CN111686230A - Yang-tonifying hair-growing composition, preparation method and application - Google Patents
Yang-tonifying hair-growing composition, preparation method and application Download PDFInfo
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- CN111686230A CN111686230A CN202010682962.5A CN202010682962A CN111686230A CN 111686230 A CN111686230 A CN 111686230A CN 202010682962 A CN202010682962 A CN 202010682962A CN 111686230 A CN111686230 A CN 111686230A
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Abstract
The invention provides a yang-tonifying hair-growing composition, a preparation method and application thereof, and relates to the field of traditional Chinese medicines. The invention provides a yang-tonifying hair-growing composition which comprises the following components in parts by weight: 12-18 parts of fructus evodiae, 8-12 parts of ginger, 12-18 parts of codonopsis pilosula, 12-18 parts of bighead atractylodes rhizome, 8-12 parts of prepared rehmannia root, 8-12 parts of Chinese yam, 18-22 parts of dogwood, 12-18 parts of medlar, 12-18 parts of mulberry, 12-18 parts of semen cuscutae, 12-18 parts of fructus psoraleae, 25-35 parts of fried spina date seed, 4-8 parts of dried orange peel, 8-12 parts of Chinese date and 4-8 parts of honey-fried licorice root. The invention also provides a preparation method of the composition. The yang-tonifying and hair-growing composition has the advantages of having excellent effects on symptoms such as alopecia, intolerance of cold, cold limbs, hypodynamia, sleep disorder and the like caused by radiotherapy and chemotherapy of various tumors. The preparation method comprises preparing raw materials by classification, filtering, concentrating to obtain beneficial components, concentrating into high concentration medicinal liquid or directly preparing into powder, and is convenient for user to drink, carry or store.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and particularly relates to a yang-tonifying hair-growing composition, a preparation method and application thereof.
Background
With the continuous progress of society, more and more people suffer from tumors, and the types of the tumors are also increased. After one person in a family suffers from a tumor, the family is greatly burdened, and the patient himself is also harmed by the household. The current method of treating tumors is surgical resection followed by further treatment with radiation or chemotherapy as appropriate. For most tumor patients, alopecia symptoms can appear after radiotherapy and chemotherapy, the whole body constitution can also be deteriorated, the limbs are cold and aversion to cold, and the patients often feel hypodynamia and are accompanied with symptoms such as sleep disorder and the like. At present, although some traditional Chinese medicine conditioning medicines for prognosis of tumor patients exist, the traditional Chinese medicine conditioning medicines have poor alopecia effect, long treatment time and large psychological stress of patients, and the life quality of the patients is reduced.
Disclosure of Invention
The invention aims to provide a yang-tonifying hair-growing composition which has excellent effects on symptoms such as alopecia, intolerance of cold, cold limbs, hypodynamia, sleep disorder and the like caused by radiotherapy and chemotherapy of various tumors.
The invention also aims to provide a preparation method of the yang-tonifying and hair-growing composition, which is characterized in that the raw materials are prepared by classification, filtered and concentrated to fully extract the beneficial components in the formula, and the beneficial components are concentrated into high-concentration liquid medicine or directly prepared into powder, so that the composition is convenient for a user to drink, carry or store.
Another object of the present invention is to provide a use of the aforementioned composition.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
In one aspect, an embodiment of the present application provides a yang-tonifying hair-growing composition, which includes the following components in parts by weight: 12-18 parts of fructus evodiae, 8-12 parts of ginger, 12-18 parts of codonopsis pilosula, 12-18 parts of bighead atractylodes rhizome, 8-12 parts of prepared rehmannia root, 8-12 parts of Chinese yam, 18-22 parts of dogwood, 12-18 parts of medlar, 12-18 parts of mulberry, 12-18 parts of semen cuscutae, 12-18 parts of fructus psoraleae, 25-35 parts of fried spina date seed, 4-8 parts of dried orange peel, 8-12 parts of Chinese date and 4-8 parts of honey-fried licorice root.
