CN106620514A - Traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal and preparation method of traditional Chinese medicine hydrophilic gel patch - Google Patents
Traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal and preparation method of traditional Chinese medicine hydrophilic gel patch Download PDFInfo
- Publication number
- CN106620514A CN106620514A CN201611089882.9A CN201611089882A CN106620514A CN 106620514 A CN106620514 A CN 106620514A CN 201611089882 A CN201611089882 A CN 201611089882A CN 106620514 A CN106620514 A CN 106620514A
- Authority
- CN
- China
- Prior art keywords
- hydrophilic gel
- chinese medicine
- dysmenorrhoea
- treated according
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal. The traditional Chinese medicine hydrophilic gel patch comprises the following components in percentage by mass: 1-10% of a salvia miltiorrhiza extract, 1-10% of a polygonum cuspidatum extract, 1-10% of a Corydalis yanhusuo extract, 1-10% of a turmeric extract, 2.5-10% of hydrophilic gel, 0-1% of a cross-linking agent, 20-40% of a moistening agent, 1-12% of a penetration enhancer, 0-5% of a surfactant, 0-0.1% of a filling agent, 1-3% of an adhesive and 40-70% of a solvent. The traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal of females is capable of regulating menstruation and removing coldness, warming wombs, activating blood and removing stasis, soothing livers and regulating qi and relieving pain, is simple in treatment and convenient to use. The patch is relatively convenient to use, is capable of overcoming the defects that a conventional patch is small in substrate medicine carrying capacity and sensitization can be easily caused, and moreover is relatively good in biocompatibility and peeling property with skin, small in toxic and/or side effect and good in patient compliance.
Description
Technical field
The present invention relates to pharmaceutical technology field, more particularly, to a kind of Chinese medicine hydrophilic gel plaster and its system for treating dysmenorrhoea
Preparation Method.
Background technology
Dysmenorrhoea is one of modal gynaecology's symptom, refers to before and after passing through or lower abdominal pain, falling inflation occurs in the menstrual period, with
The soreness of waist or other uncomfortable, serious symptom impact quality of life persons.Dysmenorrhoea is divided into primary dysmenorrhea and the class of Secondary cases two, primary pain
Jing refers to dysmenorrhoea of the reproductive organs without organic disease, accounts for dysmenorrhoea more than 90%；Acquired dysmenorrhea refers to is drawn by pelvic cavity organic disease
The dysmenorrhoea for rising.
Treating the method for dysmenorrhoea at this stage has following several：1. physical therapy：Fully rest, notes warming, using warm patch
Hot-water bag etc.；2. drug therapy；Anodyne, Chinese medicine, drug for invigorating blood circulation and eliminating stasis etc. are common are in drug therapy；3. operative treatment：It is main
It is used for organic dysmenorrhea.
But the method for above-mentioned treatment dysmenorrhoea has defect：It is administered orally, medication is inconvenient, while the side effect to human body
It is relatively large；It is long to there is the cycle in Chinese medicine conditioning, medicine is bitter, it is costly the shortcomings of.
Hydrophilic gel pleximetric paste (Babu cream) be with water-soluble high-molecular compound or hydroaropic substance as matrix, with
After medicine or Chinese medical extract mixing, external application paster made by non-woven fabrics is coated.It is biocompatibility to skin, ventilative
Property, repeat to take off pulling property preferable, and drugloading rate is big, be difficult allergy.The states such as the seventies initial stage, Japan, Europe have started to develop
Medical cataplasm, with the continuous development of medical industry, this novel form has developed in recent years in China.
The content of the invention
It is an object of the invention to overcome above-mentioned technical deficiency, propose a kind of Small side effects and drugloading rate is big, be difficult allergy
The Chinese medicine hydrophilic gel plaster for the treatment of dysmenorrhoea and preparation method thereof.
To reach above-mentioned technical purpose, technical scheme provides a kind of Chinese medicine hydrophilic gel patch for treating dysmenorrhoea
Agent, it includes the following component of mass percent：
Preferably, described hydrophilic gel is part neutralization Sodium Polyacrylate.
Preferably, described crosslinking agent is organic acid, such as tartaric acid, citric acid and aluminium hydroxide, Sodium Glycinate, sweet ammonia
The mixing of any one or more in sour aluminium, tetrasodium ethylenediamine tetraacetate.
