CN105878217A - Medical cold compress plaster and preparation process thereof - Google Patents
Medical cold compress plaster and preparation process thereof Download PDFInfo
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- CN105878217A CN105878217A CN201510016786.0A CN201510016786A CN105878217A CN 105878217 A CN105878217 A CN 105878217A CN 201510016786 A CN201510016786 A CN 201510016786A CN 105878217 A CN105878217 A CN 105878217A
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Abstract
The invention provides a medical cold compress plaster. The medical cold compress plaster is composed of a support layer, a gel layer and an isolating layer, and has the special shape according with the physiological curve of the applied part. An oil phase and a water phase forming the hydrophilic gel layer respectively comprise the following components in percentage by weight: the oil phase: 20-35% of a dispersing agent, 5-7% of macromolecule resin, 0.05-0.15% of dihydroxyaluminium aminoacetate, 0.01-0.15% of ethylene diamine tetraacetic acid, 0.15% of absolute ethyl alcohol, 0.04-0.1% of menthol, 0.1-1% of vitamin E, and 0.05-0.1% of triclosan; the water phase: 0.2-0.8% of tartaric acid, 1.2-2% of carbomer, 0.5-1% of sodium carboxymethylcellulose, 0.01-0.1% of vitamin C, the balance of medical purified water, and the total weight percentage is 100%. A preparation process comprises the following steps: dispersing all the components of the oil phase into the dispersing agent, and uniformly stirring the components; dissolving all the components of the water phase into water, and uniformly stirring the components; mixing the water phase and the oil phase, uniformly stirring the water phase and the oil phase in a vacuum mixing pot, thus obtaining the hydrophilic gel substrate of the medical cold compress plaster, coating the support layer with the hydrophilic gel substrate, meanwhile covering with the isolating layer, and carrying out cutting, solidifying and packaging to obtain the needed medical cold compress plaster product.
Description
Technical field
The present invention relates to a kind of Medical cold apply ointment or plaster, particularly relate to a kind of analgesia of local skin after closure soft tissue, laser surgery, the cold compress articles for use of cold compress physical therapy, and preparation technology.
Background technology
Closure soft tissue due to a variety of causes (such as acute soft tissue injury), or physiological needs local cooling (such as scrotum local cooling to improve the vigor of sperm), and after local skin is due to laser surgery or cold therapy, typically each need cold compress physical therapy, so as reduction local skin temperature, detumescence hemostasis, the effect eased the pain, thus reach to alleviate or the expection purpose for the treatment of disease.Traditional cold compress physical therapy method mainly sticks affected part or specific part with ice cube or ice cube complex (being generally referred to as ice bag), to reach cold compress analgesic purpose.
Although ice bag cold compress physical therapy therapeutic effect is notable, but restricted by existing ice bag inherent character, ice compress therapy yet suffers from many shortcomings and deficiencies: as frozen when ice bag fills cold, ice bag can be solidified as bulk, it is difficult to accomplish to fit completely for ice compress position during urgent use, especially joint or body curvature position；Ice bag need to fill and cold could use, and needs long cryopreservation, uses inconvenience；Ice bag is placed in refrigerator, and temperature ratio is relatively low, and for infant and position that some is special, patient can produce sense of discomfort；Basic therapeutic effect the most targetedly；Ice bag inner refrigerant leaks, contaminated wound position；And when using, patient generally has to keep certain posture, it is impossible to movable etc..Currently also having cold-producing medium is colloid and at the non-icing cold compress bag of subzero, and it can solve the problem that product is the most docile, but cannot solve equally to fix relatively difficult problem when product uses.
Patent 201310198916.8 discloses a kind of testis cold compress patch and preparation method thereof, the formula of this patent adds dihydroxyaluminum aminoacetate as cross-linking agent, but non-patch cross-linking regulator, in a small amount of process of the test, trial target can be processed, but during heavy production, be not added with cross-linking regulator, macromolecule mixture crosslinking is too fast, easily occurs being coated with phenomenon；Another after it obtains macromolecule mixture, coated on polyethylene film, make attached preparation, more attached preparation is pasted on non-woven fabrics, be coated with laggard circulation of qi promoting and cut.The method of this technique is relatively backward, adds many processing steps, is unfavorable for large-scale production, wastes time and energy；Macromolecule mixture is first coated on polyethylene film simultaneously, and macromolecule mixture easily comes off；And when completing the operation that attached preparation is pasted on non-woven fabrics, non-woven fabrics is soft, and macromolecule mixture is more moistening, and macromolecule mixture and non-woven fabrics stick docile difficulty, it may appear that non-woven fabrics gauffer, waste product easily occurs.
