CN111787930A - 针对癌症特异性抗原对t淋巴细胞的筛选 - Google Patents

针对癌症特异性抗原对t淋巴细胞的筛选 Download PDF

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Publication number
CN111787930A
CN111787930A CN201880076364.4A CN201880076364A CN111787930A CN 111787930 A CN111787930 A CN 111787930A CN 201880076364 A CN201880076364 A CN 201880076364A CN 111787930 A CN111787930 A CN 111787930A
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tcr
lymphocytes
cells
engineered
cancer
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Chinese (zh)
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Y·纳卡穆拉
J·H·帕克
S·吉村幸子
引地哲郎
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Oncotherapy Science Inc
University of Chicago
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Oncotherapy Science Inc
University of Chicago
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CN201880076364.4A 2017-10-06 2018-10-05 针对癌症特异性抗原对t淋巴细胞的筛选 Pending CN111787930A (zh)

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US201762569215P 2017-10-06 2017-10-06
US62/569,215 2017-10-06
PCT/US2018/054664 WO2019071164A1 (en) 2017-10-06 2018-10-05 SCREENING OF LYMPHOCYTES T FOR ANTIGENS SPECIFIC TO CANCER

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US (1) US11598780B2 (ja)
EP (1) EP3691662A4 (ja)
JP (1) JP7260553B2 (ja)
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AU (1) AU2018346765A1 (ja)
CA (1) CA3077085A1 (ja)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112710849A (zh) * 2020-12-24 2021-04-27 首都医科大学附属北京友谊医院 一种鉴定抗EBV免疫活性的ELISpot试剂盒、制备方法及应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021259571A1 (en) * 2020-04-22 2022-10-27 Nutcracker Therapeutics, Inc. mRNA treatment nanoparticles
CN111718409B (zh) * 2020-06-17 2021-03-02 深圳豪石生物科技有限公司 一种t细胞受体及其应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102405285A (zh) * 2009-02-18 2012-04-04 肿瘤疗法科学股份有限公司 Foxm1肽及包含它的疫苗
CN104619833A (zh) * 2012-09-11 2015-05-13 肿瘤疗法科学股份有限公司 Ube2t肽及包含它们的疫苗
WO2015075939A1 (ja) * 2013-11-21 2015-05-28 Ｒｅｐｅｒｔｏｉｒｅ Ｇｅｎｅｓｉｓ株式会社 Ｔ細胞受容体およびｂ細胞受容体レパトアの解析システムならびにその治療および診断への利用
CN106574244A (zh) * 2014-06-11 2017-04-19 保利比奥斯博特有限公司 用细胞因子组合物扩增淋巴细胞用于主动细胞免疫治疗
WO2017089768A1 (en) * 2015-11-23 2017-06-01 Immunocore Limited Peptides
CN107074932A (zh) * 2014-10-02 2017-08-18 美国卫生和人力服务部 分离对癌症特异性突变具有抗原特异性的t细胞受体的方法
WO2017161092A1 (en) * 2016-03-16 2017-09-21 Neximmune, Inc. Production of antigen-specific t-cells

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
EP0281604B1 (en) 1986-09-02 1993-03-31 Enzon Labs Inc. Single polypeptide chain binding molecules
US5714330A (en) 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6432360B1 (en) 1997-10-10 2002-08-13 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
WO2002072892A1 (en) 2001-03-12 2002-09-19 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
EP1590477B1 (en) 2003-01-29 2009-07-29 454 Corporation Methods of amplifying and sequencing nucleic acids
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
EP2230316A1 (en) 2005-02-01 2010-09-22 AB Advanced Genetic Analysis Corporation Nucleic acid sequencing by performing successive cycles of duplex extension
US7282337B1 (en) 2006-04-14 2007-10-16 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
ES2923759T3 (es) 2006-12-14 2022-09-30 Life Technologies Corp Aparato para medir analitos utilizando matrices de FET
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
CA2700278A1 (en) 2007-09-25 2009-04-02 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Modified t cell receptors and related materials and methods
US20100035252A1 (en) 2008-08-08 2010-02-11 Ion Torrent Systems Incorporated Methods for sequencing individual nucleic acids under tension
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US10202640B2 (en) * 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102405285A (zh) * 2009-02-18 2012-04-04 肿瘤疗法科学股份有限公司 Foxm1肽及包含它的疫苗
CN104619833A (zh) * 2012-09-11 2015-05-13 肿瘤疗法科学股份有限公司 Ube2t肽及包含它们的疫苗
WO2015075939A1 (ja) * 2013-11-21 2015-05-28 Ｒｅｐｅｒｔｏｉｒｅ Ｇｅｎｅｓｉｓ株式会社 Ｔ細胞受容体およびｂ細胞受容体レパトアの解析システムならびにその治療および診断への利用
CN106574244A (zh) * 2014-06-11 2017-04-19 保利比奥斯博特有限公司 用细胞因子组合物扩增淋巴细胞用于主动细胞免疫治疗
CN107074932A (zh) * 2014-10-02 2017-08-18 美国卫生和人力服务部 分离对癌症特异性突变具有抗原特异性的t细胞受体的方法
WO2017089768A1 (en) * 2015-11-23 2017-06-01 Immunocore Limited Peptides
WO2017161092A1 (en) * 2016-03-16 2017-09-21 Neximmune, Inc. Production of antigen-specific t-cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112710849A (zh) * 2020-12-24 2021-04-27 首都医科大学附属北京友谊医院 一种鉴定抗EBV免疫活性的ELISpot试剂盒、制备方法及应用

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US11598780B2 (en) 2023-03-07
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EP3691662A1 (en) 2020-08-12
WO2019071164A1 (en) 2019-04-11
JP7260553B2 (ja) 2023-04-18
JP2021502110A (ja) 2021-01-28
AU2018346765A1 (en) 2020-04-16

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