CN111700965A - A Chinese medicinal external preparation for treating fungal infection - Google Patents
A Chinese medicinal external preparation for treating fungal infection Download PDFInfo
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- CN111700965A CN111700965A CN202010792294.1A CN202010792294A CN111700965A CN 111700965 A CN111700965 A CN 111700965A CN 202010792294 A CN202010792294 A CN 202010792294A CN 111700965 A CN111700965 A CN 111700965A
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- 208000031888 Mycoses Diseases 0.000 title claims abstract description 32
- 206010017533 Fungal infection Diseases 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 241000202726 Bupleurum Species 0.000 claims abstract description 6
- 244000153955 Reynoutria sachalinensis Species 0.000 claims abstract description 6
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 claims abstract description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 6
- 239000011593 sulfur Substances 0.000 claims abstract description 6
- 244000167125 Cinnamomum japonicum Species 0.000 claims abstract description 5
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- 235000005155 Tanacetum balsamita Nutrition 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims abstract description 5
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- 239000000203 mixture Substances 0.000 claims description 7
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- 239000000843 powder Substances 0.000 claims description 2
- 229940098465 tincture Drugs 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
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- 235000017803 cinnamon Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
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- 229940040145 liniment Drugs 0.000 description 2
- 239000000865 liniment Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
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- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
- MCSXGCZMEPXKIW-UHFFFAOYSA-N 3-hydroxy-4-[(4-methyl-2-nitrophenyl)diazenyl]-N-(3-nitrophenyl)naphthalene-2-carboxamide Chemical compound Cc1ccc(N=Nc2c(O)c(cc3ccccc23)C(=O)Nc2cccc(c2)[N+]([O-])=O)c(c1)[N+]([O-])=O MCSXGCZMEPXKIW-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000605445 Anemarrhena asphodeloides Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 208000005373 Dyshidrotic Eczema Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000022535 Infectious Skin disease Diseases 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241001480037 Microsporum Species 0.000 description 1
- ALLWOAVDORUJLA-UHFFFAOYSA-N Rebamipida Chemical compound C=1C(=O)NC2=CC=CC=C2C=1CC(C(=O)O)NC(=O)C1=CC=C(Cl)C=C1 ALLWOAVDORUJLA-UHFFFAOYSA-N 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 235000018167 Reynoutria japonica Nutrition 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000405217 Viola <butterfly> Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- -1 cataplasm Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
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- 238000009501 film coating Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 201000011414 pompholyx Diseases 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 229950004535 rebamipide Drugs 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
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Abstract
The invention discloses a traditional Chinese medicine external preparation for treating fungal infection, which is prepared from the following raw material medicines in parts by weight: 2-4 parts of sulfur, cinnamomum japonicum and garden balsam seed; 6-12 parts by weight of rhizoma anemarrhenae; giant knotweed rhizome, bupleurum root and saddle leaf 9-18 weight portions. According to the traditional Chinese medicine external preparation for treating fungal infection, the raw materials are matched and coordinated with each other, so that the traditional Chinese medicine external preparation has a good curative effect on fungal infection.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine external preparation for treating fungal infection.
Background
Fungal infections are infectious skin diseases caused by dermatophytes, and body fungal infections are fungal infections occurring on the face, neck, trunk, limbs, and the like, and are also called round fungal infections and chiefly fungal infections. The fungal infection is caused by a trichofungal infection, a microsporum or an epidermoid fungal infection. The infection sources of the traditional Chinese medicine are mainly hand fungal infection, foot fungal infection, nail fungal infection, polluted clothes and the like. Common methods of treating fungal infections in western medicine: ketonic or itraconazole (sertralinol) for oral administration; externally applied mouldazole ointment, ketoconazole cream, dacron ointment, compound rebamipide liniment, compound formic acid liniment and the like. After the treatment, the body fungal infection or the femoral fungal infection is relatively reduced, and the body fungal infection reappears after the medicine is stopped. Currently, there are no specific drugs for treating fungal infections.
Disclosure of Invention
The invention aims to improve the defects of the prior art and provide the traditional Chinese medicine composition for treating fungal infection, which can effectively improve or even eliminate the clinical symptoms of patients and has the characteristics of obvious treatment effect, short treatment period, no toxic or side effect and the like.
The invention provides a traditional Chinese medicine for treating fungal infection, which is prepared from the following raw materials in parts by weight: 2-4 parts of sulfur, cinnamomum japonicum and garden balsam seed; 6-12 parts by weight of rhizoma anemarrhenae; giant knotweed rhizome, bupleurum root and saddle leaf 9-18 weight portions.
In a preferred embodiment, the traditional Chinese medicine composition for treating fungal infection consists of the following raw material medicines in parts by weight: 4 parts of sulfur, cinnamomum japonicum and garden balsam seed; 12 parts of rhizoma anemarrhenae; giant knotweed rhizome, bupleurum root and saddle leaf in 18 weight portions.
Wherein, cinnamon is pungent, sweet and hot in flavor. It enters kidney, spleen, heart and liver meridians. Tonify fire and strengthen yang, guide fire to the origin, dispel cold and alleviate pain, activate blood and dredge channels. Cinnamon has an obvious fungicidal effect.
Giant knotweed rhizome, slightly bitter and slightly cold. It enters liver, gallbladder and lung meridians. Dispel wind and remove dampness, dissipate blood stasis and relieve pain, relieve cough and resolve phlegm. Polygonum cuspidatum has strong bactericidal performance on deep red fungus-infected bacteria and interdigital fungus-infected bacteria which cause refractory fungus infection and pompholyx leucomycosis infection.
