CN109223297A - The discoloration of temperature-sensitive three-level is medical defervescence plaster used and preparation method thereof - Google Patents
The discoloration of temperature-sensitive three-level is medical defervescence plaster used and preparation method thereof Download PDFInfo
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- CN109223297A CN109223297A CN201810873913.2A CN201810873913A CN109223297A CN 109223297 A CN109223297 A CN 109223297A CN 201810873913 A CN201810873913 A CN 201810873913A CN 109223297 A CN109223297 A CN 109223297A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0059—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
- A61F2007/0063—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling
- A61F2007/0068—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling evaporating on the spot to be cooled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0226—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof adhesive, self-sticking
Abstract
The invention discloses a kind of new medical is defervescence plaster used, specifically a kind of temperature-sensitive three-level discoloration that can intuitively observe body temperature situation of change according to the change of color in use is defervescence plaster used；It includes spunlace non-woven cloth base fabric, thermosensitive aquagel layer and PP isolation film that this is defervescence plaster used, and thermosensitive aquagel is applied in spunlace non-woven cloth base fabric, then goes up PP isolation film again to obtain the final product；The present invention with crystal violet lactone, fatty alcohol, be hydrated cobalt salt mixture as leuco dye, tetradecylic acid, hexadecylic acid, stearic mixture are as electron acceptor material, and it carries out preferably, effectively promoting the discoloration sensitivity of thermo-sensitive material by the proportion to its component；By addition carragheen, konjac glucomannan, nano silica in hydrogel, its gas permeability and mechanical performance can be effectively promoted, practicability is stronger.
Description
Technical field
The present invention relates to a kind of new medical is defervescence plaster used, be specifically related to it is a kind of in use can changing according to color
Become and intuitively observe that the temperature-sensitive three-level discoloration of body temperature situation of change is medical defervescence plaster used, belongs to the field of medical instrument technology.
Background technique
Children fever is one of the cardinal symptom for threatening children's health, especially low fever's phenomenon of underage child group, because
Be not easy to express its subjective feeling for one side underage child, on the other hand, due to the factors such as environment influence, low fever tend to by
Ignore, which results in the delays of the state of an illness, gently then affect the normal development of children, heavy then can cause life threat to children；Cause
This, in order to which the generation of such carelessness is effectively reduced, it is defervescence plaster used that discoloration occurs in market, on the one hand can be directly by defervescence plaster used
Color change and the physical condition for recognizing patient, on the other hand being capable of fast cooling treatment.
Change colour defervescence plaster used because of its validity and convenience, so that it has just been liked by the majority of consumers since listing, closely
It several years, is constantly innovated by industry, various Novel color-changings are defervescence plaster used to put goods on the market in succession.
However, it is all that can only become two colors that discoloration currently on the market is defervescence plaster used, i.e., it can only distinguish fever and have no temperature,
Low fever and high fever cannot be effectively highlighted, and is very different for the therapeutic scheme of low fever and high fever, especially for baby
This kind of special population, in order to not influence its normal growth and development, unless last resort, general it is not recommended that therefore medication is opened
Send out that a kind of three-level discoloration that can highlight low fever and high fever is defervescence plaster used to have more practical value；In addition, currently used heat
Sensitive allochromatic material is easy to react with outside environmental elements such as water etc., is easy to happen physical chemistry in the case where no protection
Matter changes, and so as to cause product failure, therefore, the thermo-sensitive material for how solving conventional type is easy to maintain, easily change affected by environment
The defect of matter color development is the method for industry research.
Summary of the invention
The object of the present invention is to provide a kind of temperature-sensitive three-level discoloration it is medical defervescence plaster used so that the variation of color can not only be passed through
The physical condition of user is got information about, and can also be provided just by colouring discrimination high fever or low fever for further treatment
Benefit accelerates Rehabilitation rate.
Change colour medical defervescence plaster used preparation method it is a further object of the present invention to provide the temperature-sensitive three-level, by its technique
Optimization determine, on the one hand, promoted its change colour sensitivity, on the other hand, promote defervescence plaster used mechanical performance, thus promoted in fact
The property used.
Technical scheme is as follows:
A kind of temperature-sensitive three-level discoloration is medical defervescence plaster used, including spunlace non-woven cloth base fabric, thermosensitive aquagel layer and PP isolation film, temperature-sensitive
Hydrogel is applied in spunlace non-woven cloth base fabric, then goes up PP isolation film again to obtain the final product；Wherein, thermosensitive aquagel layer directly contacts people's
Skin absorbs human heat in colloid, then takes away intracorporal heat by the large quantity of moisture rapid evaporation stored in hydrogel
Amount, to play cooling effect.
