CN106729624A - Adjust endocrine anti-aging biological agent, preparation method and applications - Google Patents

Adjust endocrine anti-aging biological agent, preparation method and applications Download PDF

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Publication number
CN106729624A
CN106729624A CN201611261128.9A CN201611261128A CN106729624A CN 106729624 A CN106729624 A CN 106729624A CN 201611261128 A CN201611261128 A CN 201611261128A CN 106729624 A CN106729624 A CN 106729624A
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parts
biological agent
extract
water
mixed liquor
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董朝阳
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GUANGZHOU GREEN HUMAN BIOTECHNOLOGY CO Ltd
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GUANGZHOU GREEN HUMAN BIOTECHNOLOGY CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1748—Keratin; Cytokeratin
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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Abstract

The present invention relates to pharmaceutical technology field, more particularly to a kind of endocrine anti-aging biological agent of regulation.The biological agent includes the component of following mass parts：60 70 parts of water, 0.8 part of diosgenin, 0.1 part of honokiol, 1 part of honeysuckle flower extract, 0.1 part of hyaluronic acid, 0.5 part of soya-bean polypeptides, 3 parts of jojoba seed oil, 6 parts of cetostearyl alcohol, 2 parts of rilanit special, 2 parts of cetearyl glucoside, 3 parts of propane diols, 0.5 part of safflower seed oil, 1 part of stearine, 0.1 part of ethylenediamine tetra-acetic acid, 0.1 part of Sodium Benzoate, 3.5 parts of caprylic/capric triglyceride, 5 parts of red ginseng extract, 5 parts of gadol extract, 0.2 part of keratin, 3 parts of Shorthorned Epimedium P.E, 0.1 part of Cer EOS, 1 part of moutan root bark extract.The biological agent can adjust organism endocrine to normal condition, with the comprehensive function of improving skin.