Preferably, described NMF is any one or more in glycerine, propane diols, sorbierite, polyethylene glycol
Mixing.
Preferably, described surfactant is tween.
Preferably, described filler is in kaolin, zinc oxide, superfine silica gel powder, calcium carbonate, bentonite, titanium dioxide
Any one.
Preferably, described binder is any one in gelatin, sodium carboxymethylcellulose, PVP
Kind；
Preferably, described penetrating agent is ethanol, propane diols, glycerine, oleic acid, Liquid Macrogol, PEG400, low
Two or more mixing in molecule alcohols, azone, urea, peppermint, camphor, borneol, eucalyptus oil, selinum oil.
Preferably, described solvent is water.
A kind of preparation method of the Chinese medicine hydrophilic gel plaster for treating dysmenorrhoea, it comprises the steps：
(1) get the raw materials ready by following mass percent：Salvia root P.E 1～10%, Gentrin Knotweed P.E 1～10%, rhizoma corydalis are carried
Take thing 1～10%, Turmeric P.E 1～10%, hydrophilic gel 2.5%～10%, crosslinking agent 0～1%, NMF 20～
40%th, penetrating agent 1～12%, surfactant 0～5%, filler 0～0.1%, binder l～3%, solvent 40～74%；
(2) hydrophilic gel, binder, surfactant, penetrating agent, filler are dispersed under agitation
A phases are formed in NMF；
(3) by Salvia root P.E, Gentrin Knotweed P.E, rhizoma corydalis extract, Turmeric P.E and crosslinking agent in stirring condition
Under be dispersed in solvent formation B phases；
(4) B is added to into A phases, stirring 5-10 minutes under vacuum is dispersed in A phases and forms gel, then
By gel coating on non-woven fabrics, it is covered with diaphragm and uniformly cuts, Jing cold curings 12 hours is into gel paster.
Present invention offer is a kind of to treat Chinese medicine hydrophilic gel plaster of dysmenorrhoea and preparation method thereof, and it is directed to the dysmenorrhoea of women
Palace is warmed up in symptom, menstruation regulating cold dispelling, and simple and convenient use is treated in promoting blood circulation and removing blood stasis, dispersing stagnated hepatoqi, pain relieving, meanwhile, gel adhesive
Solve that traditional patch matrix drugloading rate is little, easy sensitization shortcoming, and the biocompatibility with skin, patch property can be taken off preferably,
Toxic and side effect is little, and patient compliance is good.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is not used to only to explain the present invention
Limit the present invention.
Embodiment 1
Embodiments of the invention 1 provide a kind of Chinese medicine hydrophilic gel plaster for treating dysmenorrhoea, including mass percent is such as
Under component：
(extract) Salvia root P.E 1.0%, Gentrin Knotweed P.E 1.0%, rhizoma corydalis extract 1.0%, Turmeric P.E
1.0%
(penetrating agent) azone 3.0%, PEG 7.0%
(surfactant) tween 3.0%
(binder) gelatin 1.0%
(crosslinking agent) tetrasodium ethylenediamine tetraacetate 0.125%, citric acid 0.25%
(filler) kaolin 0.1%
The glycerine 20% of (NMF) propane diols 5.0%
(hydrophilic gel) part neutralization Sodium Polyacrylate 4.0%
(solvent) water 52.525%.
The preparation method of the Chinese medicine hydrophilic gel plaster for the treatment of dysmenorrhoea is as follows：
Get the raw materials ready by following mass percent：Salvia root P.E 1.0%, Gentrin Knotweed P.E 1.0%, rhizoma corydalis extract
1.0%th, Turmeric P.E 1.0%, azone 3.0%, PEG 7.0%, tween 3.0%, gelatin 1.0%, ethylenediamine tetra-acetic acid four
Sodium 0.125%, citric acid 0.25%, kaolin 0.1%, propane diols 5.0%, glycerine 20%, part neutralization Sodium Polyacrylate
4.0%th, water 52.525%；
Part neutralization Sodium Polyacrylate, gelatin, tween, azone, PEG, kaolin are dispersed under agitation
A phases are formed in the mixture of propane diols and glycerine；By Salvia root P.E, Gentrin Knotweed P.E, rhizoma corydalis extract, Turmeric P.E
And tetrasodium ethylenediamine tetraacetate, citric acid are dispersed under agitation formation B phases in water；Again B is added to into A phases,
Stirring under vacuum condition is dispersed in A phases and forms gel for 5 minutes, then by gel coating on non-woven fabrics, is covered with protection
Film is simultaneously uniformly cut, and Jing cold curings 12 hours are into gel paster.