Patent 201410026916.4 discloses a kind of condyloma acuminatum cold compress special nursing Medical ice bag, its essence is the outer bag adding in the outside of ice bag and once containing Chinese medicine, play the effect that cold compress is administered simultaneously, expectant treatment for condyloma acuminatum, but there is the problem that cannot fix in the design of this patent, during use, the easy displacement of ice bag, come off.
Summary of the invention
It is an object of the invention to provide for the deficiencies in the prior art a kind of novel, easy to use, stick docile, use safety and there is the Medical cold of anti-inflammatory analgesic function apply ointment or plaster, and preparation technology.Present invention can apply to the cold compress analgesia of skin laser treatment Post operation and local soft tissue damage, the alleviation of eyestrain, scrotum cold compress physical therapy etc..
To achieve the object of the present invention, the technical solution used in the present invention is:
A kind of Medical cold is applied ointment or plaster, by supporting that layer, gel layer and sealing coat form, it is characterised in that the profile that Medical cold is applied ointment or plaster is the special shape meeting and using position physiological curve；Described gel layer is hydrogel, the biphase material of oil phase and aqueous phase mix, and the concrete constituent mass percentage ratio of each phase is as follows:
1) oil phase: dispersant 20～35%, macromolecule resin 5～7%, dihydroxyaluminum aminoacetate 0.05～0.15%, disodiumedetate 0.01～0.15%, dehydrated alcohol 0.15%, menthol 0.04～0.1%, vitamin E 0.1～1%, triclosan 0.05～0.1%；
2) aqueous phase: tartaric acid 0.2～0.8%, 1.2～2% carbomer, sodium carboxymethyl cellulose 0.5～1%, vitamin C 0.01～0.1%, the medical purified water of surplus complements to 100%.
The preparation technology that described Medical cold is applied ointment or plaster is as follows:
1) oil phase is first configured: by being sequentially added in dispersant dissolved with the unparalleled ethanol solution of triclosan and menthol, vitamin E, macromolecule resin, dihydroxyaluminum aminoacetate, disodiumedetate, stir, stand-by after de-bubbled；
2) aqueous phase configuration: first vitamin C, tartaric acid are dissolved in 50% water, to be dissolved completely after, the water surface dissipates carbomer, swelling 12～24 hours, stirs stand-by；Separately take remaining water, sodium carboxymethyl cellulose is dispersed in the water surface, after swelling 12～14 hours, stirs in being positioned over agitated kettle, without any caking, stand-by；By above-mentioned carboxymethylcellulose sodium solution, the mixing of carbomer solution solution, stir, be aqueous phase, stand-by after de-bubbled；
3) above-mentioned aqueous phase and oil phase are mixed, stir in vacuum stirring pot, obtain Medical-use cold compress agio gel-type vehicle, hydrogel matrix is coated on support layer, cover sealing coat simultaneously, clipped, solidify, pack after i.e. obtain required Medical cold and apply ointment or plaster product.
Described Medical cold is applied ointment or plaster, and the dispersant in its oil phase component is glycerol or sorbic acid；Macromolecule resin is polyacrylic resin, and concrete model and ratio are NP-700 0～6%, sodium polyacrylate 0～6%, AH-105X 0～3%, AH-106X 0～3%.
The material that the support layer that described Medical cold is applied ointment or plaster is selected is non-woven fabrics or compound nonwoven cloth.
The sealing coat that described Medical cold is applied ointment or plaster, for polyethylene film, scribbles the one in the release paper of silicone oil and pearl film.
Described Medical cold is applied ointment or plaster, and the special shape meeting use position physiological curve described in it is the crown shape that top has four finger structures.
Described Medical cold is applied ointment or plaster, and the special shape meeting use position physiological curve described in it is similar sanitary towel's shape for women.
Described Medical cold is applied ointment or plaster, and meets the facial film shape that special shape is split using position physiological curve described in it.
Described Medical cold is applied ointment or plaster, and the special shape meeting use position physiological curve described in it is raindrop shape.