A kind of medical defervescence plaster used preparation method of temperature-sensitive three-level discoloration, includes the following steps:
1) oily phase configuration: raw material is weighed according to the ratio, then glycerol is added in pot, adds the Sodium Polyacrylate weighed up, sweet hydroxyl
Aluminium, disodium salt, CMC, PVPP, carragheen, konjaku flour, nano silica press powder in pot, with blender, and glycerol is allowed to soak
Moisten powder, in order to avoid powder splashes when stirring, then pot and blender is installed, low speed stirs 1 minute, speed of agitator 30-35r/
Min, middling speed are stirred 8 minutes, and 60-65r/min allows glycerol to stir with powder；
2) water phase configures: polyvinylpyrrolidone being added in mixer by formula, then pure water is added by formula, stirring is equal
It is even, until can't see sticky matter in water, then the tartaric acid weighed up, preservative, discoloration microcapsules are poured into water and are stirred evenly；
3) it is stirred under vacuum: mutually successively pouring into oily and be stirred under vacuum in tank with water phase, then pennyroyal freshener is put into vacuum and is stirred
It mixes in tank, is then evacuated down to -90mpa again, then stir fastly 2-3 minutes, mixing speed 50-60HZ, then 6-5 minutes are stirred slowly i.e.
Can, mixing speed 30-40HZ；Hydrogel after de-airing mixer is mixed can put into coating machine and be coated；
4) it is coated with: the discoloration material of hydrogel three-level made from step 3) is coated on spun laced fabric, form temperature-sensitive three-level discoloration water-setting
Then glue-line goes up anti-sticking PP embossing film again, finished product is made；
5) solidify: the finished product that step 4) is obtained is placed on curing room and solidifies, until the taking-up that is cured；Up to temperature-sensitive three-level
Change colour medical defervescence plaster used bare die.
6) blister package: the defervescence plaster used bare die that step 5) is cured is put the model recess of bubble-cap machine PVC film, is then made
It is sealed, then is cut as finished product with aluminium foil film.
Wherein, the oil is mutually glycerol 7000-7500 parts, 1500 parts of Sodium Polyacrylate, CMC 100- by weight ratio
300 parts, 0-300 parts of PVPP, 40-45 parts of Dihydroxyaluminium Aminoacetate, 30-39 parts of EDTA-2 sodium salt, 30-50 parts of carragheen, konjac glucomannan 20-50
Part, 5-15 parts of nano silica.
Wherein, the water phase is 20000-22000 parts of pure water, polyvinylpyrrolidone 500-1000 by weight ratio
Part, 70-85 parts of tartaric acid, 90 parts of preservative, microcapsules 100-500 parts of discoloration.
Wherein, the pennyroyal freshener additive amount is 20-50 parts by weight.
Wherein, the discoloration microcapsule preparation method are as follows: by weight, weigh 0.3-0.8 parts of leuco dye, electronics by
It 0.3-1.6 parts of body material, 3-15 parts of polyvinyl alcohol, is dissolved in absolute alcohol, is heated to 70-80 DEG C and is stirred continuously to make its reaction
After 20min, water-cooled cooling, hereinafter, after crystallization precipitation 1-2h, filters to 30 DEG C, collects filter residue, spare；By 1-10 parts of styrene,
1-3 parts of crosslinking agent, 0.1-0.5 parts of mixing of emulsifier are soluble in water, and 40min is stirred at 40-55 DEG C makes its emulsification, add and draw
0.1 part of agent of hair, is warming up to 70-80 DEG C under agitation, and above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 1-2h, then
30 DEG C are cooled to, concentration is sprayed to obtain discoloration microcapsules.
Wherein, the leuco dye is crystal violet lactone, fatty alcohol, hydration cobalt salt by weight 0.1-1:3-5:0.5-2
Mixture.
Wherein, the electron acceptor material be tetradecylic acid, hexadecylic acid, stearic acid by weight 1:1:2.5 mixture.
Wherein, the crosslinking agent is one of divinylbenzene, hydroxymethyl acrylamide, hydroxyethyl acrylamide or more
Kind；The emulsifier is polyoxyethylene sorbitol acid anhydride mono laurate rouge, polyoxyethylene sorbitol acid anhydride list palmitic acid lipid, polyoxyethylene
One of sorbitol anhydride monostearate, polyoxyethylene sorbitol acid anhydride list olein, polyoxyethylene sorbitol acid anhydride Triolein
Or it is a variety of；The initiator is azo diisobutyl amidine hydrochloride, two isobutyl imidazoline hydrochloride of azo, azo dicyano penta
Acid, one of azo dicyclohexyl formonitrile HCN or a variety of.
The present invention has the advantage that
1. the present invention with crystal violet lactone, fatty alcohol, be hydrated the mixture of cobalt salt as leuco dye, it is tetradecylic acid, hexadecylic acid, hard
The mixture of resin acid carries out preferably, effectively promoting thermo-sensitive material by the proportion to its component as electron acceptor material
Change colour sensitivity, reaches 0.1 DEG C or more, while realizing three-level discoloration, when human body temperature is 37 degree hereinafter, being then shown as
Baby pink is then shown as colourless when human body temperature is spent for 37-38, when human body temperature is 38 degree or more, is then shown as shallow
Blue.
2. the present invention using sodium acrylate as hydrogel main body, by addition carragheen, effectively improves the transparency of colloid,
Convenient for observation, in addition, can promote hydrogel elastic by addition konjac glucomannan, promote its mechanical performance.
3. the present invention is added to porous material nano silica in hydrogel, its gas permeability can be effectively promoted, it is more sharp
In the evaporation of moisture, defervescence plaster used absorbing and cooling temperature performance is promoted.