Embodiment 2
Embodiments of the invention 2 provide a kind of Chinese medicine hydrophilic gel plaster for treating dysmenorrhoea, including mass percent is such as
Under component：
(extract) Salvia root P.E 3.0%, Gentrin Knotweed P.E 3.0%, rhizoma corydalis extract 3.0%, Turmeric P.E
3.0%
(penetrating agent) oleic acid 1.0%, azone 3.0%, PEG 1.0%
(surfactant) tween 2.0%
(binder) gelatin 1.0%
(crosslinking agent) aluminium hydroxide 0.075%, tartaric acid 0.25%
(filler) zinc oxide 0.1%
The glycerine 25% of (NMF) propane diols 5.0%
(hydrophilic gel) part neutralization Sodium Polyacrylate 4.0%
(solvent) water 45.575%.
The preparation method of the Chinese medicine hydrophilic gel plaster for the treatment of dysmenorrhoea is as follows：
Get the raw materials ready by following mass percent：Salvia root P.E 3.0%, Gentrin Knotweed P.E 3.0%, rhizoma corydalis extract
3.0%th, Turmeric P.E 3.0%, oleic acid 1.0%, azone 3.0%, PEG, 1.0%, tween 2.0%, gelatin 1.0%, hydrogen-oxygen
Change aluminium 0.075%, tartaric acid 0.25%, zinc oxide 0.1%, propane diols 5.0%, glycerine 25%, part neutralization Sodium Polyacrylate
4.0%th, water 45.575%；
Part neutralization Sodium Polyacrylate, gelatin, tween, oleic acid, azone, PEG, zinc oxide are uniformly divided under agitation
Dissipate the formation A phases in the mixture of propane diols and glycerine；Salvia root P.E, Gentrin Knotweed P.E, rhizoma corydalis extract, turmeric are carried
Take thing and aluminium hydroxide, tartaric acid are dispersed under agitation formation B phases in water；Again B is added to into A phases, in vacuum
Under the conditions of stirring be dispersed in A phases within 10 minutes and form gel, then by gel coating on non-woven fabrics, be covered with diaphragm,
And uniformly cut, Jing cold curings 12 hours are into gel paster.
Embodiment 3
Embodiments of the invention 3 provide a kind of Chinese medicine hydrophilic gel plaster for treating dysmenorrhoea, including mass percent is such as
Under component：
(extract) Salvia root P.E 4.0%, Gentrin Knotweed P.E 4.0%, rhizoma corydalis extract 5.0%, Turmeric P.E
5.0%
(crosslinking agent) aluminum glycinate 0.1%, tetrasodium ethylenediamine tetraacetate 0.025%, tartaric acid 0.25%
(NMF) propane diols 7.5%, glycerine 15%
(surfactant) tween 2.0%
(penetrating agent) azone 3.0%, urea 3.0%, peppermint 0.6%, PEG2.5%
(filler) zinc oxide 0.1%
(binder) CMC-Na 1%
(hydrophilic gel) part neutralization Sodium Polyacrylate 2.5%
(solvent) water 40.425%.
The preparation method of the Chinese medicine hydrophilic gel plaster for the treatment of dysmenorrhoea is as follows：
Get the raw materials ready by following mass percent：Salvia root P.E 4.0%, Gentrin Knotweed P.E 4.0%, rhizoma corydalis extract
5.0%th, Turmeric P.E 5.0%, aluminum glycinate 0.1%, tetrasodium ethylenediamine tetraacetate 0.025%, tartaric acid 0.25%, the third two
Alcohol 7.5%, glycerine 15%, tween 2.0%, azone 3.0%, urea 3.0%, peppermint 0.6%, PEG2.5%, zinc oxide
0.1%th, CMC-Na1%, part neutralization Sodium Polyacrylate 2.5%, water 40.425%；
By part neutralization Sodium Polyacrylate, CMC-Na, tween, azone, urea, peppermint, PEG, zinc oxide in stirring condition
Under be dispersed in the mixture of propane diols and glycerine formation A phases；Salvia root P.E, Gentrin Knotweed P.E, rhizoma corydalis are extracted
Thing, Turmeric P.E and aluminum glycinate, tetrasodium ethylenediamine tetraacetate, tartaric acid are dispersed under agitation shape in solvent
Into B phases；Again B is added to into A phases, stirring under vacuum is dispersed in A phases and forms gel for 8 minutes, then by gel
Coat on non-woven fabrics, be covered with diaphragm and uniformly cut, Jing cold curings 12 hours are into gel paster.
