CN111712259A - Fcrn抗体及其使用方法 - Google Patents

Fcrn抗体及其使用方法 Download PDF

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Publication number
CN111712259A
CN111712259A CN201880089334.7A CN201880089334A CN111712259A CN 111712259 A CN111712259 A CN 111712259A CN 201880089334 A CN201880089334 A CN 201880089334A CN 111712259 A CN111712259 A CN 111712259A
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China
Prior art keywords
seq
sequence
antibody
cdr
disease
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CN201880089334.7A
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English (en)
Chinese (zh)
Inventor
L·E·凌
D·尼克斯
N·A·克利丰
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Momenta Pharmaceuticals Inc
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Momenta Pharmaceuticals Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201880089334.7A 2017-12-13 2018-12-13 Fcrn抗体及其使用方法 Pending CN111712259A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762598402P 2017-12-13 2017-12-13
US62/598402 2017-12-13
US201862701354P 2018-07-20 2018-07-20
US62/701354 2018-07-20
PCT/US2018/065568 WO2019118791A1 (en) 2017-12-13 2018-12-13 Fcrn antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
CN111712259A true CN111712259A (zh) 2020-09-25

Family

ID=65041911

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880089334.7A Pending CN111712259A (zh) 2017-12-13 2018-12-13 Fcrn抗体及其使用方法

Country Status (10)

Country Link
US (2) US11773168B2 (enExample)
EP (1) EP3723802A1 (enExample)
JP (3) JP7420720B2 (enExample)
CN (1) CN111712259A (enExample)
AU (1) AU2018386193B2 (enExample)
BR (1) BR112020011310A2 (enExample)
CA (1) CA3085751A1 (enExample)
IL (1) IL275070A (enExample)
SG (1) SG11202005021PA (enExample)
WO (1) WO2019118791A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114129730A (zh) * 2021-09-16 2022-03-04 宁夏大学 FcRn抑制剂在制备降低炎症反应和/或防治结核病的试剂或药物中的应用
WO2023030501A1 (zh) * 2021-09-03 2023-03-09 舒泰神(北京)生物制药股份有限公司 特异性识别FcRn的抗体及其应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118667011A (zh) 2015-01-30 2024-09-20 动量制药公司 Fcrn抗体及其使用方法
BR112020011483A2 (pt) 2017-12-08 2020-11-24 Argenx Bvba uso de antagonistas de fcrn para tratamento de miastenia gravis generalizada
AU2018386193B2 (en) 2017-12-13 2025-04-24 Momenta Pharmaceuticals, Inc. FcRn antibodies and methods of use thereof
MY209122A (en) 2018-06-08 2025-06-23 argenx BV Compositions and methods for treating immune thrombocytopenia
US20220259308A1 (en) * 2019-08-01 2022-08-18 Janssen Biotech, Inc. Fcrn antibodies and methods of use thereof
EP4454711A3 (en) 2020-01-08 2025-01-08 argenx BV Methods for treating pemphigus disorders
EP4171738A1 (en) * 2020-06-17 2023-05-03 The Trustees of The University of Pennsylvania Compositions and methods for treatment of gene therapy patients
WO2022098955A1 (en) * 2020-11-06 2022-05-12 Janssen Biotech, Inc. Fcrn antibodies and methods of use thereof
IL314322A (en) * 2022-01-17 2024-09-01 argenx BV Methods of treating patients with autoantibody-mediated disease
EP4540283A1 (en) 2022-06-15 2025-04-23 argenx BV Fcrn/hsa binding molecules and methods of use
TW202517676A (zh) 2023-07-05 2025-05-01 比利時商艾伯霖克斯公司 用於治療IgG相關疾病及病症之改良FcRn拮抗劑
TW202527982A (zh) 2023-09-11 2025-07-16 美商默門塔醫藥公司 Fcrn抗體之醫藥組成物
WO2025186787A1 (en) * 2024-03-08 2025-09-12 Momenta Pharmaceuticals, Inc. Compositions and methods for treating fetal and neonatal alloimmune thrombocytopenia

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012167039A1 (en) * 2011-06-02 2012-12-06 Dyax Corp. Fc RECEPTOR BINDING PROTEINS
CN103717619A (zh) * 2011-05-25 2014-04-09 因内特制药股份有限公司 治疗发炎及自体免疫疾病之抗-kir抗体
WO2016123521A2 (en) * 2015-01-30 2016-08-04 Momenta Pharmaceuticals, Inc. Fcrn antibodies and methods of use thereof
WO2016183352A1 (en) * 2015-05-12 2016-11-17 Syntimmune, Inc. Humanized affinity matured anti-fcrn antibodies

