CN105250436A - Traditional Chinese medicine ointment for preventing fat liquefaction of abdominal incision after cesarean section - Google Patents
Traditional Chinese medicine ointment for preventing fat liquefaction of abdominal incision after cesarean section Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, relates to a gynaecological drug and particularly relates to a traditional Chinese medicine ointment for preventing fat liquefaction of an abdominal incision after cesarean section and a preparation method of the traditional Chinese medicine ointment. The traditional Chinese medicine ointment is prepared from the following eight medicinal raw materials in parts by weight: 5-15 parts of astragalus, 1-10 parts of pseudo-ginseng, 8-18 parts of angelica sinensis vines, 10-30 parts of pararuellia, 1-8 parts of Chinese galls, 3-9 parts of equisetum hyemale, 8-18 parts of madder and 5-15 parts of scutellaria baicalensis. The traditional Chinese medicine ointment not only can be used for shortening the healing time of an incision after cesarean section of a pregnant woman, but also can be used for effectively avoiding incision hardening and fat liquefaction, has no any toxic or side effects, cannot influence a lying-in woman and the lactation of an infant and is also used for greatly improving the compliance of a patient receiving treatment and the living quality of the pregnant woman and infant.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to department of obstetrics and gynecology medication, particularly relate to and a kind ofly prevent traditional Chinese herb medicine of cesarean postoperate incision of abdominal wall liquefaction of fat and preparation method thereof.
Background technology
Cesarean esction is one of mode of parturient childbirth, refers to the process of being taken out fetus by the stomach wall of surgical incision puerpera and uterus.Compared with natural labor, Cesarean esction is that one has traumatic operation, is intended to solve serious complication, difficult labour, complication etc. to reducing the M & M of mother and baby.The wound surface of operative incision is stress inflammatory reaction by otch local, Collagen, blood capillary and fibroblast proliferation, and granulation tissue grows, connective tissue reparation and re-epithelilization and reach healing.Wound healing is bad is one of common complication of surgical site infections, is also the unfavorable factor affecting patient's postoperative life quality.The bad early stage main manifestations of wound healing is otch local redness, touches a tender spot, has scleroma by it.Because of raising and the antibiotic extensive use of medical level, wound healing is bad except infective agent, and major part is caused by liquefaction of fat.
Along with development and the growth in the living standard of society, Obesity Pregnant Women gets more and more, and the incidence rate that wound healing postpones particularly liquefaction of fat has the trend of increase.Women is general, and stomach fat is thicker, and the incidence rate that use that is especially more obvious at conceived postabdomen athero, fat, electric knife makes Abdominal Wall Fat liquefy increases.Incision of abdominal wall liquefaction of fat, shows as the bland necrosis of fatty tissue, and current mechanism is still not clear, and clinical proof obesity, diabetes, anemia, malnutrition, operation technique are improper, edema during pregnancy, prolonged labor, amniotic fluid-pollution are important risk factors.
Once stomach wall generation liquefaction of fat, extend the hospital stays, add mental burden and the financial burden of patient, easily deepen conflict between doctors and patients, bring out medical tangle, that how effectively to prevent liquefaction of fat has important clinical meaning.The method of routine clinical process liquefaction of fat is grown the course for the treatment of, healing is slow, patient suffering is larger, have many scholars to propose some in recent years to improve one's methods, as liquefaction of fat intracavitary administration prednisolone, topical application Chymetin, the built-in negative pressure drainage of otch etc., these method effects are more single, are limited to wound repair.。Chinese herbal medicine and the compound Chinese medicinal preparation since ancient times with promoting muscle growth functions are usually used to treat the wound surface being difficult to heal since ancient times clinically, what the traditional Chinese medical science thought liquefied fat occurs as qi depression to blood stasis, poison heresy stagnates in blood vessels, cause local venation, QI-blood circulation smooth caused by, prevention is when based on clearing away damp-heat, Removing Blood Stasis, eliminating stagnation arteries and veins.And market is rare for the Chinese medicine preparation of cesarean postoperate incision of abdominal wall liquefaction of fat.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of traditional Chinese herb medicine preventing cesarean postoperate incision of abdominal wall liquefaction of fat, it can not only shorten cesarian section postoperative wound healing time, otch can also be effectively prevented to harden and liquefaction of fat, without any side effects, both can not affect puerpera, also can not affect baby nursing, drastically increase the compliance for the treatment of patients, improve the quality of life of pregnant baby.
For achieving the above object, the present invention adopts following technical scheme:
A kind of traditional Chinese herb medicine preventing cesarean postoperate incision of abdominal wall liquefaction of fat, it is made up of the Radix Astragali, Radix Notoginseng, Radix seu Caulis Embeliae Parviflorae, Herb Pararuelliae delavayanae, Galla Chinensis, Herba Equiseti Hiemalis, Radix Rubiae, Radix Scutellariae eight taste medicinal raw material, and in side, the weight distribution ratio of each medicinal raw material is as follows: Radix Astragali 5-15 part, Radix Notoginseng 1-10 part, Radix seu Caulis Embeliae Parviflorae 8-18 part, Herb Pararuelliae delavayanae 10-30 part, Galla Chinensis 1-8 part, Herba Equiseti Hiemalis 3-9 part, Radix Rubiae 8-18 part, Radix Scutellariae 5-15 part.
