CN111617317A - 一种生物组织的交联固定方法 - Google Patents
一种生物组织的交联固定方法 Download PDFInfo
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- CN111617317A CN111617317A CN202010278276.1A CN202010278276A CN111617317A CN 111617317 A CN111617317 A CN 111617317A CN 202010278276 A CN202010278276 A CN 202010278276A CN 111617317 A CN111617317 A CN 111617317A
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Links
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- 238000000034 method Methods 0.000 title claims abstract description 27
- 210000001519 tissue Anatomy 0.000 claims abstract description 59
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 27
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims abstract description 11
- 210000003516 pericardium Anatomy 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- 125000003277 amino group Chemical group 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
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- 239000005046 Chlorosilane Substances 0.000 claims description 4
- 125000003172 aldehyde group Chemical group 0.000 claims description 4
- KOPOQZFJUQMUML-UHFFFAOYSA-N chlorosilane Chemical compound Cl[SiH3] KOPOQZFJUQMUML-UHFFFAOYSA-N 0.000 claims description 4
- PZPGRFITIJYNEJ-UHFFFAOYSA-N disilane Chemical compound [SiH3][SiH3] PZPGRFITIJYNEJ-UHFFFAOYSA-N 0.000 claims description 4
- CWAFVXWRGIEBPL-UHFFFAOYSA-N ethoxysilane Chemical compound CCO[SiH3] CWAFVXWRGIEBPL-UHFFFAOYSA-N 0.000 claims description 4
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 claims description 4
- ARYZCSRUUPFYMY-UHFFFAOYSA-N methoxysilane Chemical compound CO[SiH3] ARYZCSRUUPFYMY-UHFFFAOYSA-N 0.000 claims description 4
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- 239000000243 solution Substances 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
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- 239000008055 phosphate buffer solution Substances 0.000 description 9
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- 238000001727 in vivo Methods 0.000 description 7
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 6
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 6
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- 239000012620 biological material Substances 0.000 description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000001575 pathological effect Effects 0.000 description 3
- 150000008442 polyphenolic compounds Chemical class 0.000 description 3
- 235000013824 polyphenols Nutrition 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
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- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
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- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
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- 238000002354 inductively-coupled plasma atomic emission spectroscopy Methods 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920002414 procyanidin Polymers 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
样品编号 | GPTMS浓度(%) | 钙元素含量(μg/mg) |
实施例2 | 1.0 | 2.1±0.7 |
实施例3 | 2.0 | 3.8±1.0 |
实施例4 | 4.0 | 2.5±0.8 |
戊二醛交联对照组 | - | 107±9.3 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202010278276.1A CN111617317B (zh) | 2020-04-10 | 2020-04-10 | 一种生物组织的交联固定方法 |
Applications Claiming Priority (1)
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CN202010278276.1A CN111617317B (zh) | 2020-04-10 | 2020-04-10 | 一种生物组织的交联固定方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111617317A true CN111617317A (zh) | 2020-09-04 |
CN111617317B CN111617317B (zh) | 2021-11-23 |
Family
ID=72267212
Family Applications (1)
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CN202010278276.1A Active CN111617317B (zh) | 2020-04-10 | 2020-04-10 | 一种生物组织的交联固定方法 |
Country Status (1)
Country | Link |
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CN (1) | CN111617317B (zh) |
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CN101461957A (zh) * | 2007-12-19 | 2009-06-24 | 天津大学 | 有机硅交联的聚乙烯醇涂膜剂和制备方法及应用 |
CN101541354A (zh) * | 2006-10-10 | 2009-09-23 | 西洛诺瓦生物科学公司 | 含聚磷氮烯的生物人工心瓣膜 |
CN101658485A (zh) * | 2009-09-10 | 2010-03-03 | 东华大学 | 具有持久广谱抗菌性能的纳米杂化水凝胶及其制备方法 |
EP2857047A1 (en) * | 2012-06-01 | 2015-04-08 | Universitat Politècnica de València | Polymer/ceramic hybrid material |
CN105412984A (zh) * | 2015-12-18 | 2016-03-23 | 华东理工大学 | 一种负载蛋白的3d组织工程支架及其制备方法 |
CN105664245A (zh) * | 2016-02-18 | 2016-06-15 | 深圳市第二人民医院 | 一种可注射型超分子水凝胶及其制备方法 |
JP2016158692A (ja) * | 2015-02-27 | 2016-09-05 | 国立研究開発法人物質・材料研究機構 | 骨補填剤、その製造方法及びその使用方法 |
CN107998453A (zh) * | 2017-12-12 | 2018-05-08 | 中山大学附属第医院 | 一种表面改性的脱细胞基质及其改性方法 |
US20180282699A1 (en) * | 2017-03-30 | 2018-10-04 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
CN109963646A (zh) * | 2016-09-23 | 2019-07-02 | 格林塞尔研究有限公司 | 用于化学固定的、定制的溶胶-凝胶衍生的基质 |
CN110152065A (zh) * | 2019-06-04 | 2019-08-23 | 四川大学 | 一种仿生微纳叠层疏水生物瓣膜及其制备方法 |
CN110507847A (zh) * | 2019-09-04 | 2019-11-29 | 中国科学院海洋研究所 | 一种用于创伤修复的有机-无机杂化敷料及其制备方法和应用 |
-
2020
- 2020-04-10 CN CN202010278276.1A patent/CN111617317B/zh active Active
Patent Citations (12)
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CN101541354A (zh) * | 2006-10-10 | 2009-09-23 | 西洛诺瓦生物科学公司 | 含聚磷氮烯的生物人工心瓣膜 |
CN101461957A (zh) * | 2007-12-19 | 2009-06-24 | 天津大学 | 有机硅交联的聚乙烯醇涂膜剂和制备方法及应用 |
CN101658485A (zh) * | 2009-09-10 | 2010-03-03 | 东华大学 | 具有持久广谱抗菌性能的纳米杂化水凝胶及其制备方法 |
EP2857047A1 (en) * | 2012-06-01 | 2015-04-08 | Universitat Politècnica de València | Polymer/ceramic hybrid material |
JP2016158692A (ja) * | 2015-02-27 | 2016-09-05 | 国立研究開発法人物質・材料研究機構 | 骨補填剤、その製造方法及びその使用方法 |
CN105412984A (zh) * | 2015-12-18 | 2016-03-23 | 华东理工大学 | 一种负载蛋白的3d组织工程支架及其制备方法 |
CN105664245A (zh) * | 2016-02-18 | 2016-06-15 | 深圳市第二人民医院 | 一种可注射型超分子水凝胶及其制备方法 |
CN109963646A (zh) * | 2016-09-23 | 2019-07-02 | 格林塞尔研究有限公司 | 用于化学固定的、定制的溶胶-凝胶衍生的基质 |
US20180282699A1 (en) * | 2017-03-30 | 2018-10-04 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
CN107998453A (zh) * | 2017-12-12 | 2018-05-08 | 中山大学附属第医院 | 一种表面改性的脱细胞基质及其改性方法 |
CN110152065A (zh) * | 2019-06-04 | 2019-08-23 | 四川大学 | 一种仿生微纳叠层疏水生物瓣膜及其制备方法 |
CN110507847A (zh) * | 2019-09-04 | 2019-11-29 | 中国科学院海洋研究所 | 一种用于创伤修复的有机-无机杂化敷料及其制备方法和应用 |
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Publication number | Publication date |
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CN111617317B (zh) | 2021-11-23 |
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