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60334678D1 (de) 2002-02-14 2010-12-09 Chugai Pharmaceutical Co Ltd Antikörper enthaltende pharmazeutische lösungen
US7662928B2 (en) 2003-08-08 2010-02-16 The Research Foundation Of State University Of New York Anti-FcRn antibodies for treatment of auto/allo immune conditions
WO2005013912A2 (en) 2003-08-08 2005-02-17 The Research Foundation Of State University Of Newyork Anti-fcrn antibodies for treatment of auto/allo immune conditions
CN101124245A (zh) 2003-11-12 2008-02-13 比奥根艾迪克Ma公司 新生儿Fc受体(FcRn)-结合多肽变体、二聚体Fc结合蛋白及其相关方法
WO2006096490A2 (en) 2005-03-08 2006-09-14 Pharmacia & Upjohn Company Llc ANTI-MAdCAM ANTIBODY COMPOSITIONS
JP2009524664A (ja) 2006-01-25 2009-07-02 ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク 自己/アロ免疫疾患の治療のための抗−fcrn抗体
EP2004690A2 (en) 2006-03-13 2008-12-24 Ablynx N.V. Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
EP2310415B8 (en) 2008-04-25 2017-12-13 Dyax Corp. Antibodies against fcrn and use thereof
JP5683581B2 (ja) 2009-06-30 2015-03-11 リサーチ ディベロップメント ファウンデーション 免疫グロブリンFcポリペプチド
GB201208370D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
US20130323242A1 (en) 2012-06-01 2013-12-05 Ophthotech Corp. Compositions comprising an anti-pdgf aptamer and a vegf antagonist
US9844594B2 (en) 2012-12-18 2017-12-19 Merck Sharp & Dohme Corp. Liquid formulations for an anti-TNF α antibody
ES2802274T3 (es) 2013-05-02 2021-01-18 Momenta Pharmaceuticals Inc Glicoproteínas sialiladas
KR101815265B1 (ko) 2013-06-20 2018-01-04 한올바이오파마주식회사 FcRn 특이적 인간 항체 및 이를 포함하는 자가면역 질환 치료용 조성물
ES2952583T3 (es) 2014-04-30 2023-11-02 Hanall Biopharma Co Ltd Anticuerpo de unión a FcRn para tratar enfermedades autoinmunes
DK3491025T3 (da) * 2016-07-29 2024-01-15 Momenta Pharmaceuticals Inc Fcrn-antistoffer og anvendelsesmetoder heraf
JP6913527B2 (ja) 2017-06-22 2021-08-04 株式会社小松製作所 油圧ポンプおよびモータ
BR112020011483A2 (pt) 2017-12-08 2020-11-24 Argenx Bvba uso de antagonistas de fcrn para tratamento de miastenia gravis generalizada
AU2018386193B2 (en) 2017-12-13 2025-04-24 Momenta Pharmaceuticals, Inc. FcRn antibodies and methods of use thereof
EP3762027A4 (en) 2018-02-13 2022-06-15 The Brigham & Women's Hospital, Inc. THERAPEUTIC FCRN-BASED BISPECIFIC MONOCLONAL ANTIBODIES
CA3106670A1 (en) 2018-07-20 2020-01-23 Momenta Pharmaceuticals, Inc. Fcrn antibody compositions
CR20210088A (es) 2018-07-20 2021-09-02 Momenta Pharmaceuticals Inc Composiciones de anticuerpos fcrn y métodos de uso de estos
KR20210078517A (ko) 2018-10-16 2021-06-28 유씨비 바이오파마 에스알엘 중증근무력증의 치료 방법
US20220259308A1 (en) 2019-08-01 2022-08-18 Janssen Biotech, Inc. Fcrn antibodies and methods of use thereof
WO2022098955A1 (en) 2020-11-06 2022-05-12 Janssen Biotech, Inc. Fcrn antibodies and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103717619A (zh) * 2011-05-25 2014-04-09 因内特制药股份有限公司 治疗发炎及自体免疫疾病之抗-kir抗体
WO2012167039A1 (en) * 2011-06-02 2012-12-06 Dyax Corp. Fc RECEPTOR BINDING PROTEINS
WO2016123521A2 (en) * 2015-01-30 2016-08-04 Momenta Pharmaceuticals, Inc. Fcrn antibodies and methods of use thereof
WO2016183352A1 (en) * 2015-05-12 2016-11-17 Syntimmune, Inc. Humanized affinity matured anti-fcrn antibodies

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CONGLEI LI 等: "The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 121, no. 11, pages 4537 - 4547, XP002790138, DOI: 10.1172/JCI57850 *
尹立雪: "现代超声心脏电生理学", vol. 1, 30 November 2007, 科学技术文献出版社, pages: 733 *
秦丽丽: "现代妇产科疾病手术学", vol. 1, 科学技术文献出版社, pages: 172 *
邓晶 等: "与母源性HLA 抗体相关的新生儿同种免疫性血小板减少症", 中国输血杂志, vol. 29, no. 9, pages 935 - 937 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023030501A1 (zh) * 2021-09-03 2023-03-09 舒泰神(北京)生物制药股份有限公司 特异性识别FcRn的抗体及其应用
CN114129730A (zh) * 2021-09-16 2022-03-04 宁夏大学 FcRn抑制剂在制备降低炎症反应和/或防治结核病的试剂或药物中的应用

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Publication number Publication date
JP2021506786A (ja) 2021-02-22
WO2019118791A1 (en) 2019-06-20
IL275070A (en) 2020-07-30
JP7690538B2 (ja) 2025-06-10
JP7420720B2 (ja) 2024-01-23
JP2024016042A (ja) 2024-02-06
US20220064290A1 (en) 2022-03-03
US11773168B2 (en) 2023-10-03
KR20200098604A (ko) 2020-08-20
BR112020011310A2 (pt) 2020-11-17
JP2025143252A (ja) 2025-10-01
CA3085751A1 (en) 2019-06-20
AU2018386193A1 (en) 2020-06-25
US20240158509A1 (en) 2024-05-16
AU2018386193B2 (en) 2025-04-24
AU2018386193A8 (en) 2020-07-02
EP3723802A1 (en) 2020-10-21
SG11202005021PA (en) 2020-07-29

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Applicant after: MOMENTA PHARMACEUTICALS, Inc.

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