Description

Adjust endocrine anti-aging biological agent, preparation method and applications
Technical field
It is biological the present invention relates to pharmaceutical technology field, more particularly to a kind of anti-aging with regulation organism endocrine function Preparation.
Background technology
The current product for being used for hormone supplemented on the market is generally following several：The first is synthetic hormone, by chemical former Material synthesis, such as progesterone, contraceptive, oestrone, estradiol, mainly use inside hospital.Second is animal sex hormone, by The embryo of animal and thymus gland are extracted, such as sheep placenta, placental hormone, and price is costly.3rd is plant hormone, such as the different Huang of soybean Female element in ketone, day etc..These HRTs have not really in the world of medicine to alleviating the aspects such as menopause symptom, menstrual period symptom , there is the flaws such as certain bounce-back, dependence in wrong curative effect, but human body long-term use foreign aid's sex hormone.
In addition, the skin care item for acting on skin are merely able to simply improve skin surface problem of aging, and determine skin senescence True kernel reason come from the aging or lesion of body tissue function, especially as women, endocrinopathy and hormone point The flat decline of bleeding, is to cause women in advance into the basic reason of early ageing.
The content of the invention
In order to solve the above technical problems, the present invention provide one kind can adjust organism endocrine to normal condition, have The biological agent of the functions such as whitening and anti-aging.
In order to realize technique effect of the invention, employ following technical scheme and be achieved：
A kind of anti-aging biological agent for adjusting organism endocrine, its component for including following mass parts：Water 60-70 parts, 0.8 part of diosgenin, 0.1 part of honokiol, 1 part of honeysuckle flower extract, 0.1 part of hyaluronic acid, 0.5 part of soya-bean polypeptides, suddenly Suddenly bar seed oil 3 parts, 6 parts of cetostearyl alcohol, 2 parts of rilanit special, 2 parts of cetearyl glucoside, 3 parts of propane diols, kardiseed 0.5 part of oil, 1 part of stearine, 0.1 part of ethylenediamine tetra-acetic acid, 0.1 part of Sodium Benzoate, caprylic/capric triglyceride 3.5 Part, 5 parts of red ginseng extract, 5 parts of gadol extract, 0.2 part of keratin, 3 parts of Shorthorned Epimedium P.E, 0.1 part of Cer EOS, 1 part of moutan root bark extract.Stearine can be that glyceryl monostearate, the double stearates of glycerine and glycerine three are stearic One or more in acid esters.
As a further improvement, the biological agent is creme.It is easy to be applied to the surface of skin using creme.When So, biological agent of the present invention can also be liquid or emulsion form.
As a further improvement, the water is deionized water.
Present invention also offers the preparation method of biological agent described above, it is comprised the steps of：
1) 85 DEG C will be warming up to being completely dissolved and obtain water phase during water, ethylenediamine tetra-acetic acid add the first container；
2) by material honokiol, jojoba seed oil, cetostearyl alcohol, rilanit special, cetearyl glucoside, red Flower seed oil, stearine, caprylic/capric triglyceride and Cer EOS are added in second container, and stirring is warming up to 80 DEG C, treat that whole materials are completely dissolved, obtain oil phase；
3) oil phase and water are added in emulsifier unit and are emulsified, obtain emulsifying uniform emulsion；
4) when emulsion temperature is 70 DEG C, to adding diosgenin in emulsion and being well mixed, the first mixed liquor is obtained；
5) when the first mixeding liquid temperature is 65 DEG C, to the mixture that hyaluronic acid and propane diols are added in the first mixed liquor And be well mixed, obtain the second mixed liquor；
6) when the second mixeding liquid temperature is 55 DEG C, to adding soya-bean polypeptides and keratin in the second mixed liquor and mix It is even, obtain the 3rd mixed liquor；
7) when the 3rd mixeding liquid temperature is 50 DEG C, extracted to honeysuckle flower extract, rhodiola root is added in the 3rd mixed liquor It is well mixed after thing, moutan root bark extract, red ginseng extract, Shorthorned Epimedium P.E, Sodium Benzoate.
As a further improvement, step 3) concrete technology be：Oil phase is first added into emulsifier unit, is added under agitation Water phase, finishes rear homogeneous 3 minutes, and 42 DEG C are incubated 15 minutes.This can be such that oil phase and water mutually preferably mixes.
As a further improvement, the first container is water phase pot；Second container is oil phase pot；Emulsifier unit is emulsification pot.
Present invention also offers the application of biological agent described above in regulation organism endocrine and anti-aging, it should It is that biological agent is applied to the surface of skin with method.
Beneficial effects of the present invention are as follows：
The present invention starts with from human body inherent mechanism, takes the combination principle of " monarch ", the key of body of gland precursor Composition diosgenin, is absorbed by transdermal penetration, can effectively realize that hormonal readiness secretion is too high and hormonal readiness secretion is too low Bidirectional modulation, with reach health poised state.Continuously observed within one month using biological agent of the present invention, it is bidirectional balanced effective Rate is up to more than 90%, and to human body without any adverse reaction and side effect.Skin can quickly be improved simultaneously yellow, black, lax State, desalinates melanin, supplements the various nutriments of skin, helps user to obtain whitening, the effect of desalination wrinkle in a short time.