In the composition provided by the invention, the compatibility of all the medicines is proper, the medicine effect is reasonable, the fructus evodiae warms the middle-jiao and lowers the qi, the pain is relieved, the cough is reversed, the chills and the fever are removed, the damp and the blood arthralgia are removed, the wind evil is removed, and the skin and muscle are opened; ginger has the effects of sweating, relieving exterior syndrome, warming middle energizer, arresting vomiting, warming lung and relieving cough; radix Codonopsis has effects in invigorating spleen and replenishing qi, regulating stomach function, promoting salivation, eliminating phlegm, relieving cough, enhancing immunity, dilating blood vessel, lowering blood pressure, improving microcirculation, and improving hemopoiesis function; the largehead atractylodes rhizome has the effects of strengthening spleen and tonifying qi, and eliminating dampness and inducing diuresis; prepared rehmannia root has the effects of enriching blood and nourishing yin, and replenishing essence and replenishing marrow, and is mainly used for treating liver and kidney yin deficiency, soreness and weakness of waist and knees, hectic fever due to yin deficiency, night sweat and spermatorrhea, internal heat and diabetes, blood deficiency and sallow complexion, palpitation and severe palpitation, irregular menstruation, metrorrhagia and metrostaxis, dizziness and tinnitus, and early white beard and hair; the Chinese yam has the homology of medicine and food, has the effects of strengthening spleen and stomach, benefiting lung and kidney, tonifying deficiency and resisting fatigue, and is used for treating poor appetite, loose stool, consumptive disease, asthma and cough; the pulp of dogwood contains 16 amino acids and other elements necessary for human body, and also contains saponin raw sugar, polysaccharide, malic acid, tartaric acid, phenols, resin, tannin, vitamin A, C with strong physiological activity, and has effects of invigorating stomach, promoting urination, nourishing liver and kidney, and invigorating qi and blood; the medlar can nourish the liver, nourish the kidney and moisten the lung; the mulberry is medicinal and edible, contains a large amount of protein and dietary fiber, and has the effects of enriching blood, nourishing yin, promoting production of body fluid and quenching thirst; semen Cuscutae has effects of nourishing liver and kidney, consolidating semen, reducing urination, and relieving diarrhea; fructus Psoraleae has effects in invigorating kidney, supporting yang, invigorating spleen, and invigorating stomach; stir-fried spina date seed has the effects of nourishing liver, calming heart and tranquilizing mind, and arresting sweating; the dried orange peel has the effects of regulating qi, strengthening spleen, regulating middle warmer, eliminating dampness and phlegm; the Chinese date is rich in protein, fat, sugar, carotene, B vitamins, vitamin C, vitamin P, calcium, phosphorus, iron, cyclic adenosine monophosphate and other nutritional ingredients, and has the effects of strengthening the middle-jiao, benefiting qi, nourishing blood and soothing the nerves; prepared licorice root, radix Glycyrrhizae Praeparata regulates the middle warmer, relieves urgency, moistens the lung, detoxifies the toxin and harmonizes the effects of the other drugs in the recipe.
In another aspect, the present invention provides a method for preparing the aforementioned composition, which comprises the following steps: (1) respectively lyophilizing fructus evodiae, rhizoma Zingiberis recens, radix Codonopsis, Atractylodis rhizoma, radix rehmanniae Preparata, rhizoma Dioscoreae, Corni fructus, fructus Lycii, Mori fructus, semen Cuscutae, fructus Psoraleae, parched semen Ziziphi Spinosae, pericarpium Citri Tangerinae, fructus Jujubae and radix Glycyrrhizae Preparata to obtain powder; (2) mixing the ginger powder, the prepared rehmannia root powder, the Chinese yam powder, the dodder seed powder and the malaytea scurfpea powder obtained in the step (1) to obtain a mixture I, adding the mixture I into water, distilling the mixture I by using water vapor, collecting distillate, and filtering to obtain a solution I; (3) mixing fructus evodiae, codonopsis pilosula, bighead atractylodes rhizome and dogwood to obtain a mixture II, adding the mixture II into an ethanol solution, heating, refluxing and extracting for 3 times, each time for 2-2.5 hours, filtering, and mixing ethanol extract of three times to obtain ethanol extract; (4) adding the solution I into an ethanol extracting solution, mixing, and recovering ethanol until no alcohol smell exists to obtain a solution II; (5) mixing the medlar, the mulberry, the fried spina date seed, the dried orange peel, the Chinese date and the honey-fried licorice root to obtain a third mixture, adding the third mixture into water for decoction and filtration to obtain a third solution, adding the second solution into the third solution for uniform mixing to obtain a fourth solution, filtering the fourth solution to obtain a filtrate, and concentrating the filtrate to obtain the yang-tonifying and hair-growing composition.
On the other hand, the invention also provides an application, namely the composition is used for preparing a conditioning medicine after tumor radiotherapy.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the yang-tonifying and hair-growing composition provided by the invention can obviously improve symptoms of alopecia, intolerance of cold, cold limbs, weakness, sleep disorder and the like of tumor patients after radiotherapy and chemotherapy, improve the life quality and improve the survival rate.