The former of this product cooling is to make, by containing high moisture in gel layer, after absorbing the heat of skin, to be distributed heat to by steam in the environment of surrounding, thus play the effect of cooling cold compress.Difformity of the present invention is for the cold compress physical therapy of different parts, the structure of the crown shape profile with four finger structures is mainly used in the Physical temperature-lowering of scrotum, special physiological structure according to scrotum position, sealing coat is removed during use, the crown shape central part alignment radix penis part of four fingers, the bottom of the bottom alignment testis of crown shape sticks, and makes this product and scrotum stick more docile；Causing the scrotum temperature auxiliary therapy higher than normal value patient as a variety of causes, the cold compress being simultaneously also used for scrotal varices patient processes；The structure of female sanitary towel shape profile is mainly used in the analgesia cold compress physical therapy after female vulva and crissum condyloma acuminatum laser therapy；Split facial film shape contour structures is mainly used in the laser beautifying of facial area or postoperative analgesia cold compress physical therapy；Raindrop shape contour structures is mainly pasted on eyelid, releases eyestrain and improves vision.
Cold compress patch is at different use positions, and the cold compress physical therapy after difference, such as laser beautifying be need not the biggest adhesion by its adequate adhesion needed, as long as ensureing not fall off, typically can cling No. 3 steel balls, other side needs bigger adhesion, it is ensured that do not fall off.The inventors discovered that, by the proportioning of different model polyacrylic resin in macromolecular material, the hydrogel of different adhesion size can be adjusted, to adapt to not allow position to stick demand.The ratio of NP-700 and AH-106 is high on the whole, and adhesion increases, and sodium polyacrylate and AH-105 content are high, and adhesion weakens.
In use, have been found that simultaneously in colloid, be not added with disodiumedetate, no problem in a small amount of colloid test, but when doing large-scale production, such as when 40-50 kg of water gel colloidal produces, at painting process, the part colloid being finally coated with will be unable to coating, because colloid is the most hardened, therefore, add disodiumedetate in the present invention as cross-linking regulator, to solve large-scale production because solidification colloid cannot be coated with problem.It addition, cmc is with being mixed into aqueous phase after water-swellable rather than being added into glycerol and mix mutually in the present invention, be conducive to the last colloid obtaining uniformity, it is to avoid CMC caking in gel occurs, causes final products waste product.
In hydrogel coating process; the present invention uses and is disposably coated with compound technique at hydrogel glue and non-woven fabrics and sealing coat; avoid such as the attached preparation of first processing described in patent 201310198916.8; again by attached preparation secondary and non-woven fabric compounded operation; simplify production technology, beneficially large-scale production.
The beneficial effects are mainly as follows:
Medical cold the most of the present invention is applied ointment or plaster single use, safety and sanitation；
Medical cold the most of the present invention is applied ointment or plaster and is had pain relieving, antiinflammatory, the effect of suppression antibacterial；
Medical cold the most of the present invention is applied ointment or plaster and can repeatedly be taken off patch, is so conducive to local to observe；
Medical cold the most of the present invention is applied ointment or plaster, and to need not pre-cooling/fill cold, i.e. tears i.e. use open, easy to use；
Medical cold the most of the present invention apply ointment or plaster initial temperature with its place environment consistent, it is to avoid low temperature stimulation；
Medical-use cold compress the most of the present invention patch good biocompatibility, is not result in that patient sticks position allergy and stimulation；
Medical cold the most of the present invention patch patch, uses according to using position, adhesion scalable, makes patient experiences comfortable；
Medical cold the most of the present invention is applied ointment or plaster,
Medical-use cold compress the most of the present invention be sticked meter different profiles, it is adaptable to the analgesia cold therapy of different parts, stick docile.
Accompanying drawing explanation
Fig. 1 is cross section structure schematic diagram of the present invention: 1, sealing coat, 2, hydrogel layer, 3, support layer；
Fig. 2 is crown shape appearance schematic diagram: 4, four fingers at crown shape profile top, 5, crown shape profile；
Fig. 3 is sanitary towel's shape appearance schematic diagram: 6, sanitary towel's shape profile；
Fig. 4 is split facial film shape appearance schematic diagram: 7, split facial film shape profile；
Fig. 5 is raindrop shape appearance schematic diagram: 8, raindrop shape profile.
Explanation of nouns:
Compound nonwoven cloth: refer in the present invention on the basis of common non-woven fabric, after being combined one layer of thin film with ventilative different water by various means, has non-woven fabrics and the non-woven fabrics of film bilayer structure.
Detailed description of the invention
Below in conjunction with the accompanying drawings the present invention and preparation technology thereof are described further, but the protection domain of invention is not limited to that.
