CN111743685A - Medical cold compress patch and preparation method thereof - Google Patents
Medical cold compress patch and preparation method thereof Download PDFInfo
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- CN111743685A CN111743685A CN202010591541.1A CN202010591541A CN111743685A CN 111743685 A CN111743685 A CN 111743685A CN 202010591541 A CN202010591541 A CN 202010591541A CN 111743685 A CN111743685 A CN 111743685A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/0241—Apparatus for the preparation of hot packs, hot compresses, cooling pads, e.g. heaters or refrigerators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0204—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing clay, mud, fango, sand, kaolin clay, volcanic or other inorganic granular solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0215—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing liquids other than water
- A61F2007/0219—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0226—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof adhesive, self-sticking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0244—Compresses or poultices for effecting heating or cooling with layers
- A61F2007/0249—Compresses or poultices for effecting heating or cooling with layers with a layer having low heat transfer capability
- A61F2007/0253—Compresses or poultices for effecting heating or cooling with layers with a layer having low heat transfer capability using a substance with low conductivity
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a medical cold compress patch and a preparation method thereof, in particular to a cold compress patch and a preparation method thereof. The invention aims to solve the problems that the existing cold compress products are ice-cold immediately after being applied without buffering, so that a user feels that the temperature difference changes suddenly and stimulation is generated. The medical cold compress patch consists of a non-woven fabric layer, a gel layer and a polyethylene film in sequence; the gel layer is prepared from a thickening agent, a humectant, natural cooling components, purified water, nano silicon dioxide and sodium silicate; the method comprises the following steps: firstly, weighing; secondly, preparing a mixed solution of a thickening agent and natural cooling ingredients; thirdly, homogenizing; fourthly, coating the homogenized mixture on a non-woven fabric layer; fifthly, preparing a mixed solution of the thickening agent and the humectant; sixthly, preparing a sodium silicate-nano silicon dioxide solution; seventhly, preparing a thickening solution containing nano silicon dioxide; pouring the mixture on the coating side of the backing layer, pressing a polyethylene film, cutting, curing and packaging. The invention relates to a medical cold compress patch and a preparation method thereof.
Description
Technical Field
The invention relates to a cold compress patch and a preparation method thereof.
Background
The medical cold compress patch is suitable for physical defervescence and cold compress physical therapy of closed soft tissues. The cold compress patch can achieve the effect of local cooling by vaporizing the water and natural cooling components contained in the cold compress patch to take away heat. The cold application can contract local capillary vessel, relieve local congestion, reduce sensitivity of nerve ending to relieve pain, reduce local blood flow, and prevent inflammation and suppuration diffusion. Can dissipate heat conduction in vivo, increase heat dissipation, and lower body temperature. The cold compress is suitable for people who need cold compress, such as early local soft tissue injury, high fever patients, heatstroke patients, toothache, redness and swelling and the like.
The medical cold compress patch product in the domestic market at present has the problems that the cold compress patch is ice-cold immediately after being used without buffering, so that a user feels that the temperature difference changes suddenly to generate stimulation, and the medical cold compress patch product is easy to influence the physique and generate stress response for suitable people with fever and the like.
Disclosure of Invention
The invention provides a medical cold compress patch and a preparation method thereof, aiming at solving the problems that the existing cold compress patch product has no buffer and is immediately cold after being applied, so that a user feels that the temperature difference changes suddenly and stimulation is generated.
A medical cold compress patch comprises a non-woven fabric layer, a gel layer and a polyethylene film from bottom to top in sequence; the gel layer is prepared from 10 to 20 parts of thickening agent, 10 to 20 parts of humectant, 5 to 10 parts of natural cooling component, 40 to 69 parts of purified water, 3 to 5 parts of nano silicon dioxide and 3 to 5 parts of sodium silicate in parts by mass;
the particle size of the nano silicon dioxide is 15 nm-20 nm.