The preparation method provided by the invention prepares the raw materials by classification, then filters and concentrates the raw materials to fully extract the beneficial components in the formula, and concentrates the beneficial components into high-concentration liquid medicine or directly prepares the liquid medicine into powder, thereby being convenient for a user to drink, carry or store.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
On one hand, the invention provides a yang-tonifying hair-growing composition which comprises the following components in parts by weight: 12-18 parts of fructus evodiae, 8-12 parts of ginger, 12-18 parts of codonopsis pilosula, 12-18 parts of bighead atractylodes rhizome, 8-12 parts of prepared rehmannia root, 8-12 parts of Chinese yam, 18-22 parts of dogwood, 12-18 parts of medlar, 12-18 parts of mulberry, 12-18 parts of semen cuscutae, 12-18 parts of fructus psoraleae, 25-35 parts of fried spina date seed, 4-8 parts of dried orange peel, 8-12 parts of Chinese date and 4-8 parts of honey-fried licorice root. The yang-tonifying and hair-growing composition provided by the invention is prepared from fructus evodiae, Chinese medicines for warming middle-jiao and descending qi, cough with dyspnea and fever, ginger, radix zingiberis, relieving exterior syndrome, warming middle-jiao and arresting vomiting, codonopsis pilosula, tonifying middle-jiao and qi, harmonizing stomach and promoting fluid production, enhancing immunity, bighead atractylodes rhizome, tonifying spleen and qi, prepared rehmannia root, tonifying blood and nourishing yin, replenishing vital essence and replenishing marrow, and has the functions of treating early graying beard and hair, Chinese yam, spleen and stomach, tonifying lung and kidney, dogwood, medlar, tonifying liver, nourishing kidney and moistening lung, mulberry, tonifying blood and nourishing yin, semen cuscutae, tonifying liver and kidney, fructus psoraleae, tonifying spleen and stomach, stir-fried spina date seeds, calming the heart and tranquilizing mind, dried orange peel. The finally obtained yang-tonifying hair-growing composition can effectively improve symptoms of alopecia, intolerance of cold, cold limbs, hypodynamia, sleep disorder and the like of tumor patients after radiotherapy and chemotherapy, improve the life quality and improve the survival rate.
In some embodiments of the present invention, the yang tonifying and hair growth promoting composition comprises the following components in parts by weight: 15 parts of fructus evodiae, 10 parts of ginger, 15 parts of codonopsis pilosula, 15 parts of bighead atractylodes rhizome, 10 parts of prepared rehmannia root, 10 parts of Chinese yam, 20 parts of dogwood, 15 parts of medlar, 15 parts of mulberry, 15 parts of semen cuscutae, 15 parts of fructus psoraleae, 30 parts of fried spina date seed, 6 parts of dried orange peel, 10 parts of Chinese date and 6 parts of honey-fried licorice root. The yang-tonifying and hair-growing composition in the proportion has the best effect of improving symptoms such as alopecia, intolerance of cold, cold limbs, hypodynamia, sleep disorder and the like of tumor patients after radiotherapy and chemotherapy.
In another aspect, the present invention provides a method for preparing the aforementioned composition, which comprises the following steps: (1) respectively lyophilizing fructus evodiae, rhizoma Zingiberis recens, radix Codonopsis, Atractylodis rhizoma, radix rehmanniae Preparata, rhizoma Dioscoreae, Corni fructus, fructus Lycii, Mori fructus, semen Cuscutae, fructus Psoraleae, parched semen Ziziphi Spinosae, pericarpium Citri Tangerinae, fructus Jujubae and radix Glycyrrhizae Preparata to obtain powder; (2) mixing the ginger powder, the prepared rehmannia root powder, the Chinese yam powder, the dodder seed powder and the malaytea scurfpea powder obtained in the step (1) to obtain a mixture I, adding the mixture I into water, distilling the mixture I by using water vapor, collecting distillate, and filtering to obtain a solution I; (3) mixing fructus evodiae, codonopsis pilosula, bighead atractylodes rhizome and dogwood to obtain a mixture II, adding the mixture II into an ethanol solution, heating, refluxing and extracting for 3 times, each time for 2-2.5 hours, filtering, and mixing ethanol extract of three times to obtain ethanol extract; (4) adding the solution I into an ethanol extracting solution, mixing, and recovering ethanol until no alcohol smell exists to obtain a solution II; (5) mixing the medlar, the mulberry, the fried spina date seed, the dried orange peel, the Chinese date and the honey-fried licorice root to obtain a third mixture, adding the third mixture into water for decoction and filtration to obtain a third solution, adding the second solution into the third solution for uniform mixing to obtain a fourth solution, filtering the fourth solution to obtain a filtrate, and concentrating the filtrate to obtain the yang-tonifying and hair-growing composition. The preparation method comprises preparing raw materials by classification, filtering, concentrating to obtain beneficial components, concentrating into high concentration medicinal liquid or directly preparing into powder, and is convenient for user to drink, carry or store.