Embodiment 1: a kind of Medical cold is applied ointment or plaster, by supporting that layer, gel layer and sealing coat form；The profile that Medical cold is applied ointment or plaster is the crown shape with four finger structures meeting and using position physiological curve.Described gel layer is hydrogel, the biphase material of oil phase and aqueous phase mix, and the concrete constituent mass percentage ratio of each phase and preparation technology are as follows,
The preparation technology that described Medical cold is applied ointment or plaster is as follows: 1) first configure oil phase: the triclosan of 0.05% and the menthol of 0.04% is added in 0.15% dehydrated alcohol and is completely dissolved solution；0.01% vitamin E, 3%NP-700 and 3%AH-106X, 0.08% dihydroxyaluminum aminoacetate, 0.01% disodiumedetate are sequentially added in the glycerol of 30%, stir, stand-by after de-bubbled；2) aqueous phase configuration: 0.01% vitamin C, 0.2% tartaric acid is dissolved in the medical purified water of 50%, to be dissolved completely after, the water surface dissipates 1.2% carbomer, swelling 12～24 hours, stirs stand-by；Separately take remaining water, 0.5% sodium carboxymethyl cellulose is dispersed in the water surface, after swelling 12～14 hours, stirs in being positioned over agitated kettle, without any caking, stand-by；By above-mentioned carboxymethylcellulose sodium solution, carbomer solution mixing, stir, be aqueous phase, stand-by after de-bubbled；3) above-mentioned aqueous phase and oil phase are mixed, stir in vacuum stirring pot, obtain Medical-use cold compress agio gel-type vehicle, hydrogel matrix is coated on support layer, cover isolating membrane simultaneously, clipped, solidify, pack after i.e. obtain required Medical cold and apply ointment or plaster product.
The material that the support layer that Medical cold described above is applied ointment or plaster is selected is compound nonwoven cloth, and sealing coat is polyethylene film.
Implement 2: a kind of Medical cold is applied ointment or plaster, by supporting that layer, gel layer and sealing coat form；The profile that Medical cold is applied ointment or plaster is the sanitary towel's shape similar for women meeting and using position physiological curve.Described gel layer is hydrogel, the biphase material of oil phase and aqueous phase mix, and the concrete constituent mass percentage ratio of each phase and preparation technology are as follows,
The preparation technology that described Medical cold is applied ointment or plaster is as follows: 1) first configure oil phase: the triclosan of 0.1% and the menthol of 0.1% is added in 0.15% dehydrated alcohol and is completely dissolved solution；0.1% vitamin E, 3%NP-700 and 3%AH-106X, 0.1% dihydroxyaluminum aminoacetate, 0.08% disodiumedetate are sequentially added in the glycerol of 25%, stir, stand-by after de-bubbled；2) aqueous phase configuration: 0.1% vitamin C, 0.4% tartaric acid is dissolved in the medical purified water of 50%, to be dissolved completely after, the water surface dissipates 2% carbomer, swelling 12～24 hours, stirs stand-by；Separately take remaining water, 1% sodium carboxymethyl cellulose is dispersed in the water surface, after swelling 12～14 hours, stirs in being positioned over agitated kettle, without any caking, stand-by；By above-mentioned carboxymethylcellulose sodium solution, carbomer solution mixing, stir, be aqueous phase, stand-by after de-bubbled；3) above-mentioned aqueous phase and oil phase are mixed, stir in vacuum stirring pot, obtain Medical-use cold compress agio gel-type vehicle, hydrogel matrix is coated on support layer, cover sealing coat simultaneously, clipped, solidify, pack after i.e. obtain required Medical cold and apply ointment or plaster product.
The material that the support layer that Medical cold described above is applied ointment or plaster is selected is compound nonwoven cloth, and sealing coat is the release paper scribbling silicone oil.