Specific embodiment
Embodiment 1:
A kind of temperature-sensitive three-level discoloration is medical defervescence plaster used, including spunlace non-woven cloth base fabric, thermosensitive aquagel layer and PP isolation film, temperature-sensitive
Hydrogel is applied in spunlace non-woven cloth base fabric, then goes up PP isolation film again to obtain the final product；Wherein, thermosensitive aquagel layer directly contacts people's
Skin absorbs human heat in colloid, then takes away intracorporal heat by the large quantity of moisture rapid evaporation stored in hydrogel
Amount, to play cooling effect；
A kind of temperature-sensitive three-level changes colour medical defervescence plaster used preparation method:
1) crystal violet lactone, fatty alcohol, hydration cobalt salt by weight, are weighed by weight 0.5 part of mixture of 0.5:4:1, ten
Tetracid, hexadecylic acid, stearic acid 10 parts of polyvinyl alcohol, are dissolved in absolute alcohol by weight 1 part of mixture of 1:1:2.5, heating
To 75 DEG C and be stirred continuously make its react 20min after, water-cooled cooling to 30 DEG C hereinafter, crystallization be precipitated 1h after, filter, collect filter
Slag, it is spare；By 6 parts of styrene, 2 parts of hydroxymethyl acrylamide, the 0.2 part of mixing of polyoxyethylene sorbitol acid anhydride list olein is dissolved in water
In, stirring 40min at 45 DEG C makes its emulsification, adds 0.1 part of azo dicyano valeric acid, is warming up to 75 under agitation
DEG C, above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 1-2h, is cooled to 30 DEG C, concentration is spraying that discoloration microcapsules are standby
With；
2) by 1500 parts of Sodium Polyacrylate and 150 parts of PVPP, 200 parts of CMC, 43 parts of Dihydroxyaluminium Aminoacetates, 35 parts EDTA-2Na and 33 part
Carragheen, 40 portions of konjaku flours in the molten addition glycerol pot of 10 parts of silica gram, press powder with blender, glycerol are allowed to infiltrate powder
End in order to avoid powder splashes when stirring, then pot and blender is installed, and low speed stirs 1 minute, speed of agitator 30r/min, middling speed
It stirs 8 minutes, 65r/min allows glycerol to stir with powder, and oily phase is made；Then again 1000 parts of polyvinyl pyrrole
Alkanone, 80 parts of tartaric acid, 90 portions of preservatives and 300 parts of discoloration microcapsules are added to the water, and water phase is made；By it is oily mutually and water phase according to
Secondary pour into is stirred under vacuum in tank, then 35 portions of pennyroyal fresheners are put into and are stirred under vacuum in tank, be then evacuated down to again-
Then 90mpa is stirred 2 minutes fastly, stir as 55HZ, then stir slowly 5 minutes, is stirred to be coated on spun laced fabric after 35HZ, is formed heat
Quick three-level discoloration hydrogel layer, then goes up anti-sticking PP embossing film again, finished product is made；Again by obtained finished product be placed on curing room into
Row solidification, until the taking-up that is cured, obtains the medical defervescence plaster used bare die of temperature-sensitive three-level discoloration；Bare die is placed in bubble-cap machine PVC film
Then model recess is sealed using aluminium foil film, then cut as finished product.
Embodiment 2:
A kind of temperature-sensitive three-level changes colour medical defervescence plaster used preparation method:
1) crystal violet lactone, fatty alcohol, hydration cobalt salt by weight, are weighed by weight 0.3 part of mixture of 0.1:5:0.5,
Tetradecylic acid, hexadecylic acid, stearic acid 3 parts of polyvinyl alcohol, are dissolved in absolute alcohol by weight 1.6 parts of mixture of 1:1:2.5,
Be heated to 80 DEG C and be stirred continuously make its react 20min after, water-cooled cooling to 30 DEG C hereinafter, crystallization be precipitated 2h after, filter, collect
Filter residue, it is spare；By 10 parts of styrene, 3 parts of hydroxyethyl acrylamide, 0.5 part of rouge of polyoxyethylene sorbitol acid anhydride mono laurate is mixed
Soluble in water, stirring 40min at 45 DEG C makes its emulsification, 0.1 part of hydrochloride of azo diisobutyl amidine is added, in stirring condition
Under be warming up to 80 DEG C, above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 2h, is cooled to 30 DEG C, concentration, spraying discoloration
Microscapsule powder is spare；
2) by 1500 parts of Sodium Polyacrylate and 300 parts of PVPP, 100 parts of CMC, 45 parts of Dihydroxyaluminium Aminoacetates, 30 parts EDTA-2Na and 35 part
Carragheen, 20 portions of konjaku flours, 15 parts of silica are added in glycerol pot, press powder with blender, glycerol is allowed to infiltrate powder, with
Exempt from powder when stirring to splash, then pot and blender are installed, low speed stirs 1 minute, and speed of agitator 35r/min, middling speed stirs 8 points
Clock, 60r/min allow glycerol to stir with powder, and oily phase is made；Then again 500 parts of polyvinylpyrrolidone, 70
The tartaric acid, 90 portions of preservatives and 500 parts of discoloration microcapsules of part are added to the water, and water phase is made；It is mutually successively poured into oily with water phase
It is stirred under vacuum in tank, then 20 portions of pennyroyal fresheners is put into and are stirred under vacuum in tank, be then evacuated down to -90mpa again, then
It stirs 3 minutes, stirs as 60HZ, then stir slowly 6 minutes fastly, stir to be coated on spun laced fabric after 40HZ, form the discoloration of temperature-sensitive three-level
Then hydrogel layer goes up anti-sticking PP embossing film again, finished product is made；Obtained finished product is placed on curing room again to solidify, directly
It is taken out to being cured, obtains the medical defervescence plaster used bare die of temperature-sensitive three-level discoloration；Bare die is placed in the model recess of bubble-cap machine PVC film,
Then it is sealed, then is cut as finished product using aluminium foil film；
Remaining is the same as embodiment 1.