The present invention has following resultant effect to human body：The women of premature menopause recovers to pass through；Significantly alleviate climacteric synthesis Disease, sleep is improved, delaying human body caducity；Frigidity crowd's sexual desire is remarkably reinforced；Make whitening skin degree, glossiness, consolidation Degree is obviously improved；Lifting function of human body immunocompetence, has clear improvement even clinical to the part proliferation of mammary gland, patients with uterine myoma Cure.
Specific embodiment
Embodiment 1
A kind of anti-aging biological agent for adjusting organism endocrine, its component for including following mass parts：62 parts of water, Chinese yam 0.8 part of sapogenin, 0.1 part of honokiol, 1 part of honeysuckle flower extract, 0.1 part of hyaluronic acid, 0.5 part of soya-bean polypeptides, Jojoba 3 parts of seed oil, 6 parts of cetostearyl alcohol, 2 parts of rilanit special, 2 parts of cetearyl glucoside, 3 parts of propane diols, safflower seed oil 0.5 It is part, 1 part of stearine, 0.1 part of ethylenediamine tetra-acetic acid, 0.1 part of Sodium Benzoate, 3.5 parts of caprylic/capric triglyceride, red 5 parts of conopsea extraction, 5 parts of gadol extract, 0.2 part of keratin, 3 parts of Shorthorned Epimedium P.E, 0.1 part of Cer EOS, tree peony 1 part of root bark extract.
The preparation method of the biological agent of the embodiment of the present invention 1 is：
1) 85 DEG C will be warming up to being completely dissolved and obtain water phase during water, ethylenediamine tetra-acetic acid add water phase pot；
2) by material honokiol, jojoba seed oil, cetostearyl alcohol, rilanit special, cetearyl glucoside, red Flower seed oil, stearine, caprylic/capric triglyceride and Cer EOS are added in oil phase pot, and stirring is warming up to 80 DEG C, Treat that whole materials are completely dissolved, obtain oil phase；
3) oil phase is first added into emulsification pot, water phase is added under agitation, homogeneous is started after finishing 3 minutes, be incubated 15 minutes, Obtain emulsifying uniform emulsion；
4) when emulsion temperature is 70 DEG C, to adding diosgenin in emulsion and being well mixed, the first mixed liquor is obtained；
5) when the first mixeding liquid temperature is 65 DEG C, to the mixture that hyaluronic acid and propane diols are added in the first mixed liquor And be well mixed, obtain the second mixed liquor；
6) when the second mixeding liquid temperature is 55 DEG C, to adding soya-bean polypeptides and keratin in the second mixed liquor and mix It is even, obtain the 3rd mixed liquor；
7) when the 3rd mixeding liquid temperature is 50 DEG C, extracted to honeysuckle flower extract, rhodiola root is added in the 3rd mixed liquor It is well mixed after thing, moutan root bark extract, red ginseng extract, Shorthorned Epimedium P.E, Sodium Benzoate, obtains the 4th mixture.
8) when the 4th mixing temperature is 42 DEG C of dischargings, stand.
4th mixture can be preserved at least 2 years at normal temperatures, will not produce the phenomenons such as rotten, precipitation.
Certainly, step 8) can also have filling later, pack, coding；After sampling observation is qualified, the step of storage.
The biological agent of the embodiment of the present invention 1 is applied to skin surface, is smeared 2 times daily, sooner or later respectively once, using effect Fruit is as follows：
1) bidirectional modulation female sex hormone so that female sex hormone returns to normal value, prevents what various hormonal problems caused Disease, clinical effective rate reaches 90%.
2) continuous to use 15-60 days, puberty women can promote chest to develop naturally, allow the fuller consolidation of chest；(this Effect application process can be to be applied to chest sooner or later daily, voluntarily massages 5-10 minutes and fully absorbs to product； Can be chest massage manipulation 15-20 minutes/time for combining beauty parlor, it is better 2 times a week.)
3) it is continuous to use 30-120 days, by adjusting adrenal gland and sexual gland, various gonadal hormones, estrogen are balanced, improve Uterus environment, has remarkable result to softening elimination fibroid；(daily sooner or later after ear, oxter, inboard arm, lumbosacral region, abdomen Butt crack, femoribus internus, vola spread product are to fully absorbing.)
4) it is continuous to use 5-15 days, mastodynia, the proliferation of mammary gland, breast lump, mastitis are significantly improved；(this Effect application process can be applied to chest sooner or later daily, voluntarily massage 5-10 minutes and fully absorb to product；Also may be used It is better 2 times a week to be chest massage manipulation 15-20 minutes/time for combining beauty parlor.)
5) first use (is applied to sooner or later daily to the effect that scapulohumeral periarthritis, arthritis, DOMS have instant relief pain Painful area skin surface)；
Ovary can be reactivated to being on the verge of menopause or women because of early ageing premature menopause, recovers normal physiological function, prolonged Slow climacteric, improve menopause symptom.(daily sooner or later after ear, oxter, inboard arm, lumbosacral region, groin, femoribus internus, Vola spread product is to fully absorbing.)
In addition, the embodiment of the present invention 1 also has having the advantages that, 1 is specifically shown in Table：
The using effect table of 1 embodiment of the present invention of table 1
Note：In table 1, each Experiment on Function crowd is 100 people, and 100 people has the problem corresponding with effect, uses After the embodiment of the present invention 1, situation is improved.For example：Effect is to reduce cholesterol (lipid-loweringing), and continuous use time is 60-120 My god, the ratio that situation is improved is 85%, means that 100 cholesterol level people high continuously use 60-120 days, 85% people's cholesterol level reduction.Certainly, using during 60-120 days, cholesterol level people up to standard can not be followed by It is continuous to use.Other various effects are also that when reaching satisfied effect, can stop using the biological agent of the embodiment of the present invention 1.