Implement 3: a kind of Medical cold is applied ointment or plaster, by supporting that layer, gel layer and sealing coat form；The profile that Medical cold is applied ointment or plaster is the split facial film shape meeting and using position physiological curve.Described gel layer is hydrogel, the biphase material of oil phase and aqueous phase mix, and the concrete constituent mass percentage ratio of each phase and preparation technology are as follows,
Described Medical cold apply ointment or plaster patch preparation technology as follows: 1) first configure oil phase: the triclosan of 0.05% and the menthol of 0.05% are added in 0.15% dehydrated alcohol and are completely dissolved solution；0.1% vitamin E, 3% sodium polyacrylate and 3%AH-105X, 0.15% dihydroxyaluminum aminoacetate, 0.1% disodiumedetate are sequentially added in the glycerol of 25%, stir, stand-by after de-bubbled；2) aqueous phase configuration: 0.1% vitamin C, 0.4% tartaric acid is dissolved in the medical purified water of 50%, to be dissolved completely after, the water surface dissipates 1.5% carbomer, swelling 12～24 hours, stirs stand-by；Separately take remaining water, 1% sodium carboxymethyl cellulose is dispersed in the water surface, after swelling 12～14 hours, stirs in being positioned over agitated kettle, without any caking, stand-by；By above-mentioned carboxymethylcellulose sodium solution, carbomer solution mixing, stir, be aqueous phase, stand-by after de-bubbled；3) above-mentioned aqueous phase and oil phase are mixed, stir in vacuum stirring pot, obtain Medical-use cold compress agio gel-type vehicle, hydrogel matrix is coated on support layer, cover sealing coat simultaneously, clipped, solidify, pack after i.e. obtain required Medical cold and apply ointment or plaster product.
The material that the support layer that Medical cold described above is applied ointment or plaster is selected is non-woven fabrics, and sealing coat is poly-pearl film.
Implement 4: a kind of Medical cold is applied ointment or plaster, by supporting that layer, gel layer and sealing coat form；The profile that Medical cold is applied ointment or plaster be meet use position physiological curve for raindrop shape.Described gel layer is hydrogel, the biphase material of oil phase and aqueous phase mix, and the concrete constituent mass percentage ratio of each phase and preparation technology are as follows,
Described Medical cold apply ointment or plaster patch preparation technology as follows: 1) first configure oil phase: the triclosan of 0.02% and the menthol of 0.02% are added in 0.15% dehydrated alcohol and are completely dissolved solution；0.1% vitamin E, 3% sodium polyacrylate and 1.5%AH-105X, 2.5%NP-700,0.15% dihydroxyaluminum aminoacetate, 0.1% disodiumedetate are sequentially added in the glycerol of 20%, stir, stand-by after de-bubbled；2) aqueous phase configuration: 0.1% vitamin C, 0.6% tartaric acid is dissolved in the medical purified water of 50%, to be dissolved completely after, the water surface dissipates 1.5% carbomer, swelling 12～24 hours, stirs stand-by；Separately take remaining water, 0.8% sodium carboxymethyl cellulose is dispersed in the water surface, after swelling 12～14 hours, stirs in being positioned over agitated kettle, without any caking, stand-by；By above-mentioned carboxymethylcellulose sodium solution, carbomer solution mixing, stir, be aqueous phase, stand-by after de-bubbled；3) above-mentioned aqueous phase and oil phase are mixed, stir in vacuum stirring pot, obtain Medical-use cold compress agio gel-type vehicle, hydrogel matrix is coated on support layer, cover sealing coat simultaneously, clipped, solidify, pack after i.e. obtain required Medical cold and apply ointment or plaster product.
The material that the support layer that Medical cold described above is applied ointment or plaster is selected is non-woven fabrics, and sealing coat is polyethylene film
Implement 5: a kind of Medical cold is applied ointment or plaster, by supporting that layer, gel layer and sealing coat form；The profile that Medical cold is applied ointment or plaster is the facial film shape for split meeting and using position physiological curve.Described gel layer is hydrogel, the biphase material of oil phase and aqueous phase mix, and the concrete constituent mass percentage ratio of each phase and preparation technology are as follows,
Described Medical cold apply ointment or plaster patch preparation technology as follows: 1) first configure oil phase: the triclosan of 0.05% and the menthol of 0.06% are added in 0.15% dehydrated alcohol and are completely dissolved solution；0.1% vitamin E, 6% sodium polyacrylate, 1%NP-700,0.15% dihydroxyaluminum aminoacetate, 0.1% disodiumedetate are sequentially added in the glycerol of 20%, stir, stand-by after de-bubbled；2) aqueous phase configuration: 0.1% vitamin C, 0.6% tartaric acid is dissolved in the medical purified water of 50%, to be dissolved completely after, the water surface dissipates 1.5% carbomer, swelling 12～24 hours, stirs stand-by；Separately take remaining water, 0.1% sodium carboxymethyl cellulose is dispersed in the water surface, after swelling 12～14 hours, stirs in being positioned over agitated kettle, without any caking, stand-by；By above-mentioned carboxymethylcellulose sodium solution, carbomer solution mixing, stir, be aqueous phase, stand-by after de-bubbled；3) above-mentioned aqueous phase and oil phase are mixed, stir in vacuum stirring pot, obtain Medical-use cold compress agio gel-type vehicle, hydrogel matrix is coated on support layer, cover sealing coat simultaneously, clipped, solidify, pack after i.e. obtain required Medical cold and apply ointment or plaster product.