Embodiment 3:
A kind of temperature-sensitive three-level changes colour medical defervescence plaster used preparation method:
1) crystal violet lactone, fatty alcohol, hydration cobalt salt by weight, are weighed by weight 0.8 part of mixture of 1:3:2,14
Acid, hexadecylic acid, stearic acid 15 parts of polyvinyl alcohol, are dissolved in absolute alcohol by weight 0.3 part of mixture of 1:1:2.5, heating
To 70 DEG C and be stirred continuously make its react 20min after, water-cooled cooling to 30 DEG C hereinafter, crystallization be precipitated 1h after, filter, collect filter
Slag, it is spare；By 1 part of styrene, 1 part of divinylbenzene, hydroxymethyl acrylamide mixture, polyoxyethylene sorbitol acid anhydride list palm
Sour rouge, polyoxyethylene sorbitol acid anhydride monostearate, the 0.1 part of mixing of lipoprotein mixture of polyoxyethylene sorbitol acid anhydride list oleic acid are dissolved in water
In, stirring 40min at 40-55 DEG C makes its emulsification, adds azo diisobutyl amidine hydrochloride, two isobutyl imidazoline salt of azo
Hydrochlorate, azo dicyano valeric acid, one of azo dicyclohexyl formonitrile HCN or 0.1 part a variety of are warming up under agitation
70 DEG C, above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 1h, is cooled to 30 DEG C, concentration, spraying discoloration microcapsule powder
End is spare；
2) by 1500 parts of Sodium Polyacrylate, 300 parts of CMC, 40 parts of Dihydroxyaluminium Aminoacetates, 39 parts of EDTA-2Na and 30 part of carragheens, 50 parts
Konjaku flour, 5 parts of silica are added in glycerol pot, press powder with blender, glycerol is allowed to infiltrate powder, in order to avoid powder when stirring
It splashing, then pot and blender is installed, low speed stirs 1 minute, speed of agitator 30r/min, and middling speed is stirred 8 minutes, 65r/min,
It allows glycerol to stir with powder, oily phase is made；Then again 1500 parts of polyvinylpyrrolidone, 85 parts of winestone
Acid, 90 portions of preservatives and 100 parts of discoloration microcapsules are added to the water, and water phase is made；Vacuum stirring is successively mutually poured into water phase by oily
In tank, then 50 portions of pennyroyal fresheners are put into and are stirred under vacuum in tank, is then evacuated down to -90mpa again, then stir 3 points fastly
Clock is stirred as 50HZ, then is stirred slowly 5 minutes, is stirred to be coated on spun laced fabric after 30HZ, is formed temperature-sensitive three-level and is changed colour hydrogel
Then layer goes up anti-sticking PP embossing film again, finished product is made；Obtained finished product is placed on curing room again to solidify, until solidification
It is good to take out, obtain the medical defervescence plaster used bare die of temperature-sensitive three-level discoloration；Bare die is placed in the model recess of bubble-cap machine PVC film, is then made
It is sealed, then is cut as finished product with aluminium foil film；
Remaining is the same as embodiment 1.
Embodiment 4:
A kind of temperature-sensitive three-level changes colour medical defervescence plaster used preparation method:
1) crystal violet lactone, fatty alcohol, hydration cobalt salt by weight, are weighed by weight 0.4 part of mixture of 1:6:3,14
Acid, hexadecylic acid, stearic acid 10 parts of polyvinyl alcohol, are dissolved in absolute alcohol by weight 1 part of mixture of 1:1:2, are heated to 80
DEG C and be stirred continuously make its react 20min after, water-cooled cooling to 30 DEG C hereinafter, crystallization be precipitated 1-2h after, filter, collect filter residue,
It is spare；By 7 parts of styrene, 2 parts of divinylbenzene, hydroxymethyl acrylamide mixture, polyoxyethylene sorbitol acid anhydride list olein,
The 0.4 part of mixing of polyoxyethylene sorbitol acid anhydride Triolein mixture is soluble in water, and 40min is stirred at 45 DEG C makes its emulsification, then
Azo dicyano valeric acid is added, 0.1 part of azo dicyclohexyl formonitrile HCN mixture, is warming up to 80 DEG C under agitation, with
Above-mentioned filter residue is added in 0.5g/min rate, after keeping the temperature 2h, is cooled to 30 DEG C, concentration is spraying that discoloration microscapsule powder is spare；
2) by 1500 parts of Sodium Polyacrylate and 180 parts of PVPP, 200 parts of CMC, 40 parts of Dihydroxyaluminium Aminoacetates, 35 parts EDTA-2Na and 30 part
Carragheen, 35 portions of konjaku flours, 8 parts of silica are added in glycerol pot, press powder with blender, glycerol is allowed to infiltrate powder, with
Exempt from powder when stirring to splash, then pot and blender are installed, low speed stirs 1 minute, and speed of agitator 30-35r/min, middling speed is stirred
8 minutes, 65r/min allowed glycerol to stir with powder, and oily phase is made；Then again 1100 parts of polyvinylpyrrolidine
Ketone, 80 parts of tartaric acid, 90 portions of preservatives and 150 parts of discoloration microcapsules are added to the water, and water phase is made；Successively by oily phase and water phase
It pours into and is stirred under vacuum in tank, then 30 portions of pennyroyal fresheners are put into and are stirred under vacuum in tank, be then evacuated down to -90mpa again,
Then it stirs 3 minutes, stirs as 50HZ, then stir slowly 5 minutes fastly, stir to be coated on spun laced fabric after 30HZ, form temperature-sensitive three-level
Change colour hydrogel layer, then goes up anti-sticking PP embossing film again, finished product is made；Obtained finished product curing room is placed on again to be consolidated
Change, until the taking-up that is cured, obtains the medical defervescence plaster used bare die of temperature-sensitive three-level discoloration；Bare die is placed in the model of bubble-cap machine PVC film
Then recess is sealed using aluminium foil film, then cut as finished product；Remaining is the same as embodiment 1.
Embodiment 5:
A kind of temperature-sensitive three-level changes colour medical defervescence plaster used preparation method:
1) crystal violet lactone, fatty alcohol, hydration cobalt salt by weight, are weighed by weight 1 part of mixture of 0.8:4:1,14
Acid, hexadecylic acid, stearic acid 10 parts of polyvinyl alcohol, are dissolved in absolute alcohol, are heated to by weight 2 parts of mixture of 1:1:2.5
70 DEG C and be stirred continuously make its react 20min after, water-cooled cooling to 30 DEG C hereinafter, crystallization be precipitated 2h after, filter, collect filter residue,
It is spare；By 8 parts of styrene, 2 parts of hydroxyethyl acrylamide, the 0.3 part of mixing of polyoxyethylene sorbitol acid anhydride monostearate is dissolved in water
In, stirring 40min at 45 DEG C makes its emulsification, adds 0.1 part of hydrochloride of azo diisobutyl amidine, heats up under agitation
To 70 DEG C, above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 2h, is cooled to 30 DEG C, concentration, spraying discoloration microcapsules
Powder is spare；
2) by 1500 parts of Sodium Polyacrylate and 250 parts of PVPP, 170 parts of CMC, 45 parts of Dihydroxyaluminium Aminoacetates, 35 parts EDTA-2Na and 35 part
Carragheen, 22 portions of konjaku flours, 13 parts of silica are added in glycerol pot, press powder with blender, glycerol is allowed to infiltrate powder, with
Exempt from powder when stirring to splash, then pot and blender are installed, low speed stirs 1 minute, and speed of agitator 35r/min, middling speed stirs 8 points
Clock, 65r/min allow glycerol to stir with powder, and oily phase is made；Then again 700 parts of polyvinylpyrrolidone, 70
The tartaric acid, 90 portions of preservatives and 350 parts of discoloration microcapsules of part are added to the water, and water phase is made；It is mutually successively poured into oily with water phase
It is stirred under vacuum in tank, then 25 portions of pennyroyal fresheners is put into and are stirred under vacuum in tank, be then evacuated down to -90mpa again, then
It stirs 3 minutes, stirs as 60HZ, then stir slowly 6 minutes fastly, stir to be coated on spun laced fabric after 30HZ, form the discoloration of temperature-sensitive three-level
Then hydrogel layer goes up anti-sticking PP embossing film again, finished product is made；Obtained finished product is placed on curing room again to solidify, directly
It is taken out to being cured, obtains the medical defervescence plaster used bare die of temperature-sensitive three-level discoloration；Bare die is placed in the model recess of bubble-cap machine PVC film,
Then it is sealed, then is cut as finished product using aluminium foil film；
Remaining is the same as embodiment 1.