A preparation method of a medical cold compress patch is carried out according to the following steps:
weighing 10-20 parts of thickening agent, 10-20 parts of humectant, 5-10 parts of natural cooling component, 40-69 parts of purified water, 3-5 parts of nano silicon dioxide and 3-5 parts of sodium silicate according to parts by weight, and then dividing the weighed 10-20 parts of thickening agent into a first part of thickening agent and a second part of thickening agent;
the mass ratio of the first part of thickening agent to the second part of thickening agent is (7-9) to 1;
the particle size of the nano silicon dioxide is 15 nm-20 nm;
dissolving the first part of thickening agent and 5-10 parts of natural cooling components in 16-27 parts of purified water, and stirring for 0.5-1 h at 80-85 ℃ and 60-65 r/min to obtain a mixture;
thirdly, under the conditions that the power is 100W-350W and the frequency is 25 KHz-30 KHz, the mixture is subjected to ultrasonic wave homogenizing mixing for 35 min-50 min to obtain a homogeneous solution;
uniformly coating the homogeneous solution on a non-woven fabric layer, and standing for later use to obtain a coated backing layer;
dissolving the second part of thickener and 10-20 parts of humectant in 16-27 parts of purified water, and stirring for 1-1.5 h at 80-85 ℃ and 60-65 r/min to obtain a mixed solution of the thickener and the humectant;
sixthly, dissolving 3 to 5 parts of nano silicon dioxide and 3 to 5 parts of sodium silicate in 8 to 15 parts of purified water, and stirring for 0.5 to 1 hour under the condition that the stirring speed is 60 to 65r/min to obtain a sodium silicate-nano silicon dioxide solution;
adding the sodium silicate-nano silicon dioxide solution into the mixed solution of the thickening agent and the humectant, and stirring for 0.5-1 h under the conditions that the temperature is 80-85 ℃ and the stirring speed is 60-65 r/mi to obtain the thickening solution containing nano silicon dioxide;
and eighthly, uniformly pouring the thickening solution containing the nano silicon dioxide on the coating side of the back lining layer, pressing a polyethylene film, and finally cutting, curing and packaging to obtain a medical cold compress finished product.
The invention has the beneficial effects that: the medical cold compress plaster has the advantages that the nano silicon dioxide component is added into the matrix component, the particle size is 15-20 nm, the medical cold compress plaster has the characteristics of extremely small particle size, extremely strong surface adsorption force, large specific surface area and the like, and the medical cold compress plaster is a white ultra-fine split body, and the space of the medical cold compress plaster is of a net structure, so that the heat conduction effect can be influenced, the medical cold compress plaster slowly cools and continuously takes away heat, a user can slowly adapt to temperature change under the condition of keeping the ice compress strength, the viscosity is ensured, the medical cold compress plaster is easier to remove, and a better effect can be achieved in a physical mode. If the silicon dioxide component with the ordinary particle size is used for replacing the nano silicon dioxide with the particle size of 15 nm-20 nm, the slow cooling and stripping effects of the cold compress patch are affected.
The product of the invention is divided into two layers after removing the covering layer, and the silicon dioxide is added into the layer close to the skin, so the process can play the slow release role greatly and is beneficial to being taken off.
The invention relates to a medical cold compress patch and a preparation method thereof.
Detailed Description
The technical solution of the present invention is not limited to the specific embodiments listed below, and includes any combination of the specific embodiments.
The first embodiment is as follows: the medical cold compress patch comprises a non-woven fabric layer, a gel layer and a polyethylene film from bottom to top in sequence; the gel layer is prepared from 10 to 20 parts of thickening agent, 10 to 20 parts of humectant, 5 to 10 parts of natural cooling component, 40 to 69 parts of purified water, 3 to 5 parts of nano silicon dioxide and 3 to 5 parts of sodium silicate in parts by mass;
the particle size of the nano silicon dioxide is 15 nm-20 nm.
The beneficial effects of the embodiment are as follows:
the medical cold compress plaster has the advantages that the nano silicon dioxide component is added into the matrix component, the particle size is 15-20 nm, the medical cold compress plaster has the characteristics of extremely small particle size, extremely strong surface adsorption force, large specific surface area and the like, and the medical cold compress plaster is a white ultra-fine split body, and the space of the medical cold compress plaster is of a net structure, so that the heat conduction effect can be influenced, the product can be slowly cooled and continuously takes away heat, a user can slowly adapt to temperature change under the condition of weight-preserving ice compress strength, the viscosity is ensured, the medical cold compress plaster is easier to take off, and a better effect can be achieved in a physical mode. If the silicon dioxide component with the ordinary particle size is used for replacing the nano silicon dioxide with the particle size of 15 nm-20 nm, the slow cooling and stripping effects of the cold compress patch are affected.
