CN111728951A - Hif羟化酶抑制剂的药物制剂 - Google Patents
Hif羟化酶抑制剂的药物制剂 Download PDFInfo
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- CN111728951A CN111728951A CN202010591483.2A CN202010591483A CN111728951A CN 111728951 A CN111728951 A CN 111728951A CN 202010591483 A CN202010591483 A CN 202010591483A CN 111728951 A CN111728951 A CN 111728951A
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- capsule
- iron oxide
- red
- isoquinoline
- phenoxy
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| WO2025111214A1 (en) | 2023-11-22 | 2025-05-30 | Fibrogen, Inc. | [(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3- carbonyl)amino]acetic acid (roxadustat) for the treatment of anemia in subjects with myelodysplastic syndrome (mds) |
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| WO2004108681A1 (en) | 2003-06-06 | 2004-12-16 | Fibrogen, Inc. | Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| CN102272117B (zh) | 2008-11-14 | 2015-06-17 | 菲布罗根有限公司 | 作为hif羟化酶抑制剂的苯并噻喃衍生物 |
| CN109369524A (zh) | 2012-07-16 | 2019-02-22 | 菲布罗根有限公司 | 脯氨酰羟化酶抑制剂的晶体形态 |
| HUE034409T2 (en) | 2012-07-16 | 2018-02-28 | Fibrogen Inc | Process for the preparation of isoquinoline compounds |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| CN105377242A (zh) | 2013-06-06 | 2016-03-02 | 菲布罗根有限公司 | Hif羟化酶抑制剂的药物制剂 |
| UA123308C2 (uk) | 2015-04-01 | 2021-03-17 | Екебіа Терапьютікс, Інк. | Композиції і способи для лікування анемії |
| WO2019042485A1 (en) | 2017-08-30 | 2019-03-07 | Zentiva, K.S. | FORMS IN THE STRONG STATE OF ROXADUSTAT |
| CA3074529C (en) | 2017-09-04 | 2022-07-05 | Sandoz Ag | Co-crystal of roxadustat with l-proline and uses thereof |
| CN110664814A (zh) * | 2019-10-24 | 2020-01-10 | 上海长海医院 | Fg-4592在制备治疗炎性肠病药物中的用途 |
| CN110934833B (zh) * | 2019-12-17 | 2022-08-19 | 河北长天药业有限公司 | 一种复方氨酚那敏颗粒 |
| US20230190731A1 (en) * | 2020-03-17 | 2023-06-22 | Zydus Lifesciences Limited | Formulation comprising hif prolyl hydroxylase inhibitors |
| US20220280482A1 (en) * | 2021-03-06 | 2022-09-08 | Mind Medicine, Inc. | Formulations of psilocin that have enhanced stability |
| CN116832005A (zh) * | 2022-03-23 | 2023-10-03 | 石药集团中奇制药技术（石家庄）有限公司 | 一种罗沙司他胶囊 |
| CN114796280B (zh) * | 2022-06-15 | 2024-06-25 | 河北长天药业有限公司 | 一种复方氨酚那敏颗粒及其制备工艺 |
| EP4321155A1 (en) * | 2022-08-08 | 2024-02-14 | Sanovel Ilac Sanayi Ve Ticaret A.S. | An oral pharmaceutical composition comprising roxadustat |
| CN118436652A (zh) * | 2024-04-18 | 2024-08-06 | 南方医科大学顺德医院(佛山市顺德区第一人民医院) | 一种罗沙司他药物制剂及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120149712A1 (en) * | 2001-12-06 | 2012-06-14 | Fibrogen, Inc. | Methods for improving kidney function |
| WO2012097331A1 (en) * | 2011-01-13 | 2012-07-19 | Fibrogen, Inc. | Methods for increasing reticulocyte hemoglobin content |
Family Cites Families (50)
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| DK0650961T3 (da) | 1993-11-02 | 1997-09-15 | Hoechst Ag | Substituerede heterocykliske carboxylsyreamider, deres fremstilling og deres anvendelse som lægemidler. |
| DE19746287A1 (de) | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| ES2414706T3 (es) | 2001-12-06 | 2013-07-22 | Fibrogen, Inc. | Métodos para aumentar la eritropoyetina endógena |
