CN111657285A - Sterilizing and disinfecting mosquito repellent liquid and preparation method thereof - Google Patents
Sterilizing and disinfecting mosquito repellent liquid and preparation method thereof Download PDFInfo
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- CN111657285A CN111657285A CN202010567792.6A CN202010567792A CN111657285A CN 111657285 A CN111657285 A CN 111657285A CN 202010567792 A CN202010567792 A CN 202010567792A CN 111657285 A CN111657285 A CN 111657285A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a sterilization, disinfection and mosquito repellent liquid, which comprises a solvent, a skin care agent, a mosquito repellent agent, an organic antibacterial agent, an inorganic antibacterial agent, a softening stabilizer and an aromatic, wherein the solvent is prepared by mixing a solvent A and a solvent B and is provided with deionized water and an alcohol solvent mutually soluble with the deionized water. According to the invention, on one hand, the double-emulsion core-spun nano antibacterial particles with large surface area can be used for adsorbing part of the mosquito repellent and the aromatic, so that the adsorption carrier is improved, the volatilization of the mosquito repellent and the aromatic is delayed, the effective duration of mosquito repellent and aromatic is prolonged, on the other hand, the problem that the activity of the inorganic antibacterial agent is ineffective due to agglomeration can be avoided, the release can be delayed, the effective duration of antibacterial is prolonged, meanwhile, the double-emulsion coating layer of the nano antibacterial particles is used for inhibiting or reducing the amount of the inorganic antibacterial agent entering human bodies or plant epidermal cells, so that the safety of products is improved, the characteristics of mosquito repellent, antibacterial, aromatic and skin protection are provided, the nano antibacterial agent is suitable for infants, and the daily.
Description
Technical Field
The invention belongs to the technical field of mosquito repellent liquid, and particularly relates to a sterilizing and disinfecting mosquito repellent liquid and a preparation method thereof.
Background
Summer and autumn are the most rampant seasons of mosquito activity, prevent mosquito and sting, eliminate the mosquito and can prevent the emergence of disease effectively, and at present, common mosquito repellent mode is: 1. physical mosquito repelling, garbage and vegetation removing, door and window closing, 2 chemical mosquito repelling, and products such as DEET, p-menthane-3, 8-diol (PMD) and the like are commonly used, but the mosquito repelling time is short and the temperature is strong when the components are used alone, so that the mosquito repelling product needs to be further improved. Meanwhile, the daily life also faces the requirements of bacteriostasis and sterilization.
Chinese published literature (CN105997675A) discloses mosquito repellent containing green prickly ash and a preparation method thereof, wherein the main active ingredients are extracts of the green prickly ash, lavender, rose, wrinkled gianthyssop and mint, the invention combines and uses various plant extracts, not only has good mosquito repellent effect, but also has the effects of refreshing brain, cooling, relieving itching, inhibiting bacteria and killing bacteria, including the effect that the skin is free from being bitten by insects, however, the plant extracts used in the invention can be completely volatilized in a short time, and the mosquito repellent and bacteria inhibiting time is short.
In addition, currently widely used antibacterial agents are mainly classified into four types, i.e., inorganic antibacterial agents, organic antibacterial agents, natural antibacterial agents, and polymeric antibacterial agents. The organic antibacterial agent has poor heat resistance and is easy to decompose, the natural and high-molecular antibacterial agents have poor heat resistance and are difficult to process, the inorganic antibacterial agent which has good heat resistance, wide antibacterial spectrum and long validity period is most widely applied at present, and the nano silver particles prepared in the form of the nanotechnology have the advantages of broad-spectrum antibacterial property, strong sterilization, high safety, no drug resistance and the like which cannot be compared with the traditional antibacterial agent. However, the use of nano silver particles alone often results in particle agglomeration due to oxidation, resulting in loss of antibacterial activity. In addition, the inorganic antibacterial agent has side effects on skin or plant surface cells, and is rarely applied to the mosquito repellent liquid directly applied to the skin.
Disclosure of Invention
In view of the defects of the prior art, the invention aims to provide the sterilizing and disinfecting mosquito repellent liquid which has the characteristics of mosquito repelling, bacteriostasis, fragrance and skin care, has high product safety, is suitable for infants and can effectively meet the daily requirements of clients.
In order to solve the technical problems, the invention adopts the technical scheme that:
the sterilizing, disinfecting and mosquito-repellent liquid comprises the following components in parts by weight: 50-80 parts of solvent, 5-20 parts of skin care agent, 5-20 parts of mosquito repellent agent, 0.1-1 part of organic antibacterial agent, 0.25-2 parts of inorganic antibacterial agent, 1-5 parts of soft stabilizer and 0.05-1 part of aromatic, wherein the solvent is prepared by mixing solvent A and solvent B into deionized water and alcohol solvent mutually soluble with the deionized water.
Preferably, the alcoholic solvent is one or more of absolute ethyl alcohol, propylene glycol, 1, 3-butylene glycol, hexylene glycol, polyethylene glycol, polyether polyol and sorbitol.
Preferably, the mosquito repellent is one or more of culicin, emennin, escin, eucalyptus oil, peppermint oil and camphor oil.
Preferably, the organic antibacterial agent is one or more of nipagin ester, germabp, methylisothiazolinone, PHMB, PHMG, benzalkonium chloride, benzalkonium bromide, cetyltrimethylammonium bromide, and bisdecyl dimethyl ammonium chloride.
Preferably, the inorganic antibacterial agent is one or more of nano silver, nano titanium oxide, nano magnesium oxide and nano zinc oxide.
Preferably, the skin care agent is one or more of glycerin, methyl silicone oil, cholesterol, vegetable oil, animal oil, and naphtha. Wherein the vegetable oil comprises one or more of jojoba ester wheat germ oil, cacao oil, oleum Olivarum, oleum Helianthi, and peanut oil, and the animal oil comprises one or more of squalane, cod liver oil, and sheep oil.
Preferably, the aromatic is one or more of artemisia alba essential oil, menthol, borneol, elecampane essential oil, lemon oil, rosemary oil, geranium oil, cysteine, peach gum powder, tea tree essential oil, milk essence, rose essential oil and lavender essential oil.
Preferably, the softening stabilizer is one or more of span, tween, glucose anhydride, dodecyl trimethyl ammonium chloride, dodecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide, sodium dodecyl sulfate and sodium dodecyl benzene sulfonate.
The invention further provides a preparation method of the sterilizing and disinfecting mosquito repellent liquid, which comprises the following steps:
s1, preparing solution A: adding a solvent A into a reaction kettle, sequentially adding a skin care agent and a mosquito repellent, and stirring to dissolve the skin care agent and the mosquito repellent into the solvent A;
s2, preparing liquid B: adding a solvent B into a reaction kettle, adding an inorganic antibacterial agent and an organic antibacterial agent, stirring to dissolve the organic antibacterial agent in the solvent B and disperse the inorganic antibacterial agent in the solvent B, wherein the solvent A and the solvent B are mutually soluble;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding a soft stabilizer, continuously stirring for 10-40 min, increasing the rotating speed, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding an aromatic after the dropwise adding is finished, and continuously stirring to completely react.
Wherein: the inorganic antibacterial agent is double-emulsion core-spun nano antibacterial particles, namely nano particles with double emulsion layers wrapped outside the nano inorganic antibacterial agent, and is pretreated before the step S2, wherein the specific treatment process comprises the following steps: dissolving PLGA in a low-boiling-point organic solvent, performing ultrasonic oscillation to obtain a PLGA solution with the concentration of 10-50 mg/ml, adding an inorganic antibacterial agent ground to be nano-scale into the PLGA solution, and stirring to enable the PLGA solution to fully wrap the inorganic antibacterial agent to form a primary emulsion; adding 10 mg/ml-50 mg/ml of sorbitan fatty acid ester solution into the primary emulsion, and performing ultrasonic oscillation and then performing soft stirring by using a magnetic stirrer at a temperature above the boiling point of the solvent to obtain inorganic antibacterial emulsion; and finally, carrying out spray drying on the inorganic antibacterial emulsion to prepare the nano particles.
Compared with the prior art, the invention has the following beneficial effects:
1. the sterilization, disinfection and mosquito repellent liquid contains a mosquito repellent, an organic antibacterial agent, an inorganic antibacterial agent, a skin care agent, a soft stabilizer and an aromatic component, all the components except the inorganic antibacterial agent are well dissolved in a compound solvent, oil-water stratification is not easy to occur, the antibacterial performance is effectively enhanced by using the organic antibacterial agent and the inorganic antibacterial agent in combination, meanwhile, as the inorganic antibacterial agent adopts double-emulsion core-spun nano antibacterial particles, on one hand, the double-emulsion core-spun nano antibacterial particles with large surface area can be used for adsorbing part of the mosquito repellent and aromatic agent, improving the adsorption carrier, delaying the volatilization of the mosquito repellent and aromatic agent, prolonging the effective time of mosquito repelling and aroma, on the other hand, the problem of activity failure of the inorganic antibacterial agent due to agglomeration can be avoided, the release can be delayed, the effective time of bacteriostasis can be prolonged, and simultaneously, the double-emulsion wrapping layer of the nano antibacterial particles is used for inhibiting or reducing the amount of the, the safety of the product is improved.
2. The sterilizing and disinfecting mosquito repellent liquid has the characteristics of mosquito repelling, bacteriostasis, fragrance and skin care, has high product safety, is suitable for infants, can effectively meet the daily requirements of customers, can be directly smeared on the skin of a human body to repel mosquitoes, can be added into a plug-in electric heating mosquito dispeller to repel the mosquitoes, and can also be used for soaking wood carbon to prepare mosquito repellent incense and the like.
Detailed Description
Example 1
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 5 parts of glycerin, 5 parts of jojoba ester, 5 parts of culicin, 0.25 part of PHMB, 0.25 part of nano-silver, 2 parts of Tween 20 and 0.05 part of tea tree essential oil, wherein the solvent A is 20 parts of absolute ethyl alcohol, and the solvent B is 30 parts of deionized water.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding absolute ethyl alcohol into a reaction kettle to serve as a solvent A, sequentially adding glycerol, jojoba ester and PHMB, controlling the temperature to be 25 ℃, the rotating speed to be 100r/min, and the reaction time to be 15min, so that the glycerol, the jojoba ester and the PHMB are dissolved in the solvent A;
s2, preparing liquid B: adding deionized water into a reaction kettle to serve as a solvent B, adding nano-silver and PHMB, controlling the temperature to be 40 ℃, the rotating speed to be 150r/min and the reaction time to be 10min, and dissolving the PHMB in the solvent B and dispersing the nano-silver in the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding Tween 20, continuously stirring for 15min, increasing the rotation speed to 300r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding tea tree essential oil after the dropwise addition is finished, and continuously stirring to completely react.
Example 2
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 5 parts of methyl silicone oil, 5 parts of olive oil, 8 parts of mint oil, 2 parts of camphor oil, 0.1 part of nipagin ester, 0.9 part of nano titanium oxide, 1 part of dodecyl trimethyl ammonium chloride and 0.01 part of rose essential oil, wherein the solvent A is 20 parts of 1, 3-butanediol, and the solvent B is 20 parts of deionized water and 20 parts of absolute ethyl alcohol.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding 1, 3-butanediol serving as a solvent A into a reaction kettle, sequentially adding methyl silicone oil, olive oil, peppermint oil and camphor oil, controlling the temperature to be 35 ℃, the rotating speed to be 200r/min and the reaction time to be 40min, and dissolving the methyl silicone oil, the olive oil, the peppermint oil and the camphor oil into the solvent A;
s2, preparing liquid B: adding deionized water and absolute ethyl alcohol which are mixed and dissolved into a reaction kettle to serve as a solvent B, adding nano titanium oxide and nipagin ester, controlling the temperature to be 35 ℃, the rotating speed to be 200r/min and the reaction time to be 30min, and dissolving the nipagin ester into the solvent B and dispersing the nano titanium oxide into the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding dodecyl trimethyl ammonium chloride, continuously stirring for 30min, then increasing the rotating speed to 500r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding rose essential oil after the dropwise addition is finished, and continuously stirring to completely react.
Example 3
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 8 parts of glycerol, 2 parts of squalane, 10 parts of eucalyptus oil, 5 parts of peppermint oil, 0.1 part of PHMG, 0.4 part of benzalkonium bromide, 0.2 part of nano titanium oxide, 2 parts of span 20, 3 parts of Tween 40 and 0.1 part of lavender essential oil, wherein the solvent A is 30 parts of propylene glycol, and the solvent B is 20 parts of deionized water and 10 parts of hexanediol.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding propylene glycol as a solvent A into a reaction kettle, sequentially adding glycerol, squalane, eucalyptus oil and peppermint oil, controlling the temperature at 25 ℃, the rotating speed at 250r/min and the reaction time at 40min, and dissolving the glycerol, squalane, eucalyptus oil and peppermint oil into the solvent A;
s2, preparing liquid B: adding deionized water and hexanediol which are mixed and dissolved into a reaction kettle to serve as a solvent B, adding nano titanium oxide, benzalkonium bromide and PHMG, controlling the temperature to be 35 ℃, the rotating speed to be 200r/min and the reaction time to be 10min, and dissolving the benzalkonium bromide and the PHMG in the solvent B and dispersing the nano titanium oxide in the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding span 20 and tween 40, continuously stirring for 10min, increasing the rotation speed to 600r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding the lavender essential oil after the dropwise adding is finished, and continuously stirring to completely react.
Example 4
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 2 parts of glycerol, 3 parts of cocoa butter, 10 parts of emerenin, 0.05 part of germa BP, 0.05 part of methylisothiazolinone, 1 part of nano-silver, 2 parts of sodium dodecyl sulfate, 0.2 part of rosemary oil and 0.8 part of geranium oil, wherein the solvent A is 25 parts of absolute ethyl alcohol and 25 parts of deionized water, and the solvent B is 30 parts of deionized water.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding anhydrous ethanol and deionized water which are mixed and dissolved into a reaction kettle to serve as a solvent A, sequentially adding glycerol, cocoa butter and the Yimengning, controlling the temperature to be 35 ℃, the rotating speed to be 350r/min, and the reaction time to be 10min, so that the glycerol, the cocoa butter and the Yimengning are dissolved into the solvent A;
s2, preparing liquid B: adding deionized water into a reaction kettle to serve as a solvent B, adding nano-silver, GemaBP and methylisothiazolinone, controlling the temperature to be 35 ℃, the rotating speed to be 200r/min and the reaction time to be 35min, and dissolving the GemaBP and methylisothiazolinone into the solvent B and dispersing the nano-silver into the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding sodium dodecyl sulfate, continuously stirring for 10min, then increasing the rotating speed to 400r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding rosemary oil and geranium oil after the dropwise adding is finished, and continuously stirring to completely react.
Example 5
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 10 parts of glycerol, 10 parts of naphtha, 5 parts of mosquito repellent amine, 15 parts of Escitin, 0.5 part of nipagin ester, 0.5 part of nano silver, 2 parts of sodium dodecyl benzene sulfonate and 0.5 part of milk essence, wherein the solvent A is 30 parts of 1, 3-butanediol, and the solvent B is 10 parts of deionized water and 10 parts of absolute ethyl alcohol.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding 1, 3-butanediol serving as a solvent A into a reaction kettle, sequentially adding glycerol, naphtha, culicifumide and Escartin, controlling the temperature to be 25 ℃, controlling the rotating speed to be 200r/min, and reacting for 30min to dissolve the glycerol, the naphtha, the culicifumide and the Escartin into the solvent A;
s2, preparing liquid B: adding deionized water and absolute ethyl alcohol which are mixed and dissolved into a reaction kettle to serve as a solvent B, adding nano-silver and paraben ester, controlling the temperature to be 40 ℃, the rotating speed to be 300r/min and the reaction time to be 25min, and dissolving the paraben ester into the solvent B and dispersing the nano-silver into the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding sodium dodecyl benzene sulfonate, continuously stirring for 30min, then increasing the rotating speed to 500r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding the milk essence after the dropwise adding is finished, and continuously stirring to completely react.
