CN113081876A - Camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream and preparation method thereof - Google Patents
Camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream and preparation method thereof Download PDFInfo
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- CN113081876A CN113081876A CN202110400480.0A CN202110400480A CN113081876A CN 113081876 A CN113081876 A CN 113081876A CN 202110400480 A CN202110400480 A CN 202110400480A CN 113081876 A CN113081876 A CN 113081876A
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- beta
- camphor oil
- inclusion compound
- mosquito
- repellent
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- 241000723346 Cinnamomum camphora Species 0.000 title claims abstract description 92
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 title claims abstract description 89
- 229960000846 camphor Drugs 0.000 title claims abstract description 87
- 229930008380 camphor Natural products 0.000 title claims abstract description 87
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 81
- 150000001875 compounds Chemical class 0.000 title claims abstract description 73
- 239000000077 insect repellent Substances 0.000 title claims abstract description 58
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 46
- 239000006071 cream Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 48
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 32
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 16
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 16
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 16
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 16
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims abstract description 16
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940075507 glyceryl monostearate Drugs 0.000 claims abstract description 16
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims abstract description 16
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 16
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000012188 paraffin wax Substances 0.000 claims abstract description 16
- 239000007787 solid Substances 0.000 claims abstract description 16
- 239000008117 stearic acid Substances 0.000 claims abstract description 16
- 239000003871 white petrolatum Substances 0.000 claims abstract description 16
- 239000004166 Lanolin Substances 0.000 claims abstract description 13
- 229940039717 lanolin Drugs 0.000 claims abstract description 13
- 235000019388 lanolin Nutrition 0.000 claims abstract description 13
- 229960000411 camphor oil Drugs 0.000 claims description 36
- 239000010624 camphor oil Substances 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 27
- 239000002994 raw material Substances 0.000 claims description 26
- 229920000858 Cyclodextrin Polymers 0.000 claims description 22
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 22
- 239000001116 FEMA 4028 Substances 0.000 claims description 19
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 19
- 229960004853 betadex Drugs 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 17
- 229960005150 glycerol Drugs 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- 229960004418 trolamine Drugs 0.000 claims description 15
- 239000003921 oil Substances 0.000 claims description 13
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000000967 suction filtration Methods 0.000 claims description 7
- 229940083575 sodium dodecyl sulfate Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 235000014104 aloe vera supplement Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 230000007794 irritation Effects 0.000 abstract description 5
- 241000255925 Diptera Species 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 10
- 229940069521 aloe extract Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- 230000006378 damage Effects 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 230000001846 repelling effect Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000003749 cleanliness Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- -1 lanoline Substances 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
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- 229960001673 diethyltoluamide Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000037072 sun protection Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000010692 aromatic oil Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
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- 238000000576 coating method Methods 0.000 description 1
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- 230000001186 cumulative effect Effects 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
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- 206010013395 disorientation Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
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- 239000003937 drug carrier Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Biotechnology (AREA)
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- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of preparation of mosquito-repellent sunscreen products, and particularly discloses camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream and a preparation method thereof. The camphor oil-beta-CD inclusion compound mosquito-repellent sun cream comprises the following components in percentage by weight: 3-8% of a sun-screening agent; 3-6% of camphor oil-beta-CD inclusion compound; 1-3% of sodium dodecyl sulfate; 0.2-0.5% of triethanolamine; 5-10% of glycerol; 0.2-0.5% of ethylparaben; 10-15% of stearic acid; 3-6% of glyceryl monostearate; 10-15% of white vaseline; 2-5% of lanolin; 3-6% of solid paraffin; the balance being water. The invention provides a brand-new camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream; the brand-new camphor oil-beta-CD inclusion compound mosquito-repellent sun cream has the advantages of low irritation, few side effects, safety and reliability.
Description
Technical Field
The invention relates to the technical field of preparation of mosquito-repellent sunscreen products, and particularly relates to camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream and a preparation method thereof.
Background
Ultraviolet radiation has a number of adverse effects on human health, primarily manifested as the possibility of causing severe effects both short-term and long-term, with short-term effects being primarily sunburn and long-term effects often being cumulative, manifested as skin erythema, photoaging, tissue destruction and skin cancer, among others. Therefore, how to reduce adverse effects of ultraviolet rays on human health by using sunscreen products as much as possible is one of the most popular topics in the cosmetic industry in recent years. The use of sunscreen cosmetics is currently the most common ultraviolet protection measure, and can prevent erythema and sunburn induced by sunlight.
Mosquitoes are one of important vectors, carry various pathogenic microorganisms in vivo and seriously harm human health. Outdoor activities in summer are often accompanied by mosquito troubles, and sunscreen cream and mosquito repellent lotion become indispensable living necessities for going out. However, the use of a mosquito repellent product containing both sunscreen and delphene has an effect on sunscreen effect, increases toxicity, and increases the frequency of applying sunscreen cream, thereby causing great inconvenience to people, and therefore, it is very important to develop a new functional sunscreen cosmetic.
The cinnamomum camphora is a evergreen cinnamomum camphora plant, has low cold resistance, is widely distributed in subtropical regions such as Guangdong and Hunan, is suitable for resource development and production in the Meizhou region, and has a cinnamomum camphora seedling base in the Meizhou region. The camphor tree has strong sprouting power, dense branches and leaves and fragrance, and the emitted fragrance has certain expelling effect on mosquitoes and insects. The camphor and the camphor oil can be extracted from all trees, 3-5 kg of camphor oil can be extracted from every 100 kg of branches and leaves of camphor trees, and the higher the tree age is, the main raw material for producing camphor oil is one of important economic trees. The camphor oil is colorless or yellowish to reddish brown oily liquid, is dissolved in ethanol and ether, has strong camphor smell, is a high ash substance, has strong volatility and special faint scent, has the functions of healing wounds, deodorizing and the like besides insect prevention and mosquito repelling, and also has the effects of resisting inflammation, relieving pain, resisting depression, resisting bacteria, killing insects, relieving laxatives, warming skin, stimulating, promoting sweat, sterilizing, relieving itching and the like, and has very wide application.
Inclusion compounds are defined as specific complexes formed by the complete or partial incorporation of one molecule into the cavity structure of another molecule. The inclusion compound technology is an ultra-micro drug carrier, wherein Cyclodextrin (CD) is mainly used as a carrier material, and drug molecules are included or embedded into a cylindrical structure of the CD to form an ultra-micro particle dispersion. The camphor oil is volatile aromatic oil with complex components, has wide boiling point distribution range and higher volatility at normal temperature and normal pressure, so that the camphor oil is easy to lose efficacy in application. The beta-CD is a compound formed by connecting 7 glucose molecules by 1, 4-glycosidic bonds, has a ring-shaped hollow cylindrical structure, and can embed drug molecules in a cavity structure thereof to form an inclusion compound. The beta-CD inclusion compound can increase the stability of the medicine, improve the solubility of the medicine, solidify the liquid medicine and greatly improve the preservation rate. Therefore, the beta-CD inclusion compound prepared from the camphor oil can prevent the volatilization of the effective components of the camphor oil and solidify the effective components so as to be convenient for preparation and application.
The mosquito-repellent sun cream is rare in the market, and no independently researched and developed mosquito-repellent sun cream product is available in China. The mosquito-repellent sun cream products on the market are generally emulsion, have more and thinner water, poorer water locking capability and poorer waterproof performance, and are easy to be removed by sweat so as to influence the product effect. Most of sunscreen creams are chemical sunscreen creams, and parts possibly harmful to skin in ultraviolet rays are absorbed through combination of certain chemical substances and cells, so that the purpose of sunscreen is achieved. The sun cream containing lead and mercury components can damage skin cells and structures after being applied for a long time. Regarding mosquito repellent products, most of the main components are DEET or anophelifuge, a certain concentration of DEET may damage central nerves, cause symptoms such as rash, disorientation and spasm, and may cause allergic reactions of some people due to individual differences, especially pregnant women and babies. The spraying agent is used in the market, the main effective components are volatile, the mosquito repelling time is short, and the spraying agent can be used for multiple times to continuously achieve the mosquito repelling effect, so that the spraying agent is troublesome.
In summary, the conditions of the present sunscreen and mosquito repellent products in China are as follows: common sunscreen cream has different components, even some sunscreen creams contain heavy metal components, and the long-term accumulation of the sunscreen cream can cause damage to the skin; most mosquito repellent products contain the chemical component of deet, so that the product is easy to irritate the skin, and is not suitable for babies, pregnant women or people who are easy to be allergic; people want to achieve the effects of sun protection and mosquito repelling in daily life, and only can use the sun protection cream and the mosquito repelling product at the same time. Although the sunscreen cream sold on the market contains a small amount of benzophenone, the sunscreen cream mixed with the deet and alcohol in the mosquito repellent product can promote the skin to absorb the chemical substances at high temperature, and is not good for the health of people.
Disclosure of Invention
The invention aims to solve at least one technical problem in the prior art and provides the mosquito repellent sunscreen cream containing the camphor oil-beta-CD inclusion compound.
The technical problem to be solved by the invention is realized by the following technical scheme:
the invention firstly provides camphor oil-beta-CD inclusion compound mosquito-repellent sun cream which comprises the following components in percentage by weight:
3-8% of a sun-screening agent; 3-6% of camphor oil-beta-CD inclusion compound; 1-3% of sodium dodecyl sulfate; 0.2-0.5% of triethanolamine; 5-10% of glycerol; 0.2-0.5% of ethylparaben; 10-15% of stearic acid; 3-6% of glyceryl monostearate; 10-15% of white vaseline; 2-5% of lanolin; 3-6% of solid paraffin; the balance being water.
The aloe extract adopted as the sun-screening component has the advantages of low irritation, less side effect, safety and reliability, and can avoid the irritation and allergy phenomena of the traditional organic sun-screening agent to the skin of a human body; the camphor oil is used as a mosquito repellent component, can effectively repel mosquitoes and has an itching relieving effect, and the camphor oil is special in fragrance and can make skin fresh and smooth; the nanometer TiO2 is a physical sun-screening component, and can reflect and scatter ultraviolet rays and absorb ultraviolet rays due to small particle size and high activity, so that the mosquito-repelling sun-screening agent has stronger blocking capability on the ultraviolet rays, and is safer and healthier to repel mosquitoes and prevent sun.
Particularly, the camphor oil is prepared into the camphor oil-beta-CD inclusion compound for the first time and is innovatively used as a main mosquito repellent component in the mosquito repellent sun cream, volatilization of the camphor oil is reduced, stability is improved, the transdermal absorption rate of a medicine is increased, irritation and toxic and side effects are reduced, and therefore the bioavailability of the camphor oil is improved.
In addition, the nano TiO2 and/or aloe extract and the camphor oil-beta-CD clathrate compound are used as main active ingredients; the invention is specially directed at the active ingredients, and a large number of experimental researches show that sodium dodecyl sulfate, triethanolamine, glycerol and ethylparaben are used as oil phases, and stearic acid, glyceryl monostearate, white vaseline, lanolin and solid paraffin are used as water phases; the camphor oil-beta-CD inclusion compound mosquito repellent sunscreen cream prepared by adding active ingredients such as nano TiO2 and/or aloe extract and camphor oil-beta-CD inclusion compound into the oil phase and the water phase has the advantages of uniform color, smoothness, fineness, proper consistency, easiness in smearing, easiness in cleaning and the like.
Preferably, the camphor oil-beta-CD clathrate mosquito-repellent sun cream comprises the following components in percentage by weight:
4-6% of a sun-screening agent; 4-5% of camphor oil-beta-CD inclusion compound; 2-3% of sodium dodecyl sulfate; 0.3-0.4% of triethanolamine; 6-8% of glycerol; 0.3-0.4% of ethylparaben; 12-14% of stearic acid; 4-5% of glyceryl monostearate; 11-13% of white vaseline; 3-4% of lanolin; 4-5% of solid paraffin; the balance being water.
Most preferably, the camphor oil-beta-CD clathrate mosquito-repellent sun cream comprises the following components in percentage by weight:
5% of a sun-screening agent; 4% of camphor oil-beta-CD inclusion compound; 2 percent of sodium dodecyl sulfate; 0.4 percent of triethanolamine; 8% of glycerol; 0.4 percent of ethylparaben; 12% of stearic acid; 4% of glyceryl monostearate; 12% of white vaseline; 3% of lanolin; 4% of solid paraffin; the balance being water.
Preferably, the sunscreen agent is selected from one or a mixture of two of nano TiO2 and aloe extract.
Preferably, the camphor oil-beta-CD inclusion compound is prepared by the following method:
adding beta-cyclodextrin into water, and heating to 55-60 ℃; and adding camphor oil, keeping the temperature at 55-60 ℃, stirring for 2.5-3 h, and performing suction filtration to obtain the camphor oil-beta-CD clathrate compound.
Preferably, the dosage ratio of the beta-cyclodextrin to the water and the camphor oil is 3-5 g: 50-70 mL: 0.8-1.2 mL.
Preferably, the dosage ratio of beta-cyclodextrin to water and camphor oil is 4 g: 60mL of: 1 mL.
The preparation method of the camphor oil-beta-CD inclusion compound not only determines the oil content in the camphor oil-beta-CD inclusion compound and the sustained release time of the camphor oil; in the invention, the inventor also surprisingly discovers that the preparation method of the camphor oil-beta-CD inclusion compound is closely related to the smoothness and fineness of the finally prepared camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream; if the preparation method of the camphor oil-beta-CD inclusion compound is not proper, the finally prepared camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream has granular feel; through a large number of experiments, the inventor finds that the smooth and exquisite mosquito repellent sunscreen cream containing the camphor oil-beta-CD inclusion compound can be obtained only by using the dosage ratio of the beta-cyclodextrin to the water and the camphor oil, and the camphor oil-beta-CD inclusion compound prepared under the conditions of the temperature, the reaction time and the like.
The invention also provides a preparation method of the camphor oil-beta-CD inclusion compound mosquito-repellent sun cream, which comprises the following steps:
uniformly mixing sodium dodecyl sulfate, triethanolamine, glycerol and ethylparaben, heating to 75-85 ℃, and stirring to dissolve the mixture to obtain an oil phase raw material;
uniformly mixing stearic acid, glyceryl monostearate, white vaseline, lanolin, solid paraffin and water, heating to 75-85 ℃, and stirring to dissolve to obtain a water phase raw material;
and mixing and stirring the oil phase raw material and the water phase raw material uniformly, adding the sun-screening agent and the camphor oil-beta-CD inclusion compound, and continuously stirring uniformly to obtain the camphor oil-beta-CD inclusion compound mosquito-repellent sun-screen cream.
Has the advantages that: the invention prepares a brand new mosquito repellent sunscreen cream containing camphor oil-beta-CD inclusion compound, aloe extract and nano TiO2 as active ingredients for the first time; the brand-new camphor oil-beta-CD inclusion compound mosquito-repellent sun cream has the advantages of low irritation, less side effects, and higher safety and reliability; particularly, the camphor oil is prepared into the camphor oil-beta-CD inclusion compound for the first time, and the camphor oil-beta-CD inclusion compound is innovatively used as a main mosquito repellent component in the mosquito repellent sun cream, so that volatilization of the camphor oil can be reduced, the stability is improved, the transdermal absorption rate of a medicament is increased, and the bioavailability of the camphor oil is improved.
Detailed Description
The present invention will be described in further detail with reference to specific examples, but the present invention is not limited to these examples in any way.
The scoring method for the camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream in the following examples is as follows: randomly extracting 20 persons to score the prepared cream, performing 20-point scoring evaluation on each index, calculating the average value of the total points, and analyzing the product by taking the average value of the total points as an index.
Grading standard:
(1) color uniformity: a. the color is uniform, light green, and has camphor fragrance, and the score of the camphor fragrance is 4; b. the color and luster were not uniform, and 0 point was obtained.