In some embodiments of the invention, in the above preparation method, the weight ratio of the mixture I and the water in the step (2) is 1: 20-30, and the extraction time is 6-8 h. The distillation condition can fully collect the beneficial components in the ginger, the prepared rehmannia root, the Chinese yam, the dodder and the malaytea scurfpea fruit, so that the finally prepared yang-tonifying and hair-growing composition has better treatment effect.
In some embodiments of the invention, in the preparation method, the ratio of the mass of the second mixture in the step (3) to the volume of the ethanol solution is 1: 8-12, and the volume percentage of the ethanol solution is 60-70%. The beneficial components in the evodia rutaecarpa, the codonopsis pilosula, the bighead atractylodes rhizome and the dogwood can be fully collected under the ethanol extraction condition, so that the finally prepared yang tonifying and hair growing composition has a better treatment effect.
In some embodiments of the invention, in the above preparation method, the weight ratio of the mixture III and water in the step (5) is 1: 18-22, and the decoction time is 3-4 h. The decoction condition can fully extract the beneficial components of the medlar, the mulberry, the fried spina date seed, the dried orange peel, the Chinese date and the honey-fried licorice root, so that the finally prepared yang-tonifying and hair-growing composition has better treatment effect.
In some embodiments of the invention, in the preparation method, in the step (6), the HPD400 macroporous resin is used for filtering the solution four, the adsorption time of the HPD400 macroporous resin for adsorbing the solution four is 8-10 hours, the elution time of the HPD400 macroporous resin is 12-14 hours, an eluent of the HPD400 macroporous resin during elution is an ethanol water solution, and the volume percentage of the ethanol water solution is 60-65%. The HPD400 macroporous resin can fully filter the unwanted impurities, so that the finally obtained yang-tonifying hair-growing composition is purer.
In some embodiments of the invention, in the above preparation method, the ratio of the filtrate concentration in the step (6) is 1: 30-40. When the concentration ratio is 1:30 hours, obtaining a relatively concentrated decoction, adding other available auxiliary materials according to the use requirement, and when the concentration ratio is 1:40, slightly drying to obtain powder, and is convenient to use and store.
In some embodiments of the present invention, in the above preparation method, the composition is prepared into a clinically acceptable preparation with or without adding pharmaceutically acceptable excipients.
On the other hand, the invention also provides an application, namely the composition is used for preparing a conditioning medicine after tumor radiotherapy.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The present embodiment aims to provide a composition for tonifying yang and promoting hair growth.
The embodiment provides a yang-tonifying hair-growing composition, which comprises: 15g of fructus evodiae, 10g of ginger, 15g of codonopsis pilosula, 15g of bighead atractylodes rhizome, 10g of prepared rehmannia root, 10g of Chinese yam, 20g of dogwood, 15g of medlar, 15g of mulberry, 15g of dodder, 15g of fructus psoraleae, 30g of fried spina date seed, 6g of dried orange peel, 10g of Chinese date and 6g of honey-fried licorice root.
The composition provided in this example was decocted for 1 dose per day for oral administration in two divided doses. 2 weeks for 1 course, and 3 courses of oral administration. The symptoms of aversion to cold, cold limbs and hypodynamia of the user are obviously improved, the sleep disorder is relieved, and the hair also begins to grow.
Example 2
The present embodiment aims to provide a composition for tonifying yang and promoting hair growth.
The embodiment provides a yang-tonifying hair-growing composition, which comprises: 12g of fructus evodiae, 8g of ginger, 12g of codonopsis pilosula, 18g of bighead atractylodes rhizome, 12g of prepared rehmannia root, 12g of Chinese yam, 18g of dogwood, 12g of medlar, 18g of mulberry, 12g of dodder, 18g of fructus psoraleae, 35g of fried spina date seed, 8g of dried orange peel, 12g of Chinese date and 4g of honey-fried licorice root.
The composition provided in this example was decocted for 1 dose per day for oral administration in two divided doses. 2 weeks for 1 course, and 3 courses of oral administration. The symptoms of aversion to cold, cold limbs and hypodynamia of the user are obviously improved, the sleep disorder is relieved, and the hair also begins to grow.
Example 3
The present embodiment aims to provide a composition for tonifying yang and promoting hair growth.
The embodiment provides a yang-tonifying hair-growing composition, which comprises: the traditional Chinese medicine composition comprises 18g of fructus evodiae, 12g of ginger, 18g of codonopsis pilosula, 12g of bighead atractylodes rhizome, 8g of prepared rehmannia root, 8g of Chinese yam, 22g of dogwood, 18g of medlar, 12g of mulberry, 18g of semen cuscutae, 12g of fructus psoraleae, 25g of fried spina date seed, 4g of dried orange peel, 8g of Chinese date and 8g of honey-fried licorice root.