The product of the embodiment is divided into two layers after the covering layer is removed, and the silicon dioxide is added into the layer close to the skin, so that the process can play a role of slow release greatly and is beneficial to being taken off.
The second embodiment is as follows: the first difference between the present embodiment and the specific embodiment is: the thickening agent is sodium polyacrylate or polyvinyl alcohol. The rest is the same as the first embodiment.
The third concrete implementation mode: this embodiment is different from the first or second embodiment in that: the humectant is glycerol or 1, 2-propylene glycol. The other is the same as in the first or second embodiment.
The fourth concrete implementation mode: the difference between this embodiment mode and one of the first to third embodiment modes is: the natural cooling component is ethanol. The others are the same as the first to third embodiments.
The fifth concrete implementation mode: the difference between this embodiment and one of the first to fourth embodiments is: the particle size of the nano silicon dioxide is 15 nm-18 nm. The rest is the same as the first to fourth embodiments.
The sixth specific implementation mode: the embodiment provides a preparation method of a medical cold compress patch, which is carried out according to the following steps:
weighing 10-20 parts of thickening agent, 10-20 parts of humectant, 5-10 parts of natural cooling component, 40-69 parts of purified water, 3-5 parts of nano silicon dioxide and 3-5 parts of sodium silicate according to parts by weight, and then dividing the weighed 10-20 parts of thickening agent into a first part of thickening agent and a second part of thickening agent;
the mass ratio of the first part of thickening agent to the second part of thickening agent is (7-9) to 1;
the particle size of the nano silicon dioxide is 15 nm-20 nm;
dissolving the first part of thickening agent and 5-10 parts of natural cooling components in 16-27 parts of purified water, and stirring for 0.5-1 h at 80-85 ℃ and 60-65 r/min to obtain a mixture;
thirdly, under the conditions that the power is 100W-350W and the frequency is 25 KHz-30 KHz, the mixture is subjected to ultrasonic wave homogenizing mixing for 35 min-50 min to obtain a homogeneous solution;
uniformly coating the homogeneous solution on a non-woven fabric layer, and standing for later use to obtain a coated backing layer;
dissolving the second part of thickener and 10-20 parts of humectant in 16-27 parts of purified water, and stirring for 1-1.5 h at 80-85 ℃ and 60-65 r/min to obtain a mixed solution of the thickener and the humectant;
sixthly, dissolving 3 to 5 parts of nano silicon dioxide and 3 to 5 parts of sodium silicate in 8 to 15 parts of purified water, and stirring for 0.5 to 1 hour under the condition that the stirring speed is 60 to 65r/min to obtain a sodium silicate-nano silicon dioxide solution;
adding the sodium silicate-nano silicon dioxide solution into the mixed solution of the thickening agent and the humectant, and stirring for 0.5-1 h under the conditions that the temperature is 80-85 ℃ and the stirring speed is 60-65 r/mi to obtain the thickening solution containing nano silicon dioxide;
and eighthly, uniformly pouring the thickening solution containing the nano silicon dioxide on the coating side of the back lining layer, pressing a polyethylene film, and finally cutting, curing and packaging to obtain a medical cold compress finished product.
The seventh embodiment: the difference between this embodiment and one of the first to sixth embodiments is: the thickening agent in the step one is sodium polyacrylate or polyvinyl alcohol. The others are the same as the first to sixth embodiments.
The specific implementation mode is eight: the present embodiment differs from one of the first to seventh embodiments in that: the humectant in the step one is glycerin or 1, 2-propylene glycol. The rest is the same as the first to seventh embodiments.
The specific implementation method nine: the present embodiment differs from the first to eighth embodiments in that: the natural cooling component in the step one is ethanol. The other points are the same as those in the first to eighth embodiments.
The detailed implementation mode is ten: the present embodiment differs from one of the first to ninth embodiments in that: the particle size of the nano silicon dioxide in the step one is 15 nm-18 nm. The other points are the same as those in the first to ninth embodiments.