| DE10209692A1 (de) | 2002-03-06 | 2003-09-18 | Merck Patent Gmbh | Isochinolinderivate |
| US7618940B2 (en) * | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| CA2507002C (en) | 2002-12-16 | 2012-09-18 | Kissei Pharmaceutical Co., Ltd. | Solid drug for oral use |
| JP4805234B2 (ja) * | 2002-12-16 | 2011-11-02 | キッセイ薬品工業株式会社 | 経口固形医薬 |
| WO2004108681A1 (en) | 2003-06-06 | 2004-12-16 | Fibrogen, Inc. | Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| WO2005011696A1 (en) | 2003-08-01 | 2005-02-10 | Fibrogen, Inc. | Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers |
| JP4789264B2 (ja) * | 2004-03-16 | 2011-10-12 | 旭化成ファーマ株式会社 | ファスジル含有製剤及びその安定性を改善する方法 |
| ATE513833T1 (de) | 2005-03-02 | 2011-07-15 | Fibrogen Inc | Thienopyridinverbindungen und verfahren zu ihrer verwendung |
| EP1893186A2 (en) | 2005-06-06 | 2008-03-05 | Fibrogen, Inc. | Improved treatment for anemia using a hif-alpha stabilising agent |
| DE602006014843D1 (de) | 2005-06-15 | 2010-07-22 | Fibrogen Inc | Verwendung von hif 1alfa modulatoren zur behandlung von krebs |
| UA97349C2 (uk) * | 2005-09-08 | 2012-02-10 | Х. Луннбэк А/С | Стійкі тверді склади сертиндолу |
| EA016713B1 (ru) | 2005-10-31 | 2012-07-30 | Кова Ко., Лтд. | Таблетка с насечкой, обладающая превосходной фотостабильностью |
| GB0523810D0 (en) | 2005-11-23 | 2006-01-04 | Astrazeneca Ab | Pharmaceutical compositions |
| DK2044028T3 (da) | 2006-01-27 | 2012-08-20 | Fibrogen Inc | Cyanoisoquinolinforbindelser til stabilisering af den hypoxiinducerende faktor (HIF) |
| ES2342727T3 (es) * | 2006-02-09 | 2010-07-13 | Teva Pharmaceutical Industries Ltd. | Formulaciones farmaceuticas estables de montelukast sodico. |
| WO2007097929A1 (en) | 2006-02-16 | 2007-08-30 | Fibrogen, Inc. | Compounds and methods for treatment of stroke |
| BRPI0710527B8 (pt) | 2006-04-04 | 2021-05-25 | Fibrogen Inc | compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende |
| US20100172984A1 (en) * | 2006-06-06 | 2010-07-08 | Bijay Kumar Padhi | tablet dosage form comprising cetirizine and pseudoephedrine |
| US20070293575A1 (en) | 2006-06-15 | 2007-12-20 | Fibrogen, Inc. | Compounds and methods for treatment of cancer-related anemia |
| US7713986B2 (en) | 2006-06-15 | 2010-05-11 | Fibrogen, Inc. | Compounds and methods for treatment of chemotherapy-induced anemia |
| JP5683058B2 (ja) * | 2007-04-27 | 2015-03-11 | ニプロ株式会社 | 経口固形製剤及びその製造方法 |
| CN101896210A (zh) | 2007-10-12 | 2010-11-24 | 阿斯利康(瑞典)有限公司 | 含有甘露醇和/或微晶纤维素的齐泊腾坦组合物 |
| AU2008319229A1 (en) | 2007-11-02 | 2009-05-07 | Fibrogen, Inc. | Methods for reducing blood pressure |
| US8269008B2 (en) | 2007-12-03 | 2012-09-18 | Fibrogen, Inc. | Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions |
| WO2009075824A1 (en) | 2007-12-06 | 2009-06-18 | Fibrogen, Inc. | Methods for increasing endothelial progentior cells |
| WO2009075826A1 (en) | 2007-12-07 | 2009-06-18 | Fibrogen, Inc. | Methods for increasing white blood cells |
| WO2009089547A1 (en) | 2008-01-11 | 2009-07-16 | Fibrogen, Inc. | Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity |
| WO2009100250A1 (en) | 2008-02-05 | 2009-08-13 | Fibrogen, Inc. | Chromene derivatives and use thereof as hif hydroxylase activity inhibitors |
| WO2010022240A1 (en) | 2008-08-20 | 2010-02-25 | Fibrogen, Inc. | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators |
| WO2010024908A1 (en) | 2008-08-26 | 2010-03-04 | Fibrogen, Inc. | Methods for treatment of multiple sclerosis |
| CN102272117B (zh) | 2008-11-14 | 2015-06-17 | 菲布罗根有限公司 | 作为hif羟化酶抑制剂的苯并噻喃衍生物 |
| US20100144737A1 (en) | 2008-12-08 | 2010-06-10 | Fibrogen, Inc. | Methods for inhibiting t helper cell differentiation |
| EP2382971A4 (en) | 2009-01-29 | 2014-01-08 | Dainippon Sumitomo Pharma Co | ORAL DISINTEGRATING TABLE COMPRISING AN INDOOR CORE |
| JP2010248106A (ja) * | 2009-04-14 | 2010-11-04 | Dainippon Sumitomo Pharma Co Ltd | フィルムコーティング錠 |
| JP2012176899A (ja) | 2009-05-19 | 2012-09-13 | Mitsubishi Tanabe Pharma Corp | ２−（１−ピペラジニル）−５−メチルベンゼンスルホン酸誘導体を含む注射用水溶液 |
| WO2012097329A1 (en) | 2011-01-13 | 2012-07-19 | Fibrogen, Inc. | Methods for increasing mean corpuscular volume |
| WO2012106472A1 (en) | 2011-02-02 | 2012-08-09 | Fibrogen, Inc. | Naphthyridine derivatives as inhibitors of hypoxia inducible factor (hif) hydroxylase |
| WO2013013609A1 (en) | 2011-07-22 | 2013-01-31 | Zhejiang Beta Pharma Incorporation | Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof |
| WO2013070908A1 (en) | 2011-11-09 | 2013-05-16 | Fibrogen, Inc. | Therapeutic method |
| SG11201405574UA (en) | 2012-03-09 | 2014-10-30 | Fibrogen Inc | 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| HUE034409T2 (en) | 2012-07-16 | 2018-02-28 | Fibrogen Inc | Process for the preparation of isoquinoline compounds |
| CN109369524A (zh) | 2012-07-16 | 2019-02-22 | 菲布罗根有限公司 | 脯氨酰羟化酶抑制剂的晶体形态 |
| EP2951159B1 (en) | 2013-01-24 | 2018-08-22 | Fibrogen, Inc. | Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid |
| CN105377242A (zh) | 2013-06-06 | 2016-03-02 | 菲布罗根有限公司 | Hif羟化酶抑制剂的药物制剂 |
-
2014
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120149712A1 (en) * | 2001-12-06 | 2012-06-14 | Fibrogen, Inc. | Methods for improving kidney function |
| WO2012097331A1 (en) * | 2011-01-13 | 2012-07-19 | Fibrogen, Inc. | Methods for increasing reticulocyte hemoglobin content |
Non-Patent Citations (7)
| Title |
|---|
| [日]株式会社医药杂志社编辑部编: "最新药物制剂技术及应用", 31 October 1992, 中国医药科技出版社, pages: 430 - 433 * |
| 《国家执业药师资格考试历年真题试卷与解析》编写组编写: "国家执业药师资格考试历年真题试卷与解析.药学专业", 30 April 2012, 中国医药科技出版社, pages: 268 * |
| ICH指导委员会编: "药品注册的国际技术要求质量部分", 30 September 2000, 人民卫生出版社, pages: 20 * |
| 国家食品药品监督管理局药品认证管理中心编写: "固体口服制剂：药品GMP指南", 31 August 2011, 中国医药科技出版社, pages: 127 * |
| 崔福德等主编: "药剂学", 31 January 2011, 中国医药科技出版社, pages: 132 - 197 * |
| 张健等主编: "医院药事管理学", 31 August 2006, 浙江科学技术出版社, pages: 103 * |
| 罗明生等主编: "药剂辅料大全", 31 March 1993, 四川科学技术出版社, pages: 45 - 46 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025111214A1 (en) | 2023-11-22 | 2025-05-30 | Fibrogen, Inc. | [(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3- carbonyl)amino]acetic acid (roxadustat) for the treatment of anemia in subjects with myelodysplastic syndrome (mds) |
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