The material that the support layer that Medical cold described above is applied ointment or plaster is selected is non-woven fabrics, and sealing coat is polyethylene film.
Claims (9)
1. a Medical cold is applied ointment or plaster, by supporting that layer, gel layer and sealing coat form, it is characterised in that the profile that Medical cold is applied ointment or plaster is symbol
Close the special shape using position physiological curve；Described gel layer is hydrogel, the biphase material of oil phase and aqueous phase mix,
The concrete constituent mass percentage ratio of each phase is as follows:
1) oil phase: dispersant 20～35%, macromolecule resin 5～7%, dihydroxyaluminum aminoacetate 0.05～0.15%, ethylenediaminetetraacetic acid two
Sodium 0.01～0.15%, dehydrated alcohol 0.15%, menthol 0.04～0.1%, vitamin E 0.1～1%, triclosan 0.05～
0.1%, Tween 80 0.01～0.5%；
2) aqueous phase: tartaric acid 0.2～0.8%, 1.2～2% carbomer, sodium carboxymethyl cellulose 0.5～1%, vitamin C 0.01～
0.1%, the medical purified water of surplus complements to 100%.
2. Medical cold as claimed in claim 1 is applied ointment or plaster, it is characterised in that the preparation technology that Medical cold is applied ointment or plaster is as follows:
1) oil phase is first configured: by dissolved with the unparalleled ethanol solution of triclosan and menthol, vitamin E, macromolecule resin, sweet hydroxyl
Aluminum, disodiumedetate are sequentially added in dispersant, stir, stand-by after de-bubbled；
2) aqueous phase configuration: first by vitamin C, tartaric acid is dissolved in the water of 50%, to be dissolved completely after, the water surface dissipates card
Ripple nurse, swelling 12～24 hours, stirs stand-by；Separately take remaining water, sodium carboxymethyl cellulose is dispersed
At the water surface, after swelling 12～14 hours, stir in being positioned over agitated kettle, without any caking, stand-by；By above-mentioned
Carboxymethylcellulose sodium solution, carbomer solution mixing, stir, be aqueous phase, stand-by after de-bubbled；
3) above-mentioned aqueous phase and oil phase are mixed, stir in vacuum stirring pot, obtain Medical-use cold compress agio gel-type vehicle, will
Hydrogel matrix is coated on support layer, covers sealing coat simultaneously, clipped, solidify, pack after i.e. obtain required doctor
Use cold compress patch product.
3. Medical cold as claimed in claim 1 is applied ointment or plaster, it is characterised in that the described dispersant in oil phase component is glycerol or Pyrusussuriensis
Acid；Macromolecule resin is polyacrylic resin, concrete model and ratio are NP-700 0～6%, sodium polyacrylate 0～
6%, AH-105X 0～3%, AH-106X 0～3%.
4. Medical cold as claimed in claim 1 is applied ointment or plaster, it is characterised in that the material that described support layer is selected is non-woven fabrics or compound
Non-woven fabrics.
5. Medical cold as claimed in claim 1 is applied ointment or plaster, it is characterised in that described sealing coat, for polyethylene film, scribbles silicone oil
Release paper and pearl film in one.
Medical cold the most according to claim 1 is applied ointment or plaster, it is characterised in that described meets the special shape using position physiological curve
There is the crown shape of four finger structures for top.
Medical cold the most according to claim 1 is applied ointment or plaster, it is characterised in that described meets the special shape using position physiological curve
For similar sanitary towel's shape for women.
Medical cold the most according to claim 1 is applied ointment or plaster, it is characterised in that described meets the special shape using position physiological curve
Facial film shape for split.
Medical cold the most according to claim 1 is applied ointment or plaster, it is characterised in that described meets the special shape using position physiological curve
For raindrop shape.
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| CN201510016786.0A CN105878217A (en) | 2015-01-12 | 2015-01-12 | Medical cold compress plaster and preparation process thereof |
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Application publication date: 20160824 |