Fang Zhong: Herb Pararuelliae delavayanae toil, cool in nature, can heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling; Radix Rubiae bitter cold, cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling; Two medicine compatibility antiinflammatory are drawn out pus by applying a plaster to the affected part, and dissipating blood stasis tissue regeneration promoting power is strong, is monarch drug.The sweet temperature of the Radix Astragali, hemostasis by invigorating QI, arresting collape syndrome by astringents granulation promoting, to accelerate the evil outer row of wound poison; Radix seu Caulis Embeliae Parviflorae is enriched blood and is invigorated blood circulation, and to strengthen the effect of monarch drug promoting blood circulation to restore menstrual flow, and does not just hinder; Radix Notoginseng dissipating blood stasis stops blooding, and subduing swelling and relieving pain, to strengthen the merit of monarch drug blood circulation promoting and blood stasis dispelling, is ministerial drug altogether.Radix Scutellariae bitter cold, heat clearing and damp drying, eliminating fire and detoxication; Herba Equiseti Hiemalis's wind and heat dispersing, Galla Chinensis arresting sweating stops blooding, and removing dampness sore, tool is adjuvant drug.Full side, combined into it, has effect of blood circulation promoting and blood stasis dispelling, dissipating blood stasis for subsidence of swelling, heat-clearing and toxic substances removing, expelling pus and promoting granulation.
Further preferably, prevent a traditional Chinese herb medicine for cesarean postoperate incision of abdominal wall liquefaction of fat, it is by the medicinal raw material elaborate of following weight: Radix Astragali 8-13 part, Radix Notoginseng 3-7 part, Radix seu Caulis Embeliae Parviflorae 10-15 part, Herb Pararuelliae delavayanae 23-28 part, Galla Chinensis 5-8 part, Herba Equiseti Hiemalis 6-9 part, Radix Rubiae 10-15 part, Radix Scutellariae 8-12 part.
One of preferred version is further preferably: a kind of traditional Chinese herb medicine preventing cesarean postoperate incision of abdominal wall liquefaction of fat, and it is by the medicinal raw material elaborate of following weight: the Radix Astragali 9 parts, Radix Notoginseng 4 parts, Radix seu Caulis Embeliae Parviflorae 12 parts, Herb Pararuelliae delavayanae 25 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 8 parts, 10 parts, Radix Rubiae, Radix Scutellariae 9 parts.
One of preferred version is further preferably: a kind of traditional Chinese herb medicine preventing cesarean postoperate incision of abdominal wall liquefaction of fat, and it is by the medicinal raw material elaborate of following weight: the Radix Astragali 12 parts, Radix Notoginseng 7 parts, Radix seu Caulis Embeliae Parviflorae 15 parts, Herb Pararuelliae delavayanae 25 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 7 parts, 15 parts, Radix Rubiae, Radix Scutellariae 10 parts.
Character feature and the function of the present invention's medicinal raw material used cure mainly:
The Radix Astragali: [nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.[usage and dosage] 9 ~ 30g.
Radix Notoginseng: [nature and flavor] sweet, micro-hardship, temperature.[return through] returns liver, stomach warp.[function cures mainly] dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.[usage and dosage] 3 ~ 9g; Levigation is swallowed, a 1 ~ 3g.Suitable amount used externally.
Radix seu Caulis Embeliae Parviflorae: [nature and flavor] are bitter; Puckery; Warm in nature.[return through] liver; Kidney channel.[function cures mainly] enriches blood; Invigorate blood circulation; Strong waist knee joint.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Puerperal asthenia; Waist and leg ache; Injury and bone fracture.[usage and dosage] takes orally: decoct soup, 15 ~ 30g.External: appropriate, fresh goods is smash deposited.
Herb Pararuelliae delavayanae: [nature and flavor] mildly bitter flavor; Pungent; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main cough due to lung-heat; Laryngopharynx swelling and pain; Mumps; Scrofula; Carbuncle sore tumefacting virus; Injury and bone fracture; Trauma infection contamination.[usage and dosage] takes orally: decoct soup, 9-15g.External: appropriate, grinds into powder and spreads or decoct soup and wash.
Galla Chinensis: [nature and flavor] are sour, puckery, cold.[return through] returns lung, large intestine, kidney channel.[function cures mainly] astringes the lung pathogenic fire reducing, relieving diarrhea with astringents, and arresting sweating stops blooding, removing dampness sore.For chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, night sweat, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.[usage and dosage] 3 ~ 6g; Suitable amount used externally.