Zhi mu is bitter, sweet and cold. It enters lung, stomach and kidney meridians. Clear heat and purge fire, promote fluid production and moisten dryness. The rhizoma anemarrhenae decoction has stronger antibacterial effect on some common pathogenic dermatophyte infectious bacteria such as Klebsiella pneumoniae fungal infectious bacteria and Mongolian variants thereof, concentric trichome fungal infectious bacteria, Viola trichome fungal infectious bacteria, Rhodotrichum trichome infectious bacteria, flocculent epidermal fungal infectious bacteria, rust trichome fungal infectious bacteria, plantar trichome fungal infectious bacteria, interdigital trichome fungal infectious bacteria, dog microspore and the like on a saber culture medium.
Semen Impatientis slightly bitter, pungent and warm; has little toxicity. It enters lung and liver meridians. Break blood and soften hardness, remove food stagnation. The semen Impatientis extract also contains a certain amount of effective components with anti-inflammatory and antibacterial effects, and has obvious antibacterial effect on red epidermoid fungus infectious bacteria, violet hair fungus infectious bacteria and inguinal epidermoid fungus infectious bacteria, and golf epidermoid fungus infectious bacteria.
The bupleurum root is pungent; bitter; is cool in nature. Enter liver and gallbladder meridians. Wind dispelling and heat discharging; detoxify and detumescence. The traditional Chinese medicine liquid has a capability of killing red fungus infectious bacteria, and the inventor washes 10 patients infected by the fungus for about 10 years for 5-10 times, and the patients are all cured.
And (3) sulfur: an acid; heating; is toxic. Returning to the kidney; a spleen; liver; the large intestine channel. Tonifying fire and strengthening yang; warming spleen and relaxing bowels; kill parasites and relieve itching. Can be used for treating scabies; refractory fungal infections; baldness sores; pemphigus; eczema and carbuncle; carrying out erosion of the vulva; deep rooted carbuncle of yin type; malignant sores, etc.
Saddle leaf: remove damp toxin, remove putrefaction and promote granulation. Can be used for treating pemphigus, refractory fungal infection, skin eczema, skin ulcer, carbuncle, ulcer, burn, and scald.
The invention is prepared from Chinese traditional herbal medicines, and the Chinese traditional medicine for effectively treating fungal infection is combined by orderly matching certain natural extracts with definite components and clear effects.
The traditional Chinese medicine composition has the advantages of easily available raw materials, simple process, low cost and high efficiency, and is beneficial to pharmaceutical enterprises for medicine production and quality control; the product has low price and is easy to be accepted by patients.
The traditional Chinese medicine composition has a remarkable effect of treating fungal infection, and clinical experiment results show that the pruritus is relieved after the traditional Chinese medicine composition is applied for 1 time generally; the disease can be cured after 3-10 times.
The invention also provides an external preparation prepared from the traditional Chinese medicine composition for treating cellulitis, which comprises solution, tincture, spirit, powder, lotion, oil, emulsion, ointment, cataplasm, plaster, film coating agent, gel, aerosol and the like.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.
Claims (4)
1. A traditional Chinese medicine external preparation for treating fungal infection is characterized by comprising the following raw material medicines in parts by weight: 2-4 parts of sulfur, cinnamomum japonicum and garden balsam seed; 6-12 parts by weight of rhizoma anemarrhenae; giant knotweed rhizome, bupleurum root and saddle leaf 9-18 weight portions.
2. The traditional Chinese medicine external preparation for treating fungal infection according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 4 parts of sulfur, cinnamomum japonicum and garden balsam seed; 12 parts of rhizoma anemarrhenae; giant knotweed rhizome, bupleurum root and saddle leaf in 18 weight portions.
3. An external preparation for treating fungal infection, which is prepared from the Chinese medicinal composition of any one of claims 1 or 2.
4. The external preparation for treating cellulitis according to claim 3, which comprises solution, tincture and spirit, powder, lotion, oil, emulsion, ointment, cataplasm, plaster, plastics, gel, aerosol, etc., preferably ointment, aerosol.
Priority Applications (1)
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CN202010792294.1A CN111700965A (en) | 2020-08-09 | 2020-08-09 | A Chinese medicinal external preparation for treating fungal infection |
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CN202010792294.1A CN111700965A (en) | 2020-08-09 | 2020-08-09 | A Chinese medicinal external preparation for treating fungal infection |
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CN111700965A true CN111700965A (en) | 2020-09-25 |
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CN202010792294.1A Pending CN111700965A (en) | 2020-08-09 | 2020-08-09 | A Chinese medicinal external preparation for treating fungal infection |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107397928A (en) * | 2017-07-27 | 2017-11-28 | 四川聚豪生物科技有限公司 | It is a kind of effectively to treat Chinese medicine composition of fungal infection and preparation method thereof |
CN107582805A (en) * | 2017-10-19 | 2018-01-16 | 广西民族大学 | One kind controls beriberi |
CN109646340A (en) * | 2017-10-11 | 2019-04-19 | 谭友明 | A kind of antibacterial Chinese herbal medicines extracting solution |
-
2020
- 2020-08-09 CN CN202010792294.1A patent/CN111700965A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107397928A (en) * | 2017-07-27 | 2017-11-28 | 四川聚豪生物科技有限公司 | It is a kind of effectively to treat Chinese medicine composition of fungal infection and preparation method thereof |
CN109646340A (en) * | 2017-10-11 | 2019-04-19 | 谭友明 | A kind of antibacterial Chinese herbal medicines extracting solution |
CN107582805A (en) * | 2017-10-19 | 2018-01-16 | 广西民族大学 | One kind controls beriberi |
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