(2) Fineness of texture: a. smooth and fine, without granular feeling, 4 points are obtained; b. have a granular feel and a score of 0.
(3) Consistency: a. scratches can be scribed and recovered in a short time to obtain 4 points; b. scratches can be marked out and do not recover to the original shape in a short time, and the score is 2; c. thinner, with fluidity, 0 point.
(4) Coating dispersibility: a. easy to apply, without whitening, 4 points are obtained; b. easy to apply, but whiten, get 2 points; c. it should not be smeared to 0 point.
(5) Cleaning property: a. the cleaning can be easily carried out without using a cleaning agent, and the score is 4; b. the detergent can be easily cleaned, and the score is 2; c. not easy to wash, 0 point is obtained.
Example 1 preparation of mosquito repellent sunscreen cream containing camphor oil-beta-CD clathrate
The weight percentage of the raw materials is as follows: nano-grade TiO 24%; 1% of aloe extract; 4% of camphor oil-beta-CD inclusion compound; 2 percent of sodium dodecyl sulfate; 0.4 percent of triethanolamine; 8% of glycerol; 0.4 percent of ethylparaben; 12% of stearic acid; 4% of glyceryl monostearate; 12% of white vaseline; 3% of lanolin; 4% of solid paraffin; the balance being water.
The camphor oil-beta-CD inclusion compound is prepared by the following method: adding beta-cyclodextrin into water, and heating to 58 ℃; then adding camphor oil, keeping the temperature at 58 ℃, stirring for 2.5 hours, and performing suction filtration to obtain the camphor oil-beta-CD clathrate; wherein the dosage ratio of the beta-cyclodextrin to the water to the camphor oil is 4 g: 60mL of: 1 mL.
The preparation method comprises the following steps: uniformly mixing sodium dodecyl sulfate, triethanolamine, glycerol and ethylparaben, heating to 80 ℃, and stirring to dissolve to obtain an oil phase raw material; mixing stearic acid, glyceryl monostearate, white vaseline, lanoline, solid paraffin and water, heating to 80 deg.C, stirring for dissolving, and making into water phase raw material; and mixing and stirring the oil phase raw material and the water phase raw material uniformly, adding the sun-screening agent and the camphor oil-beta-CD inclusion compound, and continuously stirring uniformly to obtain the camphor oil-beta-CD inclusion compound mosquito-repellent sun-screen cream.
The mosquito-repellent sun cream containing the camphor oil-beta-CD inclusion compound prepared in the embodiment has a color uniformity score of 4; the texture fineness score was 4 points; the consistency score was 4 points; the smearing dispersibility score was 4; a cleanliness score of 4; the total score was 20 points.
Example 2 preparation of mosquito repellent sunscreen cream containing camphor oil-beta-CD clathrate
The weight percentage of the raw materials is as follows: nano-grade TiO 23%; 5% of aloe extract; 3% of camphor oil-beta-CD inclusion compound; 3 percent of sodium dodecyl sulfate; 0.5 percent of triethanolamine; 5% of glycerol; 0.2 percent of ethylparaben; 15% of stearic acid; 6% of glyceryl monostearate; 10% of white vaseline; 2% of lanolin; 3% of solid paraffin; the balance being water.
The camphor oil-beta-CD inclusion compound is prepared by the following method: adding beta-cyclodextrin into water, and heating to 55 ℃; then adding camphor oil, keeping the temperature at 55 ℃, stirring for 3 hours, and carrying out suction filtration to obtain the camphor oil-beta-CD inclusion compound; wherein the dosage ratio of the beta-cyclodextrin to the water to the camphor oil is 3 g: 70mL of: 0.8 mL.
The preparation method comprises the following steps: uniformly mixing sodium dodecyl sulfate, triethanolamine, glycerol and ethylparaben, heating to 80 ℃, and stirring to dissolve to obtain an oil phase raw material; mixing stearic acid, glyceryl monostearate, white vaseline, lanoline, solid paraffin and water, heating to 80 deg.C, stirring for dissolving, and making into water phase raw material; and mixing and stirring the oil phase raw material and the water phase raw material uniformly, adding the sun-screening agent and the camphor oil-beta-CD inclusion compound, and continuously stirring uniformly to obtain the camphor oil-beta-CD inclusion compound mosquito-repellent sun-screen cream.