In addition, in table 1, when application point is lipid-loweringing or skin, its application process is：Daily sooner or later by the embodiment of the present invention 1 Product be applied to need improve area skin surface to skin fully absorb.
When application point is endocrine, its application process is：Daily sooner or later after ear, oxter, inboard arm, lumbosacral region, abdomen Butt crack, femoribus internus, vola spread product are to fully absorbing.
When application point is for spirit, its application process is：Daily sooner or later after ear, between neck side, two breast, inboard arm, Thick, vola spread product is to fully absorbing in lumbosacral region, groin, thigh.
When application point is other, its application process is：Daily sooner or later after ear, between neck side, infraclavicular fossa, two breast it Between, inboard arm, lumbosacral region, both sides waist, groin, at femoribus internus, popliteal nests, vola spread product is to fully absorbing i.e. Can.
No. CAS of Cer EOS is 100403-19-8 in the present invention；The title is international cosmetic raw material standard Chinese Title specified in Names Catalogue.
Embodiment 1 is illustrated by taking creme as an example, and certainly, in embodiment 1 in addition to water, other constitutive materials are not Become, when changing water consumption, biological agent of the present invention can be liquid or emulsion form.For example it is frost when water consumption is 60 parts Agent, is emulsion when water consumption is 70 parts.
In a word, the characteristic of biological agent of the present invention is：
1) bidirectional modulation, balancing hormones
Use biological agent of the invention, it is to avoid hormonal readiness too high (carcinogenic), too low (various diseases after the middle age occur Shape) negative consequence, especially skin, this is especially useful (delaying senility function) to the women after entering 30 years old, and it can be people The hormonal readiness that body has occurred is disorderly by bidirectional modulation, is allowed to reach poised state again.
2) direct single hormone supplemented or supplement synthetic hormone it are not
Biological agent of the present invention is not in itself hormone, and also without hormone, but supplement human body itself produces the forerunner of hormone Material, is to stimulate human body itself to secrete an instrument for producing hormone；The biological system of endocrine anti-aging is adjusted by external smearing Agent, makes people oneself produce hormone in vivo, allows body secreting hormone according to their needs.The hormone that human body itself is produced is the mankind Friend, it is not to enter internal with the identity of exogenous hormone to autohormone, therefore will not give people to bring side effect.From root Help improve the various problems such as solution acne, spot, chest, wrinkle, stature.
3) Transdermal absorption ability is good
Biological agent of the present invention is carried before can largely inducing human endocrine body of gland to produce hormone with through-transmission technique Material is driven, skin is penetrated in the extremely short time, and do not destroy its activity, the active ingredient entrained by it is promptly released into In fine vascular, into blood circulation, and each organ of body is reached, so as to induce each endocrine cell generation of human body various Required hormone, and by autologous bidirectional modulation, allow it to reach poised state.The through-transmission technique, A, can carry most Drug ingedient, and the activity of medicine is not destroyed；B., there is very strong transdermal capability, and this transdermal must be not damaged Property；C, penetrate skin after entrained insoluble drug release can be entered blood.
Its mechanism of action is：The molecular weight very little of product each composition, by skin absorption, blood is reached by subcutaneous osmotic Liquid, body of gland is reached by blood circulation conveying products composition (this process is only needed 7 seconds).Body of gland is absorbed (predecessor of hormone) Hormone, so as to stimulate the corresponding hormone of glandular secretion of human body, is then sent to whole body by diosgenin by blood circulation again Each internal organs organ, the hormone of body is reached balance.It is finally completed the conditioning and improvement of inferior health problem.
Moreover, biological agent of the present invention is external preparation, it is not necessary to absorbed by liver, it is to avoid to the poison of liver Side effect；Assimilation effect improves 80 times (avoiding gastral decomposition destruction)；Skin is first beneficiary, especially Action effect to subcutaneous fat is notable.
4) no dependence, has no side effect
Many raw materials are extracted using pure plant in biological agent of the present invention, and human body is made without any dependence and poison pair With can for a long time maintain and use.
Hormone of the present invention is usually hormone hormone.
As described above, only the preferred embodiments of the invention, when the scope that implementation of the invention can not be limited with this, I.e. generally according to simple equivalence changes done by the content described in the claims in the present invention and description of the invention with modification, all still Within category the claims in the present invention scope.Additionally, summary part and title are intended merely to auxiliary patent document searches it With not for limiting the interest field of the present invention.