The composition provided in this example was decocted for 1 dose per day for oral administration in two divided doses. 2 weeks for 1 course, and 3 courses of oral administration. The symptoms of aversion to cold, cold limbs and hypodynamia of the user are obviously improved, the sleep disorder is relieved, and the hair also begins to grow.
Example 4
The present embodiment aims to provide a method for preparing a composition for tonifying yang and promoting hair growth.
The preparation method of the yang tonifying and hair growth promoting composition provided in this embodiment is used for preparing the yang tonifying and hair growth promoting composition of embodiment 1, and specifically includes the following steps:
(1) respectively lyophilizing fructus evodiae, rhizoma Zingiberis recens, radix Codonopsis, Atractylodis rhizoma, radix rehmanniae Preparata, rhizoma Dioscoreae, Corni fructus, fructus Lycii, Mori fructus, semen Cuscutae, fructus Psoraleae, parched semen Ziziphi Spinosae, pericarpium Citri Tangerinae, fructus Jujubae and radix Glycyrrhizae Preparata to obtain powder;
(2) mixing the ginger powder, the prepared rehmannia root powder, the Chinese yam powder, the dodder powder and the malaytea scurfpea powder obtained in the step (1) to obtain a mixture I, adding the mixture I into water according to the material-liquid ratio (weight ratio) of 1:25, distilling the mixture I for 6-8 hours by using water vapor, collecting distillate, and filtering to obtain a solution I;
(3) mixing fructus evodiae, codonopsis pilosula, bighead atractylodes rhizome and dogwood to obtain a second mixture, adding the second mixture into a 60-70% ethanol solution (volume percentage), heating, refluxing and extracting for 3 times (2 hours each time), wherein the ratio of the mass of the second mixture to the volume of the ethanol solution is 1:10(g: ml), filtering, and mixing three ethanol extracting solutions to obtain an ethanol extracting solution;
(4) adding the solution I into an ethanol extracting solution, mixing, and recovering ethanol until no alcohol smell exists to obtain a solution II;
(5) mixing the medlar, the mulberry, the fried spina date seed, the dried orange peel, the Chinese date and the honey-fried licorice root to obtain a third mixture, adding the third mixture into water for decoction, and filtering to obtain a third solution, wherein the weight ratio of the third mixture to the water is 1:20, and the decoction time is 3 hours;
(6) adding the solution II into the solution III, uniformly mixing to obtain a solution IV, filtering the solution IV with HPD400 macroporous resin, wherein the adsorption time is 10 hours, the elution time is 12 hours, and the eluent is ethanol water solution with volume percentage of 60-65%, so as to obtain filtrate, and concentrating the filtrate according to the ratio of 1: 30-40, so as to obtain the yang tonifying and hair growing composition. Concentrating at a ratio of 1:40, and drying for a short time to obtain powder.
Example 5
The present embodiment aims to provide a method for preparing a composition for tonifying yang and promoting hair growth.
The preparation method of the yang tonifying and hair growth promoting composition provided in this embodiment is used for preparing the yang tonifying and hair growth promoting composition of embodiment 2, and specifically includes the following steps:
(1) respectively lyophilizing fructus evodiae, rhizoma Zingiberis recens, radix Codonopsis, Atractylodis rhizoma, radix rehmanniae Preparata, rhizoma Dioscoreae, Corni fructus, fructus Lycii, Mori fructus, semen Cuscutae, fructus Psoraleae, parched semen Ziziphi Spinosae, pericarpium Citri Tangerinae, fructus Jujubae and radix Glycyrrhizae Preparata to obtain powder;
(2) mixing the ginger powder, the prepared rehmannia root powder, the Chinese yam powder, the dodder powder and the malaytea scurfpea powder obtained in the step (1) to obtain a mixture I, adding the mixture I into water according to the material-liquid ratio (weight ratio) of 1:30, distilling the mixture I for 6-8 hours by using water vapor, collecting distillate, and filtering to obtain a solution I;
(3) mixing fructus evodiae, codonopsis pilosula, bighead atractylodes rhizome and dogwood to obtain a second mixture, adding the second mixture into a 60-70% ethanol solution (volume percentage), heating, refluxing and extracting for 3 times (2 hours each time), wherein the ratio of the mass of the second mixture to the volume of the ethanol solution is 1:12(g: ml), filtering, and mixing three ethanol extracting solutions to obtain an ethanol extracting solution;
(4) adding the solution I into an ethanol extracting solution, mixing, and recovering ethanol until no alcohol smell exists to obtain a solution II;
(5) mixing the medlar, the mulberry, the fried spina date seed, the dried orange peel, the Chinese date and the honey-fried licorice root to obtain a third mixture, adding the third mixture into water for decoction, and filtering to obtain a third solution, wherein the weight ratio of the third mixture to the water is 1:18, and the decoction time is 4 hours;
(6) adding the solution II into the solution III, uniformly mixing to obtain a solution IV, filtering the solution IV with HPD400 macroporous resin, wherein the adsorption time is 8 hours, the elution time is 14 hours, and the eluent is ethanol water solution with volume percentage of 60-65%, so as to obtain filtrate, and concentrating the filtrate according to the ratio of 1: 30-40, so as to obtain the yang tonifying and hair growing composition. Concentrating at a ratio of 1:40, and drying for a short time to obtain powder.