The medicine that Application Example 1 is made carries out clinical treatment to 30 patients, the age of patient at 16～40 years old, greatly
It is most unmarried, it is primary dysmenorrhea.Begin to use within first day from clean period, continuous patch 7 days, be within 7th a course for the treatment of.Do not heal
Person, then the next menstrual cycle proceed the next course for the treatment of.Healing person, does not use.
Therapeutic effect：Most of patients can be cured using 3～4 courses for the treatment of, the course of disease is longer, the state of an illness than more severe case, need clothes
It is specific as follows with 6～8 courses for the treatment of：After three courses for the treatment of of treatment：Cure 16, take a turn for the better 11, invalid 3.Five courses for the treatment of of treatment
Afterwards：Cure 22, take a turn for the better 8, invalid 0.
Model case
Zhang, female, 32 years old, unbearably, chilly was cold for menstrual period hypogastralgia, palpitation and short breath, cold perspiration, pale complexion.Make
Treated with the medicine (embodiment 1) of the present invention, after 5 courses for the treatment of of treatment, symptom mitigation, after 8 courses for the treatment of of treatment, symptom disappears, after
It is continuous to consolidate 2 courses for the treatment of, recurrence that so far there are no.
It is high so-and-so, female, 16 years old, patient suffered from dysmenorrhoea, and bellyache in menstrual period, nausea, weak, cold perspiration, cold limbs, many kinds of Jing is controlled
Treat, effect is bad.The medicine (embodiment 1) for taking the present invention afterwards is treated, and after 3 courses for the treatment of of treatment, symptom substantially mitigates, and continues
2 courses for the treatment of are taken, is cured.Follow-up so far there are no recurrence.
Present invention offer is a kind of to treat Chinese medicine hydrophilic gel plaster of dysmenorrhoea and preparation method thereof, for the dysmenorrhoea disease of women
Palace is warmed up in shape, menstruation regulating cold dispelling, and simple and convenient use is treated in promoting blood circulation and removing blood stasis, dispersing stagnated hepatoqi, pain relieving.Patch uses more square
Just, it is possible to resolve traditional patch matrix drugloading rate is little, easy sensitization shortcoming, and the biocompatibility with skin, can take off patch property compared with
Good, toxic and side effect is little, and patient compliance is good.
The specific embodiment of present invention described above, does not constitute limiting the scope of the present invention.Any basis
Various other corresponding change and deformation that the technology design of the present invention is made, should be included in the guarantor of the claims in the present invention
In the range of shield.
Claims (10)
1. a kind of Chinese medicine hydrophilic gel plaster for treating dysmenorrhoea, it is characterised in that including the following component of mass percent：
2. the Chinese medicine hydrophilic gel plaster of dysmenorrhoea is treated according to claim 1, it is characterised in that described hydrophilic gel
For part neutralization Sodium Polyacrylate.
3. the Chinese medicine hydrophilic gel plaster of dysmenorrhoea is treated according to claim 1, it is characterised in that described crosslinking agent is have
Machine acid, such as in tartaric acid, citric acid and aluminium hydroxide, Sodium Glycinate, aluminum glycinate, tetrasodium ethylenediamine tetraacetate any one
Or various mixing.
4. the Chinese medicine hydrophilic gel plaster of dysmenorrhoea is treated according to claim 1, it is characterised in that described NMF is sweet
The mixing of any one or more in oil, propane diols, sorbierite, polyethylene glycol.
5. the Chinese medicine hydrophilic gel plaster of dysmenorrhoea is treated according to claim 1, it is characterised in that described surfactant
For tween.