Example 6
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 5 parts of glycerol, 5 parts of cholesterol, 5 parts of Yimening, 5 parts of eucalyptus oil, 0.3 part of bisdecyl dimethyl ammonium chloride, 0.5 part of nano magnesium oxide, 1.5 parts of hexadecyl trimethyl ammonium bromide, 0.2 part of artemisia alba essential oil and 0.5 part of costus root essential oil, wherein a solvent A is 20 parts of deionized water and 20 parts of polyethylene glycol, and a solvent B is 5 parts of deionized water and 10 parts of sorbitol.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding deionized water and polyethylene glycol which are mixed and dissolved into a reaction kettle to serve as a solvent A, sequentially adding glycerol, cholesterol, elminin and eucalyptus oil, controlling the temperature to be 20 ℃, the rotating speed to be 100r/min and the reaction time to be 35min, and dissolving the glycerol, the cholesterol, the elminin and the eucalyptus oil into the solvent A;
s2, preparing liquid B: adding deionized water and sorbitol which are mixed and dissolved into a reaction kettle to serve as a solvent B, adding nano magnesium oxide and bisdecyl dimethyl ammonium chloride, controlling the temperature to be 30 ℃, the rotating speed to be 350r/min, and the reaction time to be 15min, so that the bisdecyl dimethyl ammonium chloride is dissolved in the solvent B and the nano magnesium oxide is dispersed in the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding hexadecyl trimethyl ammonium bromide, continuously stirring for 40min, increasing the rotating speed to 800r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding artemisia alba essential oil and elecampane essential oil after dropwise adding is finished, and continuously stirring to completely react.
Example 7
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 10 parts of methyl silicone oil, 5 parts of wheat germ oil, 5 parts of culicifumide, 10 parts of Yimening, 5 parts of peppermint oil, 0.2 part of benzalkonium chloride, 1 part of nano zinc oxide, 1 part of glucose anhydride, 0.2 part of menthol, 0.05 part of borneol and 0.5 part of lemon oil, wherein the solvent A comprises 20 parts of deionized water and 30 parts of hexanediol, and the solvent B comprises 10 parts of deionized water and 20 parts of propylene glycol.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding deionized water and hexanediol which are mixed and dissolved into a reaction kettle as a solvent A, sequentially adding methyl silicone oil, wheat germ oil, culicifumide, Yimeining and peppermint oil, controlling the temperature at 40 ℃, the rotating speed at 200r/min and the reaction time at 25min, and dissolving the methyl silicone oil, the wheat germ oil, the culicifumide, the Yimeining and the peppermint oil into the solvent A;
s2, preparing liquid B: adding deionized water and propylene glycol which are mixed and dissolved into a reaction kettle to serve as a solvent B, adding nano zinc oxide and benzalkonium chloride, controlling the temperature to be 60 ℃, the rotating speed to be 500r/min and the reaction time to be 20min, and dissolving the benzalkonium chloride in the solvent B and dispersing the nano zinc oxide in the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding the glucose anhydride, continuously stirring for 20min, then increasing the rotating speed to 1000r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding the menthol, the borneol and the lemon oil after the dropwise adding is finished, and continuously stirring to completely react.
Example 8
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 5 parts of glycerol, 8 parts of olive oil, 10 parts of eimer's amine, 0.1 part of PHMB, 0.1 part of hexadecyl trimethyl ammonium bromide, 2 parts of nano silver, 2.5 parts of dodecyl trimethyl ammonium chloride and 0.5 part of geranium oil, wherein the solvent A is 15 parts of deionized water and 10 parts of polyether polyol, and the solvent B is 5 parts of deionized water and 20 parts of 1, 3-butanediol.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding the deionized water and polyether polyol which are mixed and dissolved into a reaction kettle to serve as a solvent A, sequentially adding glycerol, olive oil and the Yimengning, controlling the temperature to be 20 ℃, controlling the rotating speed to be 200r/min, and controlling the reaction time to be 20min so that the glycerol, the olive oil and the Yimengning are dissolved into the solvent A;
s2, preparing liquid B: adding deionized water and 1, 3-butanediol which are mixed and dissolved into a reaction kettle to serve as a solvent B, adding nano-silver, PHMB and hexadecyl trimethyl ammonium bromide, controlling the temperature to be 30 ℃, controlling the rotating speed to be 800r/min, and controlling the reaction time to be 30min, so that the PHMB and the hexadecyl trimethyl ammonium bromide are dissolved in the solvent B and the nano-silver is dispersed in the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding dodecyl trimethyl ammonium chloride, continuously stirring for 30min, then increasing the rotating speed to 1200r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding geranium oil after the dropwise adding is finished, and continuously stirring to completely react.
Example 9
The embodiment provides a sterilization, disinfection and mosquito repellent liquid which comprises the following components in parts by weight: 5 parts of naphtha, 10 parts of jojoba ester, 10 parts of Escarlatine, 10 parts of peppermint oil, 1 part of methylisothiazolinone, 0.5 part of nano titanium oxide, 2 parts of dodecyl trimethyl ammonium chloride, 0.1 part of menthol and 0.2 part of rosemary oil, wherein the solvent A is 10 parts of deionized water and 30 parts of absolute ethyl alcohol, and the solvent B is 20 parts of absolute ethyl alcohol.
The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid specifically comprises the following steps:
s1, preparing solution A: adding deionized water and absolute ethyl alcohol which are mixed and dissolved into a reaction kettle to serve as a solvent A, sequentially adding naphtha, jojoba ester, Ecagreltin and mint oil, controlling the temperature to be 25 ℃, the rotating speed to be 250r/min and the reaction time to be 30min, and dissolving the naphtha, the jojoba ester, the Ecagreltin and the mint oil into the solvent A;
s2, preparing liquid B: adding absolute ethyl alcohol into a reaction kettle to serve as a solvent B, adding nano titanium oxide and methylisothiazolinone, controlling the temperature to be 25 ℃, the rotating speed to be 300r/min and the reaction time to be 50min, and dissolving the methylisothiazolinone into the solvent B and dispersing the nano titanium oxide into the solvent B;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding dodecyl trimethyl ammonium chloride, continuously stirring for 25min, then increasing the rotating speed to 600r/min, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding menthol and rosemary oil after the dropwise addition is finished, and continuously stirring to completely react.
The inorganic antibacterial agents of the above examples 1 to 9 are double-emulsion core-spun nano antibacterial particles, that is, double-emulsion layer nano particles wrapped outside the nano-scale inorganic antibacterial agent. The inorganic antibacterial agent is pretreated before the step S2, and the specific treatment process comprises the following steps: dissolving PLGA in a low-boiling-point organic solvent, performing ultrasonic oscillation to obtain a PLGA solution with the concentration of 10-50 mg/ml, adding an inorganic antibacterial agent ground to be nano-scale into the PLGA solution, and stirring to enable the PLGA solution to fully wrap the inorganic antibacterial agent to form a primary emulsion; adding 10 mg/ml-50 mg/ml of sorbitan fatty acid ester solution into the primary emulsion, and performing ultrasonic oscillation and then performing soft stirring by using a magnetic stirrer at a temperature above the boiling point of the solvent to obtain inorganic antibacterial emulsion; finally, the inorganic antibacterial emulsion is sprayed and dried to prepare nano particles, and the particle size is preferably 50nm to 800 nm. Wherein, the solvents in the PLGA solution and the sorbitan fatty acid ester solution are both acetone or absolute ethyl alcohol.
Comparative example 1
This comparative example 1 is different from the above example 1 only in that nano silver is a general particle, and the nano antibacterial particle is not double-emulsion core-spun. The preparation method of the mosquito repellent liquid is the same as that of the embodiment 1.
Comparative example 2
The comparative example 2 is different from the above example 3 only in the preparation of nano titanium oxide, specifically: adding nano titanium oxide ground to be nano-scale into Arabic gum solution of 10-50 mg/ml, carrying out ultrasonic oscillation, and then carrying out soft stirring by using a magnetic stirrer at the temperature above the boiling point of the solvent to obtain inorganic antibacterial emulsion; finally, the inorganic antibacterial emulsion is sprayed and dried to prepare nano particles, and the particle size is preferably 50nm to 800 nm.
An indoor drug effect test method and an evaluation experiment of the mosquito repellent liquid are carried out according to a method of national standard GB/T13917.9-2009. The experiment selects Aedes albopictus (Aedes albopictus), and the adult female which does not take blood after 3-5 days of emergence. The temperature is 26+1 ℃; relative humidity 65% + 10%. The specific process comprises the following steps: 300 mosquitoes are put into a mosquito cage with the thickness of 300mm x 400mm, 4 testers (half of men and women, no wine, tea or coffee should be drunk before and during the test, and products containing essences are not used) are selected, skin areas of 50mm x 50mm are drawn on the backs of the hands of the two testers respectively, one of the two hands is evenly coated with the mosquito repellent liquid to be tested according to the dosage of 1.5 muL/cm 2, the skin of 40mm x 40mm is exposed, the rest parts are closely shielded, and the other hand is a blank control. Smearing mosquito repellent liquid for 2h, placing hands in a cage for 2min, and observing whether there is mosquito coming and falling before and sucking blood. And then testing once every 0.5h, and judging that the mosquito repellent liquid is invalid as long as one mosquito sucks blood in front.
The antibacterial and disinfection performance is tested according to the experimental method for determining the activity of the antibacterial agent under the dynamic condition of ASTME2149-13a, and the antibacterial effect is respectively tested after 0.5h, 5h and 10 h. The components of the mosquito repellent liquid of each embodiment of the invention are shown in table 1, and the mosquito repellent and antibacterial effect test data are shown in table 2.
Table 1: mosquito repellent formula table of embodiments 1-9 of the invention
Table 2: mosquito repellent test data table of examples 1-9 and comparative examples 1-2 of the present invention
While there have been shown and described what are at present considered the fundamental principles and essential features of the invention and its advantages, it will be understood by those skilled in the art that the invention is not limited by the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the invention as defined by the appended claims and their equivalents.
Claims (10)
1. The sterilizing and disinfecting mosquito repellent liquid is characterized in that: the composition comprises the following components in parts by weight: 50-80 parts of solvent, 5-20 parts of skin care agent, 5-20 parts of mosquito repellent agent, 0.1-1 part of organic antibacterial agent, 0.25-2 parts of inorganic antibacterial agent, 1-5 parts of soft stabilizer and 0.05-1 part of aromatic, wherein the solvent is prepared by mixing solvent A and solvent B into deionized water and alcohol solvent mutually soluble with the deionized water.
2. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the alcohol solvent is one or more of absolute ethyl alcohol, propylene glycol, 1, 3-butanediol, hexanediol, polyethylene glycol, polyether polyol and sorbitol.
3. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the mosquito repellent is one or more of culicifumide, Yimeining, Ecameratin, eucalyptus oil, peppermint oil and camphor oil.
4. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the organic antibacterial agent is one or more of nipagin ester, Gemama BP, methylisothiazolinone, PHMB, PHMG, benzalkonium chloride, benzalkonium bromide, cetyl trimethyl ammonium bromide and bisdecyl dimethyl ammonium chloride.
5. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the inorganic antibacterial agent is one or more of nano silver, nano titanium oxide, nano magnesium oxide and nano zinc oxide.
6. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the skin care agent is one or more of glycerol, methyl silicone oil, cholesterol, vegetable oil, animal oil and naphtha.
7. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the aromatic is one or more of Artemisia alba essential oil, menthol, Borneolum Syntheticum, radix aucklandiae essential oil, lemon oil, rosemary oil, geranium oil, cysteine, peach gum powder, tea tree essential oil, milk essence, rose essential oil, and lavender essential oil.
8. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the softening stabilizer is one or more of span, tween, dextran, dodecyl trimethyl ammonium chloride, dodecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide, dodecyl sodium sulfate and dodecyl sodium benzenesulfonate.
9. The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid as claimed in claim 1, is characterized in that: the method specifically comprises the following steps:
s1, preparing solution A: adding a solvent A into a reaction kettle, sequentially adding a skin care agent and a mosquito repellent, and stirring to dissolve the skin care agent and the mosquito repellent into the solvent A;
s2, preparing liquid B: adding a solvent B into a reaction kettle, adding an inorganic antibacterial agent and an organic antibacterial agent, stirring to dissolve the organic antibacterial agent in the solvent B and disperse the inorganic antibacterial agent in the solvent B, wherein the solvent A and the solvent B are mutually soluble;
s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding a soft stabilizer, continuously stirring for 10-40 min, increasing the rotating speed, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding an aromatic after the dropwise adding is finished, and continuously stirring to completely react.
10. The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid according to claim 9, characterized in that: the inorganic antibacterial agent is pretreated before the step S2, and the specific treatment process comprises the following steps: dissolving PLGA in a low-boiling-point organic solvent, performing ultrasonic oscillation to obtain a PLGA solution with the concentration of 10-50 mg/ml, adding an inorganic antibacterial agent ground to be nano-scale into the PLGA solution, and stirring to enable the PLGA solution to fully wrap the inorganic antibacterial agent to form a primary emulsion; adding 10 mg/ml-50 mg/ml of sorbitan fatty acid ester solution into the primary emulsion, and performing ultrasonic oscillation and then performing soft stirring by using a magnetic stirrer at a temperature above the boiling point of the solvent to obtain inorganic antibacterial emulsion; and finally, carrying out spray drying on the inorganic antibacterial emulsion to prepare the nano particles.
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