Example 6
The present embodiment aims to provide a method for preparing a composition for tonifying yang and promoting hair growth.
The preparation method of the yang tonifying and hair growth promoting composition provided in this embodiment is used for preparing the yang tonifying and hair growth promoting composition of embodiment 1, and specifically includes the following steps:
(1) respectively lyophilizing fructus evodiae, rhizoma Zingiberis recens, radix Codonopsis, Atractylodis rhizoma, radix rehmanniae Preparata, rhizoma Dioscoreae, Corni fructus, fructus Lycii, Mori fructus, semen Cuscutae, fructus Psoraleae, parched semen Ziziphi Spinosae, pericarpium Citri Tangerinae, fructus Jujubae and radix Glycyrrhizae Preparata to obtain powder;
(2) mixing the ginger powder, the prepared rehmannia root powder, the Chinese yam powder, the dodder powder and the malaytea scurfpea powder obtained in the step (1) to obtain a mixture I, adding the mixture I into water according to the material-liquid ratio (weight ratio) of 1:20, distilling the mixture I for 6-8 hours by using water vapor, collecting distillate, and filtering to obtain a solution I;
(3) mixing fructus evodiae, codonopsis pilosula, bighead atractylodes rhizome and dogwood to obtain a second mixture, adding the second mixture into a 60-70% ethanol solution (volume percentage), heating, refluxing and extracting for 3 times (2.5 hours each time), wherein the ratio of the mass of the second mixture to the volume of the ethanol solution is 1:8(g: ml), filtering, and mixing the three ethanol extract solutions to obtain an ethanol extract;
(4) adding the solution I into an ethanol extracting solution, mixing, and recovering ethanol until no alcohol smell exists to obtain a solution II;
(5) mixing the medlar, the mulberry, the fried spina date seed, the dried orange peel, the Chinese date and the honey-fried licorice root to obtain a third mixture, adding the third mixture into water for decoction, and filtering to obtain a third solution, wherein the weight ratio of the third mixture to the water is 1:22, and the decoction time is 3 hours;
(6) adding the solution II into the solution III, uniformly mixing to obtain a solution IV, filtering the solution IV with HPD400 macroporous resin, wherein the adsorption time is 10 hours, the elution time is 12 hours, and the eluent is ethanol water solution with volume percentage of 60-65%, so as to obtain filtrate, and concentrating the filtrate according to the ratio of 1: 30-40, so as to obtain the yang tonifying and hair growing composition. Concentrating at a ratio of 1:40, and drying for a short time to obtain powder.
Test example 1
Volunteers carrying out chemotherapy and/or radiotherapy after tumor recruitment use the compositions provided in examples 1-6 of the present invention. The compositions obtained in examples 1-6 were taken and orally administered in two times, 1 dose per day (i.e., the composition prepared from the drugs with the contents shown in examples 1-3, or the composition prepared from the drugs with the contents shown in examples 1-3, prepared by the preparation methods shown in examples 4-6), 2 weeks for 1 treatment course, and continuously orally administered for 3 treatment courses. Each set of conditions was as follows:
in 8 of the groups using the yang tonifying and hair growth promoting composition provided in example 1, alopecia symptoms were improved, cold limbs and aversion to cold symptoms were relieved, energy was abundant, sleep quality was improved, prognosis quality of life was improved, and productivity was also improved;
in 6 people in the group using the yang tonifying and hair growth promoting composition provided in example 2, alopecia symptoms are improved, cold limbs and aversion to cold symptoms are relieved, energy is sufficient, sleep quality is improved, prognosis life quality is improved, and productivity is improved;
7 of the groups using the yang tonifying and hair growth promoting composition provided in example 3 had improved alopecia symptoms, alleviated cold limbs and aversion to cold symptoms, vigorous, improved sleep quality, improved prognosis quality of life, and increased productivity;
in 9 of the groups using the yang tonifying and hair growth promoting composition provided in example 4, alopecia symptoms were improved, cold limbs and aversion to cold symptoms were relieved, energy was abundant, sleep quality was improved, prognosis quality of life was improved, and productivity was also improved;
7 of the groups using the yang tonifying and hair growth promoting composition provided in example 5 had improved alopecia symptoms, alleviated cold limbs and aversion to cold symptoms, vigorous, improved sleep quality, improved prognosis quality of life, and increased productivity;
in 9 of the groups using the yang tonifying and hair growth promoting composition provided in example 6, alopecia symptoms were improved, cold limbs and aversion to cold symptoms were relieved, energy was abundant, sleep quality was improved, prognosis quality of life was improved, and productivity was also improved;
from the above comparison results, it is understood that the number of people who improve the symptoms such as alopecia and chilly after using the yang tonifying and hair growth promoting composition provided in examples 1 to 3 of the present invention is substantially equivalent to the number of people who have the effect of the yang tonifying and hair growth promoting composition provided in examples 4 to 6, and it is demonstrated that the preparation method provided in examples 4 to 6 not only can make the administration of the composition easier, but also can obtain the effect substantially equivalent to or even superior to the original decoction.
In conclusion, the composition provided by the invention has proper compatibility of the medicines and reasonable drug effect, and the fructus evodiae has the effects of warming middle-jiao and descending qi, relieving pain, coughing up, expelling cold and heat, removing damp and blood arthralgia, expelling wind evil and opening striae; ginger has the effects of sweating, relieving exterior syndrome, warming middle energizer, arresting vomiting, warming lung and relieving cough; radix Codonopsis has effects in invigorating spleen and replenishing qi, regulating stomach function, promoting salivation, eliminating phlegm, relieving cough, enhancing immunity, dilating blood vessel, lowering blood pressure, improving microcirculation, and improving hemopoiesis function; the largehead atractylodes rhizome has the effects of strengthening spleen and tonifying qi, and eliminating dampness and inducing diuresis; prepared rehmannia root has the effects of enriching blood and nourishing yin, and replenishing essence and replenishing marrow, and is mainly used for treating liver and kidney yin deficiency, soreness and weakness of waist and knees, hectic fever due to yin deficiency, night sweat and spermatorrhea, internal heat and diabetes, blood deficiency and sallow complexion, palpitation and severe palpitation, irregular menstruation, metrorrhagia and metrostaxis, dizziness and tinnitus, and early white beard and hair; the Chinese yam has the homology of medicine and food, has the effects of strengthening spleen and stomach, benefiting lung and kidney, tonifying deficiency and resisting fatigue, and is used for treating poor appetite, loose stool, consumptive disease, asthma and cough; the pulp of dogwood contains 16 amino acids and other elements necessary for human body, and has effects of invigorating stomach, promoting urination, nourishing liver and kidney, and invigorating qi and blood; the medlar can nourish the liver, nourish the kidney and moisten the lung; the mulberry is medicinal and edible, contains a large amount of protein and dietary fiber, and has the effects of enriching blood, nourishing yin, promoting production of body fluid and quenching thirst; semen Cuscutae has effects of nourishing liver and kidney, consolidating semen, reducing urination, and relieving diarrhea; fructus Psoraleae has effects in invigorating kidney, supporting yang, invigorating spleen, and invigorating stomach; stir-fried spina date seed has the effects of nourishing liver, calming heart and tranquilizing mind, and arresting sweating; the dried orange peel has the effects of regulating qi, strengthening spleen, regulating middle warmer, eliminating dampness and phlegm; the Chinese date is rich in nutritional ingredients such as protein, fat, sugar, carotene and the like, and has the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves; prepared licorice root, radix Glycyrrhizae Praeparata, harmonizes the middle warmer and relieves urgency, moistens the lung, detoxifies and harmonizes the drugs in the recipe. Can obviously improve the symptoms of alopecia, intolerance of cold, cold limbs, hypodynamia, sleep disorder and the like of tumor patients after radiotherapy and chemotherapy, improve the life quality and improve the survival rate.
The preparation method provided by the invention prepares the raw materials by classification, then filters and concentrates the raw materials to fully extract the beneficial components in the formula, and concentrates the beneficial components into high-concentration liquid medicine or directly prepares the liquid medicine into powder, thereby being convenient for a user to drink, carry or store.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The composition for tonifying yang and growing hair is characterized by comprising the following components in parts by weight: 12-18 parts of fructus evodiae, 8-12 parts of ginger, 12-18 parts of codonopsis pilosula, 12-18 parts of bighead atractylodes rhizome, 8-12 parts of prepared rehmannia root, 8-12 parts of Chinese yam, 18-22 parts of dogwood, 12-18 parts of medlar, 12-18 parts of mulberry, 12-18 parts of semen cuscutae, 12-18 parts of fructus psoraleae, 25-35 parts of fried spina date seed, 4-8 parts of dried orange peel, 8-12 parts of Chinese date and 4-8 parts of honey-fried licorice root.