Herba Equiseti Hiemalis: [nature and flavor] sweetness and bitterness; Flat; Nontoxic.[return through] lung; Liver; Gallbladder meridian.[function cures mainly] wind and heat dispersing; Cooling blood for hemostasis; Improving acuity of vision and removing nebula.The hot conjunctival congestion of main air; The raw nebula of order; Epiphora induced by wind; Discharging fresh blood stool; Hemorrhoidal bleeding; Dysentery; Married woman's metrorrhagia; Proctoptosis.[usage and dosage] takes orally: decoct soup, 3-10g; Or enter ball, loose.External: appropriate, grind into powder spread deposited.
Radix Rubiae: [nature and flavor] are bitter, cold.[return through] returns Liver Channel.[function cures mainly] removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.[usage and dosage] 6 ~ 9g.
Radix Scutellariae: [nature and flavor] are bitter, cold.[return through] returns lung, gallbladder, spleen, large intestine, small intestine meridian.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.[usage and dosage] 3 ~ 9g.
Traditional Chinese herb medicine of the present invention is active component by the Radix Astragali, Radix Notoginseng, Radix seu Caulis Embeliae Parviflorae, Herb Pararuelliae delavayanae, Galla Chinensis, Herba Equiseti Hiemalis, Radix Rubiae, Radix Scutellariae or its water or its extractive with organic solvent, adds to prepare the conventional adjuvant of traditional Chinese herb medicine or complementary composition is prepared from meticulously.
The present inventor also finds under study for action, by optimized fabrication method, can when remaining valid medicine, remove impurity or the part without drug effect, reduce impurity to the interference of therapeutic effect, more effectively, more fastoperation is in lesion to make this Chinese medicinal ointment, and reduces the consumption of medicine thus.Therefore, present invention also offers a kind of method preparing the traditional Chinese herb medicine of prevention cesarean postoperate incision of abdominal wall liquefaction of fat, the method comprises the following steps:
One, the preparation of clear paste:
The Radix Astragali, Radix Notoginseng, Radix seu Caulis Embeliae Parviflorae, Herb Pararuelliae delavayanae, Galla Chinensis, Herba Equiseti Hiemalis, Radix Rubiae, Radix Scutellariae are decocted with water secondary, first time add water into described parts by weight of raw materials 5-8 doubly, decoct 2.0-3.0 hour, second time add water into described parts by weight of raw materials 3-4 doubly, decoct 1.5-2.0 hour, collecting decoction, filters, filtrate reduced in volume, adding ethanol makes determining alcohol be 50%, place 8-12 hour, filter, being concentrated into the relative density of gained clear paste 60 DEG C time is 1.05-1.09;
Two, the preparation of ointment:
1) simethicone, azone, octadecanol, stearic acid are put in oil phase pot, be heated to dissolve completely;
2) sieving after being mixed with appropriate purified water by glycerol sucks in main cooker;
3) be placed in aqueous phase pot by clear paste, add ethylparaben, disodiumedetate, Polyethylene glycol-2000 and appropriate purified water, be heated to boiling, add mix homogeneously in main cooker while hot, main kettle temperature remains on 60 DEG C-70 DEG C;
4) in aqueous phase pot, add the purified water of triethanolamine and remainder, then heat medicinal liquid, and add while hot in main cooker;
5) raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, and stir immediately;
6) stir stopping, cooling main cooker, obtains traditional Chinese herb medicine of the present invention.
Preferably, in the preparation of ointment described above, the weight of adjuvant used is: simethicone 30-50 part, azone 10-20 part, octadecanol 20-45 part, stearic acid 45-70 part, glycerol 50-100 part, ethylparaben 1.0-1.5 part, disodiumedetate 1.0-2.5 part, Polyethylene glycol-2000 20-30 part, triethanolamine 10-25 part, purified water 300-500 part.
Preferably, in the preparation of ointment described above, step 2) temperature in main cooker remains on 65 DEG C-70 DEG C.
Preferably, in the preparation of ointment described above, step 4) heating-up temperature of purified water of triethanolamine and remainder remains on 70 DEG C-75 DEG C.
Preferably, in the preparation of ointment described above, step 5) speed that stirs is 2500-2800rpm.
Glycerol first mixes with purified water by the present invention, because glycerol is liquid, mixes in advance can ensure that aqueous phase is mixed homogeneously with water below with water; Clear paste and other aqueous phase materials solid-state or semi-solid are heated to boil, and can make fusing each other completely and fully mix, and then ensureing next step emulsifying effectiveness; The traditional Chinese herb medicine uniform and smooth obtained by method of the present invention, is with glossy, and rare denseness is moderate, and skin attachment is better.
During use, by even for traditional Chinese herb medicine of the present invention mulching in wound surface, can, a little more than skin about 1mm, can suitably widen to wound surface 1-2cm place, adopt sterile gauze to cover, every day changes dressings 1-2 time.
Beneficial effect of the present invention is:
The present invention has effect of blood circulation promoting and blood stasis dispelling, dissipating blood stasis for subsidence of swelling, heat-clearing and toxic substances removing, expelling pus and promoting granulation, wound location blood circulation can be promoted, from outward appearance to inner essence promote that medicine permeates, absorbs in local organization, reach dredging the meridian, blood circulation promoting and blood stasis dispelling and lenitive object, clinical observation experiment shows that it obviously can accelerate the healing of cesarean postoperate incision of abdominal wall, effectively prevents sclerosis and the liquefaction of fat of cutting part.In addition Chinese medicine ointment uniform and smooth of the present invention, easily coating after launching, the holdup time is long, without any side effects, drastically increases the compliance for the treatment of patients, improves the quality of life of patient.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Embodiment 1
One, the preparation of clear paste:
Constituent (weight portion): the Radix Astragali 9 parts, Radix Notoginseng 4 parts, Radix seu Caulis Embeliae Parviflorae 12 parts, Herb Pararuelliae delavayanae 25 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 8 parts, 10 parts, Radix Rubiae, Radix Scutellariae 9 parts.
The Radix Astragali, Radix Notoginseng, Radix seu Caulis Embeliae Parviflorae, Herb Pararuelliae delavayanae, Galla Chinensis, Herba Equiseti Hiemalis, Radix Rubiae, Radix Scutellariae are decocted with water secondary, first time add water into described parts by weight of raw materials 5-8 doubly, decoct 2.0-3.0 hour, second time add water into described parts by weight of raw materials 3-4 doubly, decoct 1.5-2.0 hour, collecting decoction, filters, filtrate reduced in volume, adding ethanol makes determining alcohol be 50%, place 8-12 hour, filter, being concentrated into the relative density of gained clear paste 60 DEG C time is 1.07;
Two, the preparation of ointment:
The weight of adjuvant: simethicone 35 parts, azone 12 parts, octadecanol 30 parts, stearic acid 55 parts, glycerol 60 parts, ethylparaben 1.0 parts, disodiumedetate 1.0 parts, Polyethylene glycol-2000 24 parts, triethanolamine 15 parts, purified water 450 parts.
1) simethicone, azone, octadecanol, stearic acid are put in oil phase pot, be heated to dissolve completely;
2) sieving after being mixed with appropriate purified water by glycerol sucks in main cooker; Temperature in main cooker remains on 68 DEG C.
3) be placed in aqueous phase pot by clear paste, add ethylparaben, disodiumedetate, Polyethylene glycol-2000 and appropriate purified water, be heated to boiling, add mix homogeneously in main cooker while hot, main kettle temperature remains on 65 DEG C;
4) in aqueous phase pot, add the purified water of triethanolamine and remainder, then heat medicinal liquid to 73 DEG C, and add while hot in main cooker;
5) at the uniform velocity sucked in main cooker after filtering by the raw material in oil phase pot, and stir immediately, the speed of stirring is 2600rpm;
6) stir stopping, cooling main cooker, obtains traditional Chinese herb medicine of the present invention.
Embodiment 2
One, the preparation of clear paste:
Constituent (weight portion) constituent (weight portion): the Radix Astragali 12 parts, Radix Notoginseng 7 parts, Radix seu Caulis Embeliae Parviflorae 15 parts, Herb Pararuelliae delavayanae 25 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 7 parts, 15 parts, Radix Rubiae, Radix Scutellariae 10 parts.
The Radix Astragali, Radix Notoginseng, Radix seu Caulis Embeliae Parviflorae, Herb Pararuelliae delavayanae, Galla Chinensis, Herba Equiseti Hiemalis, Radix Rubiae, Radix Scutellariae are decocted with water secondary, first time add water into described parts by weight of raw materials 5-8 doubly, decoct 2.0-3.0 hour, second time add water into described parts by weight of raw materials 3-4 doubly, decoct 1.5-2.0 hour, collecting decoction, filters, filtrate reduced in volume, adding ethanol makes determining alcohol be 50%, place 8-12 hour, filter, being concentrated into the relative density of gained clear paste 60 DEG C time is 1.06;
Two, the preparation of ointment:
The weight of adjuvant: simethicone 35 parts, azone 15 parts, octadecanol 40 parts, stearic acid 50 parts, glycerol 70 parts, ethylparaben 1.0 parts, disodiumedetate 1.0 parts, Polyethylene glycol-2000 22 parts, triethanolamine 17 parts, purified water 450 parts.
1) simethicone, azone, octadecanol, stearic acid are put in oil phase pot, be heated to dissolve completely;
2) sieving after being mixed with appropriate purified water by glycerol sucks in main cooker; Temperature in main cooker remains on 67 DEG C.
3) be placed in aqueous phase pot by clear paste, add ethylparaben, disodiumedetate, Polyethylene glycol-2000 and appropriate purified water, be heated to boiling, add mix homogeneously in main cooker while hot, main kettle temperature remains on 67 DEG C;
4) in aqueous phase pot, add the purified water of triethanolamine and remainder, then heat medicinal liquid to 70 DEG C, and add while hot in main cooker;
5) at the uniform velocity sucked in main cooker after filtering by the raw material in oil phase pot, and stir immediately, the speed of stirring is 2650pm;
6) stir stopping, cooling main cooker, obtains traditional Chinese herb medicine of the present invention.
Embodiment 3
One, the preparation of clear paste:
Constituent (weight portion): the Radix Astragali 9 parts, Radix Notoginseng 4 parts, Radix seu Caulis Embeliae Parviflorae 12 parts, Herb Pararuelliae delavayanae 25 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 8 parts, 10 parts, Radix Rubiae, Radix Scutellariae 9 parts.
The Radix Astragali, Radix Notoginseng, Radix seu Caulis Embeliae Parviflorae, Herb Pararuelliae delavayanae, Galla Chinensis, Herba Equiseti Hiemalis, Radix Rubiae, Radix Scutellariae are decocted with water secondary, first time add water into described parts by weight of raw materials 5-8 doubly, decoct 2.0-3.0 hour, second time add water into described parts by weight of raw materials 3-4 doubly, decoct 1.5-2.0 hour, collecting decoction, filters, filtrate reduced in volume, adding ethanol makes determining alcohol be 50%, place 8-12 hour, filter, being concentrated into the relative density of gained clear paste 60 DEG C time is 1.05;
Two, the preparation of ointment:
The weight of adjuvant: simethicone 40 parts, azone 15 parts, octadecanol 33 parts, stearic acid 60 parts, glycerol 60 parts, ethylparaben 1.0 parts, disodiumedetate 1.0 parts, Polyethylene glycol-2000 25 parts, triethanolamine 15 parts, purified water 400 parts.
1) simethicone, azone, octadecanol, stearic acid are put in oil phase pot, be heated to dissolve completely;
2) sieving after being mixed with appropriate purified water by glycerol sucks in main cooker; Temperature in main cooker remains on 70 DEG C.
3) be placed in aqueous phase pot by clear paste, add ethylparaben, disodiumedetate, Polyethylene glycol-2000 and appropriate purified water, be heated to boiling, add mix homogeneously in main cooker while hot, main kettle temperature remains on 70 DEG C;
4) in aqueous phase pot, add the purified water of triethanolamine and remainder, then heat medicinal liquid to 70 DEG C, and add while hot in main cooker;
5) at the uniform velocity sucked in main cooker after filtering by the raw material in oil phase pot, and stir immediately, the speed of stirring is 2700rpm;
6) stir stopping, cooling main cooker, obtains traditional Chinese herb medicine of the present invention.
Embodiment 4
One, the preparation of clear paste:
Constituent (weight portion): the Radix Astragali 10 parts, Radix Notoginseng 6 parts, Radix seu Caulis Embeliae Parviflorae 15 parts, Herb Pararuelliae delavayanae 23 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 8 parts, 10 parts, Radix Rubiae, Radix Scutellariae 5 parts.
Preparation method: reference example 1-3.
Two, the preparation of ointment:
The weight of adjuvant: simethicone 35 parts, azone 10 parts, octadecanol 25 parts, stearic acid 50 parts, glycerol 55 parts, ethylparaben 1.2 parts, disodiumedetate 1.5 parts, Polyethylene glycol-2000 20 parts, triethanolamine 15 parts, purified water 350 parts.
Preparation method: reference example 1-3.
Embodiment 5
One, the preparation of clear paste:
Constituent (weight portion): the Radix Astragali 10 parts, Radix Notoginseng 6 parts, Radix seu Caulis Embeliae Parviflorae 8 parts, Herb Pararuelliae delavayanae 20 parts, Galla Chinensis 3 parts, Herba Equiseti Hiemalis 5 parts, 12 parts, Radix Rubiae, Radix Scutellariae 8 parts.
Preparation method: reference example 1-3.
Two, the preparation of ointment:
The weight of adjuvant: simethicone 36 parts, azone 14 parts, octadecanol 45 parts, stearic acid 58 parts, glycerol 60 parts, ethylparaben 1.0 parts, disodiumedetate 1.5 parts, Polyethylene glycol-2000 20 parts, triethanolamine 14 parts, purified water 400 parts.
Preparation method: reference example 1-3.
Embodiment 6
One, the preparation of clear paste:
Constituent (weight portion): the Radix Astragali 15 parts, Radix Notoginseng 10 parts, Radix seu Caulis Embeliae Parviflorae 15 parts, Herb Pararuelliae delavayanae 20 parts, Galla Chinensis 3 parts, Herba Equiseti Hiemalis 6 parts, 15 parts, Radix Rubiae, Radix Scutellariae 10 parts.
Preparation method: reference example 1-3.
Two, the preparation of ointment:
The weight of adjuvant: simethicone 40 parts, azone 10 parts, octadecanol 35 parts, stearic acid 60 parts, glycerol 80 parts, ethylparaben 1.5 parts, disodiumedetate 2.0 parts, Polyethylene glycol-2000 22 parts, triethanolamine 18 parts, purified water 500 parts.
Preparation method: reference example 1-3.
Embodiment 7
One, the preparation of clear paste:
Constituent (weight portion): the Radix Astragali 12 parts, Radix Notoginseng 3 parts, Radix seu Caulis Embeliae Parviflorae 10 parts, Herb Pararuelliae delavayanae 30 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 6 parts, 13 parts, Radix Rubiae, Radix Scutellariae 12 parts.
Preparation method: reference example 1-3.
Two, the preparation of ointment:
The weight of adjuvant: simethicone 40 parts, azone 20 parts, octadecanol 25 parts, stearic acid 55 parts, glycerol 75 parts, ethylparaben 1.0 parts, disodiumedetate 1.5 parts, Polyethylene glycol-2000 22 parts, triethanolamine 12 parts, purified water 350 parts.
Preparation method: reference example 1-3.
Embodiment 8
One, the preparation of clear paste:
Constituent (weight portion): the Radix Astragali 11 parts, Radix Notoginseng 7 parts, Radix seu Caulis Embeliae Parviflorae 15 parts, Herb Pararuelliae delavayanae 28 parts, Galla Chinensis 9 parts, Herba Equiseti Hiemalis 6 parts, 12 parts, Radix Rubiae, Radix Scutellariae 10 parts.
Preparation method: reference example 1-3.
Two, the preparation of ointment:
The weight of adjuvant: simethicone 50 parts, azone 10 parts, octadecanol 25 parts, stearic acid 65 parts, glycerol 85 parts, ethylparaben 1.0 parts, disodiumedetate 1.8 parts, Polyethylene glycol-2000 30 parts, triethanolamine 20 parts, purified water 400 parts.
Preparation method: reference example 1-3.
The safety evaluation test of embodiment 9 traditional Chinese herb medicine of the present invention
1. the Skin Irritation Test of ointment of the present invention
New zealand white rabbit 20, body weight 2.5-2.8kg, before administration, 24h is by rabbit spinal column both sides 8% sodium sulfide unhairing, and unhairing district is body surface area 10% (about 150cm
2), after unhairing, 24h checks that whether skin of unhairing is injured because of unhairing.Be divided into 4 groups, i.e. intact skin matched group, intact skin administration group, damaged skin matched group and damaged skin administration group, the making of damaged skin adopts sterilization syringe needle unhairing to be sterilized on skin and draws " # " word, and with skin oozing of blood for degree, the damaged degree of left and right sides skin is basically identical.1. intact skin matched group: be only coated in spinal column epilating area with ointment base 2g/ prepared by the embodiment of the present invention 1; 2. intact skin administration group: be only coated in spinal column epilating area with ointment 2g/ prepared by the embodiment of the present invention 1; 3. damaged skin matched group: be only coated in spinal column epilating area with ointment base 2g/ prepared by the embodiment of the present invention 1; 4. damaged skin administration group: be only coated in spinal column epilating area with ointment 2g/ prepared by the embodiment of the present invention 1.With except tested material observing after 24h, then smear identical tested material, continuous 3d, and after last coating l, 24,48,72h observes depilation district dermoreaction.There is erythema and edema score value in record, goes forward side by side to assassinate and swash intensity evaluation.
Result of the test: in experiment, single-dose and multiple dosing damaged skin group have 1 rabbit skin to occur slight erythema respectively, but can disappear voluntarily in 48h, other has no erythema and edema reaction.Result is by skin irritation intensity evaluation, and display said preparation contacts nonirritant to guinea pig skin.
2. the skin allergy test of ointment of the present invention
Cavia porcellus 30, male and female half and half, body weight 280 ± 25g.Remove both sides, back by hair, area 3cm × 3cm with depilatory before experiment, observe after 24h and determine not damaged.Cavia porcellus after process is divided into three groups at random, often organizes 10.First group to tested material (the traditional Chinese herb medicine 0.2g/ of the embodiment of the present invention 1 preparation only), second group of blank (the substrate 0.2g/ of drug containing is not only), 3rd group of positive controls (1% 2,4-dinitro-chloro-benzene solution, positive excimer is 0.1%2,4-dinitrochlorobenzene), then observe evaluating skin allergic conditions respectively at 0h, 24h, 48h, 72h.
Result shows: erythema and edema do not appear in tested group and each 10 guinea pig skins of blank group, occur erythema after positive controls animal skin tested district self-excitation administration 1h, 6h is the most obvious, and 24h disappears gradually, after 72h, erythema is still visible reluctantly, and sensitization rate reaches 100%.Do not occur in 72h after tested group of guinea pig skin tested district self-excitation administration that erythema and edema are formed, compare indifference with blank group, illustrate that traditional Chinese herb medicine of the present invention can not cause skin allergy.
Embodiment 10 clinical observation experiment
1 data and method
1.1 physical data: select in October, 2013 ~ 2014 example in year October 188 the puerpera of my institute's row Cesarean operation, all there is the bad high risk factor of wound healing in whole puerpera, 124 routine transverse incision puerperas, 64 routine longitudinal incision puerperas, 130 routine puerpera's row Cesarean esction, 58 routine puerpera's row secondary Cesarean esction.Puerpera is divided into matched group and observation group, often organizes 94 examples.21 ~ 39 years old matched group age, average (28.3 ± 4.2) year, operating time (43.9 ± 10.4) min, otch fat thickness (4.25 ± 0.56) cm.20 ~ 38 years old observation group's age, average (27.9 ± 4.6) year, operating time (41.3 ± 9.6) min, otch fat thickness (4.19 ± 0.64) cm.Two groups of physical data comparing difference not statistically significants (P > 0.05), have comparability.
1.2 Therapeutic Method: two groups of postoperative antibiotic prophylaxis that all use of puerpera infect, 3d altogether.As otch have sepage or other infect sign and then get secretions and do antibacterial culturing and add drug sensitive experiment, extend antibiotics service time, and according to the use of drug sensitivity tests change antibiotics.
Matched group: after cesarean postoperate plays use 0.5% povidone iodine routine disinfection abdominal incision on the 2nd day, cover sterile gauze, every day changes dressings once.
Observation group: the postoperative 2nd day traditional Chinese herb medicine in the preparation of puerpera's incision of abdominal wall surface uniform mulching 1mm embodiment of the present invention 1, then adopts sterile gauze to cover otch, changes dressings every day 1 time.
1.3 observation index: two groups of equal postoperative hospital observe 7 days incision of abdominal wall healing states, continue after leaving hospital to follow up a case by regular visits to 30 days puerperal, main detection liquefied fat situation.
Wound healing average evaluation standard: Wound healing by first intention: wound is without infection, hematoma and slough, and healing is good; Second class heals: wound has the infection conditions such as redness, scleroma, pain, but does not suppurate; Third class heals: pyogenic infection or cracking appear in wound.
Liquefaction of fat standard: 1. mostly occur 5 ~ 7 days after surgery, most of puerpera except telling otch and having more sepage, without other subjective symptomss; Part puerpera finds that when routine examination otch dressing has yellow sepage, and otch is subcutaneous more sepage in pressing.2. wound healing is bad, and subcutaneous tissue dissociates, the visible fat drop floated in sepage.3. otch is without red and swollen and tenderness, and notching edge and subcutaneous tissue are without downright bad sign.4. the visible significant quantities of fat of transudate smear for microscopic examination is dripped, and cultivates without bacterial growth for continuous 3 times.
1.4 statistical methods: application SPSS16.0 statistical software.Measurement data with
represent, and adopt t inspection to data, enumeration data adopts X 2 test, and P < 0.05 has statistical significance for difference.
2 results
Two groups of puerpera's stomach wall wound healing situations compare: observation group's otch Wound healing by first intention 93 example, and healing rate is that woman's subcutaneous induration appears in 98.9%, 1 routine patient; Matched group Wound healing by first intention 84 example, healing rate is 86.2%, 5 routine puerpera's liquefaction of fat, 5 routine puerpera's subcutaneous indurations, and 3 routine puerpera's cut surface are red and swollen, and two groups of comparing differences have statistical significance (P < 0.05), in table 1.
A table 1 liang group maternal wound heal situation compares (n)
| Group | Wound healing by first intention | Liquefaction of fat | Subcutaneous induration | Cut surface is red and swollen |
| Observation group (n=94) | 93* | 0* | 1* | 0* |
| Matched group (n=94) | 81 | 5 | 5 | 3 |
Note: compare with matched group, * P < 0.05.
In this research, the red and swollen incidence rate of matched group puerpera liquefaction of fat, subcutaneous induration and cut surface is all higher than observation group, difference has statistical significance (P < 0.05), all there is not infection of incisional wound in two groups of puerperas, no significant difference (P > 0.05).Above statistical data display, tackle puerpera to prevent operative incision liquefaction of fat and apply traditional Chinese herb medicine of the present invention, the infiltration rate of wound inflammatory reaction exudate can be made to accelerate, thus shorten the rehabilitation process of puerpera, effectively improve and optimize body constitution and the quality of life of puerpera.
Claims (10)
1. prevent a traditional Chinese herb medicine for cesarean postoperate incision of abdominal wall liquefaction of fat, it is characterized in that being made up of the Radix Astragali, Radix Notoginseng, Radix seu Caulis Embeliae Parviflorae, Herb Pararuelliae delavayanae, Galla Chinensis, Herba Equiseti Hiemalis, Radix Rubiae, Radix Scutellariae eight taste medicinal raw material.
2. traditional Chinese herb medicine as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following weight: Radix Astragali 5-15 part, Radix Notoginseng 1-10 part, Radix seu Caulis Embeliae Parviflorae 8-18 part, Herb Pararuelliae delavayanae 10-30 part, Galla Chinensis 1-8 part, Herba Equiseti Hiemalis 3-9 part, Radix Rubiae 8-18 part, Radix Scutellariae 5-15 part.
3. traditional Chinese herb medicine as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Radix Astragali 8-13 part, Radix Notoginseng 3-7 part, Radix seu Caulis Embeliae Parviflorae 10-15 part, Herb Pararuelliae delavayanae 23-28 part, Galla Chinensis 5-8 part, Herba Equiseti Hiemalis 6-9 part, Radix Rubiae 10-15 part, Radix Scutellariae 8-12 part.
4. traditional Chinese herb medicine as claimed in claim 3, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: the Radix Astragali 9 parts, Radix Notoginseng 4 parts, Radix seu Caulis Embeliae Parviflorae 12 parts, Herb Pararuelliae delavayanae 25 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 8 parts, 10 parts, Radix Rubiae, Radix Scutellariae 9 parts.
5. traditional Chinese herb medicine as claimed in claim 3, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: the Radix Astragali 12 parts, Radix Notoginseng 7 parts, Radix seu Caulis Embeliae Parviflorae 15 parts, Herb Pararuelliae delavayanae 25 parts, Galla Chinensis 6 parts, Herba Equiseti Hiemalis 7 parts, 15 parts, Radix Rubiae, Radix Scutellariae 10 parts.
6. the traditional Chinese herb medicine as described in claim 1-5, is characterized in that preparation method comprises the following steps:
One, the preparation of clear paste:
The Radix Astragali, Radix Notoginseng, Radix seu Caulis Embeliae Parviflorae, Herb Pararuelliae delavayanae, Galla Chinensis, Herba Equiseti Hiemalis, Radix Rubiae, Radix Scutellariae are decocted with water secondary, first time add water into described parts by weight of raw materials 5-8 doubly, decoct 2.0-3.0 hour, second time add water into described parts by weight of raw materials 3-4 doubly, decoct 1.5-2.0 hour, collecting decoction, filters, filtrate reduced in volume, adding ethanol makes determining alcohol be 50%, place 8-12 hour, filter, being concentrated into the relative density of gained clear paste 60 DEG C time is 1.05-1.09;
Two, the preparation of ointment:
1) simethicone, azone, octadecanol, stearic acid are put in oil phase pot, be heated to dissolve completely;
2) suck in main cooker after glycerol being mixed with appropriate purified water;
3) be placed in aqueous phase pot by clear paste, add ethylparaben, disodiumedetate, Polyethylene glycol-2000 and appropriate purified water, be heated to boiling, add mix homogeneously in main cooker while hot, main kettle temperature remains on 60 DEG C-70 DEG C;
4) in aqueous phase pot, add the purified water of triethanolamine and remainder, then heat medicinal liquid, and add while hot in main cooker;
5) raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, and stir immediately;
6) stir stopping, cooling main cooker, obtains traditional Chinese herb medicine of the present invention.
7. traditional Chinese herb medicine as claimed in claim 6, is characterized in that the weight of adjuvant used in the preparation of ointment is: simethicone 30-50 part, azone 10-20 part, octadecanol 20-45 part, stearic acid 45-70 part, glycerol 50-100 part, ethylparaben 1.0-1.5 part, disodiumedetate 1.0-2.5 part, Polyethylene glycol-2000 20-30 part, triethanolamine 10-25 part, purified water 300-500 part.
8. traditional Chinese herb medicine as claimed in claim 6, is characterized in that step 2 in the preparation of ointment) temperature in main cooker remains on 65 DEG C-70 DEG C.
9. traditional Chinese herb medicine as claimed in claim 6, is characterized in that step 4 in the preparation of ointment) heating-up temperature of the purified water of triethanolamine and remainder remains on 70 DEG C-75 DEG C.
10. traditional Chinese herb medicine as claimed in claim 6, is characterized in that step 5 in the preparation of ointment) speed that stirs is 2500-2800rpm.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999102A (en) * | 2016-07-01 | 2016-10-12 | 宋相珠 | Compound medicine for treating fat liquefaction of abdominal incision after cesarean section |
| CN113940914A (en) * | 2021-10-15 | 2022-01-18 | 江苏集萃新型药物制剂技术研究所有限公司 | Transdermal ointment, drug-loaded composition and drug-loaded preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103405546A (en) * | 2013-08-23 | 2013-11-27 | 北京首儿药厂 | Preparation method of traditional Chinese medicine ointment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103405546A (en) * | 2013-08-23 | 2013-11-27 | 北京首儿药厂 | Preparation method of traditional Chinese medicine ointment |
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| 李青: "血竭大黄散治疗妇产科术后腹部切口脂肪液化及会阴伤口愈合不良临床观察", 《中国中西医结合杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999102A (en) * | 2016-07-01 | 2016-10-12 | 宋相珠 | Compound medicine for treating fat liquefaction of abdominal incision after cesarean section |
| CN113940914A (en) * | 2021-10-15 | 2022-01-18 | 江苏集萃新型药物制剂技术研究所有限公司 | Transdermal ointment, drug-loaded composition and drug-loaded preparation thereof |
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Application publication date: 20160120 |