CN111671896A - 骨髓间充质干细胞和单克隆抗体联合治疗癌症的用途 - Google Patents
骨髓间充质干细胞和单克隆抗体联合治疗癌症的用途 Download PDFInfo
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Abstract
Description
名称 | 缓冲体系 | 浓度mg/ml | 体积ml | 总量mg | 纯度 |
410A | 0.01MPBS | 2.3 | 5.8 | 13.34 | >96% |
组别 | 细胞个数 |
实验组 | 28.21±4.55 |
对照组1 | 35.41±9.63 |
对照组2 | 70.29±16.23 |
阴性对照组 | 119.86±13.12 |
Claims (6)
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112961240A (zh) * | 2021-04-06 | 2021-06-15 | 北京欣颂生物科技有限公司 | 一种靶向TGF-β1的单克隆抗体及其与间充质干细胞外泌体的联合应用 |
CN115806935A (zh) * | 2022-08-26 | 2023-03-17 | 广州连达科技有限公司 | 脐带间充质干细胞培养方法 |
CN115975036A (zh) * | 2022-08-18 | 2023-04-18 | 北京诺赛国际医学研究院 | 包含干细胞的药物组合物及其治疗癌症的用途 |
CN115975035A (zh) * | 2022-08-18 | 2023-04-18 | 北京诺赛国际医学研究院 | 干细胞和抗体联合治疗癌症的用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009114826A3 (en) * | 2008-03-13 | 2010-02-18 | Angiodynamics, Inc. | Treatment systems and methods for renal-related diseases |
WO2011069121A1 (en) * | 2009-12-04 | 2011-06-09 | Neostem, Inc. | Mesenchymal stem cells (mscs) isolated from mobilized peripheral blood |
CN107454844A (zh) * | 2015-03-06 | 2017-12-08 | 亚洲大学校产学协力团 | 用于癌症治疗的细胞治疗剂以及使用该细胞治疗剂的联合治疗 |
CN108715832A (zh) * | 2018-06-01 | 2018-10-30 | 段海峰 | 一种抑制肿瘤生长的间充质干细胞及制备方法和应用 |
-
2020
- 2020-07-31 CN CN202010754890.0A patent/CN111671896B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009114826A3 (en) * | 2008-03-13 | 2010-02-18 | Angiodynamics, Inc. | Treatment systems and methods for renal-related diseases |
WO2011069121A1 (en) * | 2009-12-04 | 2011-06-09 | Neostem, Inc. | Mesenchymal stem cells (mscs) isolated from mobilized peripheral blood |
CN107454844A (zh) * | 2015-03-06 | 2017-12-08 | 亚洲大学校产学协力团 | 用于癌症治疗的细胞治疗剂以及使用该细胞治疗剂的联合治疗 |
CN108715832A (zh) * | 2018-06-01 | 2018-10-30 | 段海峰 | 一种抑制肿瘤生长的间充质干细胞及制备方法和应用 |
Non-Patent Citations (3)
Title |
---|
SOYOUNG BAEK等: "Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: results from a phase I/II trial", 《JOURNAL OF TRANSLATIONAL MEDICINE》 * |
梁亮等: "驱化因子CCL5介导骨髓间充质干细胞增加肾透明细胞癌细胞侵袭迁移能力", 《现代肿瘤医学》 * |
邓震等: "骨髓间充质干细胞抑制肾癌A498细胞增殖及侵袭能力", 《第二军医大学学报》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112961240A (zh) * | 2021-04-06 | 2021-06-15 | 北京欣颂生物科技有限公司 | 一种靶向TGF-β1的单克隆抗体及其与间充质干细胞外泌体的联合应用 |
CN115975036A (zh) * | 2022-08-18 | 2023-04-18 | 北京诺赛国际医学研究院 | 包含干细胞的药物组合物及其治疗癌症的用途 |
CN115975035A (zh) * | 2022-08-18 | 2023-04-18 | 北京诺赛国际医学研究院 | 干细胞和抗体联合治疗癌症的用途 |
CN115975035B (zh) * | 2022-08-18 | 2023-08-18 | 北京诺赛国际医学研究院 | 干细胞和抗体联合治疗癌症的用途 |
CN115806935A (zh) * | 2022-08-26 | 2023-03-17 | 广州连达科技有限公司 | 脐带间充质干细胞培养方法 |
CN115806935B (zh) * | 2022-08-26 | 2023-07-07 | 厦门莫森凯尔细胞生物科技有限公司 | 脐带间充质干细胞培养方法 |
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