The following examples were used to demonstrate the beneficial effects of the present invention:
the first embodiment is as follows:
a preparation method of a medical cold compress patch is carried out according to the following steps:
firstly, weighing:
weighing 20 parts of thickening agent, 10 parts of humectant, 10 parts of natural cooling component, 50 parts of purified water, 5 parts of nano silicon dioxide and 5 parts of sodium silicate according to the mass parts, and then dividing the weighed 20 parts of thickening agent into a first part of thickening agent and a second part of thickening agent;
the mass ratio of the first part of thickening agent to the second part of thickening agent is 9: 1;
secondly, dissolving the first part of thickening agent and 10 parts of natural cooling ingredients which are weighed into 20 parts of purified water, and stirring for 1 hour at the temperature of 80 ℃ and the stirring speed of 60r/min to obtain a mixture;
thirdly, carrying out ultrasonic homogenization and mixing on the mixture for 40min under the conditions that the power is 200W and the frequency is 30KHz, so as to obtain a homogeneous solution;
uniformly coating the homogeneous solution on a non-woven fabric layer, and standing for later use to obtain a coated backing layer;
dissolving the second part of thickening agent and 10 parts of humectant in 20 parts of purified water, and stirring for 1.5 hours at the temperature of 80 ℃ and the stirring speed of 60r/min to obtain a mixed solution of the thickening agent and the humectant;
sixthly, dissolving 5 parts of nano silicon dioxide and 5 parts of sodium silicate in 10 parts of purified water, and stirring for 1 hour under the condition that the stirring speed is 60r/min to obtain a sodium silicate-nano silicon dioxide solution;
adding the sodium silicate-nano silicon dioxide solution into the mixed solution of the thickening agent and the humectant, and stirring for 0.5h at the temperature of 80 ℃ and the stirring speed of 60r/min to obtain a thickening solution containing nano silicon dioxide;
and eighthly, uniformly pouring the thickening solution containing the nano silicon dioxide on the coating side of the back lining layer, pressing a polyethylene film, and finally cutting, curing and packaging to obtain a medical cold compress finished product.
The thickening agent in the step one is sodium polyacrylate.
The humectant in the step one is glycerin.
The natural cooling component in the step one is ethanol.
The particle size of the nano silicon dioxide is 15 nm.
Other five kinds of medical cold compress plasters on the market are randomly selected and respectively numbered as reference numbers 1-5, reference number 6 is obtained by changing nano silicon dioxide with the particle size of 15nm in the formula of the embodiment into silicon dioxide with the particle size of 45 μm, and other processes are not changed, and then the cooling effect, the analgesic effect and the peeling effect are respectively compared.
The experimental method comprises the following steps: selecting 56 female volunteers (sensitive skin, local soft tissue injury, no skin ulceration, age 20-40 years) and dividing into 7 groups, wherein 8 female volunteers in each group use the product of the embodiment and controls 1-6 respectively for 10 days, and comparing the cooling effect, the analgesic effect and the stripping effect.
The cooling effect is divided into four grades, namely, I (immediately cold and pungent), II (immediately cold and tolerable), III (not immediately cold and unobvious in cooling effect after slow cooling) and IV (not immediately cold and better in continuous cooling effect after slow cooling);
the analgesic effect is divided into four grades of class I (general analgesic), class II (good analgesic effect), class III (good analgesic effect) and class IV (good analgesic effect).
The peel residue effect was classified into four grades, i.e., I (with adhesion and gel residue during peeling), II (with adhesion and no gel residue during peeling), III (without adhesion during peeling), and IV (without adhesion and without adhesion due to direct peeling).
The cold compress sample is pasted on the plastic plate, the plastic plate is fixed and vertical to the ground, one end of the upper part of the cold compress pasted on the plastic plate is downwards reversely folded for 180 degrees, a chuck for hanging 150g chips is fixed at one end of the upper part of the downward reversely folded for 180 degrees, the chips are slowly and stably sent out, the complete peeling time of the cold compress is observed, the cold compress sample is divided into 7 groups, and each group comprises 8 samples.
The peel strength effect is divided into four grades of I (too strong adhesiveness, falling within more than 60 seconds), II (good adhesiveness, falling within 30-60 seconds), III (good adhesiveness, falling within 10-30 seconds) and IV (poor adhesiveness, falling within 10 seconds).
And counting the number of the evaluated persons and the number of samples in each grade. The test results are shown in table 1 below.
TABLE 1
As can be seen from the table, the cold compress patch prepared by the embodiment has better analgesic, stripping and ice compress effects, and is superior to products 1-5 purchased in the market and a comparison 6 using a common silicon dioxide component to replace a nano silicon dioxide component.
Claims (10)
1. A medical cold compress patch is characterized in that the medical cold compress patch consists of a non-woven fabric layer, a gel layer and a polyethylene film from bottom to top in sequence; the gel layer is prepared from 10 to 20 parts of thickening agent, 10 to 20 parts of humectant, 5 to 10 parts of natural cooling component, 40 to 69 parts of purified water, 3 to 5 parts of nano silicon dioxide and 3 to 5 parts of sodium silicate in parts by mass;
the particle size of the nano silicon dioxide is 15 nm-20 nm.
2. The medical cold compress pack according to claim 1, wherein the thickening agent is sodium polyacrylate or polyvinyl alcohol.
3. The medical cold patch according to claim 1, wherein the humectant is glycerin or 1, 2-propylene glycol.
4. The medical cold patch according to claim 1, wherein the natural cooling component is ethanol.
5. The medical cold compress patch according to claim 1, wherein the nano silica has a particle size of 15nm to 18 nm.
6. The method for preparing a medical cold compress patch according to claim 1, which is carried out according to the following steps:
weighing 10-20 parts of thickening agent, 10-20 parts of humectant, 5-10 parts of natural cooling component, 40-69 parts of purified water, 3-5 parts of nano silicon dioxide and 3-5 parts of sodium silicate according to parts by weight, and then dividing the weighed 10-20 parts of thickening agent into a first part of thickening agent and a second part of thickening agent;
the mass ratio of the first part of thickening agent to the second part of thickening agent is (7-9) to 1;
the particle size of the nano silicon dioxide is 15 nm-20 nm;
dissolving the first part of thickening agent and 5-10 parts of natural cooling components in 16-27 parts of purified water, and stirring for 0.5-1 h at 80-85 ℃ and 60-65 r/min to obtain a mixture;
thirdly, under the conditions that the power is 100W-350W and the frequency is 25 KHz-30 KHz, the mixture is subjected to ultrasonic wave homogenizing mixing for 35 min-50 min to obtain a homogeneous solution;
uniformly coating the homogeneous solution on a non-woven fabric layer, and standing for later use to obtain a coated backing layer;
dissolving the second part of thickener and 10-20 parts of humectant in 16-27 parts of purified water, and stirring for 1-1.5 h at 80-85 ℃ and 60-65 r/min to obtain a mixed solution of the thickener and the humectant;
sixthly, dissolving 3 to 5 parts of nano silicon dioxide and 3 to 5 parts of sodium silicate in 8 to 15 parts of purified water, and stirring for 0.5 to 1 hour under the condition that the stirring speed is 60 to 65r/min to obtain a sodium silicate-nano silicon dioxide solution;
adding the sodium silicate-nano silicon dioxide solution into the mixed solution of the thickening agent and the humectant, and stirring for 0.5-1 h under the conditions that the temperature is 80-85 ℃ and the stirring speed is 60-65 r/mi to obtain the thickening solution containing nano silicon dioxide;
and eighthly, uniformly pouring the thickening solution containing the nano silicon dioxide on the coating side of the back lining layer, pressing a polyethylene film, and finally cutting, curing and packaging to obtain a medical cold compress finished product.
7. The method for preparing a medical cold compress pack according to claim 6, wherein the thickening agent in the first step is sodium polyacrylate or polyvinyl alcohol.
8. The method for preparing a medical cold patch according to claim 6, wherein the humectant in the first step is glycerin or 1, 2-propylene glycol.
9. The method for preparing a medical cold patch according to claim 6, wherein the natural cooling component in the first step is ethanol.
10. The method for preparing a medical cold compress pack according to claim 6, wherein the particle size of the nano silicon dioxide in the step one is 15nm to 18 nm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010591541.1A CN111743685B (en) | 2020-06-24 | 2020-06-24 | Medical cold compress subsides |
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| CN202010591541.1A CN111743685B (en) | 2020-06-24 | 2020-06-24 | Medical cold compress subsides |
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