Claims (7)

1. it is a kind of adjust organism endocrine anti-aging biological agent, it is characterised in that its component for including following mass parts：Water 60-70 parts, 0.8 part of diosgenin, 0.1 part of honokiol, 1 part of honeysuckle flower extract, 0.1 part of hyaluronic acid, soya-bean polypeptides 0.5 part, 3 parts of jojoba seed oil, 6 parts of cetostearyl alcohol, 2 parts of rilanit special, 2 parts of cetearyl glucoside, propane diols 3 Part, 0.5 part of safflower seed oil, 1 part of stearine, 0.1 part of ethylenediamine tetra-acetic acid, 0.1 part of Sodium Benzoate, caprylic/capric are sweet Oily 3.5 parts of three ester, 5 parts of red ginseng extract, 5 parts of gadol extract, 0.2 part of keratin, 3 parts of Shorthorned Epimedium P.E, neural acyl 1 0.1 parts of amine, 1 part of moutan root bark extract.
2. biological agent as claimed in claim 1, it is characterised in that the biological agent is creme.
3. biological agent as claimed in claim 1, it is characterised in that the water is deionized water.
4. the preparation method of the biological agent as described in claim 1-3 any one, it is characterised in that comprise the steps of：
1) 85 DEG C will be warming up to being completely dissolved and obtain water phase during water, ethylenediamine tetra-acetic acid add the first container；
2) by material honokiol, jojoba seed oil, cetostearyl alcohol, rilanit special, cetearyl glucoside, kardiseed Oil, stearine, caprylic/capric triglyceride and Cer EOS are added in second container, and stirring is warming up to 80 DEG C, treats Whole materials are completely dissolved, and obtain oil phase；
3) oil phase and water are added in emulsifier unit and are emulsified, obtain emulsifying uniform emulsion；
4) when emulsion temperature is 70 DEG C, to adding diosgenin in emulsion and being well mixed, the first mixed liquor is obtained；
5) when the first mixeding liquid temperature is 65 DEG C, to adding the mixture of hyaluronic acid and propane diols in the first mixed liquor and mix Close uniform, obtain the second mixed liquor；
6) when the second mixeding liquid temperature is 55 DEG C, to adding soya-bean polypeptides and keratin in the second mixed liquor and be well mixed, Obtain the 3rd mixed liquor；
7) when the 3rd mixeding liquid temperature is 50 DEG C, to adding honeysuckle flower extract, gadol extract, male in the 3rd mixed liquor It is well mixed after red root bark extract, red ginseng extract, Shorthorned Epimedium P.E, Sodium Benzoate.
5. the preparation method of biological agent as claimed in claim 4, it is characterised in that step 3) concrete technology be：First will Oil phase adds emulsifier unit, and water phase is added under agitation, finishes rear homogeneous 3 minutes, and 15 minutes are incubated at 42 DEG C.
6. the preparation method of biological agent as claimed in claim 4, it is characterised in that the first container is water phase pot；Second holds Device is oil phase pot；Emulsifier unit is emulsification pot.
7. application of the biological agent as described in claim 1-3 any one in regulation organism endocrine and anti-aging, its It is characterised by, its application process is that biological agent is applied to the surface of skin.
CN201611261128.9A 2016-12-30 2016-12-30 Adjust endocrine anti-aging biological agent, preparation method and applications Pending CN106729624A (en)

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CN108686052A (en) * 2018-07-02 2018-10-23 郑州大学第附属医院 It is a kind of to adjust endocrine anti-aging biological agent, preparation method and applications
CN108743478A (en) * 2018-07-11 2018-11-06 赣州龙九科技有限公司 A kind of external application adjusts the equilibrium cream and preparation method thereof for skin of releiving
CN113244355A (en) * 2021-05-24 2021-08-13 广州德蔓生物科技有限公司 Hormone double controlled release regulating patch and preparation method thereof
CN113413350A (en) * 2021-07-13 2021-09-21 广州芳利医药科技有限公司 Composition for improving female hormone level and preparation method and application thereof
CN114028463A (en) * 2021-10-25 2022-02-11 马虹 Moistening cream for relieving various gynecological diseases

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108686052A (en) * 2018-07-02 2018-10-23 郑州大学第附属医院 It is a kind of to adjust endocrine anti-aging biological agent, preparation method and applications
CN108743478A (en) * 2018-07-11 2018-11-06 赣州龙九科技有限公司 A kind of external application adjusts the equilibrium cream and preparation method thereof for skin of releiving
CN113244355A (en) * 2021-05-24 2021-08-13 广州德蔓生物科技有限公司 Hormone double controlled release regulating patch and preparation method thereof
CN113413350A (en) * 2021-07-13 2021-09-21 广州芳利医药科技有限公司 Composition for improving female hormone level and preparation method and application thereof
CN114028463A (en) * 2021-10-25 2022-02-11 马虹 Moistening cream for relieving various gynecological diseases

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