CN111655692B - 含氮杂环酰胺化合物及其医药用途 - Google Patents

含氮杂环酰胺化合物及其医药用途 Download PDF

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CN111655692B
CN111655692B CN201980010396.9A CN201980010396A CN111655692B CN 111655692 B CN111655692 B CN 111655692B CN 201980010396 A CN201980010396 A CN 201980010396A CN 111655692 B CN111655692 B CN 111655692B
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compound
methyl
diabetes
mixture
formula
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CN111655692A (zh
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前场贵树
须泽孝一
古德将之
增尾律己
元田大
山冈信贵
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Japan Tobacco Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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CN201980010396.9A 2018-02-01 2019-01-30 含氮杂环酰胺化合物及其医药用途 Active CN111655692B (zh)

Applications Claiming Priority (3)

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JP2018016328 2018-02-01
JP2018-016328 2018-02-01
PCT/JP2019/003052 WO2019151274A1 (ja) 2018-02-01 2019-01-30 含窒素複素環アミド化合物及びその医薬用途

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US (3) US10800784B2 (enExample)
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US20220362215A1 (en) 2018-09-11 2022-11-17 Japan Tobacco Inc. Therapeutic or prophylactic agent for chronic kidney disease containing pyrazole-amide compound
CN110407744A (zh) * 2019-08-13 2019-11-05 上海毕得医药科技有限公司 一种1-(4-氨基吡啶-2-基)乙酮的合成方法
CN119874775A (zh) 2020-02-07 2025-04-25 加舒布鲁姆生物公司 杂环glp-1激动剂
MX2022010950A (es) * 2020-03-04 2022-10-07 Japan Tobacco Inc Compuesto triciclico fusionado y uso farmaceutico del mismo.
EP4211139A4 (en) * 2020-09-10 2024-12-18 Gasherbrum Bio, Inc. HETEROCYCLIC GLP-1 AGONISTS
CA3213837A1 (en) * 2021-03-23 2022-09-29 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Heterocycle substituted ketone derivative, and composition and medicinal use thereof
EP4438040A4 (en) 2021-09-01 2025-08-20 Japan Tobacco Inc NITROGEN-CONTAINING TRICYCLIC COMPOUND AND ITS PHARMACEUTICAL USE
KR20250168210A (ko) 2023-02-16 2025-12-02 가셔브룸 바이오, 인크. 헤테로시클릭 glp-1 효능제

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WO2008132162A1 (en) * 2007-04-26 2008-11-06 Boehringer Ingelheim International Gmbh 3- (sulphonylamino) -phenyl-2 -hydroxy-ethylamino derivatives useful as beta-agonists, processes for preparing them and their use as medicaments
WO2008153792A2 (en) * 2007-06-01 2008-12-18 Schering Corporation Gamma secretase modulators
WO2009095253A1 (en) * 2008-02-01 2009-08-06 Merz Pharma Gmbh & Co. Kgaa 6-halo-pyrazolo[1, 5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mglur) modulators
WO2013000084A1 (en) * 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
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WO2013187646A1 (en) * 2012-06-12 2013-12-19 Chong Kun Dang Pharmaceutical Corp. Piperidine derivatives for gpr119 agonist
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AU2019214048A1 (en) 2020-06-25
EP3747888A4 (en) 2021-12-15
SG11202006916SA (en) 2020-08-28
TW201934553A (zh) 2019-09-01
ZA202004548B (en) 2021-10-27
CL2020002003A1 (es) 2020-10-23
MX2020008126A (es) 2020-09-18
EP3747888A1 (en) 2020-12-09
JP2023071925A (ja) 2023-05-23
US20240300952A1 (en) 2024-09-12
WO2019151274A1 (ja) 2019-08-08
MY205011A (en) 2024-09-27
CA3090219A1 (en) 2019-08-08
JP2024116307A (ja) 2024-08-27
US20210284644A1 (en) 2021-09-16
JP2019131544A (ja) 2019-08-08
IL276386B2 (en) 2023-06-01
US20200017505A1 (en) 2020-01-16
BR112020014177A2 (pt) 2020-12-08
AR114237A1 (es) 2020-08-05
PH12020500613A1 (en) 2021-05-31
KR102725118B1 (ko) 2024-11-04
CN111655692A (zh) 2020-09-11
AU2019214048B2 (en) 2023-03-16
TWI803570B (zh) 2023-06-01
SA520412473B1 (ar) 2023-02-12
US10800784B2 (en) 2020-10-13
KR20200115566A (ko) 2020-10-07
CO2020009420A2 (es) 2020-08-10
IL276386A (en) 2020-09-30
JP7241556B2 (ja) 2023-03-17
PE20211273A1 (es) 2021-07-19
RU2020128593A (ru) 2022-03-03

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