Embodiment 6:
A kind of temperature-sensitive three-level changes colour medical defervescence plaster used preparation method:
1) crystal violet lactone, fatty alcohol, hydration cobalt salt by weight, are weighed by weight 0.2 part of mixture of 0.5:3:1.5,
Tetradecylic acid, hexadecylic acid, stearic acid 10 parts of polyvinyl alcohol, are dissolved in absolute alcohol by weight 0.2 part of mixture of 1:1:2.5,
Be heated to 70 DEG C and be stirred continuously make its react 20min after, water-cooled cooling to 30 DEG C hereinafter, crystallization be precipitated 2h after, filter, collect
Filter residue, it is spare；By 1 part of styrene, 1 part of hydroxymethyl acrylamide, the 0.1 part of mixing of polyoxyethylene sorbitol acid anhydride Triolein is dissolved in
In water, stirring 40min at 45 DEG C makes its emulsification, adds 0.1 part of two isobutyl imidazoline hydrochloride of azo, under agitation
80 DEG C are warming up to, above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 2h, is cooled to 30 DEG C, concentration is spraying that discoloration is micro-
Capsule powders are spare；
2) by 1500 parts of Sodium Polyacrylate and 165 parts of PVPP, 225 parts of CMC, 45 parts of Dihydroxyaluminium Aminoacetates, 34 parts EDTA-2Na and 33 part
Carragheen, 45 portions of konjaku flours, 11 parts of silica are added in glycerol pot, press powder with blender, glycerol is allowed to infiltrate powder, with
Exempt from powder when stirring to splash, then pot and blender are installed, low speed stirs 1 minute, and speed of agitator 35r/min, middling speed stirs 8 points
Clock, 65r/min allow glycerol to stir with powder, and oily phase is made；Then again 950 parts of polyvinylpyrrolidone, 78
The tartaric acid, 90 portions of preservatives and 450 parts of discoloration microcapsules of part are added to the water, and water phase is made；It is mutually successively poured into oily with water phase
It is stirred under vacuum in tank, then 40 portions of pennyroyal fresheners is put into and are stirred under vacuum in tank, be then evacuated down to -90mpa again, then
It stirs 3 minutes, stirs as 50HZ, then stir slowly 6 minutes fastly, stir to be coated on spun laced fabric after 40HZ, form the discoloration of temperature-sensitive three-level
Then hydrogel layer goes up anti-sticking PP embossing film again, finished product is made；Obtained finished product is placed on curing room again to solidify, directly
It is taken out to being cured, obtains the medical defervescence plaster used bare die of temperature-sensitive three-level discoloration；Bare die is placed in the model recess of bubble-cap machine PVC film,
Then it is sealed, then is cut as finished product using aluminium foil film；
Remaining is the same as embodiment 1.
Embodiment 7:
A kind of temperature-sensitive three-level changes colour medical defervescence plaster used preparation method:
1) crystal violet lactone, fatty alcohol, hydration cobalt salt by weight, are weighed by weight 0.5 part of mixture of 0.7:3:2, ten
Tetracid, hexadecylic acid, stearic acid 11 parts of polyvinyl alcohol, are dissolved in absolute alcohol, add by weight 1.5 parts of mixture of 1:1:2.5
Heat to 80 DEG C and be stirred continuously make its react 20min after, water-cooled cooling to 30 DEG C hereinafter, crystallization be precipitated 2h after, filter, collect filter
Slag, it is spare；By 1 part of styrene, 3 parts of hydroxymethyl acrylamide, the 0.5 part of mixing of polyoxyethylene sorbitol acid anhydride list olein is dissolved in water
In, stirring 40min at 50 DEG C makes its emulsification, adds azo dicyano valeric acid, azo dicyclohexyl formonitrile HCN mixture 0.1
Part, it is warming up to 70 DEG C under agitation, above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 2h, is cooled to 30 DEG C, it is dense
Contracting, it is spraying that discoloration microscapsule powder is spare；
2) by 1500 parts of Sodium Polyacrylate and 145 parts of PVPP, 130 parts of CMC, 40 parts of Dihydroxyaluminium Aminoacetates, 33 parts EDTA-2Na and 9 part two
Silica is added in glycerol pot, presses powder with blender, glycerol is allowed to infiltrate powder, in case powder splashes when stirring, then by pot
It is installed with blender, low speed stirs 1 minute, speed of agitator 35r/min, and middling speed is stirred 8 minutes, 65r/min, allows glycerol and powder
It stirs, oily phase is made；Then again 1500 parts of polyvinylpyrrolidone, 70 parts of tartaric acid, 90 portions of preservatives
And 500 parts of discoloration microcapsules are added to the water, and water phase is made；It mutually successively pours into oily and is stirred under vacuum in tank with water phase, then by 35 parts
Pennyroyal freshener, which is put into, to be stirred under vacuum in tank, is then evacuated down to -90mpa again, is then stirred fastly 3 minutes, stirs as 60HZ,
It stirs 5 minutes, stirs to be coated on spun laced fabric after 30HZ slowly again, form temperature-sensitive three-level discoloration hydrogel layer, it is then upper anti-sticking again
PP embossing film, is made finished product；Obtained finished product is placed on curing room again to solidify, until the taking-up that is cured, obtains temperature-sensitive three
The medical defervescence plaster used bare die of grade discoloration；Bare die is placed in the model recess of bubble-cap machine PVC film, is then sealed using aluminium foil film, then
Cutting becomes finished product；
Remaining is the same as embodiment 1.