2. The composition for tonifying yang and growing hair according to claim 1, which comprises the following components in parts by weight: 15 parts of fructus evodiae, 10 parts of ginger, 15 parts of codonopsis pilosula, 15 parts of bighead atractylodes rhizome, 10 parts of prepared rehmannia root, 10 parts of Chinese yam, 20 parts of dogwood, 15 parts of medlar, 15 parts of mulberry, 15 parts of semen cuscutae, 15 parts of fructus psoraleae, 30 parts of fried spina date seed, 6 parts of dried orange peel, 10 parts of Chinese date and 6 parts of honey-fried licorice root.
3. A process for the preparation of a composition according to any one of claims 1 or 2, characterized in that it comprises the following steps:
(1) respectively lyophilizing fructus evodiae, rhizoma Zingiberis recens, radix Codonopsis, Atractylodis rhizoma, radix rehmanniae Preparata, rhizoma Dioscoreae, Corni fructus, fructus Lycii, Mori fructus, semen Cuscutae, fructus Psoraleae, parched semen Ziziphi Spinosae, pericarpium Citri Tangerinae, fructus Jujubae and radix Glycyrrhizae Preparata to obtain powder;
(2) mixing the ginger powder, the prepared rehmannia root powder, the Chinese yam powder, the dodder seed powder and the malaytea scurfpea powder obtained in the step (1) to obtain a mixture I, adding the mixture I into water, distilling the mixture I by using water vapor, collecting distillate, and filtering to obtain a solution I;
(3) mixing fructus evodiae, codonopsis pilosula, bighead atractylodes rhizome and dogwood to obtain a mixture II, adding the mixture II into an ethanol solution, heating, refluxing and extracting for 3 times, each time for 2-2.5 hours, filtering, and mixing ethanol extract of three times to obtain ethanol extract;
(4) adding the solution I into an ethanol extracting solution, mixing, and recovering ethanol until no alcohol smell exists to obtain a solution II;
(5) mixing fructus Lycii, Mori fructus, parched semen Ziziphi Spinosae, pericarpium Citri Tangerinae, fructus Jujubae and radix Glycyrrhizae Preparata to obtain mixture III, decocting the mixture III in water, filtering to obtain solution III,
(6) adding the solution II into the solution III, uniformly mixing to obtain a solution IV, filtering the solution IV to obtain a filtrate, and concentrating the filtrate to obtain the yang-tonifying and hair-growing composition.
4. The preparation method according to claim 3, wherein the weight ratio of the mixture I and the water in the step (2) is 1: 20-30, and the extraction time is 6-8 h.
5. The preparation method according to claim 4, wherein the ratio of the mass of the second mixture to the volume of the ethanol solution in the step (3) is 1: 8-12, and the volume percentage of the ethanol solution is 60-70%.
6. The preparation method according to claim 5, wherein the weight ratio of the mixture III to the water in the step (5) is 1: 18-22, and the decoction time is 3-4 h.
7. The preparation method according to claim 6, wherein in the step (6), the solution IV is filtered by using HPD400 macroporous resin, the adsorption time of the solution IV adsorbed by the HPD400 macroporous resin is 8-10 h, the elution time of the HPD400 macroporous resin is 12-14 h, the eluent of the HPD400 macroporous resin during elution is ethanol water, and the volume percentage of the ethanol water is 60-65%.
8. The preparation method according to claim 7, wherein the ratio of the filtrate concentration in the step (6) is 1: 30-40.
9. The preparation method of claim 8, wherein the composition is prepared into a clinically acceptable preparation with or without pharmaceutically acceptable excipients.
10. Use of a composition according to claim 1 or 2 for the preparation of a medicament for conditioning after radiotherapy of a tumour.
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| CN1054370A (en) * | 1991-03-30 | 1991-09-11 | 江西永丰制药二厂 | A kind of manufacture method of kidney-tonifying health-care medicament |
| CN105358168A (en) * | 2013-07-04 | 2016-02-24 | 株式会社爱茉莉太平洋 | Composition having a function for alleviating premenstrual syndrome and menstrual pain |
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| CN1054370A (en) * | 1991-03-30 | 1991-09-11 | 江西永丰制药二厂 | A kind of manufacture method of kidney-tonifying health-care medicament |
| CN105358168A (en) * | 2013-07-04 | 2016-02-24 | 株式会社爱茉莉太平洋 | Composition having a function for alleviating premenstrual syndrome and menstrual pain |
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