6. the Chinese medicine hydrophilic gel plaster of dysmenorrhoea is treated according to claim 1, it is characterised in that described filler is height
Any one in ridge soil, zinc oxide, superfine silica gel powder, calcium carbonate, bentonite, titanium dioxide.
7. the Chinese medicine hydrophilic gel plaster of dysmenorrhoea is treated according to claim 1, it is characterised in that described binder is bright
Any one in glue, sodium carboxymethylcellulose, PVP.
8. the Chinese medicine hydrophilic gel plaster of dysmenorrhoea is treated according to claim 1, it is characterised in that described penetrating agent is second
Alcohol, propane diols, glycerine, oleic acid, Liquid Macrogol, PEG400, low molecule alcohol, azone, urea, peppermint, camphor, ice
Two or more mixing in piece, eucalyptus oil, selinum oil.
9. the Chinese medicine hydrophilic gel plaster of dysmenorrhoea is treated according to claim 1, it is characterised in that described solvent is water.
10. a kind of preparation method of the Chinese medicine hydrophilic gel plaster for treating dysmenorrhoea, it is characterised in that comprise the steps：
(1) get the raw materials ready by following mass percent：Salvia root P.E 1～10%, Gentrin Knotweed P.E 1～10%, rhizoma corydalis extract 1
～10%, Turmeric P.E 1～10%, hydrophilic gel 2.5%～10%, crosslinking agent 0～1%, NMF 20～40%, rush
Penetration enhancer 1～12%, surfactant 0～5%, filler 0～0.1%, binder l～3%, solvent 40～74%；
(2) hydrophilic gel, binder, surfactant, penetrating agent, filler are dispersed in under agitation moisturizing
A phases are formed in agent；
(3) it is Salvia root P.E, Gentrin Knotweed P.E, rhizoma corydalis extract, Turmeric P.E and crosslinking agent is equal under agitation
It is even to be scattered in formation B phases in solvent；
(4) B is added to into A phases, stirring 5-10 minutes under vacuum is dispersed in A phases and forms gel, then will be solidifying
Glue is coated on non-woven fabrics, is covered with diaphragm and is uniformly cut, and Jing cold curings 12 hours are into gel paster.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611089882.9A CN106620514A (en) | 2016-12-01 | 2016-12-01 | Traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal and preparation method of traditional Chinese medicine hydrophilic gel patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611089882.9A CN106620514A (en) | 2016-12-01 | 2016-12-01 | Traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal and preparation method of traditional Chinese medicine hydrophilic gel patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106620514A true CN106620514A (en) | 2017-05-10 |
Family
ID=58814025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611089882.9A Pending CN106620514A (en) | 2016-12-01 | 2016-12-01 | Traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal and preparation method of traditional Chinese medicine hydrophilic gel patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106620514A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108543051A (en) * | 2018-07-20 | 2018-09-18 | 河南姜生堂生物科技有限公司 | A kind of natural ginger oil composition hydrogel patch and preparation method thereof |
| CN109394943A (en) * | 2018-12-12 | 2019-03-01 | 上海美哈医药科技有限公司 | A kind of plants herb warms up palace gelling agent and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269201A (en) * | 2007-12-29 | 2008-09-24 | 天津市中宝制药有限公司 | Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof |
| CN101269208A (en) * | 2007-12-29 | 2008-09-24 | 天津市中宝制药有限公司 | Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof |
| CN104510853A (en) * | 2014-12-16 | 2015-04-15 | 山东京御堂国药有限公司 | Traditional Chinese medicinal effective part composition for treating dysmenorrhea of women and application of traditional Chinese medicinal effective part composition |
| CN104510854A (en) * | 2014-12-16 | 2015-04-15 | 山东京御堂国药有限公司 | Traditional Chinese medicinal composition for treating dysmenorrhea of women and application of traditional Chinese medicinal composition |
| CN104547797A (en) * | 2014-09-23 | 2015-04-29 | 苏州市天灵中药饮片有限公司 | Dampness-affected analgesic cataplasm and preparation method thereof |
-
2016
- 2016-12-01 CN CN201611089882.9A patent/CN106620514A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269201A (en) * | 2007-12-29 | 2008-09-24 | 天津市中宝制药有限公司 | Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof |
| CN101269208A (en) * | 2007-12-29 | 2008-09-24 | 天津市中宝制药有限公司 | Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof |
| CN104547797A (en) * | 2014-09-23 | 2015-04-29 | 苏州市天灵中药饮片有限公司 | Dampness-affected analgesic cataplasm and preparation method thereof |
| CN104510853A (en) * | 2014-12-16 | 2015-04-15 | 山东京御堂国药有限公司 | Traditional Chinese medicinal effective part composition for treating dysmenorrhea of women and application of traditional Chinese medicinal effective part composition |
| CN104510854A (en) * | 2014-12-16 | 2015-04-15 | 山东京御堂国药有限公司 | Traditional Chinese medicinal composition for treating dysmenorrhea of women and application of traditional Chinese medicinal composition |
Non-Patent Citations (4)
| Title |
|---|
| 倪建俐；等: "中药复方治疗痛经用药规律", 《中西医结合学报》 * |
| 杨华生；等: "药用辅料在中药经皮给药制剂中的应用", 《中医外治杂志》 * |
| 肖雯晖;等: "中药巴布剂治疗痛经的主要药效学实验研究", 《中国实验方剂学杂志》 * |
| 黄海量: "中药虎杖药理作用研究进展", 《西部中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108543051A (en) * | 2018-07-20 | 2018-09-18 | 河南姜生堂生物科技有限公司 | A kind of natural ginger oil composition hydrogel patch and preparation method thereof |
| CN109394943A (en) * | 2018-12-12 | 2019-03-01 | 上海美哈医药科技有限公司 | A kind of plants herb warms up palace gelling agent and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101732528B (en) | Chinese medicament for treating of hyperplasia of mammary gland | |
| CN104906066A (en) | Lincomycin hydrochloride compound vaginal effervescent tablets and preparation method thereof | |
| CN100571736C (en) | A kind of Chinese medicine preparation for the treatment of habitual abortion | |
| CN103623182A (en) | Medicine for treating gynecological inflammations and preparation method thereof | |
| CN101934015B (en) | Traditional Chinese medicinal composition for treating thyroid and method for preparing dispelling-goitre cataplasm thereof | |
| CN106620514A (en) | Traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal and preparation method of traditional Chinese medicine hydrophilic gel patch | |
| CN101972466A (en) | Traditional Chinese medicine cataplasm capable of rapidly relieving pain of dysmenorrhea and regulating menstruation and preparation method thereof | |
| CN109568427A (en) | A kind of activating microcirculation and removing stasis medicinal, the traditional Chinese medicine extraction preparation soft muscle dissipating bind, alleviated muscular strain, improve debilitating pain | |
| CN102579807B (en) | Chinese medicine composition for treating dental ulcer | |
| CN103301365B (en) | Cataplasm for treating cervical spondylosis and preparation method thereof | |
| CN104706953A (en) | Traditional Chinese medicine preparation for treating chronic cervicitis | |
| CN105770669A (en) | Medicinal preparation for treating colour spots and application thereof | |
| CN103071096B (en) | External preparation for treating senile vaginitis and preparation method of external preparation | |
| CN111329972B (en) | Compound uterus warming and pain relieving foot bath effervescent tablet and preparation method thereof | |
| CN103550384A (en) | Traditional Chinese medicine composition for treating liver-blood deficiency type night sweat | |
| CN103550521A (en) | Traditional Chinese medicine composition for treating night sweat | |
| CN102949689A (en) | Traditional Chinese medicine preparation for treating spontaneous perspiration and leaking sweat | |
| CN103599321B (en) | Traditional Chinese medicine composition for treating osteoporosis | |
| CN103028040B (en) | Traditional Chinese medicine composition for treating infantile chronic nasosinusitis and preparation method of traditional Chinese medicine composition | |
| CN103223098B (en) | Traditional Chinese medicine pressure reduction tea | |
| CN103041194B (en) | Traditional Chinese medicine composition for curing chronic eczema and preparation method thereof | |
| CN111658716A (en) | Hydrogel magnetic therapy traditional Chinese medicine plaster and preparation method thereof | |
| CN105250436A (en) | Traditional Chinese medicine ointment for preventing fat liquefaction of abdominal incision after cesarean section | |
| CN104840557A (en) | Traditional Chinese medicine tea for treating primary dysmenorrhea | |
| CN105148137B (en) | A kind of Chinese medicinal herb external medicine for treating hyperplasia of prostate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |