CN111643702B - Automatic control system for continuous sterilization - Google Patents
Automatic control system for continuous sterilization Download PDFInfo
- Publication number
- CN111643702B CN111643702B CN202010401335.XA CN202010401335A CN111643702B CN 111643702 B CN111643702 B CN 111643702B CN 202010401335 A CN202010401335 A CN 202010401335A CN 111643702 B CN111643702 B CN 111643702B
- Authority
- CN
- China
- Prior art keywords
- sterilization
- valve
- pipeline
- hot water
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D27/00—Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00
- G05D27/02—Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00 characterised by the use of electric means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Automation & Control Theory (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a continuous sterilization automatic control system, belonging to the technical field of disinfection and sterilization, in particular to a system for automatically controlling sterilization of fluid materials, which comprises temperature, pressure, flow and liquid level sensors, a regulating valve, a frequency converter and a Programmable Logic Controller (PLC), equivalent sterilization time mathematical models at different temperatures are introduced, by programming calculation and execution programs, the sterilization temperature which can be reached by the steam pressure, the optimal sterilization time is determined, the variable frequency regulation of the flow of the feedback knockout pump is taken as the main part, the regulation of the flow of the sterile material discharge port is taken as the auxiliary part, the double-insurance accurate control of the temperature and the time which can ensure the sterilization effect and cannot cause the over sterilization is realized, the program control of the PLC realizes the orderly opening, closing and regulation of each valve and each pump on the pipeline, and the sterilization work can be orderly, efficiently and automatically carried out under the condition of no or little manual intervention.
Description
Technical Field
The invention belongs to the technical field of disinfection and sterilization, and particularly relates to a system for sterilizing various fluid materials and automatically controlling the sterilization.
Background
China is a big country in the biopharmaceutical, biochemical and food industries, and the production and sale of various related products occupy a large share in the international market, and some products are even in monopoly status. However, these industries are high-energy-consumption and high-pollution households, wherein the consumption of the sterilizing steam is the second largest energy consumption which is only second to the consumption of electricity, and accounts for about 10% -20% of the total energy consumption. Along with the steam consumption, a large amount of cooling water for cooling the sterilized materials and a large amount of petrochemical energy for steam generation are consumed, so that the environment is seriously treated.
In addition, the sterilization work is performed manually in the past, and the operation environment is very severe due to high temperature, high humidity and high noise. And the manual operation parameter control has large fluctuation and is easy to generate errors, so that the sterilization is not thorough or excessive, the quality of the sterilized material liquid is reduced if the external microorganism pollution is caused, and the production loss is caused and the product quality is influenced.
In view of the above, there is an urgent need for a novel sterilization technique that reduces the energy consumption for sterilization and cooling, reduces the external microbial contamination, and improves the sterilization quality. In recent years, through introducing and digesting foreign technologies, energy-saving continuous sterilization equipment for recovering sterilization waste heat by using a heat exchanger has appeared in China and is in the trend of rapid development, but due to the defects of the foreign technologies, digestion failure and lack of theoretical guidance, the equipment has many problems in the domestic production and application processes:
1. the heat exchanger is improper in type selection, material storage dead angles exist in the heat exchanger, material scaling is easy to occur in the sterilization process, and the inside of the material scaling is not easy to sterilize thoroughly, so that microbial pollution is caused;
2. high-pressure steam is needed when the steam ejector is used for heating, so that the noise and the vibration are high, local overheating is easily caused, the sterilized materials are burnt, and the sterilization quality is reduced;
3. the maintenance tank is used for maintaining the heat preservation, the maintenance precision is poor, the central flow rate of the tank is high, and the sterilization is easy and incomplete; the flow velocity at the tank wall is slow, the heating time is long, the quality of the sterilization liquid is influenced, and the scale is easy to form;
4. the pipeline is used for heat preservation maintenance, the occupied area is large, the heat dissipation area is large, energy waste is caused, the pipe wall is easy to scale, and cleaning is difficult after scaling;
5. the throttle valve is used for controlling, so that the power consumption is large;
6. the whole continuous sterilization equipment has low automation degree, complex operation, severe operation environment and high labor intensity, or the automation device is too complex, large in investment and poor in reliability, and dead corners are easily formed when pipelines are connected, so that the potential hazards of bacterial contamination are caused;
7. used equipment need carry out empty sterilization to whole pipeline with steam, bakes inside stock easily, causes the passageway to obstruct, and the heat transfer effect of heat exchanger descends.
In view of the above, there is an urgent need for a novel continuous sterilization system with more compact structure, better energy saving effect, simple and easy automation and more reliable operation.
Disclosure of Invention
The invention provides a continuous sterilization automatic control system with high automation degree and simple operation.
The invention adopts the following technical scheme:
a continuous sterilization automation control system comprising: the device comprises a controller and a temperature control unit electrically connected with the controller, equivalent sterilization time mathematical models at different temperatures are introduced, and the optimal sterilization time is determined by the sterilization temperature which can be reached by steam pressure through programming calculation and execution programs; the controller is used for signal acquisition, conversion, calculation and program execution, and displaying a graph and an execution signal of sterilization process data, and the temperature control unit is mainly used for feeding back variable frequency regulation of material flow, and is assisted by regulating a regulating valve to automatically control the material temperature; the temperature control unit includes: the device comprises a flow sensor, a temperature sensor, a second material pressure sensor, a steam pressure sensor, a sterile discharging regulating valve and a frequency converter; the flow sensor is arranged on the pipeline of the feed inlet of the preheating material pipeline of the heat exchange heat retainer, is used for measuring the material flow and sends a measuring signal to the controller; the temperature sensor is arranged on a heat-insulation pipeline feeding port pipeline or a heat-insulation pipeline discharging port pipeline of the heat-exchange heat retainer, is used for measuring the sterilization temperature and sends a measurement signal to the controller; the second material pressure sensor is arranged on a pipeline between a preheating material pipeline discharge port of the heat exchange heat retainer and a feed port of the injection pump and is used for detecting the pressure of a discharge port of the booster pump, sending a measurement signal to the controller and implementing variable frequency control when the booster pump is in overpressure; the steam pressure sensor is arranged on a steam pipeline between the steam pressure reducing valve and the injection pump and used for detecting steam pressure, sending a measurement signal to the controller, calculating a sterilization temperature which can be reached according to the pressure signal to be used as a set point temperature for sterilization temperature control, calculating sterilization time according to the sterilization temperature and the set point temperature, determining the flow required by the material beating pump, and implementing variable frequency control of the rotating speed of the booster pump or adjustment control of the sterile discharging regulating valve; the sterile discharging regulating valve is arranged on a pipeline of a discharging port of a heat-exchanging warmer heat-insulating pipeline, and the frequency converter is arranged on a power supply input pipeline of a booster pump motor; the aseptic discharging regulating valve and the frequency converter are used for regulating the flow of materials, so that the sterilization steam pressure, the sterilization temperature and the corresponding sterilization time are matched, and stable sterilization temperature control is implemented.
The device further comprises a pipeline cleaning control unit for cleaning the pipeline at high temperature, wherein the pipeline cleaning control unit is electrically connected with the controller; the line cleaning control unit includes: the system comprises a saturated hot water tank liquid level sensor, a saturated hot water tank pressure sensor, a saturated hot water tank exhaust valve and a second steering valve; the saturated hot water tank liquid level sensor is arranged in the saturated hot water tank and used for detecting the liquid level of the saturated hot water tank and sending a measurement signal to the controller to implement automatic water supply; the saturated hot water tank pressure sensor is arranged at an exhaust port of the saturated hot water tank and used for detecting the internal pressure of the saturated hot water tank and sending a measurement signal to the controller to control the internal pressure of the saturated hot water tank; the exhaust valve of the saturated hot water tank is arranged at the exhaust port of the saturated hot water tank and is used for adjusting the internal pressure of the saturated hot water tank so as to control the temperature of the cleaning agent in the saturated hot water tank; the second steering valve is arranged on a pipeline at a discharge port of the heat exchange and heat retainer heat preservation pipeline and used for heating up by using a cleaning agent, sterile discharging and circulating cleaning of the pipeline.
The cleaning agent pressure maintaining control unit is used for maintaining the pressure of the sterile cleaning agent and is electrically connected with the controller; the cleaning agent pressure maintaining control unit comprises a steam bypass valve and a first steam valve; the steam bypass valve is arranged at a steam inlet of the injection pump and used for controlling the steam air inflow and maintaining the pressure of the sterile cleaning agent in the whole system equipment and pipeline through the intermittent switch of the steam bypass valve; the first steam valve is arranged on one side of the air inlet of the steam pressure reducing valve and used for closing air inlet of the steam pressure reducing valve when the system is switched to a pressure maintaining state of the sterile cleaning agent.
Further, the device also comprises an auxiliary function unit, wherein the auxiliary function unit is used for discharging air in the pipeline and is electrically connected with the controller; the auxiliary function unit includes: the system comprises a first material pressure sensor, a first material reflux valve, a second material reflux valve and a distribution station blow-down valve; the first material pressure sensor is arranged on a pipeline between the material outlet of the knockout pump and the feed inlet of the preheating pipeline of the heat exchange heat retainer heat exchange unit, and is used for detecting the pressure of the material outlet of the knockout pump, sending a measurement signal to the controller and implementing the on-off control of the first material reflux valve; the first material reflux valve is arranged on a discharge port pipeline of a preheating material pipeline of the heat exchange heat retainer and used for discharging gas in the pipeline; the second material reflux valve is arranged on a discharge port pipeline of the booster pump and used for discharging gas in the pipeline; the distribution station blow-down valve is arranged on a discharge port pipeline of the sterile material distribution station and used for discharging residual materials in the cleaning process.
Further, the first material pressure sensor, the flow sensor, the saturated hot water tank liquid level sensor, the saturated hot water tank pressure sensor, the transfer tank liquid level sensor, the temperature sensor, the second material pressure sensor and the steam pressure sensor all comprise transmitter modules.
Further, the controller comprises a Programmable Logic Controller (PLC) and a touch screen, the touch screen is used for setting operation process parameters, the PLC receives the parameters of the touch screen and automatically controls the operation process according to the parameters, and the touch screen is in communication connection with the PLC.
Furthermore, the device also comprises an alarm for sending an audible and visual alarm signal, wherein the alarm is electrically connected with the controller.
Further, still include the switch board, the controller, the converter all sets up inside the switch board.
Further, still include soft water storage tank bottom valve, soft water storage tank bottom valve is used for according to the liquid level information of transfer jar liquid level sensor feedback supplyes the cleaner in to the transfer jar.
The invention has the following positive effects:
the invention discloses a continuous sterilization automatic control system, which has the advantages of less automatic components, simple installation and difficult formation of dead storage corners on pipelines, thereby reducing investment and steam consumption for sterilization and simultaneously avoiding storage scaling and pipeline obstruction after long-term use. The dynamic sterilization temperature and sterilization time are controlled, different sterilization temperatures and corresponding sterilization times can be selected according to the steam pressure, and the steam pressure sterilization device is suitable for occasions with certain fluctuation of the steam pressure. The temperature feedback control scheme with the frequency conversion regulation as the main regulation valve regulation as the auxiliary regulation is adopted, so that the performance of a power grid can be improved, the power consumption of a pump is reduced, the service lives of the pump and a pump motor are prolonged, the control precision is high, the control program is simple, the sterilization temperature is stably and reliably controlled, and the sterilization quality is ensured. The use of the liquid level sensor and the automatic switch valve is combined, the automation of the whole sterilization process including auxiliary processes of cleaning, saturated hot water circulation heating sterilization, saturated hot water top washing after material sterilization, saturated hot water sterile pressure maintaining and the like can be realized, the manual intervention is rarely needed, and the working efficiency is improved.
Drawings
FIG. 1 is a schematic structural diagram of a piping system according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of an electrical system according to an embodiment of the present invention;
FIG. 3 is a flow chart of an automatic control according to an embodiment of the present invention.
In the figure: the system comprises a heat exchange warmer 1, a first material one-way valve 2, a first material pressure sensor 3, a material beating pump 4, a transfer tank 5, a flow sensor 6, a first steering valve 7, a saturated hot water tank 8, a saturated hot water tank liquid level sensor 9, a saturated hot water tank safety valve 10, a saturated hot water tank pressure sensor 11, a saturated hot water tank exhaust valve 12, a material delivery pump 13, a controller 14, a control cabinet 15, a frequency converter 16, a soft water storage tank 17, a soft water storage tank bottom valve 18, a transfer tank liquid level sensor 19, a temperature sensor 20, a first material return valve 21, a booster pump 22, a second material return valve 23, a second material pressure sensor 24, a second material one-way valve 25, an injection pump 26, a steam one-way valve 27, a steam pressure sensor 28, a steam bypass valve 29, a steam pressure reducing valve 31, a first steam valve 32, a distribution station blow-down valve 33, a sterile material distribution station 34, a sterile control valve 35, a sterile control valve, A second steering valve 36, a transfer tank blow-down valve 39, a pre-cooling pipeline feeding port 111, a pre-cooling pipeline discharging port 112, a pre-heating pipeline feeding port 121, a pre-heating pipeline discharging port 122, a heat preservation pipeline feeding port 131 and a heat preservation pipeline discharging port 132.
Detailed Description
As shown in fig. 1-3, the heat exchange and insulation unit uses a heat exchange and insulation device 1 as a core, the upper part is sequentially provided with a first port, a second port and a third port from left to right, the lower part is sequentially provided with a fourth port, a fifth port and a sixth port from left to right, the first port and the sixth port are two ports of a preheating pipeline, the second port and the fifth port are two ports of an insulation pipeline, and the third port and the fourth port are two ports of a precooling pipeline. In this embodiment, the sixth port is a preheating pipe inlet 121, the first port is a preheating pipe outlet 122, the third port is a precooling pipe inlet 111, the fourth port is a precooling pipe outlet 112, the fifth port is a heat preservation pipe inlet 131, and the second port is a heat preservation pipe outlet 132. The heat exchange warmer 1 heats the preheated material to a target temperature by an injection pump 26 communicated with an external steam pipeline through an air inlet. The jet pump 26 is a fluid-dynamic pump. The fluid power pump has no mechanical transmission and mechanical working components, and uses the energy of another working fluid as a power source to convey low-energy liquid, so that the fluid power pump has good safety when being used for pumping inflammable and explosive materials. A pump for delivering fluid by the jetting action of a high pressure working fluid. Comprises a nozzle, a mixing chamber, an expansion pipe and the like. For smooth operation, a vacuum chamber (also called suction chamber) is provided at the throat; in order to allow for sufficient mixing of the two fluids, a mixing chamber is followed by a vacuum chamber. In operation, the working fluid is ejected from the nozzle at a high velocity, creating a low pressure in the vacuum chamber, causing the liquid being delivered to be drawn into the vacuum chamber and then into the mixing chamber. The high-energy working fluid and the low-energy transported liquid are fully mixed in the mixing chamber, so that the energy is exchanged, the speed is gradually consistent, the working fluid enters the diffusion chamber from the throat, the speed is slowed down, the static pressure is increased again, and the purpose of transporting the liquid is achieved. In this embodiment, the air inlet of the jet pump 26 is communicated with an external steam pipeline for providing heat energy for heating the material, the feed inlet is communicated with the discharge outlet of the booster pump 22 for providing the preheated material, and the discharge outlet is used for discharging the heated material and is communicated with the heat-preserving pipeline feed inlet 131 of the heat-exchanging heat retainer 1. The feed inlet of the injection pump 26 is provided with a second material one-way valve 25, and the gas inlet is provided with a steam one-way valve 27 for preventing backflow of the material and the steam respectively. The intake port of the injection pump 26 is also provided with a steam relief valve 31 and a steam pressure sensor 28. The steam pressure reducing valve 31 is used to adjust the steam pressure so that the steam pressure entering the inlet of the jet pump 26 can be stabilized to a reasonable range, and has one end communicating with the external steam line and the other end communicating with the steam pressure sensor 28. The steam pressure sensor 28 is used for measuring the steam pressure in real time, and the feeding hole is provided with the second material pressure sensor 24 for measuring the material pressure in real time. The feed inlet of the booster pump 22 is communicated with the discharge outlet 122 of the preheating pipeline of the heat exchange heat retainer 1 for increasing the material circulation pressure, the motor of the booster pump 22 is electrically connected with the frequency converter 16, and the controller 14 controls the rotating speed of the motor of the booster pump 22 through the frequency converter 16, thereby achieving the purpose of controlling the booster pump 22 to regulate the material flow in the pipeline.
The heat exchange warmer 1 is communicated with the pre-cooling pipeline feeding port 111 through a temperature sensor 20, and is used for detecting the temperature of the material heated by the jet pump 26. The preheating pipeline feed inlet 121 of the heat exchange warmer 1 is also provided with a first material one-way valve 2 for preventing materials from flowing backwards, and the feed inlet of the first material one-way valve 2 is communicated with a flow sensor 6 for measuring the material flow. The pre-cooling pipeline discharge port 112 of the heat exchange and insulation device 1 is communicated with the sterile discharge regulating valve 35, the regulating valve is a two-position two-way valve, the size of the flow cross section of the regulating valve can be adjusted, the valve is electrically connected with the controller 14, and the controller 14 can also achieve the purpose of adjusting the material flow in the pipeline by adjusting the size of the flow cross section of the valve.
The temperature control system includes: the controller 14 and the temperature control unit electrically connected with the controller 14, and introduce the equivalent sterilization time mathematical model under different temperatures, through programming calculation and execution program, the sterilization temperature that can be reached by the steam pressure, determine the optimal sterilization time; the controller 14 is used for signal acquisition, conversion, calculation and program execution, and displays graphs and execution signals of sterilization process data, the controller 14 comprises a Programmable Logic Controller (PLC) and a touch screen, the touch screen is used for setting operation process parameters, the PLC receives the parameters of the touch screen and performs automatic control according to the parameters, and the touch screen is in communication connection with the PLC. The programmable logic controller PLC is also implanted with a calculation program which is programmed according to two mathematical models of corresponding saturated water temperature under different steam pressures and corresponding equivalent sterilization time under different sterilization temperatures, the set point of the sterilization temperature and the corresponding sterilization time are determined according to the detected steam pressure, the dynamic optimization control of the sterilization temperature and the sterilization time is implemented, the programmable logic controller PLC can adapt to the fluctuation of the steam pressure within a certain range, and the stability and the reliability of the sterilization effect are kept. The temperature control unit mainly feeds back the frequency conversion regulation of the material flow, and the sterile material discharge regulating valve 34 regulates the flow as an auxiliary regulating valve, so as to automatically control the material temperature.
The temperature control unit includes: the flow sensor 6, the temperature sensor 20, the second material pressure sensor 24, the steam pressure sensor 28, the sterile discharging regulating valve 35 and the frequency converter 16; the flow sensor 6 is used for measuring the flow of the materials in the pipeline and sending a measuring signal to the programmable logic controller PLC; the temperature sensor 20 is used for measuring the sterilization temperature and sending a measurement signal to the programmable logic controller PLC; the second material pressure sensor 24 is used for detecting the pressure at the discharge port of the booster pump 22 and sending a measurement signal to the programmable logic controller PLC to implement variable frequency control when the booster pump 22 is in overpressure; the steam pressure sensor 28 is used for detecting steam pressure, sending a measurement signal to the programmable logic controller PLC, calculating a sterilization temperature which can be reached according to the pressure signal, taking the sterilization temperature as a set point temperature for sterilization temperature control, calculating sterilization time according to the sterilization temperature, determining the flow rate required by the material-pumping pump 4, and implementing variable frequency control of the rotating speed of the booster pump 22 or adjusting control of the sterile material-discharging adjusting valve 35; the aseptic discharge regulating valve 35 and the frequency converter 16 are used for regulating the flow of the materials, so that the sterilization steam pressure, the sterilization temperature and the corresponding sterilization time are matched, and stable sterilization temperature control is implemented.
As is known to all, the internationally recognized moist heat sterilization process which can reach the sterilization guarantee level is 121 ℃ and 30min, and the invention deduces the equivalent sterilization time mathematical models at different temperatures according to the thermodynamic principle as follows:
τ=30×10（121-t）/z
wherein t is sterilization temperature, DEG C
τ -Sterilization time (i.e.holding time at sterilization temperature), min
Z-Heat resistance of microorganism, DEG C
For sterilization, the Z values are very different for different sterilization media and different target microorganisms, so that the equivalent sterilization time derived from the above derivation formula is also very different, and the second table and the third table can be used as references for selecting the Z values.
TABLE 1 average Z values of several extremely thermostable microorganisms
| Bacterial strains | Z value |
| Bacillus stearothermophilus C953 | 9.1 |
| Bacillus stearothermophilus J16B | 13.1 |
| Heat-resistant bacillus B93-20-12 | 14.2 |
| Thermotolerant bacillusMB921 | 13.2 |
TABLE 2Z values of B.stearothermophilus in different solutions
| Solutions of | Z value |
| Aqueous glucose solution | 8.4 |
| Water for injection | 10.3 |
| Ringer's solution of glucose and lactic acid | 11.3 |
| |
7.6 |
| Average | 9.4 |
Note: the bacillus stearothermophilus is used as a sterilization marker bacterium at home and abroad.
The sterilization time corresponding to the sterilization temperature and the ratio set value of the cooperative control of the frequency converter and the regulating valve can be obtained by an equivalent sterilization time mathematical model, and are listed in the table III.
TABLE 3 equivalent sterilization time corresponding to sterilization temperature and proportional set value for variable frequency regulation and regulating valve regulation cooperative control
| Sterilization temperature (. degree.C.) | Sterilization time(s) | Regulating valve regulation (%) | Frequency conversion adjustment (%) |
| 135 | 123 | 75 | 51.1 |
| 136 | 101 | 80 | 58.0 |
| 137 | 84 | 85 | 66.2 |
| 138 | 69 | 90 | 75.7 |
| 139 | 57 | 95 | 86.9 |
| 140 | 47 | 100 | 100.0 |
| 141 | 39 | 100 | 100.0 |
| 142 | 32 | 100 | 105.0 |
By adopting the automatic system for ultrahigh-temperature instant sterilization, the sterilization temperature can be as high as 140-142 ℃, the sterilization time at the temperature can be as low as 47-32 seconds for extremely heat-resistant target microorganisms (Z = 12) contained in a biopharmaceutical fermentation raw material, and the sterilization time at the temperature can be as low as 5-1 seconds for common microorganisms (Z = 7.5) generally contained in a food industry finished product, so that the ultrahigh-temperature instant sterilization is realized in a real sense.
When the system is used, after the pipeline is sterilized at high temperature, the temperature displayed by the temperature sensor 20 is raised to 141 ℃ by adjusting the pressure displayed by the second material pressure sensor 24 and the pressure displayed by the steam pressure sensor 28, the set point temperature of the temperature automatic control program is adjusted to 140 ℃, the material conveying device is started to convey the material to the heat exchange heat retainer 1, the aseptic discharging regulating valve 35 is opened, the continuous sterilization of the material is carried out under the control of the temperature control program in the programmable logic controller PLC, the frequency conversion regulation of the frequency converter 16 is taken as the main part, the proportion regulation of the aseptic discharging regulating valve 35 is taken as the auxiliary part, the sterilization temperature is controlled to 140 +/-1 ℃, and the material to be sterilized is delivered.
The sterilization automation system has almost no manual intervention, the automation level is very high, the temperature control is mainly realized by frequency conversion adjustment, the adjusting valve is used as an auxiliary part, the adjusting valve is started to adjust when the frequency conversion adjustment exceeds a controllable range, and the energy-saving effect and the pump loss-saving effect are obvious.
Further, in real-time high temperature pipeline sterilization process, adopt steam sterilization, repeatedly wash with steam to cause to use process steam consumption big, still there is the risk of microbial contamination equally, still easily with inside stock dry, cause the passageway to obstruct, the heat transfer effect of heat exchanger descends, in view of this, it is necessary to adopt high temperature cleaner to wash, the most common high temperature water of high temperature cleaner is difficult to reach sterilization temperature under the ordinary pressure, according to the empirical mathematical model between saturated hot water temperature and the corresponding steam pressure as follows:
t=59.950963+0.5623749p-0.00212262p2+0.00000543p3-0.00000001p4
in the formula, p-vapor pressure (absolute pressure), kPa
t-corresponding to saturated hot water temperature,. degree.C
The saturated hot water temperatures corresponding to different steam pressures and the corresponding sterilization control set point temperatures are obtained as listed in table one:
TABLE 4 saturated hot water temperature corresponding to steam pressure and corresponding sterilization control set point
| Steam pressure (kPa) | Saturated Hot Water temperature (. degree.C.) | Sterilization set temperature (. degree.C.) |
| 415 | 145 | 135 |
| 427 | 146 | 136 |
| 439 | 147 | 137 |
| 451 | 148 | 138 |
| 463 | 149 | 139 |
| 476 | 150 | 140 |
| 489 | 151 | 141 |
| 502 | 152 | 142 |
Note: 1. steam pressure refers to the pressure before entering the jet pump.
2. Sterilization below 135 ℃ is not recommended, and sterilization above 142 ℃ is generally not recommended.
According to the experimental model, through correlation analysis, the correlation coefficient reaches R2=0.99999, so that the correlation between the steam pressure and the saturated hot water temperature can be accurately simulated.
According to the model, a system which also comprises a cleaning agent high-temperature cleaning control function is established on the system, and the system also comprises a pipeline cleaning control unit, a transfer control unit, a cleaning agent pressure maintaining control unit and an auxiliary function unit.
The pipeline cleaning device is a sealable container, internal air pressure is increased by heating, and according to an empirical mathematical model between the saturated hot water temperature and the corresponding steam pressure, a cleaning agent such as water is heated to a target temperature such as 140 ℃. The core of the device is a saturated hot water tank 8, the saturated hot water tank 8 is provided with an exhaust port, a discharge port and a feed port, and the three ports are closed to realize the sealing effect. The exhaust port of the saturated hot water tank is communicated with a safety valve 10 for preventing internal gas from being discharged protectively when the pressure of a container is overhigh, the saturated hot water tank pressure sensor 11 is used for measuring the internal air pressure of the saturated hot water tank 8 and feeding back a signal to a programmable logic controller PLC (programmable logic controller) for implementing automatic control, and the exhaust valve 12 of the saturated hot water tank is controlled by the programmable logic controller PLC so as to adjust the internal pressure of the saturated hot water tank 8; the saturated hot water tank 8 is internally provided with a saturated hot water tank liquid level sensor 9 for measuring the liquid level, detecting the internal liquid level, matching with a saturated hot water circulation bypass valve 35 communicated with a feed inlet of the saturated hot water tank 8 and a first steering valve 7 communicated with a discharge outlet of the saturated hot water tank, and realizing internal liquid level control. The saturated hot water circulation bypass valve 35 is used for switching a cleaning agent circulation loop inside the saturated hot water tank 8, one end of the saturated hot water circulation bypass valve is communicated with the pre-cooling pipeline discharge port 112 of the heat exchange and insulation device 1, and the other end of the saturated hot water circulation bypass valve is communicated with the feed port of the saturated hot water tank 8.
The pipeline cleaning control unit is electrically connected with the programmable logic controller PLC; the pipe cleaning control unit includes: a saturated hot water tank liquid level sensor 9, a saturated hot water tank pressure sensor 11, a saturated hot water tank exhaust valve 12 and a saturated hot water circulation bypass valve 35; the saturated hot water tank liquid level sensor 9 is arranged inside the saturated hot water tank 8 and is used for detecting the liquid level of the saturated hot water tank 8 and sending a measurement signal to the programmable logic controller PLC to implement automatic water supply; the saturated hot water tank pressure sensor 11 is arranged at an exhaust port of the saturated hot water tank 8 and is used for detecting the internal pressure of the saturated hot water tank 8 and sending a measurement signal to the programmable logic controller PLC to implement internal pressure control of the saturated hot water tank 8; the exhaust valve 12 of the saturated hot water tank is arranged at the exhaust port of the saturated hot water tank 8 and is used for adjusting the internal pressure of the saturated hot water tank 8 so as to control the temperature of the cleaning agent in the saturated hot water tank 8; the saturated hot water circulation bypass valve 35 is disposed at the heat-insulating pipeline discharge port 132 of the heat-exchanging heat retainer 1, and is used for heating by a cleaning agent and circulating cleaning of the pipeline.
The transfer control unit is used for storing and transferring materials, and the core of the transfer control unit is a transfer tank 5. The transfer tank 5 is used for storing transfer materials, such as cleaning agents, materials to be sterilized and the like. The transfer tank 5 is provided with a feed inlet and a discharge outlet, and the discharge outlet is communicated with the first steering valve 7. The 7-position three-way valve of the first steering valve is used for selecting materials communicated with the heat exchange heat retainer 1, the valve comprises two feed inlets and a discharge outlet, the two feed inlets are respectively communicated with the discharge outlet of the transfer tank 7 and the discharge outlet of the saturated hot water tank 8, and the materials at the discharge outlet are conveyed to the preheating pipeline feed inlet 121 of the heat exchange heat retainer 1 through the material conveying pump 4. The material conveying pump 13 is used for conveying external materials to the transfer tank 5, a feed inlet of the material conveying pump 13 is communicated with an external material pipeline, and a discharge outlet is communicated with a feed inlet of the transfer tank 5. The material beating pump 4 is used for conveying materials communicated with a discharge hole of the first steering valve 7 to a preheating pipeline feed inlet 121 of the heat exchange heat retainer 1, and a discharge hole of the material beating pump 4 is provided with a first material one-way valve 2 for preventing the materials from flowing backwards and a first material pressure sensor 3 for detecting the pressure of the discharge hole of the material beating pump 4. The flow sensor 6 is arranged on a pipeline between the feeding hole of the knockout pump 4 and the discharging hole of the first steering valve 7.
The transfer control unit is electrically connected with the programmable logic controller PLC; the material transfer control unit comprises a material pump 4, a first steering valve 7, a material delivery pump 13 and a transfer tank liquid level sensor 19; the first steering valve 7 is a three-way valve, two feed inlets are respectively communicated with the discharge ports of the transfer tank 5 and the saturated hot water tank 8, and the discharge ports are communicated with a material conveying pipeline and used for selecting a material source entering the pipeline in different steps; the material pumping pump 4 is arranged on a discharge port pipeline of the first steering valve 7 and is used for conveying materials communicated with the first steering valve 7 to a heat exchange pipeline of the heat exchange heat retainer 1; the delivery pump 13 is arranged on a pipeline of a feeding port of the transfer tank 5 and used for delivering external materials to the interior of the transfer tank 5; the transfer tank liquid level sensor 19 is provided inside the transfer tank 5, and detects the liquid level of the transfer tank 5 and sends a measurement signal to the controller 14 to perform automatic feeding.
Considering that the condition of continuous production is considered at a time interval after the pipeline is cleaned at high temperature, the system is also provided with a cleaning agent pressure maintaining function, and a cleaning agent pressure maintaining control unit is electrically connected with a Programmable Logic Controller (PLC); the cleaning agent pressure maintaining control unit comprises a steam bypass valve 29 and a first steam valve 32; the steam bypass valve 29 is arranged at a steam inlet of the injection pump 26 and is used for controlling the steam air inflow, and the pressure of the sterile cleaning agent in the whole system equipment and pipeline is maintained through the intermittent switch of the steam bypass valve 29; the first steam valve 32 is arranged on one side of the air inlet of the steam pressure reducing valve 31 and used for closing the air inlet of the steam pressure reducing valve 31 when the system is switched to the aseptic cleaning agent pressure maintaining state.
In order to evacuate gas in the pipeline and prevent equipment cavitation, the device is also provided with a pressure sensor and a return valve for detecting pipeline pressure, the first material return valve 21 is a two-position two-way valve, one end of the first material return valve is communicated with a preheating pipeline discharge hole 122 of the heat exchange heat retainer 1, and the other end of the first material return valve is communicated with a feed hole of the transfer tank 5; the second material reflux valve 23 is a two-position two-way valve, one end of which is communicated with the discharge hole of the booster pump 22, and the other end of which is communicated with the feed hole of the transfer tank 5. The pressure measuring port of the first material pressure sensor 3 is communicated with the discharge port of the knockout pump 4. A distribution station blow-down valve 33 for discharging residual materials in the pipeline is also arranged, and the discharge hole of an aseptic discharge regulating valve 35 is communicated with the feed hole of an aseptic material distribution station 34; the aseptic material distribution station 34 is provided with a feed inlet, a discharge outlet and a plurality of distribution ports, wherein the feed inlet is always communicated with the discharge outlet, and the distribution ports are used for discharging sterilized materials to a plurality of fermentation tanks or aseptic material storage tanks communicated with the distribution ports. The distribution station blow-down valve 33 is a two-position two-way valve, one end of which is communicated with the discharge hole of the sterile material distribution station 34, and the other end is used for blow-down.
The auxiliary function unit and the programmable logic controller PLC; the auxiliary function unit includes: a first material pressure sensor 3, a first material return valve 21, a second material return valve 23 and a distribution station blowdown valve 33; the first material pressure sensor 3 is arranged on a pipeline between the discharge hole of the material mixing pump 4 and the feed inlet of the preheating pipeline of the heat exchange unit of the heat-preservation device 1, and is used for detecting the pressure of the discharge hole of the material mixing pump 4, sending a measurement signal to a Programmable Logic Controller (PLC), and implementing the on-off control of the first material reflux valve 21; the first material reflux valve 21 is arranged on a discharge port pipeline of the preheating pipeline of the heat exchange heat retainer 1 and used for discharging gas in the pipeline; the second material reflux valve 23 is arranged on a discharge port pipeline of the booster pump 22 and is used for discharging gas in the pipeline; a station blow-down valve 33 is provided on the discharge port line of the sterile material distribution station 34 for discharging residual material during the cleaning process.
In addition, the system also comprises a soft water storage tank bottom valve 18, the soft water tank 16 is used for storing softened water or cleaning agent, and the soft water storage tank bottom valve 18 is used for supplementing softened water or cleaning agent into the transfer tank 5 according to the liquid level information fed back by the transfer tank liquid level sensor 19.
As shown in figure 3, when in use, the automatic operation steps of the continuous sterilization automatic control system are as follows:
1. cleaning: transferring the first steering valve 7 to the transfer tank 5 to be communicated with the material beating pump 4, adding clean tap water into the transfer tank to enable the liquid level display of the transfer tank 5 to reach a middle position or a high position set point, sequentially opening the material beating pump 4 and the first material return valve 21, closing the first material return valve 21 when the pressure detected by the first pressure sensor 3 reaches a set point or the pump-on time of the material beating pump 4 reaches 15 seconds, sequentially opening the booster pump 22 and the second material return valve 23, closing the second material return valve 23 when the pressure detected by the second material pressure sensor 24 reaches a low position set point or the pump-on time of the booster pump 22 reaches 15 seconds, then turning the second steering valve 36 to a three-position communicated position under the condition that all valves leading to each fermentation tank or each sterile material storage tank on the sterile material distribution station 34 are closed, opening the sterile discharging regulating valve 35 and the distribution station drain valve 33, after the liquid level of the transfer tank 5 is displayed and reaches a low set point, the blowoff valve 33 of the distribution station, the sterile discharge regulating valve 35, the first material reflux valve 21 and the material beating pump 4 are sequentially closed, the first steering valve 7 is turned to the saturated hot water tank 8 to be communicated with the material beating pump 4 after cleaning is finished, the blowoff valve 39 of the transfer tank is opened, and the stored water in the saturated hot water tank is emptied. The whole process is automatically completed under the program instruction pre-implanted in the programmable controller 14.
2. Saturated hot water circulation heating: the first steering valve 7 is turned to the transfer pot 5 to be communicated with the material beating pump 4, so that the residual water in the transfer pot 5 is emptied through the transfer pot blow-down valve 39, the transfer pot blow-down valve 39 is closed, the soft water storage pot bottom valve 18 is opened, soft water is injected into the transfer pot 5 from the soft water storage pot 17, after the liquid level of the transfer pot 5 reaches a middle set point, the material beating pump 4 and the first material return valve 21 are sequentially opened, when the pressure detected by the first pressure sensor 3 reaches a set point or the pump-on time of the material beating pump 4 reaches 15 seconds, the first material return valve 21 is closed, the booster pump 22 and the second material return valve 23 are sequentially opened, when the pressure detected by the second material pressure sensor 24 reaches a low set point or the pump-on time of the booster pump 22 reaches 15 seconds, the second material return valve 23 is closed, the second steering valve 36 is confirmed to be at a three-position, the exhaust valve 12 of the saturated hot water pot is opened, when the pressure displayed by the second material pressure sensor 24 reaches a high-level set point, a first steam valve 32 is opened, a steam pressure stabilizing valve 31 is adjusted to enable the pressure displayed by a steam pressure sensor 28 to be stabilized at 270-300 kPa, a saturated hot water source heated by an injection pump 26 enters a saturated hot water tank 8, after the liquid level displayed by a saturated hot water tank liquid level sensor 9 reaches the high-level set point, a first steering valve 7 is turned to the saturated hot water tank 8 to be communicated with a material beating pump 4, the saturated hot water circulation heating is started, after the pressure displayed by a saturated hot water tank pressure sensor 11 reaches a low-level set point, an exhaust valve 12 of the saturated hot water tank is automatically closed, the saturated hot water circulation heating is continued until the temperature displayed by a temperature sensor 20 reaches 130 ℃, in the process, if the pressure displayed by the saturated hot water tank pressure sensor 11 reaches the high-level set point, the exhaust valve 12 of the saturated hot water tank is automatically opened, and the valve is automatically closed after 5 seconds of pressure relief.
3. Saturated hot water circulation sterilization: when the temperature displayed by the temperature sensor 20 reaches 130 ℃, a temperature control program in the controller 14 is started, the set point temperature is adjusted to 130 ℃, the booster pump 22 adjusts the pressure displayed by the second material pressure sensor 24 to be matched with the steam pressure displayed by the steam pressure sensor 28, so that the temperature displayed by the temperature sensor 20 is stabilized at 130 +/-1 ℃, the temperature is maintained for 10 minutes, in the process, when the pressure displayed by the saturated hot water tank pressure sensor 11 reaches 5 to a high set point, the exhaust valve 12 of the saturated hot water tank is automatically opened, the exhaust valve is automatically closed after the pressure is relieved for 5 seconds, and the process is repeated.
4. Material sterilization: during the saturated hot water circulation sterilization, the material conveying pump 13 is started, the material to be sterilized from the material distribution tank is conveyed into the transfer tank 5, and the operation of the material conveying pump 13 is suspended after the liquid level displayed by the liquid level sensor 19 of the transfer tank reaches a high-level set point. When the saturated hot water circulation sterilization is nearly finished, the pressure displayed by the second material pressure sensor 24 and the pressure displayed by the steam pressure sensor 28 are both increased by 50-100 kPa, the temperature displayed by the temperature sensor 20 is increased to 141 ℃, the set point temperature of the temperature automatic control program is adjusted to 140 ℃, the first steering valve 7 is turned to the transfer tank 5 to be communicated with the material beating pump 4, the second steering valve 36 is turned to the sterile discharge regulating valve 35 to be communicated with the heat exchange heat insulator 1 and to be isolated from the saturated hot water tank 8, the sterile discharge regulating valve 35 and the corresponding fermentation tank or valve of the sterile material storage tank on the sterile material distribution station 34 are opened, the continuous sterilization of the materials is carried out under the control of the temperature control program in the controller 14, the variable frequency regulation of the booster pump 22 is mainly used, the proportion regulation of the sterile discharge regulating valve 35 is assisted, the sterilization temperature is controlled to 140 ℃ +/-1 ℃, in the process, the material conveying pump 13 is automatically started when the liquid level displayed by the transfer tank liquid level sensor 19 is lower than the set point, and (4) stopping the material conveying pump 13 when the high-level set point is reached until the materials to be sterilized in the material mixing tank are conveyed completely.
5. Top washing with high-temperature saturated hot water: after the liquid level displayed by the liquid level sensor 18 of the transfer tank reaches a low set point, the first steering valve 7 is turned to the saturated hot water tank 8 to be communicated with the material-pumping pump 4, the whole system is continuously topped at the set point temperature of 140 ℃, the bottom valve 18 of the soft water storage tank is opened at the same time, 5-10 minutes of soft water is injected into the transfer tank 5 from the soft water storage tank 17, after the liquid level displayed by the liquid level sensor 9 of the saturated hot water tank reaches the low set point, the first steering valve 7 is turned to the transfer tank 5 to be communicated with the material-pumping pump 4, the soft water in the transfer tank 5 is continuously sterilized at the set point temperature of 140 ℃, and until the liquid level displayed by the liquid level sensor 19 of the transfer tank reaches the low set point.
6. And (3) sterile soft water pressure maintaining: after the soft water top washing in the transfer tank 5 is completed, after the liquid level displayed by the transfer tank liquid level sensor 19 reaches a low set point, the valves on the aseptic material distribution station 34 corresponding to the fermentation tank or the aseptic material storage tank, the aseptic discharge regulating valve 35, the booster pump 22 and the knockout pump 4 are sequentially closed, the steam bypass valve 29 is slightly opened, the first steam valve 32 and the second steam valve 30 are closed, the pressure control program in the programmable controller 14 is started, the pressure displayed by the steam pressure sensor 24 is controlled within the range of 150-200 kPa through the intermittent switch of the steam bypass valve 28, and the aseptic water pressure maintaining is performed on the equipment and the pipeline of the whole system under the low-pressure steam top pressure.
The above steps are the operation steps in the first use, and only the above 3-6 steps are needed in the later use. It should be noted that, in both the saturated hot water circulation sterilization and the material sterilization, once the sterilization temperature displayed by the temperature sensor 20 deviates downward from the set point by more than or equal to 0.5 ℃ even when the frequency displayed by the frequency converter 16 is as low as 75%, the programmable controller 14 will start the temperature auto-control program using the sterile material outlet regulating valve 35 as the actuator immediately when the frequency of the current frequency conversion is unchanged to ensure the sterilization temperature to be stable, and when the sterile material outlet regulating valve 35 has been opened to nearly 100% and the temperature displayed by the temperature sensor 19 still continues to rise to deviate from the set point by more than or equal to 0.5 ℃, the programmable controller 14 will start the temperature auto-control program using the sterile material outlet regulating valve 35 again 6 to maintain the opening degree of the sterile material outlet regulating valve 35 and immediately resume the temperature program using the variable frequency booster pump 22 controlled by the frequency converter 16 as the actuator. In addition, it should be noted that the first material pressure sensor 3, the flow sensor 6, the saturated hot water tank liquid level sensor 9, the saturated hot water tank pressure sensor 11, the transfer tank liquid level sensor 19, the temperature sensor 20, the second material pressure sensor 24 and the steam pressure sensor 28 all include a transmitter module, and the transmitter module is used for detecting a process parameter and transmitting a measured value in a specific signal form for displaying and adjusting. The automatic detection and regulation system has the function of converting various process parameters such as temperature, pressure, flow, liquid level, components and other physical quantities into a unified standard signal, then transmitting the unified standard signal to a regulator and an indication recorder for regulation, indication and recording, for example, a transmitter can convert various measured parameters into 0-10 mA or 4-20 mA (a unified standard signal of direct current) so as to transmit the unified standard signal to other units of the automatic control system.
The system also comprises an alarm for sending an audible and visual alarm signal, wherein the alarm is electrically connected with the controller 14, and the alarm can send the audible and visual alarm signal to prompt an operator to perform the next operation after the operation of the steps is completed.
The system further comprises a control cabinet 15, the controller 14 and the frequency converter 16 are arranged inside the control cabinet 15, and the controller 14 and the frequency converter 16 are arranged inside the control cabinet 15, so that the electric unit is far away from the external damp and hot working environment.
By adopting the automatic system for ultrahigh-temperature instant sterilization, the sterilization temperature can be as high as 140-142 ℃, the sterilization time at the temperature can be as low as 47-32 seconds for extremely heat-resistant target microorganisms (Z = 12) contained in a biopharmaceutical fermentation raw material, and the sterilization time at the temperature can be as low as 5-1 seconds for common microorganisms (Z = 7.5) generally contained in a food industry finished product, so that the ultrahigh-temperature instant sterilization is realized in a real sense.
The automatic system for ultrahigh-temperature instant sterilization not only can be used for automatically controlling fermentation culture media, supplementary material sterilization, semi-finished products and finished product sterilization in the biopharmaceutical industry, the biochemical industry, the food industry and the like, but also can be used for automatically controlling the inactivation of cultures such as genetically engineered bacteria, pathogenic microorganisms, animal cells, viruses and the like.
The embodiments described above are only preferred embodiments of the invention and are not exhaustive of the possible implementations of the invention. Any obvious modifications to the above would be obvious to those of ordinary skill in the art, but would not bring the invention so modified beyond the spirit and scope of the present invention.
Claims (9)
1. A continuous sterilization automation control system, comprising: a controller (14) and a temperature control unit electrically connected with the controller (14), and introducing equivalent sterilization time mathematical models at different temperatures, and determining the optimal sterilization time according to the sterilization temperature reached by steam pressure by programming, calculating and executing programs;
the controller (14) is used for signal acquisition, conversion, calculation and program execution, and displaying a graph and an execution signal of sterilization process data, and the temperature control unit is mainly used for feeding back the variable frequency regulation of material flow, and is assisted by the regulation of a regulating valve to automatically control the material temperature;
the temperature control unit includes: a flow sensor (6), a temperature sensor (20), a second material pressure sensor (24), a steam pressure sensor (28), a sterile discharging regulating valve (35) and a frequency converter (16);
the flow sensor (6) is arranged on a pipeline of a preheating pipeline feed inlet (121) of the heat exchange heat retainer (1), is used for measuring the material flow and sends a measuring signal to the controller (14);
the temperature sensor (20) is arranged on a heat-insulation pipeline feeding port (131) pipeline or a heat-insulation pipeline discharging port (132) pipeline of the heat-exchange heat retainer (1), is used for measuring the sterilization temperature and sends a measuring signal to the controller (14);
the second material pressure sensor (24) is arranged on a pipeline between a preheating pipeline discharge port (122) of the heat exchange heat retainer (1) and a feed port of the injection pump (26) and is used for detecting the pressure of a discharge port of the booster pump (22) and sending a measurement signal to the controller (14), and the controller (14) performs frequency conversion control when the booster pump (22) is in overpressure;
the steam pressure sensor (28) is arranged on a steam pipeline between the steam pressure reducing valve (31) and the injection pump (26) and used for detecting steam pressure and sending a measuring signal to the controller (14), the controller (14) calculates an expected sterilization temperature to be reached according to the pressure signal to serve as a set point temperature for sterilization temperature control, calculates sterilization time accordingly, determines the flow rate required by the material feeding pump (4), and implements frequency conversion control of the rotating speed of the booster pump (22) or adjustment control of the sterile discharging adjusting valve (35);
the sterile discharge regulating valve (35) is arranged on a pipeline of a discharge port (132) of a heat-insulation pipeline of the heat-exchange warmer (1), and the frequency converter (16) is arranged on a power supply input pipeline of a motor of the booster pump (22); the aseptic discharging adjusting valve (35) and the frequency converter (16) are used for adjusting the flow of materials, so that the sterilization steam pressure, the sterilization temperature and the corresponding sterilization time are matched, and stable sterilization temperature control is implemented.
2. The continuous sterilization automation control system according to claim 1, further comprising a line cleaning control unit for line high temperature cleaning, said line cleaning control unit being electrically connected with said controller (14); the line cleaning control unit includes: a saturated hot water tank liquid level sensor (9), a saturated hot water tank pressure sensor (11), a saturated hot water tank exhaust valve (12) and a second steering valve (36);
the saturated hot water tank liquid level sensor (9) is arranged inside the saturated hot water tank (8) and is used for detecting the liquid level of the saturated hot water tank (8) and sending a measurement signal to the controller (14) to implement automatic water supply;
the saturated hot water tank pressure sensor (11) is arranged at an exhaust port of the saturated hot water tank (8) and is used for detecting the internal pressure of the saturated hot water tank (8), sending a measurement signal to the controller (14) and implementing the internal pressure control of the saturated hot water tank (8);
the exhaust valve (12) of the saturated hot water tank is arranged at the exhaust port of the saturated hot water tank (8) and is used for adjusting the internal pressure of the saturated hot water tank (8) so as to control the temperature of a cleaning agent in the saturated hot water tank (8);
the second steering valve (36) is arranged on a pipeline of a heat preservation pipeline discharge port (132) of the heat exchange warmer (1) and is used for heating of a cleaning agent, sterile discharging and pipeline circulating cleaning.
3. The continuous sterilization automation control system according to claim 2, further comprising a cleaning agent dwell control unit for aseptic cleaning agent dwell, electrically connected to said controller (14); the cleaning agent pressure maintaining control unit comprises a steam bypass valve (29) and a first steam valve (32);
the steam bypass valve (29) is arranged at a steam inlet of the injection pump (26) and is used for controlling the steam air inflow, and the controller (14) maintains the pressure of the sterile cleaning agent in the whole system equipment and pipeline through the intermittent switch of the steam bypass valve (29);
the first steam valve (32) is arranged on one side of an air inlet of the steam pressure reducing valve (31) and used for closing air inlet of the steam pressure reducing valve (31) when the system is switched to a sterile cleaning agent pressure maintaining state.
4. The continuous sterilization automation control system according to claim 3, further comprising an auxiliary functional unit for exhausting air in a pipeline, said auxiliary functional unit being electrically connected with said controller (14); the auxiliary function unit includes: the system comprises a first material pressure sensor (3), a first material return valve (21), a second material return valve (23) and a distribution station blow-down valve (33);
the first material pressure sensor (3) is arranged on a pipeline between the discharge port of the material mixing pump (4) and the feed port (121) of the preheating pipeline of the heat exchange unit of the heat exchange warmer (1) and is used for detecting the pressure of the discharge port of the material mixing pump (4), sending a measurement signal to the controller (14) and implementing the on-off control of the first material reflux valve (21);
the first material reflux valve (21) is arranged on a pipeline of a preheating pipeline discharge port (122) of the heat exchange heat retainer (1) and is used for discharging gas in the pipeline;
the second material reflux valve (23) is arranged on a discharge port pipeline of the booster pump (22) and used for discharging gas in the pipeline;
the distribution station blow-down valve (33) is arranged on a discharge port pipeline of the sterile material distribution station (34) and used for discharging residual materials in the cleaning process.
5. The continuous sterilization automation control system of claim 4, further comprising: the transfer tank liquid level sensor (19), the transfer tank liquid level sensor (19) is used for detecting the liquid level of the transfer tank (5); the first material pressure sensor (3), the flow sensor (6), the saturated hot water tank liquid level sensor (9), the saturated hot water tank pressure sensor (11), the transfer tank liquid level sensor (19), the temperature sensor (20), the second material pressure sensor (24) and the steam pressure sensor (28) all include a transmitter module.
6. The continuous sterilization automation control system according to claim 5, characterized in that the controller (14) comprises a Programmable Logic Controller (PLC) and a touch screen, the touch screen is used for setting operation process parameters, the PLC receives the parameters of the touch screen and performs automatic control according to the parameters, and the touch screen is in communication connection with the PLC.
7. The continuous sterilization automation control system according to claim 6, further comprising an alarm for emitting an audible and visual alarm signal, said alarm being electrically connected to the controller (14).
8. The continuous sterilization automation control system according to claim 7, further comprising a control cabinet (15), wherein the controller (14) and the frequency converter (16) are both disposed inside the control cabinet (15).
9. The continuous sterilization automation control system according to claim 8, further comprising a soft water storage tank bottom valve (18), wherein the soft water storage tank bottom valve (18) is used for supplementing cleaning agent to the transfer tank (5) according to the liquid level information fed back by the transfer tank liquid level sensor (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010401335.XA CN111643702B (en) | 2020-05-13 | 2020-05-13 | Automatic control system for continuous sterilization |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010401335.XA CN111643702B (en) | 2020-05-13 | 2020-05-13 | Automatic control system for continuous sterilization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111643702A CN111643702A (en) | 2020-09-11 |
| CN111643702B true CN111643702B (en) | 2021-12-21 |
Family
ID=72342371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010401335.XA Active CN111643702B (en) | 2020-05-13 | 2020-05-13 | Automatic control system for continuous sterilization |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111643702B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112322478A (en) * | 2020-10-21 | 2021-02-05 | 南京延长反应技术研究院有限公司 | Erythromycin processing system and erythromycin processing method |
| CN112300919A (en) * | 2020-10-21 | 2021-02-02 | 南京延长反应技术研究院有限公司 | Micro-interface fermentation system and fermentation method thereof |
| CN112301084A (en) * | 2020-10-21 | 2021-02-02 | 南京延长反应技术研究院有限公司 | Penicillin refining system and method |
| CN112322477A (en) * | 2020-10-21 | 2021-02-05 | 南京延长反应技术研究院有限公司 | Fermentation system and fermentation method thereof |
| CN112506158A (en) * | 2020-12-14 | 2021-03-16 | 云南煜锜环保科技有限公司 | Automatic mud phosphorus distillation temperature control system |
| CN113115887A (en) * | 2021-05-21 | 2021-07-16 | 昂磐智能装备(山东)有限公司 | Energy-saving sterilization unit and use method |
| CN114410458B (en) * | 2022-03-30 | 2022-07-12 | 江苏中有信科技有限公司 | Pharmacy fermentation cylinder and fermentation control system |
| CN114868799B (en) * | 2022-06-06 | 2023-06-13 | 上海斯太堡实业有限公司 | Pasteurization system |
| CN116036320A (en) * | 2022-12-01 | 2023-05-02 | 椰枫堂（广州）生物科技有限公司 | Ultra-high temperature instantaneous sterilization equipment |
| CN117356671B (en) * | 2023-12-07 | 2024-02-02 | 北京雁栖月盛斋清真食品有限公司 | Sterilization tank and sterilization method |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202909140U (en) * | 2012-11-20 | 2013-05-01 | 徐亲民 | Frequency-conversion-controlled energy-saving continuous sterilization system |
| CN103894359A (en) * | 2012-12-28 | 2014-07-02 | 上海宝钢工业技术服务有限公司 | Washing device for bearing blocks of continuous casting sectioned rollers of steel mills |
| CN205431930U (en) * | 2016-02-02 | 2016-08-10 | 弥勒市轩和机械设备安装有限公司 | Steam sterilization system based on PLC control |
| EP3088862A3 (en) * | 2015-04-30 | 2016-11-16 | Spirax-Sarco Limited | Apparatus and method for determining an amount of non-condensable gas |
| CN107648623A (en) * | 2017-06-12 | 2018-02-02 | 北京中鼎恒业科技股份有限公司 | Biopharmaceutical production processes continuous sterilization automatic control system and its technological process |
| CN109762736A (en) * | 2019-03-21 | 2019-05-17 | 石家庄吉瑞节能技术有限公司 | Liquefying starchiness raw material-saccharification-bactericidal unit |
| CN209829675U (en) * | 2019-03-08 | 2019-12-24 | 广西梧州制药（集团）股份有限公司 | Circulating cleaning equipment of freeze dryer |
-
2020
- 2020-05-13 CN CN202010401335.XA patent/CN111643702B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202909140U (en) * | 2012-11-20 | 2013-05-01 | 徐亲民 | Frequency-conversion-controlled energy-saving continuous sterilization system |
| CN103894359A (en) * | 2012-12-28 | 2014-07-02 | 上海宝钢工业技术服务有限公司 | Washing device for bearing blocks of continuous casting sectioned rollers of steel mills |
| EP3088862A3 (en) * | 2015-04-30 | 2016-11-16 | Spirax-Sarco Limited | Apparatus and method for determining an amount of non-condensable gas |
| CN205431930U (en) * | 2016-02-02 | 2016-08-10 | 弥勒市轩和机械设备安装有限公司 | Steam sterilization system based on PLC control |
| CN107648623A (en) * | 2017-06-12 | 2018-02-02 | 北京中鼎恒业科技股份有限公司 | Biopharmaceutical production processes continuous sterilization automatic control system and its technological process |
| CN209829675U (en) * | 2019-03-08 | 2019-12-24 | 广西梧州制药（集团）股份有限公司 | Circulating cleaning equipment of freeze dryer |
| CN109762736A (en) * | 2019-03-21 | 2019-05-17 | 石家庄吉瑞节能技术有限公司 | Liquefying starchiness raw material-saccharification-bactericidal unit |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111643702A (en) | 2020-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111643702B (en) | Automatic control system for continuous sterilization | |
| CN110656043A (en) | Microbial fermentation tank for producing liquid feed additive | |
| CN109568612B (en) | Continuous sterilization system and method for fermentation medium containing starch | |
| CN206675745U (en) | A kind of efficient quick bactericidal unit of Plant Tissue Breeding utensil | |
| CN207276611U (en) | A kind of methanol effective sterilizing system of high density fermentation | |
| CN210394377U (en) | Anaerobe culture system | |
| CN205907158U (en) | Mud waste liquid pyrohydrolysis equipment | |
| CN105368708A (en) | Horizontal solid fermentation system | |
| CN210586330U (en) | Kitchen waste wet-heat hydrolysis unit and treatment equipment | |
| CN209722163U (en) | Low-temperature heating system for cultivation | |
| CN209352882U (en) | A kind of low energy consumption constant temperature pickle fermentation system | |
| CN112608833A (en) | Material heat exchange system and method for fermentation reaction | |
| CN217997194U (en) | Fermentation device | |
| CN216663021U (en) | Movable microbial fermentation device for environmental remediation | |
| CN209113895U (en) | Fermentation defoaming agent add-on system | |
| CN203794900U (en) | Automatic-control solid bacterium strain fermentation room | |
| CN214854138U (en) | Constant-temperature hot water circulation system for removing fishy smell of soybeans | |
| CN219342133U (en) | Water elimination system without superheated water tank | |
| CN211584375U (en) | Antibiotic production is moved kind pipeline water and is disappeared device | |
| CN111184882A (en) | High-temperature sterilization system | |
| CN111728026A (en) | Ultrasonic double-set coil pipe milk sterilization system | |
| CN219480942U (en) | Continuous elimination system | |
| CN213182456U (en) | Constant-temperature heating system for food | |
| CN220877311U (en) | Empty system of eliminating of fermentation tube way | |
| CN114085764A (en) | Movable microbial fermentation system and method for environmental remediation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |