CN104000842B - ammonium chloride cooling patch and preparation method thereof - Google Patents
ammonium chloride cooling patch and preparation method thereof Download PDFInfo
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- CN104000842B CN104000842B CN201410219765.4A CN201410219765A CN104000842B CN 104000842 B CN104000842 B CN 104000842B CN 201410219765 A CN201410219765 A CN 201410219765A CN 104000842 B CN104000842 B CN 104000842B
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Abstract
Ammonium chloride cooling patch, Adherents junction has backing layer, gel layer, mucigel and anti-stick layer successively from outside to inside, gel layer is composed of the following components by mass percentage: polyvinyl alcohol 3% ~ 6%, methacrylic acid 10% ~ 15%, pressure sensitive adhesive 10% ~ 15%, glycerol 10% ~ 15%, polylactic acid 3% ~ 6%, pregelatinized Starch 0.3% ~ 1%, ammonium chloride 9% ~ 18%, surplus is water; The invention also discloses its preparation method: said components is mixed and made into gel, backing layer applies said components and is mixed and made into gel as gel layer, then on gel layer, apply mucigel, finally on mucigel, apply anti-stick layer, namely obtain.Ammonium chloride cooling patch of the present invention, cooling-down effect is obvious, and one is walk human body amount of localized heat by the vaporization zone of moisture in gel, plays the effect of partial warm down; Two is that amount of heat is taken away in chloride leach heat absorption, has dual effect of bringing down a fever.
Description
Technical field
The invention belongs to medical assistance applied technical field, be specifically related to a kind of ammonium chloride cooling patch, the invention still further relates to the preparation method of this ammonium chloride cooling patch.
Background technology
Temperature-reducing paste is a class medical treatment auxiliary agent, the fields such as medicine, sports goods, beauty treatment, articles for daily use such as its application has been applied to alleviating pain, refreshment, relaxs one's muscles, improving water flood, skin moisture-keeping beauty treatment.
Existing temperature-reducing paste is mostly three-decker, is made up of backing layer, gel layer, anti-stick layer, and backing layer adopts non-woven fabrics, and gel layer is made up of hydrophilic macromolecule gel, and anti-stick layer adopts transparent plastic film.It utilizes hydrogel to prepare from the theory of evaporation endothermic more, because moisture evaporation can take away human heat rapidly.In addition, existing temperature-reducing paste many by add the cool medicinal such as Herba Menthae, Borneolum Syntheticum composition carry out impression assist, this kind of Chinese medicine ingredients is by stimulating human nerve, people is made to produce refrigerant sensation, its actual cooling-down effect is poor, meanwhile, these ingredients have larger stimulation to eye and wound, easily make troubles to patient during use.
Summary of the invention
The object of this invention is to provide a kind of ammonium chloride cooling patch, solve the problem of the cooling-down effect difference of existing temperature-reducing paste.
Another object of the present invention is to provide a kind of preparation method of above-mentioned ammonium chloride cooling patch.
The technical solution adopted in the present invention is, ammonium chloride cooling patch, Adherents junction has backing layer, gel layer, mucigel and anti-stick layer successively from outside to inside, and gel layer is composed of the following components by mass percentage: polyvinyl alcohol 3% ~ 6%, methacrylic acid 10% ~ 15%, pressure sensitive adhesive 10% ~ 15%, glycerol 10% ~ 15%, polylactic acid 3% ~ 6%, pregelatinized Starch 0.3% ~ 1%, ammonium chloride 9% ~ 18%, surplus is water, and above constituent mass percentage ratio sum is 100%.
Feature of the present invention is also,
The thickness of gel layer is 0.5 ~ 1mm.
Backing layer is non-woven fabrics.
Anti-stick layer is for having the one in the PE thin film of asperities, PU thin film or PET film.
The degree of polymerization of polyvinyl alcohol is 1350 ~ 2050; The degree of polymerization of polylactic acid is 500 ~ 800.
Another technical scheme of the present invention is, the preparation method of ammonium chloride cooling patch, and concrete steps are as follows:
Step 1, take respectively by mass percentage: polyvinyl alcohol 3% ~ 6%, methacrylic acid 10% ~ 15%, pressure sensitive adhesive 10% ~ 15%, glycerol 10% ~ 15%, polylactic acid 3% ~ 6%, pregelatinized Starch 0.3% ~ 1%, ammonium chloride 9% ~ 18%, surplus is water, and above constituent mass percentage ratio sum is 100%;
Step 2, by the mixture of polyvinyl alcohol, pregelatinized Starch and polylactic acid, soluble in water and at 70 DEG C ~ 80 DEG C heating dissolve to clarification, methacrylic acid, pressure sensitive adhesive and glycerol is added again after cooling, pour into after stirring in mould, at-15 DEG C ~-12 DEG C, cold moulding is shaped, and adds ammonium chloride again after thawing, cold moulding again, obtains gel;
Step 3, adopt non-woven fabrics as backing layer, on backing layer, coating thickness is that the gel of 0.5 ~ 1mm is as gel layer, then on gel layer, acrylic resin is applied as mucigel, last on mucigel coating there is the PE thin film of asperities, PU thin film or PET film as anti-stick layer, namely obtain ammonium chloride cooling patch.
Feature of the present invention is also,
In step 1, the degree of polymerization of polyvinyl alcohol is 1350 ~ 2050; The degree of polymerization of polylactic acid is 500 ~ 800.
The invention has the beneficial effects as follows,
1. ammonium chloride cooling patch of the present invention adopts four-layer structure, and prevent gel layer and direct skin contact, avoid gel layer to the zest of skin, mucigel is polyacrylic resin, non-stimulated to skin, has the good compatibility with skin; And mucigel permeability is good, allow moisture of skin through, keep skin surface comfortable.
2. ammonium chloride cooling patch of the present invention, cooling-down effect is obvious, and cooling mainly contains two aspects, and one is walk human body amount of localized heat by the vaporization zone of moisture in gel, plays the effect of partial warm down; Amount of heat is taken away in chloride leach heat absorption on the other hand, has dual effect of bringing down a fever.
3. the preparation method of ammonium chloride cooling patch of the present invention is simple, easy to operate, and cost is low.
Accompanying drawing explanation
Fig. 1 is the structure chart of ammonium chloride of the present invention cooling patch;
The attaching time of Fig. 2 ammonium chloride cooling of the present invention patch and temperature variation curve;
Fig. 3 ammonium chloride of the present invention cooling patch and common temperature-reducing paste practical application comparison diagram.
In figure, 1. backing layer, 2. gel layer, 3. mucigel, 4. anti-stick layer.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, the present invention is described in detail.
Ammonium chloride cooling patch of the present invention, as shown in Figure 1, Adherents junction has backing layer 1, gel layer 2, mucigel 3 and anti-stick layer 4 successively from outside to inside, gel layer 2 is composed of the following components by mass percentage: polyvinyl alcohol 3% ~ 6%, methacrylic acid 10% ~ 15%, pressure sensitive adhesive 10% ~ 15%, glycerol 10% ~ 15%, polylactic acid 3% ~ 6%, pregelatinized Starch 0.3% ~ 1%, ammonium chloride 9% ~ 18%, surplus is water, above constituent mass percentage ratio sum is 100%, and the degree of polymerization of polyvinyl alcohol is 1350 ~ 2050; The degree of polymerization of polylactic acid is 500 ~ 800.
The thickness of gel layer 2 is 0.5 ~ 1mm; Backing layer is non-woven fabrics.
Anti-stick layer 4 is for having the one in the PE thin film of asperities, PU thin film or PET film.
Ammonium chloride cooling patch of the present invention adopts four-layer structure, and prevent gel layer and direct skin contact, avoid gel layer to the zest of skin, mucigel is polyacrylic resin, non-stimulated to skin, has the good compatibility with skin; And mucigel permeability is good, allow moisture of skin through, keep skin surface comfortable.Ammonium chloride cooling patch of the present invention, cooling mainly contains two aspects, and one is walk human body amount of localized heat by the vaporization zone of moisture in gel, plays the effect of partial warm down; Amount of heat is taken away in chloride leach heat absorption on the other hand, has dual effect of bringing down a fever.
In gel layer 2, polyvinyl alcohol is gel skeleton, and after contact human body obtains body temperature, the vaporization zone of the moisture in gel walks human body amount of localized heat, plays the effect of partial warm down; On the other hand, the moisture in gel is when evaporating, and the constantly immobilized ammonia chloride crystal in gel layer of contact, makes ammonia chloride crystal that dissolving and heat absorbing reaction constantly occur, also play the effect of cooling; Pregelatinized Starch is used for improving molding time and the shaping strength of polyvinyl alcohol gel; Pressure sensitive adhesive and polylactic acid are thickening agent, increase the vicidity of polyvinyl alcohol gel; Glycerol, as wetting agent, maintains polyvinyl alcohol gel moisture, reduces the loss of gel moisture; Methacrylic acid is moisture-inhibiting agent, makes moisture of skin enter gel layer.
Acrylic resin can reach good heat-transfer effect.
Ask clean skin surface sweat stain, greasy dirt before ammonium chloride cooling patch of the present invention uses, tear anti-stick layer during use, mucigel is closely attached to and wants freezing position, according to the area using position, the use of suitable size can be cut into; Also can ammonium chloride of the present invention cooling patch be sticked before volume or temple or be affixed on cervical region DAZHUI acupoint, in order to accelerate cooling rate, several pieces patches available be affixed on human body left and right carotid artery, left and right femoral artery simultaneously.Ammonium chloride cooling patch limit single use of the present invention, every day 1-3 time, often pastes sustainable use 3 hours.
The preparation method of above-mentioned ammonium chloride cooling patch, concrete steps are as follows:
Step 1, take respectively by mass percentage: the degree of polymerization is the polyvinyl alcohol 3% ~ 6% of 1350 ~ 2050, methacrylic acid 10% ~ 15%, pressure sensitive adhesive 10% ~ 15%, glycerol 10% ~ 15%, the degree of polymerization is the polylactic acid 3% ~ 6% of 500 ~ 800, pregelatinized Starch 0.3% ~ 1%, ammonium chloride 9% ~ 18%, surplus is water, and above constituent mass percentage ratio sum is 100%;
Step 2, by the mixture of polyvinyl alcohol, pregelatinized Starch and polylactic acid, soluble in water and at 70 DEG C ~ 80 DEG C heating dissolve to clarification, methacrylic acid, pressure sensitive adhesive and glycerol is added again after cooling, pour into after stirring in mould, at-15 DEG C ~-12 DEG C, cold moulding is shaped, and adds ammonium chloride again after thawing, cold moulding again, obtains gel;
Step 3, adopt non-woven fabrics as backing layer, the side of backing layer is printed on pattern, do not have coating thickness on the side of pattern to be that the gel of 0.5 ~ 1mm is as gel layer at backing layer, then on gel layer, acrylic resin is applied as mucigel, last on mucigel coating there is the PE thin film of asperities, PU thin film or PET film as anti-stick layer, namely obtain ammonium chloride cooling patch.
Embodiment 1
Step 1, takes by mass percentage respectively: the degree of polymerization is the polyvinyl alcohol 0.9g of 1950, methacrylic acid 3.6g, pressure sensitive adhesive 3.0g, glycerol 3.6g, and the degree of polymerization is the polylactic acid 0.9g of 600, pregelatinized Starch 0.15g, ammonium chloride 3.6g, water 14.25g;
Step 2, by the mixture of polyvinyl alcohol, pregelatinized Starch and polylactic acid, soluble in water and at 70 DEG C heating dissolve to clarification, methacrylic acid, pressure sensitive adhesive and glycerol is added again after cooling, pour into after stirring in mould, at-12 DEG C, cold moulding is shaped, and adds ammonium chloride again after thawing, cold moulding again, obtains gel;
Step 3, adopt non-woven fabrics as backing layer, the side of backing layer is printed on pattern, do not have coating thickness on the side of pattern to be that the gel of 0.5mm is as gel layer at backing layer, then on gel layer, acrylic resin is applied as mucigel, finally on mucigel, coating has the PE thin film of asperities as anti-stick layer, namely obtains ammonium chloride cooling patch.
Embodiment 2
Step 1, takes by mass percentage respectively: the degree of polymerization is the polyvinyl alcohol 1.6g of 2050, methacrylic acid 4.0g, pressure sensitive adhesive 4.8g, glycerol 6.0g, and the degree of polymerization is the polylactic acid 1.6g of 500, pregelatinized Starch 0.12g, ammonium chloride 3.6g, water 18.28g;
Step 2, by the mixture of polyvinyl alcohol, pregelatinized Starch and polylactic acid, soluble in water and at 80 DEG C heating dissolve to clarification, methacrylic acid, pressure sensitive adhesive and glycerol is added again after cooling, pour into after stirring in mould, at-13 DEG C, cold moulding is shaped, and adds ammonium chloride again after thawing, cold moulding again, obtains gel;
Step 3, adopt non-woven fabrics as backing layer, the side of backing layer is printed on pattern, do not have coating thickness on the side of pattern to be that the gel of 0.62mm is as gel layer at backing layer, then on gel layer, acrylic resin is applied as mucigel, finally on mucigel, coating has the PU thin film of asperities as anti-stick layer, namely obtains ammonium chloride cooling patch.
Embodiment 3
Step 1, takes by mass percentage respectively: the degree of polymerization is the polyvinyl alcohol 1.0g of 1350, methacrylic acid 3.0g, pressure sensitive adhesive 2.6g, glycerol 2.0g, and the degree of polymerization is the polylactic acid 1.0g of 700, pregelatinized Starch 0.2g, ammonium chloride 3.6g, water 6.6g;
Step 2, by the mixture of polyvinyl alcohol, pregelatinized Starch and polylactic acid, soluble in water and at 75 DEG C heating dissolve to clarification, methacrylic acid, pressure sensitive adhesive and glycerol is added again after cooling, pour into after stirring in mould, at-14 DEG C, cold moulding is shaped, and adds ammonium chloride again after thawing, cold moulding again, obtains gel;
Step 3, adopt non-woven fabrics as backing layer, the side of backing layer is printed on pattern, do not have coating thickness on the side of pattern to be that the gel of 0.81mm is as gel layer at backing layer, then on gel layer, acrylic resin is applied as mucigel, finally on mucigel, coating has the PET film of asperities as anti-stick layer, namely obtains ammonium chloride cooling patch.
Embodiment 4
Step 1, takes by mass percentage respectively: the degree of polymerization is the polyvinyl alcohol 1.8g of 1650, methacrylic acid 3.9g, pressure sensitive adhesive 4.5g, glycerol 3.9g, and the degree of polymerization is the polylactic acid 1.8g of 800, pregelatinized Starch 0.24g, ammonium chloride 4.5g, water 9.36g;
Step 2, by the mixture of polyvinyl alcohol, pregelatinized Starch and polylactic acid, soluble in water and at 80 DEG C heating dissolve to clarification, methacrylic acid, pressure sensitive adhesive and glycerol is added again after cooling, pour into after stirring in mould, at-15 DEG C, cold moulding is shaped, and adds ammonium chloride again after thawing, cold moulding again, obtains gel;
Step 3, adopt non-woven fabrics as backing layer, the side of backing layer is printed on pattern, do not have coating thickness on the side of pattern to be that the gel of 1mm is as gel layer at backing layer, then on gel layer, acrylic resin is applied as mucigel, finally on mucigel, coating has the PU thin film of asperities as anti-stick layer, namely obtains ammonium chloride cooling patch.
Be described below by the cooling-down effect of experiment to ammonium chloride cooling patch of the present invention.
(1) with constant temperature heating plate simulation human body temperature test cooling-down effect, ammonium chloride cooling patch of the present invention is placed on the constant temperature heating plate of 39 DEG C, the temperature of the temperature-constant plate (i.e. temperature-reducing paste and temperature-constant plate contact surface) under measuring cooling patch every 1 minute, test constantly 40 minutes.
As shown in Figure 2, abscissa is application time to result, and vertical coordinate is measured temperature.As can be seen from Figure 2, pasting by front temperature-constant plate temperature is about 39 DEG C, paste and decline obvious (about 37 DEG C) by temperature after 5 minutes, paste by local temperature about 36.8 DEG C after 10 minutes, paste and weaken gradually with cooling-down effect after 25 minutes, local temperature about 36.5 DEG C, in effective time 30 minutes, the temperature of temperature-constant plate is less than 37 DEG C always, illustrates that ammonium chloride of the present invention cooling patch has good cooling-down effect.
(2) with constant temperature heating plate simulation human body temperature test cooling-down effect, by ammonium chloride of the present invention cooling patch and common cooling patch on the constant temperature heating plate of 38 DEG C, the temperature of the temperature-constant plate (i.e. temperature-reducing paste and temperature-constant plate contact surface) under measuring cooling patch every 10 minutes, test constantly 200 minutes.
As shown in Figure 3, Fig. 3 is the cooling-down effect comparison diagram of ordinary gel paster and ammonium chloride of the present invention cooling patch to result.Abscissa is application time, and vertical coordinate is measured temperature.As can be seen from Figure 3, paste with front, common temperature-reducing paste temperature is 35.5 DEG C, this ammonium chloride cooling patch temperature is 33 DEG C, can find out that ammonium chloride low temperature of the present invention cooling patch is lower than the self-temperature of common temperature-reducing paste significantly, and in experience temperature gradually uphill process, ammonium chloride cooling patch of the present invention heats up slower than common cooling patch, when 100 minutes, common temperature-reducing paste temperature rises to about 36.5 DEG C, this ammonium chloride cooling patch temperature reaches about 35 DEG C, illustrates that ammonium chloride of the present invention cooling patch has good cooling-down effect than common cooling patch.
Claims (6)
1. ammonium chloride cooling patch, it is characterized in that, Adherents junction has backing layer, gel layer, mucigel and anti-stick layer successively from outside to inside, and described gel layer is composed of the following components by mass percentage: polyvinyl alcohol 3% ~ 6%, methacrylic acid 10% ~ 15%, pressure sensitive adhesive 10% ~ 15%, glycerol 10% ~ 15%, polylactic acid 3% ~ 6%, pregelatinized Starch 0.3% ~ 1%, ammonium chloride 9% ~ 18%, surplus is water, and above constituent mass percentage ratio sum is 100%; The degree of polymerization of polyvinyl alcohol is 1350 ~ 2050; The degree of polymerization of polylactic acid is 500 ~ 800.
2. ammonium chloride cooling patch according to claim 1, it is characterized in that, the thickness of described gel layer is 0.5 ~ 1mm.
3. ammonium chloride cooling patch according to claim 1, it is characterized in that, described backing layer is non-woven fabrics.
4. ammonium chloride according to claim 1 cooling patch, is characterized in that, described anti-stick layer is for having the one in the PE thin film of asperities, PU thin film or PET film.
5. the preparation method of ammonium chloride cooling patch, it is characterized in that, concrete steps are as follows:
Step 1, take respectively by mass percentage: polyvinyl alcohol 3% ~ 6%, methacrylic acid 10% ~ 15%, pressure sensitive adhesive 10% ~ 15%, glycerol 10% ~ 15%, polylactic acid 3% ~ 6%, pregelatinized Starch 0.3% ~ 1%, ammonium chloride 9% ~ 18%, surplus is water, and above constituent mass percentage ratio sum is 100%;
Step 2, by the mixture of polyvinyl alcohol, pregelatinized Starch and polylactic acid, soluble in water and at 70 DEG C ~ 80 DEG C heating dissolve to clarification, methacrylic acid, pressure sensitive adhesive and glycerol is added again after cooling, pour into after stirring in mould, at-15 DEG C ~-12 DEG C, cold moulding is shaped, and adds ammonium chloride again after thawing, cold moulding again, obtains gel;
Step 3, adopt non-woven fabrics as backing layer, on backing layer, coating thickness is that the gel of 0.5 ~ 1mm is as gel layer, then on gel layer, acrylic resin is applied as mucigel, last on mucigel coating there is the PE thin film of asperities, PU thin film or PET film as anti-stick layer, namely obtain ammonium chloride cooling patch.
6. the preparation method of ammonium chloride cooling patch according to claim 5, it is characterized in that, in step 1, the degree of polymerization of polyvinyl alcohol is 1350 ~ 2050; The degree of polymerization of polylactic acid is 500 ~ 800.
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Families Citing this family (7)
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| CN105213087A (en) * | 2015-09-24 | 2016-01-06 | 江门市新时代外用制剂有限公司 | One is defervescence plaster used and preparation method thereof |
| CN105476827B (en) * | 2015-11-24 | 2019-07-23 | 南京斯瑞奇医疗用品有限公司 | A kind of water ripples physical therapy flesh patch and preparation method thereof with massage effect |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105687446A (en) * | 2016-04-21 | 2016-06-22 | 吴美燕 | Preparation method of intelligent traditional Chinese medicine fever abatement paste |
| CN105998251A (en) * | 2016-06-17 | 2016-10-12 | 刘泰 | Preparation method of antipyretic patch |
| CN109248020A (en) * | 2018-07-19 | 2019-01-22 | 卢加贵 | Zygomoplasty orthopaedics binding device |
| CN115105462A (en) * | 2022-07-22 | 2022-09-27 | 绍兴百立盛新材料科技有限公司 | Preparation method of antipyretic gel |
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| CN101095634A (en) * | 2007-07-12 | 2008-01-02 | 长春吉原生物科技有限公司 | Temperature-reducing paste and method of manufacturing the same |
| CN202355497U (en) * | 2011-11-23 | 2012-08-01 | 浙江鼎泰药业有限公司 | Cold compressing patch |
| CN103602320B (en) * | 2013-11-21 | 2016-01-20 | 陕西科技大学 | Ammonium chloride temperature control particle and preparation method thereof |
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Inventor after: Lin Yibin Inventor before: Shen Wen Inventor before: Zhang Guanghua Inventor before: Gao Yabo Inventor before: Wang Lan |
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Effective date of registration: 20170524 Address after: The second Industrial Zone No. 04B2-1 B factory Jinping District 515000 Guangdong province Shantou city A area 4 floor Patentee after: Guangdong reached Hong Biotechnology Co.,Ltd. Address before: 518000 Guangdong province Shenzhen city Longhua District Office of Longsheng big wave gold dragon road community e-commerce incubator exhibition Tao Commercial Plaza A block 206-2 Patentee before: Shenzhen Meliao Technology Transfer Center Co.,Ltd. Effective date of registration: 20170524 Address after: 518000 Guangdong province Shenzhen city Longhua District Office of Longsheng big wave gold dragon road community e-commerce incubator exhibition Tao Commercial Plaza A block 206-2 Patentee after: Shenzhen Meliao Technology Transfer Center Co.,Ltd. Address before: 710021 Shaanxi city of Xi'an province Weiyang University Park Patentee before: SHAANXI University OF SCIENCE & TECHNOLOGY |