The mosquito-repellent sun cream containing the camphor oil-beta-CD inclusion compound prepared in the embodiment has a color uniformity score of 4; the texture fineness score was 4 points; the consistency score was 4 points; the smearing dispersibility score was 4; a cleanliness score of 4; the total score was 20 points.
Example 3 preparation of mosquito repellent sunscreen cream containing camphor oil-beta-CD clathrate
The weight percentage of the raw materials is as follows: nano-grade TiO 22%; 1% of aloe extract; 6% of camphor oil-beta-CD inclusion compound; 1% of sodium dodecyl sulfate; 0.2 percent of triethanolamine; 10% of glycerol; 0.5 percent of ethylparaben; 10% of stearic acid; 3% of glyceryl monostearate; 15% of white vaseline; 5% of lanolin; 6% of solid paraffin; the balance being water.
The camphor oil-beta-CD inclusion compound is prepared by the following method: adding beta-cyclodextrin into water, and heating to 60 ℃; then adding camphor oil, keeping the temperature at 60 ℃, stirring for 3 hours, and carrying out suction filtration to obtain the camphor oil-beta-CD inclusion compound; wherein the dosage ratio of the beta-cyclodextrin to the water to the camphor oil is 5 g: 50mL of: 1.2 mL.
The preparation method comprises the following steps: uniformly mixing sodium dodecyl sulfate, triethanolamine, glycerol and ethylparaben, heating to 80 ℃, and stirring to dissolve to obtain an oil phase raw material; mixing stearic acid, glyceryl monostearate, white vaseline, lanoline, solid paraffin and water, heating to 80 deg.C, stirring for dissolving, and making into water phase raw material; and mixing and stirring the oil phase raw material and the water phase raw material uniformly, adding the sun-screening agent and the camphor oil-beta-CD inclusion compound, and continuously stirring uniformly to obtain the camphor oil-beta-CD inclusion compound mosquito-repellent sun-screen cream.
The mosquito-repellent sun cream containing the camphor oil-beta-CD inclusion compound prepared in the embodiment has a color uniformity score of 4; the texture fineness score was 4 points; the consistency score was 4 points; the smearing dispersibility score was 4; a cleanliness score of 4; the total score was 20 points.
Comparative example 1 preparation of mosquito repellent sunscreen cream containing camphor oil-beta-CD clathrate
The raw material weight ratio and the preparation method of the comparative example 1 are the same as those of the example 1, except that: the preparation methods of the camphor oil-beta-CD inclusion compound are different. The camphor oil-beta-CD clathrate of comparative example 1 was prepared as follows: adding beta-cyclodextrin into water, and heating to 50 ℃; then adding camphor oil, keeping the temperature at 50 ℃, stirring for 1.5h, and performing suction filtration to obtain the camphor oil-beta-CD clathrate; wherein the dosage ratio of the beta-cyclodextrin to the water to the camphor oil is 2 g: 60mL of: 2 mL. Comparative example 1 the reaction temperature, reaction time and the amount ratio of beta-cyclodextrin to water and camphor oil in the preparation method of the camphor oil-beta-CD inclusion compound were not within the ranges of the present invention. Tests prove that compared with the example 1, the mosquito repellent sun cream containing the naphtha-beta-CD inclusion compound prepared by the comparative example has the advantages of non-fine texture and granular feeling.
Comparative example 2 preparation of mosquito repellent sunscreen cream containing camphor oil-beta-CD clathrate
The raw material weight ratio and the preparation method of the comparative example 2 are the same as those of the example 1, except that: the preparation methods of the camphor oil-beta-CD inclusion compound are different. The camphor oil-beta-CD clathrate of comparative example 2 was prepared as follows: adding beta-cyclodextrin into water, and heating to 58 ℃; then adding camphor oil, keeping the temperature at 58 ℃, stirring for 2.5 hours, and performing suction filtration to obtain the camphor oil-beta-CD clathrate; wherein the dosage ratio of the beta-cyclodextrin to the water to the camphor oil is 6 g: 60mL of: 1.5 mL. Comparative example 2 the amount ratio of beta-cyclodextrin to water and camphor oil in the process for preparing the camphor oil-beta-CD inclusion compound is not within the range of the present invention. Tests prove that compared with the example 1, the mosquito repellent sun cream containing the naphtha-beta-CD inclusion compound prepared by the comparative example has the advantages of non-fine texture and granular feeling.
Claims (8)
1. The camphor oil-beta-CD inclusion compound mosquito-repellent sun cream is characterized by comprising the following components in percentage by weight:
3-8% of a sun-screening agent; 3-6% of camphor oil-beta-CD inclusion compound; 1-3% of sodium dodecyl sulfate; 0.2-0.5% of triethanolamine; 5-10% of glycerol; 0.2-0.5% of ethylparaben; 10-15% of stearic acid; 3-6% of glyceryl monostearate; 10-15% of white vaseline; 2-5% of lanolin; 3-6% of solid paraffin; the balance being water.
2. The camphor oil-beta-CD clathrate mosquito-repellent sunscreen cream according to claim 1, characterized by comprising the following components in percentage by weight:
4-6% of a sun-screening agent; 4-5% of camphor oil-beta-CD inclusion compound; 2-3% of sodium dodecyl sulfate; 0.3-0.4% of triethanolamine; 6-8% of glycerol; 0.3-0.4% of ethylparaben; 12-14% of stearic acid; 4-5% of glyceryl monostearate; 11-13% of white vaseline; 3-4% of lanolin; 4-5% of solid paraffin; the balance being water.
3. The camphor oil-beta-CD clathrate mosquito-repellent sunscreen cream according to claim 1, characterized by comprising the following components in percentage by weight:
5% of a sun-screening agent; 4% of camphor oil-beta-CD inclusion compound; 2 percent of sodium dodecyl sulfate; 0.4 percent of triethanolamine; 8% of glycerol; 0.4 percent of ethylparaben; 12% of stearic acid; 4% of glyceryl monostearate; 12% of white vaseline; 3% of lanolin; 4% of solid paraffin; the balance being water.
4. The camphor oil-beta-CD clathrate mosquito-repellent sunscreen cream according to claim 1, wherein the sunscreen agent is one or a mixture of two of nano TiO2 and aloe vera extract.
5. The camphor oil-beta-CD clathrate mosquito-repellent sunscreen cream according to claim 1, wherein the camphor oil-beta-CD clathrate is prepared by the following method:
adding beta-cyclodextrin into water, and heating to 55-60 ℃; and adding camphor oil, keeping the temperature at 55-60 ℃, stirring for 2.5-3 h, and performing suction filtration to obtain the camphor oil-beta-CD clathrate compound.
6. The camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream according to claim 5, wherein the dosage ratio of beta-cyclodextrin to water to camphor oil is 3-5 g: 50-70 mL: 0.8-1.2 mL.
7. The camphor oil-beta-CD inclusion compound mosquito-repellent sunscreen cream according to claim 6, wherein the dosage ratio of the beta-cyclodextrin to the water to the camphor oil is 4 g: 60mL of: 1 mL.
8. The preparation method of the camphor oil-beta-CD clathrate mosquito-repellent sun cream disclosed by any one of claims 1 to 7 is characterized by comprising the following steps:
uniformly mixing sodium dodecyl sulfate, triethanolamine, glycerol and ethylparaben, heating to 75-85 ℃, and stirring to dissolve the mixture to obtain an oil phase raw material;
uniformly mixing stearic acid, glyceryl monostearate, white vaseline, lanolin, solid paraffin and water, heating to 75-85 ℃, and stirring to dissolve to obtain a water phase raw material;
and mixing and stirring the oil phase raw material and the water phase raw material uniformly, adding the sun-screening agent and the camphor oil-beta-CD inclusion compound, and continuously stirring uniformly to obtain the camphor oil-beta-CD inclusion compound mosquito-repellent sun-screen cream.
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