Embodiment 8:
A kind of temperature-sensitive three-level changes colour medical defervescence plaster used preparation method:
1) crystal violet lactone, fatty alcohol, hydration cobalt salt by weight, are weighed by weight 0.3 part of mixture of 1:5:0.5, ten
Tetracid, hexadecylic acid, stearic acid 15 parts of polyvinyl alcohol, are dissolved in absolute alcohol, add by weight 0.3 part of mixture of 1:1:2.5
Heat to 80 DEG C and be stirred continuously make its react 20min after, water-cooled cooling to 30 DEG C hereinafter, crystallization be precipitated 1h after, filter, collect filter
Slag, it is spare；By 10 parts of styrene, 3 parts of divinylbenzene, hydroxymethyl acrylamide mixture, three oil of polyoxyethylene sorbitol acid anhydride
The 0.1 part of mixing of sour rouge is soluble in water, and 40min is stirred at 45 DEG C makes its emulsification, adds 0.1 part of azo dicyano valeric acid,
It is warming up to 80 DEG C under stirring condition, above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 2h, is cooled to 30 DEG C, is concentrated, spray
The mist microscapsule powder that must change colour is spare；
2) by 1500 parts of Sodium Polyacrylate and 150 parts of PVPP, 190 parts of CMC, 45 parts of Dihydroxyaluminium Aminoacetates, 39 parts EDTA-2Na and 35 part
Carragheen, 40 portions of konjaku flours are added in glycerol pot, press powder with blender, glycerol is allowed to infiltrate powder, in order to avoid powder when stirring
It splashing, then pot and blender is installed, low speed stirs 1 minute, speed of agitator 35r/min, and middling speed is stirred 8 minutes, 65r/min,
It allows glycerol to stir with powder, oily phase is made；Then again 1500 parts of polyvinylpyrrolidone, 70 parts of winestone
Acid, 90 portions of preservatives and 500 parts of discoloration microcapsules are added to the water, and water phase is made；Vacuum stirring is successively mutually poured into water phase by oily
In tank, then 20 portions of pennyroyal fresheners are put into and are stirred under vacuum in tank, is then evacuated down to -90mpa again, then stir 3 points fastly
Clock is stirred as 60HZ, then is stirred slowly 5 minutes, is stirred to be coated on spun laced fabric after 40HZ, is formed temperature-sensitive three-level and is changed colour hydrogel
Then layer goes up anti-sticking PP embossing film again, finished product is made；Obtained finished product is placed on curing room again to solidify, until solidification
It is good to take out, obtain the medical defervescence plaster used bare die of temperature-sensitive three-level discoloration；Bare die is placed in the model recess of bubble-cap machine PVC film, is then made
It is sealed, then is cut as finished product with aluminium foil film；
Remaining is the same as embodiment 1.
Embodiment 9:
Measure defervescence plaster used mechanical performance, the thermal diffusivity, discoloration sensitivity of embodiment 1-8 preparation；Wherein, mechanical performance includes adhesion
Power and peel strength, adhesion strength test are placed in dry insulating box to take 1, sample, 10min are dried under the conditions of 65 DEG C and removes surface
Moisture is placed in long 30cm after cooling, clings No. 1 steel ball residence time with horizontal plane (3s or more is i.e. at testing it on 15 ° of inclined-planes
For qualification)；Peel strength test is that coupongs are a piece of, is affixed on plastic plate, plastic plate is fixed, perpendicular to the ground, is attached to modeling
180 ° of the downward reflexed in one end above flitch, is fixed on special carrier, the counterweight that quality is 150g is hung vertically in dedicated
On collet, record falls off the time and (is fallen off in 1min as qualification)；Thermal diffusivity is measured as the defervescence plaster used of preparation while as adding
The heat insulation glass on piece of heat to 40 DEG C, observation heat dissipation patch surface water drops amount situation, the more more then "+" of droplet are more, show thermal diffusivity
It is stronger；The Sensitirity va1ue that changes colour is smaller, indicate thermo-responsive more accurate, discoloration sensitivity is higher；
Above-mentioned experimental data is analyzed it is found that embodiment 1-3 uses the present invention program, it is seen that mechanical performance, thermal diffusivity and discoloration
Sensitivity is superior to other embodiments；Leuco dye used in embodiment 4 and electron acceptor material proportion be not using the application text
In range provided by part, it is seen that cannot achieve three-level discoloration；Leuco dye used in embodiment 5 and embodiment 6, electron acceptor
The usage amount of material is not in the range provided by present specification, it is seen that discoloration sensitivity decline, and mechanical performance is unqualified；
Embodiment 7 is not added with carragheen and konjac glucomannan, it is seen that discoloration sensitivity decline, and mechanical performance is unqualified；Embodiment 8 is not added with
Nano silica, it is seen that its thermal diffusivity is poor, and the sensitivity that changes colour also declines；It can be inferred that using the present invention
Discoloration high sensitivity can be made in scheme, and thermal diffusivity and the stronger temperature-sensitive three-level discoloration of practicability are defervescence plaster used.
Claims (9)
1. a kind of discoloration of temperature-sensitive three-level is medical defervescence plaster used, it is characterised in that: including spunlace non-woven cloth base fabric, thermosensitive aquagel layer and
PP isolation film, thermosensitive aquagel are applied in spunlace non-woven cloth base fabric, then go up PP isolation film again to obtain the final product；Wherein, thermosensitive aquagel
Layer directly contacts the skin of people.
The medical defervescence plaster used preparation method 2. a kind of temperature-sensitive three-level as described in claim 1 changes colour, it is characterised in that:
Include the following steps:
1) oily phase configuration: raw material is weighed according to the ratio, then glycerol is added in pot, adds the Sodium Polyacrylate weighed up, sweet hydroxyl
Aluminium, disodium salt, CMC, PVPP, carragheen, konjaku flour, nano silica press powder in pot, with blender, and glycerol is allowed to soak
Moisten powder, in order to avoid powder splashes when stirring, then pot and blender is installed, low speed stirs 1 minute, speed of agitator 30-35r/
Min, middling speed are stirred 8 minutes, and 60-65r/min allows glycerol to stir with powder；
2) water phase configures: polyvinylpyrrolidone being added in mixer by formula, then pure water is added by formula, stirring is equal
It is even, until can't see sticky matter in water, then the tartaric acid weighed up, preservative, discoloration microcapsules are poured into water and are stirred evenly；
3) it is stirred under vacuum: mutually successively pouring into oily and be stirred under vacuum in tank with water phase, then pennyroyal freshener is put into vacuum and is stirred
It mixes in tank, is then evacuated down to -90mpa again, then stir fastly 2-3 minutes, mixing speed 50-60HZ, then 5-6 minutes are stirred slowly i.e.
Can, mixing speed 30-40HZ；Hydrogel after de-airing mixer is mixed can put into coating machine and be coated；
4) it is coated with: the discoloration material of hydrogel three-level made from step 3) is coated on spun laced fabric, form temperature-sensitive three-level discoloration water-setting
Then glue-line goes up anti-sticking PP embossing film again, finished product is made；
5) solidify: the finished product that step 4) is obtained is placed on curing room and solidifies, until the taking-up that is cured；Up to temperature-sensitive three-level
Change colour medical defervescence plaster used bare die；
6) blister package: the defervescence plaster used bare die that step 5) is cured is put the model recess of bubble-cap machine PVC film, is then used
The heat-sealing of aluminium foil film, then cut as finished product.
The medical defervescence plaster used preparation method 3. a kind of temperature-sensitive three-level according to claim 2 changes colour, it is characterised in that: step
1) oil described in is mutually glycerol 7000-7500 parts, 1500 parts of Sodium Polyacrylate, 100-300 parts of CMC, PVPP by weight ratio
0-300 parts, 40-45 parts of Dihydroxyaluminium Aminoacetate, 30-39 parts of EDTA-2 sodium salt, 30-50 parts of carragheen, 20-50 parts of konjac glucomannan, nano-silica
5-15 parts of SiClx.
The medical defervescence plaster used preparation method 4. a kind of temperature-sensitive three-level according to claim 2 changes colour, it is characterised in that: step
2) water phase described in is 20000-22000 parts of pure water, 500-1000 parts of polyvinylpyrrolidone, tartaric acid by weight ratio
70-85 parts, 90 parts of preservative, microcapsules 100-500 parts of discoloration.
The medical defervescence plaster used preparation method 5. a kind of temperature-sensitive three-level according to claim 2 changes colour, it is characterised in that: step
3) the pennyroyal freshener additive amount described in is 20-50 parts by weight.
The medical defervescence plaster used preparation method 6. a kind of temperature-sensitive three-level according to claim 2 changes colour, it is characterised in that: step
2) the discoloration microcapsule preparation method described in are as follows: by weight, weigh 0.3-0.8 parts of leuco dye, electron acceptor material 0.3-
1.6 parts, 3-15 parts of polyvinyl alcohol, be dissolved in absolute alcohol, be heated to 70-80 DEG C and be stirred continuously make its react 20min after, water
It is cold to be cooled to 30 DEG C hereinafter, suction filtration collects filter residue, spare after crystallization precipitation 1-2h；By 1-10 parts of styrene, crosslinking agent 1-3
Part, 0.1-0.5 parts of mixing of emulsifier are soluble in water, and 40min is stirred at 40-55 DEG C makes its emulsification, add initiator 0.1
Part, it is warming up to 70-80 DEG C under agitation, above-mentioned filter residue is added with 0.5g/min rate, after keeping the temperature 1-2h, is cooled to 30
DEG C, concentration is sprayed to obtain discoloration microcapsules.
The medical defervescence plaster used preparation method 7. a kind of temperature-sensitive three-level according to claim 6 changes colour, it is characterised in that: described
Leuco dye is crystal violet lactone, fatty alcohol, is hydrated cobalt salt by weight the mixture of 0.1-1:3-5:0.5-2.
The medical defervescence plaster used preparation method 8. a kind of temperature-sensitive three-level according to claim 6 changes colour, it is characterised in that: described
Electron acceptor material be tetradecylic acid, hexadecylic acid, stearic acid by weight 1:1:2.5 mixture.
The medical defervescence plaster used preparation method 9. a kind of temperature-sensitive three-level according to claim 6 changes colour, it is characterised in that: described
Crosslinking agent is one of divinylbenzene, hydroxymethyl acrylamide, hydroxyethyl acrylamide or a variety of；The emulsifier is poly-
Ethylene oxide sorbitol anhydride mono laurate rouge, polyoxyethylene sorbitol acid anhydride list palmitic acid lipid, polyoxyethylene sorbitol acid anhydride monostearate
One of rouge, polyoxyethylene sorbitol acid anhydride list olein, polyoxyethylene sorbitol acid anhydride Triolein are a variety of；The initiator
For azo diisobutyl amidine hydrochloride, two isobutyl imidazoline hydrochloride of azo, azo dicyano valeric acid, azo diisopropyl imidazoles
One of quinoline is a variety of.
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