重量%的甘油、约0.1重量%至约5重量%的尿囊素、约0.1重量%至约5重量%的辛酸/癸酸甘油三酯、罗望子种子多糖、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约3重量%的海茴香提取物、约0.1重量%至约5重量%的氢化植物油、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约3重量%的互叶白千层(茶树)叶油、约0.1重量%至约5重量%的西番莲(百香果)种子油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油、约0.1重量%至约3重量%的生育酚、约0.1重量%至约1.0重量%的苯氧乙醇、约0.1重量%至约1.0重量%的乙基己基甘油和约10重量%至约90重量%的水。
32.一种试剂盒,其包含设置于容器内的权利要求1所述的组合物。
33.一种局部皮肤护理组合物,其包含约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。
34.一种用于抑制或治疗中度至重度寻常痤疮的维持治疗方法(regime)/方案(regimen),其包括:
首先向需要这样的治疗的受试者局部给予治疗有效量的第一局部皮肤护理组合物,持续1至14天的第一预定时间段,该组合物包含黑柳树皮提取物、猫爪藤提取物和血竭提取物;和
在1至14天的第一预定时间段之后,将治疗有效量的第二局部皮肤护理组合物局部施用到需要这样的治疗的受试者的受影响的皮肤区域上,持续最长达8周的第二预定时间段,该组合物包含苦配巴香脂树脂、卡姆果果实提取物、苦油树种子油、阿萨伊果油、pequi果油。
35.权利要求34所述的方法(regime)/方案(regimen),其中所述局部皮肤护理组合物包含配制到可接受的局部载体中的约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
36.权利要求34所述的方法(regime)/方案(regimen),其中每天局部施用一次固定剂量组合。
37.权利要求34所述的方法(regime)/方案(regimen),其中所述可接受的局部载体包括乳液、凝胶、水凝胶、乳膏、洗剂、精华液或溶液。
38.权利要求34所述的方法(regime)/方案(regimen),其中所述第二局部皮肤护理组合物包含约0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。
39.一种采用组合物治疗皮肤病症的方法,所述皮肤病症选自皮肤干燥、皮肤瘙痒、皮肤发炎、红斑、皮肤敏感、瘙痒症、疹斑、细纹或皱纹、阳光损伤的皮肤、皮炎、银屑病、毛囊炎、瑕疵、酒渣鼻、痤疮、湿疹、晒伤、皮肤烧伤和皮肤发炎的皮肤病症,所述组合物包含配制到可接受的局部载体中的约0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物。
40.一种抗瑕疵和抗衰老的组合物,其包含0.5重量%至约10重量%的黑柳树皮提取物、约0.2重量%至约7重量%的猫爪藤提取物和约0.2重量%至约8重量%的血竭提取物、0.1重量%至约5重量%的古巴香胶树(苦配巴香脂)树脂、约0.1重量%至约4.0重量%的疑拟香桃木(卡姆果)果实提取物、约0.1重量%至约5重量%的圭亚那苦油楝(苦油树)种子油、约0.1重量%至约3重量%的巴西莓(阿萨伊)果油、约0.1重量%至约5重量%的巴西油桃木(pequi)果油。
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US20200384055A1 (en) | 2020-12-10 |
JP2021509123A (ja) | 2021-03-18 |
WO2019136105A1 (en) | 2019-07-11 |
EP3735258A4 (en) | 2021-10-13 |
AU2019205238A1 (en) | 2020-07-23 |
EP3735258A1 (en) | 2020-11-11 |
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